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Our Science – Boyer Website

Paul L. Boyer, Ph.D.

Selected Publications

1)  Ivetac A, Swift SE, Boyer PL, Diaz A, Naughton J, Young JA, Hughes SH, McCammon JA.
Discovery of Novel Inhibitors of HIV-1 Reverse Transcriptase Through Virtual Screening of Experimental and Theoretical Ensembles.
Chem Biol Drug Des. 2014.
2)  Dunn LL, Boyer PL, Clark PK, Hughes SH.
Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease.
Virology. 444: 241-9, 2013.
3)  Boyer PL, Clark PK, Hughes SH.
HIV-1 and HIV-2 reverse transcriptases: different mechanisms of resistance to nucleoside reverse transcriptase inhibitors.
J. Virol. 86: 5885-94, 2012.
4)  Vu BC, Boyer PL, Siddiqui MA, Marquez VE, Hughes SH.
4"-C-methyl-2"-deoxyadenosine and 4"-C-ethyl-2"-deoxyadenosine inhibit HIV-1 replication.
Antimicrob. Agents Chemother. 55: 2379-89, 2011.
5)  Lee EG, Roy J, Jackson D, Clark P, Boyer PL, Hughes SH, Linial ML.
Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation.
J. Virol. 85: 1655-61, 2011.
6)  Tu X, Das K, Han Q, Bauman JD, Clark AD, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E.
Structural basis of HIV-1 resistance to AZT by excision.
Nat. Struct. Mol. Biol. 17: 1202-9, 2010.
7)  Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, Tuske S, Tu X, Clark AD, Boyer PL, Hou X, Gaffney BL, Jones RA, Miller MD, Hughes SH, Arnold E.
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
J. Biol. Chem. 284: 35092-100, 2009.
8)  Boyer PL, Vu BC, Ambrose Z, Julias JG, Warnecke S, Liao C, Meier C, Marquez VE, Hughes SH.
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.
J. Med. Chem. 52: 5356-64, 2009.
9)  Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E.
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.
Nucleic Acids Res. 36: 5083-92, 2008.
10)  Delviks-Frankenberry KA, Nikolenko GN, Boyer PL, Hughes SH, Coffin JM, Jere A, Pathak VK.
HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision.
Proc. Natl. Acad. Sci. U.S.A. 105: 10943-8, 2008.
11)  Saneyoshi H, Vu BC, Hughes SH, Boyer PL, Sarafianos SG, Marquez VE.
Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.
Nucleic Acids Symp Ser (Oxf). 623-4, 2008.
12)  Gao L, Hanson MN, Balakrishnan M, Boyer PL, Roques BP, Hughes SH, Kim B, Bambara RA.
Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.
J. Biol. Chem. 283: 9196-205, 2008.
13)  Comin MJ, Vu BC, Boyer PL, Liao C, Hughes SH, Marquez VE.
D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.
ChemMedChem. 3: 1129-34, 2008.
14)  Das K, Sarafianos SG, Clark AD, Boyer PL, Hughes SH, Arnold E.
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.
J. Mol. Biol. 365: 77-89, 2007.
15)  Boyer PL, Stenbak CR, Hoberman D, Linial ML, Hughes SH.
In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT.
Virology. 367: 253-64, 2007.
16)  Boyer PL, Julias JG, Ambrose Z, Siddiqui MA, Marquez VE, Hughes SH.
The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants.
J. Mol. Biol. 371: 873-82, 2007.
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This page was last updated on 3/12/2014.