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Our Science – Gattinoni Website

Luca Gattinoni, M.D.

Selected Publications

1)  Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, Roychoudhuri R, Palmer DC, Muranski P, Karoly ED, Mohney RP, Klebanoff CA, Lal A, Finkel T, Restifo NP, Gattinoni L.
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.
J. Clin. Invest. 123: 4479-4488, 2013.
[Journal]
2)  Dudda JC, Salaun B, Ji Y, Palmer DC, Monnot GC, Merck E, Boudousquie C, Utzschneider DT, Escobar TM, Perret R, Muljo SA, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo NP, Held W, Gattinoni L, Romero P.
MicroRNA-155 Is Required for Effector CD8(+) T Cell Responses to Virus Infection and Cancer.
Immunity. 38: 742-53, 2013.
[Journal]
3)  Ji Y, Pos Z, Rao M, Klebanoff CA, Yu Z, Sukumar M, Reger RN, Palmer DC, Borman ZA, Muranski P, Wang E, Schrump DS, Marincola FM, Restifo NP, Gattinoni L.
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8(+) T cells.
Nat. Immunol. 12: 1230-7, 2011.
[Journal]
4)  Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, Roederer M, Restifo NP.
A human memory T cell subset with stem cell-like properties.
Nat. Med. 17: 1290-7, 2011.
[Journal]
5)  Gattinoni L, Zhong XS, Palmer DC, Ji Y, Hinrichs CS, Yu Z, Wrzesinski C, Boni A, Cassard L, Garvin LM, Paulos CM, Muranski P, Restifo NP.
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.
Nat. Med. 15: 808-13, 2009.
[Journal]
6)  Restifo NP, Gattinoni L.
Lineage relationship of effector and memory T cells.
Curr. Opin. Immunol. 25: 556-63, 2013.
[Journal]
7)  Thaventhiran JE, Fearon DT, Gattinoni L.
Transcriptional regulation of effector and memory CD8(+) T cell fates.
Curr. Opin. Immunol. 25: 321-8, 2013.
[Journal]
8)  Gattinoni L, Klebanoff CA, Restifo NP.
Paths to stemness: building the ultimate antitumour T cell.
Nat. Rev. Cancer. 12: 671-84, 2012.
[Journal]
9)  Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP.
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.
Nature. 498: 506-10, 2013.
[Journal]
10)  Gattinoni L, Klebanoff CA, Palmer DC, Wrzesinski C, Kerstann K, Yu Z, Finkelstein SE, Theoret MR, Rosenberg SA, Restifo NP.
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
J. Clin. Invest. 115: 1616-26, 2005.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 8/11/2014.