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Our Science – Grewal Website

Shiv Grewal, Ph.D.

Selected Publications

1)  Anver S, Roguev A, Zofall M, Krogan NJ, Grewal SI, Harmer SL.
Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
EMBO Rep. 15: 894-902, 2014.
2)  Aygün O, Mehta S, Grewal SI.
HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin.
Nat. Struct. Mol. Biol. 20: 547-54, 2013.
3)  Guo Y, Park JM, Cui B, Humes E, Gangadharan S, Hung S, FitzGerald PC, Hoe KL, Grewal SI, Craig NL, Levin HL.
Integration profiling of gene function with dense maps of transposon integration.
Genetics. 195: 599-609, 2013.
4)  Lee NN, Chalamcharla VR, Reyes-Turcu F, Mehta S, Zofall M, Balachandran V, Dhakshnamoorthy J, Taneja N, Yamanaka S, Zhou M, Grewal SI.
Mtr4-like Protein Coordinates Nuclear RNA Processing for Heterochromatin Assembly and for Telomere Maintenance.
Cell. 155: 1061-74, 2013.
5)  Yamanaka S, Mehta S, Reyes-Turcu FE, Zhuang F, Fuchs RT, Rong Y, Robb GB, Grewal SI.
RNAi triggered by specialized machinery silences developmental genes and retrotransposons.
Nature. 493: 557-60, 2013.
6)  Lorenz DR, Mikheyeva IV, Johansen P, Meyer L, Berg A, Grewal SI, Cam HP.
CENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons.
Mol. Cell. Biol. 32: 4215-25, 2012.
7)  Reyes-Turcu FE, Grewal SI.
Different means, same end-heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast.
Curr. Opin. Genet. Dev. 22: 156-63, 2012.
8)  Shim YS, Choi Y, Kang K, Cho K, Oh S, Lee J, Grewal SI, Lee D.
Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin.
EMBO J. 31: 4375-87, 2012.
9)  Zofall M, Yamanaka S, Reyes-Turcu FE, Zhang K, Rubin C, Grewal SI.
RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation.
Science. 335: 96-100, 2012.
10)  Matsuda E, Sugioka-Sugiyama R, Mizuguchi T, Mehta S, Cui B, Grewal SI.
A homolog of male sex-determining factor SRY cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination.
Proc. Natl. Acad. Sci. U.S.A. 108: 18754-9, 2011.
11)  Yamane K, Mizuguchi T, Cui B, Zofall M, Noma K, Grewal SI.
Asf1/HIRA Facilitate Global Histone Deacetylation and Associate with HP1 to Promote Nucleosome Occupancy at Heterochromatic Loci.
Mol. Cell. 41: 56-66, 2011.
12)  Zhang K, Fischer T, Porter RL, Dhakshnamoorthy J, Zofall M, Zhou M, Veenstra T, Grewal SI.
Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.
Science. 331: 1624-7, 2011.
13)  Reyes-Turcu FE, Zhang K, Zofall M, Chen E, Grewal SI.
Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.
Nature Struct Mol Biol. 18:: 1132-8, 2011.
14)  Aygun O, Grewal S.
The assembly and functions of heterochromatin in fission yeast genome.
Cold Spring Harb. Symp. Quant. Biol. 75: 259-267, 2011.
15)  Aygün O, Grewal SI.
Assembly and functions of heterochromatin in the fission yeast genome.
Cold Spring Harb. Symp. Quant. Biol. 75: 259-67, 2010.
16)  Iwasaki O, Tanaka A, Tanizawa H, Grewal SI, Noma K.
Centromeric localization of dispersed Pol III genes in fission yeast.
Mol. Biol. Cell. 21: 254-65, 2010.
17)  Grewal SI.
RNAi-dependent formation of heterochromatin and its diverse functions.
Curr. Opin. Genet. Dev. 20: 134-41, 2010.
18)  Ni T, Tu K, Wang Z, Song S, Wu H, Xie B, Scott KC, Grewal SI, Gao Y, Zhu J.
The prevalence and regulation of antisense transcripts in Schizosaccharomyces pombe.
PLoS ONE. 5: e15271, 2010.
19)  Fischer T, Cui B, Dhakshnamoorthy J, Zhou M, Rubin C, Zofall M, Veenstra TD, Grewal SI.
Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.
Proc. Natl. Acad. Sci. U.S.A. 2009.
20)  Zofall M, Fischer T, Zhang K, Zhou M, Cui B, Veenstra TD, Grewal SI.
Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs.
Nature. [Epub ahead of print], 2009.
21)  Cam HP, Chen ES, Grewal SI.
Transcriptional scaffolds for heterochromatin assembly.
Cell. 136: 610-4, 2009.
22)  Chen ES, Zhang K, Nicolas E, Cam HP, Zofall M, Grewal SI.
Cell cycle control of centromeric repeat transcription and heterochromatin assembly.
Nature. 451: 734-7, 2008.
Full Text Article. [Journal]
23)  Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park H, Hayles J, Hoe K, Kim D, Ideker T, Grewal SI, Weissman JS, Krogan NJ.
Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast.
Science. [Epub ahead of print], 2008.
24)  Cam HP, Noma K, Ebina H, Levin HL, Grewal SI.
Host genome surveillance for retrotransposons by transposon-derived proteins.
Nature. 451: 431-436, 2008.
Full Text Article. [Journal]
25)  Zhang K, Mosch K, Fischle W, Grewal SI.
Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.
Nat. Struct. Mol. Biol. 15: 381-8, 2008.
26)  Cromie GA, Hyppa RW, Cam HP, Farah JA, Grewal SI, Smith GR.
A discrete class of intergenic DNA dictates meiotic DNA break hotspots in fission yeast.
PLoS Genet. 3: e141, 2007.
27)  Nicolas E, Yamada T, Cam HP, Fitzgerald PC, Kobayashi R, Grewal SI.
Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection.
Nat. Struct. Mol. Biol. 14: 372-80, 2007.
28)  Grewal SI, Jia S.
Heterochromatin revisited.
Nat. Rev. Genet. 8: 35-46, 2007.
29)  Zofall M, Grewal SI.
HULC, a Histone H2B Ubiquitinating Complex, Modulates Heterochromatin Independent of Histone Methylation in Fission Yeast.
J. Biol. Chem. 282: 14065-72, 2007.
30)  Sugiyama T, Cam HP, Sugiyama R, Noma K, Zofall M, Kobayashi R, Grewal SI.
SHREC, an Effector Complex for Heterochromatic Transcriptional Silencing.
Cell. 128: 491-504, 2007.
31)  Grewal SI, Elgin SC.
Transcription and RNA interference in the formation of heterochromatin.
Nature. 447: 399-406, 2007.
32)  Noma K, Cam HP, Maraia RJ, Grewal SI.
A role for TFIIIC transcription factor complex in genome organization.
Cell. 125: 859-72, 2006.
33)  Zofall M, Grewal SI.
RNAi-mediated heterochromatin assembly in fission yeast.
Cold Spring Harb. Symp. Quant. Biol. 71: 487-96, 2006.
34)  Zofall M, Grewal SI.
Swi6/HP1 Recruits a JmjC Domain Protein to Facilitate Transcription of Heterochromatic Repeats.
Mol. Cell. 22: 681-92, 2006.
35)  Cam HP, Sugiyama T, Chen ES, Chen X, FitzGerald PC, Grewal SI.
Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome.
Nat Genet. 37: 809-19, 2005.
36)  Sugiyama T, Cam H, Verdel A, Moazed D, Grewal SI.
RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.
Proc Natl Acad Sci U S A. 102: 152-157, 2005.
37)  Yamada T, Fischle W, Sugiyama T, Allis CD, Grewal SI.
The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast.
Mol Cell. 20: 173-85, 2005.
38)  Jia S, Kobayashi R, Grewal SI.
Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin.
Nat Cell Biol. 7: 1007-13, 2005.
39)  Lee BS, Grewal SI, Klar AJ.
Biochemical Interactions between Proteins and mat1 cis-Acting Sequences Required for Imprinting in Fission Yeast.
Mol Cell Biol. 24: 9813-22, 2004.
40)  Jia S, Yamada T, Grewal SI.
Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombination.
Cell. 119: 469-80, 2004.
41)  Grewal SI, Rice JC.
Regulation of heterochromatin by histone methylation and small RNAs.
Curr Opin Cell Biol. 16: 230-8, 2004.
42)  Noma K, Sugiyama T, Cam H, Verdel A, Zofall M, Jia S, Moazed D, Grewal SI.
RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing.
Nat Genet. 36: 1174-80, 2004.
43)  Cam H, Grewal S.
RNA interference and epigenetic control of heterochromatin assembly in fission yeast.
Cold Spring Harb. Symp. Quant. Biol. 69: 419-427, 2004.
44)  Jia S, Noma K, Grewal SI.
RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins.
Science. 304: 1971-6, 2004.
45)  Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D.
RNAi-mediated targeting of heterochromatin by the RITS complex.
Science. 303: 672-6, 2004.
46)  Ayoub N, Noma K, Isaac S, Kahan T, Grewal SI, Cohen A.
A novel jmjC domain protein modulates heterochromatization in fission yeast.
Mol Cell Biol. 23: 4356-4370, 2003.
47)  Nakayama J, Xiao G, Noma K, Malikzay A, Bjerling P, Ekwall K, Kobayashi R, Grewal SI.
Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity.
EMBO J. 22: 2776-87, 2003.
48)  Grewal SI, Moazed D.
Heterochromatin and epigenetic control of gene expression.
Science. 301: 798-802, 2003.
49)  Elgin SC, Grewal SI.
Heterochromatin: silence is golden.
Curr Biol. 13: R895-8, 2003.
50)  Hall IM, Noma K, Grewal SI.
RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast.
Proc Natl Acad Sci U S A. 100: 193-8, 2003.
51)  Shankaranarayana GD, Motamedi MR, Moazed D, Grewal SI.
Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast.
Curr Biol. 13: 1240-1246, 2003.
52)  Hall IM, Shankaranarayana GD, Noma K, Ayoub N, Cohen A, Grewal SI.
Establishment and maintenance of a heterochromatin domain.
Science. 297: 2232-7, 2002.
53)  Bjerling P, Silverstein RA, Thon G, Caudy A, Grewal S, Ekwall K.
Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity.
Mol Cell Biol. 22: 2170-81, 2002.
54)  Grewal SI, Elgin SC.
Heterochromatin: new possibilities for the inheritance of structure.
Curr Opin Genet Dev. 12: 178-187, 2002.
55)  Noma K, Grewal SI.
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast.
Proc. Natl. Acad. Sci. U.S.A. 99 Suppl 4: 16438-45, 2002.
56)  Noma K, Grewal S.
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast.
Proc Natl Acad Sci. 99 (Suppl): 16438-164445, 2002.
57)  Nonaka N, Kitajima T, Yokobayashi S, Xiao G, Yamamoto M, Grewal SI, Watanabe Y.
Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast.
Nat Cell Biol. 4: 89-93, 2002.
58)  Volpe TA, Kidner C, Hall IM, Teng G, Grewal SI, Martienssen RA.
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.
Science. 297: 1833-1837, 2002.
59)  Min J, Zhang X, Cheng X, Grewal SI, Xu RM.
Structure of the SET domain histone lysine methyltransferase Clr4.
Nat Struct Biol. 9: 828-32, 2002.
60)  Nakayama Ji , Allshire RC, Klar AJ, Grewal SI.
A role for DNA polymerase alpha in epigenetic control of transcriptional silencing in fission yeast.
EMBO J. 20: 2857-2866, 2001.
61)  Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SI.
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly.
Science. 292: 110-113, 2001.
62)  Noma K , Allis CD, Grewal SI.
Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries.
Science. 293: 1150-1155, 2001.
63)  Nakayama J, Klar AJ, Grewal SI.
A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis.
Cell. 101: 307-317, 2000.
64)  Grewal SI.
Transcriptional silencing in fission yeast.
J Cell Physiol. 184: 311-318, 2000.
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This page was last updated on 8/15/2014.