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Our Science – O'Keefe Website

Barry R. O'Keefe, Ph.D.

Selected Publications

1)  Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, O'Keefe BR.
Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.
PLoS ONE. 8: e64449, 2013.
[Journal]
2)  Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.
Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors.
J. Med. Chem. 55: 7297, 2012.
[Journal]
3)  Alexandre KB, Gray ES, Lambson BE, Moore PL, Choge IA, Mlisana K, Karim SS, McMahon J, O'Keefe B, Chikwamba R, Morris L.
Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin.
Virology. 402: 187-96, 2010.
[Journal]
4)  Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J.
The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites.
Eukaryotic Cell. 9: 1661-8, 2010.
[Journal]
5)  Maderia M, Wu J, Bax A, Shenoy S, O'Keefe B, Marquez VE, Barchi JJ.
Engineering DNA topology with locked nucleosides: a structural study.
Nucleosides Nucleotides Nucleic Acids. 24: 687-90, 2005.
[Journal]
6)  O'Keefe BR, Beecher C.
Isolation and Characterization of S-Adenosyl-L-Methionine:Tetrahydroberberine-cis-N-Methyltransferase from Suspension Cultures of Sanguinaria canadensis L.
Plant Physiol. 105: 395-403, 1994.
[Journal]
7)  Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingam A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.
Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
J. Med. Chem. 55: 4457-78, 2012.
[Journal]
8)  Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.
The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells.
Virology. 423: 175-86, 2012.
[Journal]
9)  Alexandre KB, Gray ES, Pantophlet R, Moore PL, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.
Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site.
J. Virol. 85: 9039-50, 2011.
[Journal]
10)  Kouokam JC, Huskens D, Schols D, Johannemann A, Riedell SK, Walter W, Walker JM, Matoba N, O'Keefe BR, Palmer KE.
Investigation of griffithsin"s interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate.
PLoS ONE. 6: e22635, 2011.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 9/4/2013.