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Our Science – Beutler Website

John A. Beutler, Ph.D.

Selected Publications

1)  Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee M, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L.
Englerin A Stimulates PKCtheta to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality.
Cancer Cell. 23: 228-37, 2013.
2)  Turbyville TJ, Gürsel DB, Tuskan RG, Walrath JC, Lipschultz CA, Lockett SJ, Wiemer DF, Beutler JA, Reilly KM.
Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.
Mol. Cancer Ther. 9: 1234-43, 2010.
3)  Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.
Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.
Org. Lett. 11: 57-60, 2009.
4)  Boyd MR, Farina C, Belfiore P, Gagliardi S, Kim JW, Hayakawa Y, Beutler JA, McKee TC, Bowman BJ, Bowman EJ.
Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases.
J Pharmacol Exp Ther. 297: 114-20, 2001.
5)  Beutler JA, Shoemaker RH, Johnson T, Boyd MR.
Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.
J. Nat. Prod. 61: 1509-12, 1998.
6)  Devkota KP, Wilson JA, Henrich CJ, McMahon JB, Reilly KM, Beutler JA.
Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells.
Phytochem Lett. 7: 42-45, 2014.
7)  Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes A, Baldwin GS, Nikfarjam M, He H.
Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.
Cancer Lett. 346: 264-272, 2014.
8)  Lockett S, Cui C, Gudia P, Nandy K, Mimaki Y, Fuchs P, Jaja J, Reilly K, Beutler J, Turbyville T.
Quantitative analysic of F-actin redistribution in astrocytoma cells treated with candidate pharmaceuticals.
Cytometry A. 85: 512-521, 2014.
9)  Hartung AM, Beutler JA, Navarro HA, Wiemer DF, Neighbors JD.
Stilbenes as kappa-selective, non-nitrogenous opioid receptor antagonists.
J. Nat. Prod. 77: 311-9, 2014.
10)  Kodet JG, Beutler JA, Wiemer DF.
Synthesis and structure activity relationships of schweinfurthin indoles.
Bioorg. Med. Chem. 22: 2542-2552, 2014.
Click Here to View Expanded Bibliography.

This page was last updated on 7/11/2014.