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Our Science – Gustafson Website

Kirk R. Gustafson, Ph.D.

Selected Publications

1)  Oku N, Takada K, Fuller RW, Wilson JA, Peach ML, Pannell LK, McMahon JB, Gustafson KR.
Isolation, structural elucidation, and absolute stereochemistry of enigmazole A, a cytotoxic phosphomacrolide from the Papua New Guinea marine sponge Cinachyrella enigmatica.
J. Am. Chem. Soc. 132: 10278-85, 2010.
2)  Versiani MA, Diyabalanage T, Ratnayake R, Henrich CJ, Bates SE, McMahon JB, Gustafson KR.
Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2.
J. Nat. Prod. 74: 262-6, 2011.
3)  Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR.
Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.
Bioorg. Med. Chem. Lett. 21: 4397-9, 2011.
4)  Grkovic T, Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, Gustafson KR.
Cryptocaryols A-H, alpha-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4.
J. Nat. Prod. 74: 1015-20, 2011.
5)  Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brune B.
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase beta-TrCP1.
PLoS ONE. 7: e46567, 2012.
6)  Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauß TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.
Biochem. Pharmacol. 88: 313-21, 2014.
7)  Gustafson KR.
Fattorusso E, Gerwick WH, Taglialatela-Scafati O, eds.
NMR Methods for Stereochemical Assignments. In: Handbook of Marine Natural Products.
Heidelberg: Springer Reference; 2012. p. 547-570 [Book Chapter]
8)  Diyabalanage T, Ratnayake R, Bokesch HR, Ransom TT, Henrich CJ, Beutler JA, McMahon JB, Gustafson KR.
Flabelliferins A and B, Sesterterpenoids from the South Pacific Sponge Carteriospongia flabellifera.
J Nat Prod. 75: 1490-4, 2012.
9)  McKee TC, Rabe D, Bokesch HR, Grkovic T, Whitson EL, Diyabalanage T, Van Wyk AW, Marcum SR, Gardella RS, Gustafson KR, Linehan WM, McMahon JB, Bottaro DP.
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
J. Nat. Prod. 75: 1632-6, 2012.
10)  Sando L, Henriques ST, Foley F, Simonsen SM, Daly NL, Hall KN, Gustafson KR, Aguilar MI, Craik DJ.
A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor.
Chembiochem. 12: 2456-62, 2011.
11)  Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, McMahon JB, Gustafson KR, McKee TC.
Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression.
Bioorg. Med. Chem. Lett. 21: 2113-5, 2011.
12)  Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.
Bioorg. Med. Chem. Lett. 20: 3848-50, 2010.
13)  Takada K, Imamura N, Gustafson KR, Henrich CJ.
Synthesis and structure-activity relationship of botryllamides that block the ABCG2 multidrug transporter.
Bioorg. Med. Chem. Lett. 20: 1330-3, 2010.
14)  Kang MI, Henrich CJ, Bokesch HR, Gustafson KR, McMahon JB, Baker AR, Young MR, Colburn NH.
A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits".
Mol. Cancer Ther. 8: 571-81, 2009.
15)  Henrich CJ, Robey RW, Takada K, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, McMahon JB, Gustafson KR.
Botryllamides: natural product inhibitors of ABCG2.
ACS Chem. Biol. 4: 637-47, 2009.
16)  Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.
Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.
Org. Lett. 11: 57-60, 2009.
17)  Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.
J. Nat. Prod. 71: 47-52, 2008.
18)  Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.
Cyclotides as natural anti-HIV agents.
Biopolymers. 90: 51-60, 2008.
19)  Mayer AM, Gustafson KR.
Marine pharmacology in 2005-2006: antitumour and cytotoxic compounds.
Eur. J. Cancer. 44: 2357-87, 2008.
20)  Smee DF, Bailey KW, Wong MH, O'Keefe BR, Gustafson KR, Mishin VP, Gubareva LV.
Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.
Antiviral Res. 80: 266-71, 2008.
21)  Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB.
An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.
J. Nat. Prod. 70: 1647-9, 2007.
22)  Henrich CJ, Goncharova EI, Wilson JA, Gardella RS, Johnson TR, McMahon JB, Takada K, Bokesch HR, Gustafson KR.
Natural products active in aberrant c-Kit signaling.
Chem Biol Drug Des. 69: 321-30, 2007.
23)  Takada K, Choi BW, Rashid MA, Gamble WR, Cardellina JH, Van QN, Lloyd JR, McMahon JB, Gustafson KR.
Structural assignment of poecillastrins B and C, macrolide lactams from the deep-water Caribbean sponge Poecillastra species.
J. Nat. Prod. 70: 428-31, 2007.
24)  Helle F, Wychowski C, Vu-Dac N, Gustafson KR, Voisset C, Dubuisson J.
Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans.
J. Biol. Chem. 281: 25177-83, 2006.
25)  Mayer AM, Gustafson KR.
Marine pharmacology in 2003-2004: anti-tumour and cytotoxic compounds.
Eur. J. Cancer. 42: 2241-70, 2006.
26)  Oku N, Krishnamoorthy R, Benson AG, Ferguson RL, Lipton MA, Phillips LR, Gustafson KR, McMahon JB.
Complete stereochemistry of neamphamide A and absolute configuration of the beta-methoxytyrosine residue in papuamide B.
J Org Chem. 70: 6842-7, 2005.
27)  Chen B, Colgrave ML, Daly NL, Rosengren KJ, Gustafson KR, Craik DJ.
Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.
J Biol Chem. 280: 22395-405, 2005.
28)  Koltay A, Daly N, Gustafson K, Craik D.
Structure of Circulin B and Implications for Antimicrobial Activity of the Cyclotides.
Int J Pept Res Ther. 11: 51-58, 2005.
29)  Gustafson KR, McKee TC, Bokesch HR.
Anti-HIV cyclotides.
Curr Protein Pept Sci. 5: 331-40, 2004.
30)  Gustafson K, Oku N, Milanowski D.
Antiviral Marine Natural Products.
Curr Antiinfect Agents Med Chem. 3: 233-249, 2004.
31)  Milanowski DJ, Gustafson KR, Kelley JA, McMahon JB.
Caulibugulones A-F, Novel Cytotoxic Isoquinoline Quinones and Iminoquinones from the Marine Bryozoan Caulibugula intermis.
J Nat Prod. 67: 70-3, 2004.
32)  Hess S, Gustafson KR, Milanowski DJ, Alvira E, Lipton MA, Pannell LK.
Chirality determination of unusual amino acids using precolumn derivatization and liquid chromatography-electrospray ionization mass spectrometry.
J Chromatogr A. 1035: 211-9, 2004.
33)  Tsai CC, Emau P, Jiang Y, Agy MB, Shattock RJ, Schmidt A, Morton WR, Gustafson KR, Boyd MR.
Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models.
AIDS Res Hum Retroviruses. 20: 11-8, 2004.
34)  Milanowski DJ, Rashid MA, Gustafson KR, O'Keefe BR, Nawrocki JP, Pannell LK, Boyd MR.
Cyclonellin, a new cyclic octapeptide from the marine sponge Axinella carteri.
J Nat Prod. 67: 441-4, 2004.
35)  Milanowski DJ, Gustafson KR, Rashid MA, Pannell LK, McMahon JB, Boyd MR.
Gymnangiamide, a cytotoxic pentapeptide from the marine hydroid Gymnangium regae.
J Org Chem. 69: 3036-42, 2004.
36)  Mayer AM, Gustafson KR.
Marine pharmacology in 2001-2: antitumour and cytotoxic compounds.
Eur J Cancer. 40: 2676-704, 2004.
37)  Oku N, Gustafson KR, Cartner LK, Wilson JA, Shigematsu N, Hess S, Pannell LK, Boyd MR, McMahon JB.
Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi.
J Nat Prod. 67: 1407-11, 2004.
38)  Barry DG, Daly NL, Bokesch HR, Gustafson KR, Craik DJ.
Solution Structure of the Cyclotide Palicourein: Implications for the Development of a Pharmaceutical Framework.
Structure. 12: 85-94, 2004.
39)  Lopanik N, Gustafson KR, Lindquist N.
Structure of bryostatin 20: a symbiont-produced chemical defense for larvae of the host bryozoan, Bugula neritina.
J Nat Prod. 67: 1412-4, 2004.
40)  Daly NL, Gustafson KR, Craik DJ.
The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1.
FEBS Lett. 574: 69-72, 2004.
41)  Tsai CC, Emau P, Jiang Y, Tian B, Morton WR, Gustafson KR, Boyd MR.
Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques.
AIDS Res Hum Retroviruses. 19: 535-41, 2003.
42)  Bowman EJ, Gustafson KR, Bowman BJ, Boyd MR.
Identification of a New Chondropsin Class of Antitumor Compound the Selectively Inhibits V-ATPases.
J Biol Chem. 278: 44147-44152, 2003.
43)  Mayer AM, Gustafson KR.
Marine pharmacology in 2000: antitumor and cytotoxic compounds.
Int J Cancer. 105: 291-9, 2003.
44)  Erickson KL, Gustason KR, Milanowski DJ, Pannell LK, Boyd MR.
Myriastramides A-C, New Modified Cyclic Peptides from the Philippines Marine Sponge Myriastra clavosa.
Tetrahedron. 59: 10231-10238, 2003.
45)  O'Keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Mori T, Blakeslee D, Buckheit R, Boyd MR.
Potent Anti-influenza Activity and Viral Hemagutinin Interactions of Cyanovirin-N.
Antimicrob Agents Chemother. 47: 2518-2525, 2003.
46)  Rashid MA, Gustafson KR, Crouch RC, Groweiss A, Pannell LK, Van QN, Boyd MR.
Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin a, a new antitumor macrolide lactam from the sponge poecillastra species.
Org Lett. 4: 3293-6, 2002.
47)  Erickson KL, Gustafson KR, Pannell LK, Beutler JA, Boyd MR.
New dimeric macrolide glycosides from the marine sponge Myriastra clavosa.
J Nat Prod. 65: 1303-6, 2002.
48)  Charan RD, McKee TC, Gustafson KR, Pannell LK, Boyd MR.
Thorectandramine, a Novel beta-Carboline Alkaloid from the Marine Sponge Thorectandra sp.
Tetrahedron Letters. 43: 5201-5204, 2002.
49)  Rashid MA, Gustafson KR, Boyd MR.
A new isoquinoline alkaloid from the marine sponge Haliclona species.
J Nat Prod. 64: 1249-50, 2001.
50)  Rashid MA, Gustafson KR, Cardellina JH, Boyd MR.
Absolute stereochemistry and anti-HIV activity of minquartynoic acid, a polyacetylene from Ochanostachys amentacea.
Nat Prod Lett. 15: 21-6, 2001.
51)  Rashid MA, Cantrell CL, Gustafson KR, Boyd MR.
Chondropsin D, a new 37-membered-ring macrolide lactam from the marine sponge Chondropsis species.
J Nat Prod. 64: 1341-4, 2001.
52)  Rashid MA, Gustafson KR, Cartner LK, Shigematsu N, Pannell LK, Boyd MR.
Microspinosamide, a new HIV-inhibitory cyclic depsipeptide from the marine sponge Sidonops microspinosa.
J Nat Prod. 64: 117-21, 2001.
53)  Rashid MA, Gustafson KR, Boyd MR.
New chonropsin macrolide lactams from marine sponges in the genus Ircinia.
Tetrahedron Lett. 42: 1623-1626, 2001.
54)  Rashid MA, Gustafson KR, Boyd MR.
New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde.
J Nat Prod. 64: 1454-6, 2001.
55)  Rashid MA, Gustafson KR, Cartner LK, Pannell LK, Boyd MR.
New nitrogenous constituents from the South African marine ascidian Pseudodistoma sp.
Tetrahedron Lett. 57: 5751-5755, 2001.
56)  Rashid MA, Gustafson KR, Cardellina II JH, Boyd MR.
A new podophyllotoxin derivative from Bridelia ferruginea.
Nat. Prod. Lett. 14: 285-292, 2000.
57)  Cantrell CL, Gustafson KR, Cecere MR, Pannell LK, Boyd MR.
Chondropsins A and B: Novel tumor cell growth-inhibitory macrolide lactams from the marine sponge Chondropsis sp.
J. Am. Chem. Soc. 122: 8825-8829, 2000.
58)  Rashid MA, Gustafson KR, Boswell JL, Boyd MR.
Haligramides A and B, two new cytotoxic hexapeptides from the marine sponge Haliclona nigra.
J Nat Prod. 63: 956-9, 2000.
59)  Rashid MA, Gustafson KR, Boyd MR.
HIV-inhibitory cembrane derivatives from a Philippines collection of the soft coral Lobophytum species.
J Nat Prod. 63: 531-3, 2000.
60)  Biswas MH, Amin AR, Islam MA, Hasan CM, Gustafson KR, Boyd MR, Pannell LK, Rashid MA.
Monocillinols A and B, novel fungal metabolites from a Monocillium sp.
Tetrahedron Lett. 41: 7177-7180, 2000.
61)  Gustafson KR, Walton LK, Sowder RC, Johnson DG, Pannell LK, Cardellina JH, Boyd MR.
New circulin macrocyclic polypeptides from Chassalia parvifolia.
J Nat Prod. 63: 176-8, 2000.
62)  Rashid MA, Gustafson KR, Boyd MR.
Pellynol I, a new cytotoxic polyacetylene from the sponge Pellina sp.
Nat. Prod. Lett. 14: 387-392, 2000.
63)  Davies-Coleman MT, Gustafson KR, Cantrell CL, Beutler JA, Pannell LK, Boyd MR.
Stolonic acids A and B, new cytotoxic cyclic peroxides from an Indian Ocean ascidian Stolonica species.
J Nat Prod. 63: 1411-3, 2000.
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This page was last updated on 7/7/2014.