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Our Science – Boyer Website

Paul L. Boyer, Ph.D.

Selected Publications

1)  Ivetac A, Swift SE, Boyer PL, Diaz A, Naughton J, Young JA, Hughes SH, McCammon JA.
Discovery of Novel Inhibitors of HIV-1 Reverse Transcriptase Through Virtual Screening of Experimental and Theoretical Ensembles.
Chem Biol Drug Des. 83: 521-31, 2014.
2)  Dunn LL, Boyer PL, Clark PK, Hughes SH.
Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease.
Virology. 444: 241-9, 2013.
3)  Boyer PL, Clark PK, Hughes SH.
HIV-1 and HIV-2 reverse transcriptases: different mechanisms of resistance to nucleoside reverse transcriptase inhibitors.
J. Virol. 86: 5885-94, 2012.
4)  Vu BC, Boyer PL, Siddiqui MA, Marquez VE, Hughes SH.
4"-C-methyl-2"-deoxyadenosine and 4"-C-ethyl-2"-deoxyadenosine inhibit HIV-1 replication.
Antimicrob. Agents Chemother. 55: 2379-89, 2011.
5)  Lee EG, Roy J, Jackson D, Clark P, Boyer PL, Hughes SH, Linial ML.
Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation.
J. Virol. 85: 1655-61, 2011.
6)  Tu X, Das K, Han Q, Bauman JD, Clark AD, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E.
Structural basis of HIV-1 resistance to AZT by excision.
Nat. Struct. Mol. Biol. 17: 1202-9, 2010.
7)  Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, Tuske S, Tu X, Clark AD, Boyer PL, Hou X, Gaffney BL, Jones RA, Miller MD, Hughes SH, Arnold E.
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
J. Biol. Chem. 284: 35092-100, 2009.
8)  Boyer PL, Vu BC, Ambrose Z, Julias JG, Warnecke S, Liao C, Meier C, Marquez VE, Hughes SH.
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.
J. Med. Chem. 52: 5356-64, 2009.
9)  Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E.
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.
Nucleic Acids Res. 36: 5083-92, 2008.
10)  Delviks-Frankenberry KA, Nikolenko GN, Boyer PL, Hughes SH, Coffin JM, Jere A, Pathak VK.
HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision.
Proc. Natl. Acad. Sci. U.S.A. 105: 10943-8, 2008.
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This page was last updated on 4/28/2014.