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Our Science – Ward Website

Yvona Ward, Ph.D.

Selected Publications

1)  Ward Y, Gupta S, Jensen P, Wartmann M, Davis RJ, Kelly K.
Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1.
Nature. 367: 651-4, 1994.
2)  Ward Y, Wang W, Woodhouse E, Linnoila I, Liotta L, Kelly K.
Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways.
Mol. Cell. Biol. 21: 5958-69, 2001.
3)  Wang T, Ward Y, Tian L, Lake R, Guedez L, Stetler-Stevenson WG, Kelly K.
CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells.
Blood. 105: 2836-44, 2005.
4)  Ward Y, Lake R, Yin JJ, Heger CD, Raffeld M, Goldsmith PK, Merino M, Kelly K.
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.
Cancer Res. 71: 7301-11, 2011.
5)  Ward Y, Lake R, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng S, Santoro M, Garcia-Rostan G, Kelly K.
CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model.
Oncogene. 32: 2726-38, 2013.
6)  Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG.
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Nat. Cell Biol. 16: 55-65, 2014.
7)  Basseville A, Tamaki A, Ieranò C, Trostel S, Ward Y, Robey RW, Hegde RS, Bates SE.
Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter.
Cancer Res. 72: 3642-51, 2012.
8)  Casey OM, Fang L, Hynes PG, Abou-Kheir WG, Martin PL, Tillman HS, Petrovics G, Awwad HO, Ward Y, Lake R, Zhang L, Kelly K.
TMPRSS2- driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation.
PLoS ONE. 7: e41668, 2012.
9)  Meany HJ, Sackett DL, Maris JM, Ward Y, Krivoshik A, Cohn SL, Steinberg SM, Balis FM, Fox E.
Clinical outcome in children with recurrent neuroblastoma treated with ABT-751 and effect of ABT-751 on proliferation of neuroblastoma cell lines and on tubulin polymerization in vitro.
Pediatr Blood Cancer. 54: 47-54, 2010.
10)  Polgar O, Ierano C, Tamaki A, Stanley B, Ward Y, Xia D, Tarasova N, Robey RW, Bates SE.
Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.
Biochemistry. 49: 2235-45, 2010.
11)  Romanova LY, Holmes G, Bahte SK, Kovalchuk AL, Nelson PJ, Ward Y, Gueler F, Mushinski JF.
Phosphorylation of paxillin at threonine 538 by PKCdelta regulates LFA1-mediated adhesion of lymphoid cells.
J. Cell. Sci. 123: 1567-77, 2010.
12)  Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE.
Arginine 383 is a crucial residue in ABCG2 biogenesis.
Biochim. Biophys. Acta. 1788: 1434-43, 2009.
13)  Borojerdi JP, Ming J, Cooch C, Ward Y, Semino-Mora C, Yu M, Braun HM, Taylor BJ, Poirier MC, Olivero OA.
Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells.
Mutat. Res. 665: 67-74, 2009.
14)  Yu M, Ward Y, Poirier MC, Olivero OA.
Centrosome amplification induced by the antiretroviral nucleoside reverse transcriptase inhibitors lamivudine, stavudine, and didanosine.
Environ. Mol. Mutagen. 2009.
15)  Aprelikova O, Pandolfi S, Tackett S, Ferreira M, Salnikow K, Ward Y, Risinger JI, Barrett JC, Niederhuber J.
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.
Cancer Res. 69: 616-24, 2009.
16)  Ha VL, Bharti S, Inoue H, Vass WC, Campa F, Nie Z, de Gramont A, Ward Y, Randazzo PA.
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
J. Biol. Chem. 283: 14915-26, 2008.
17)  Poruchynsky MS, Sackett DL, Robey RW, Ward Y, Annunziata C, Fojo T.
Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.
Cell Cycle. 7: 940-9, 2008.
18)  Oberst MD, Beberman SJ, Zhao L, Yin JJ, Ward Y, Kelly K.
TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.
BMC Cancer. 8: 189, 2008.
19)  Wang T, Tian L, Haino M, Gao JL, Lake R, Ward Y, Wang H, Siebenlist U, Murphy PM, Kelly K.
Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97.
Infect. Immun. 75: 1144-53, 2007.
20)  Ibrahim R, Frederickson H, Parr A, Ward Y, Moncur J, Khleif SN.
Expression of FasL in squamous cell carcinomas of the cervix and cervical intraepithelial neoplasia and its role in tumor escape mechanism.
Cancer. 106: 1065-77, 2006.
21)  Polgar O, Ozvegy-Laczka C, Robey RW, Morisaki K, Okada M, Tamaki A, Koblos G, Elkind NB, Ward Y, Dean M, Sarkadi B, Bates SE.
Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization.
Biochemistry. 45: 5251-60, 2006.
22)  Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA.
Structure-function studies of the G-domain from human gem, a novel small G-protein.
FEBS Lett. 580: 5959-64, 2006.
23)  Kuznetsova SA, Issa P, Perruccio EM, Zeng B, Sipes JM, Ward Y, Seyfried NT, Fielder HL, Day AJ, Wight TN, Roberts DD.
Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells.
J. Cell. Sci. 119: 4499-509, 2006.
24)  Ward Y, Kelly K.
Gem protein signaling and regulation.
Meth. Enzymol. 407: 468-83, 2005.
25)  Vance BA, Harley PH, Backlund PS, Ward Y, Phelps TL, Gress RE.
Human CD69 associates with an N-terminal fragment of calreticulin at the cell surface.
Arch. Biochem. Biophys. 438: 11-20, 2005.
26)  Chen Y, Knezevic V, Ervin V, Hutson R, Ward Y, Mackem S.
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.
Development. 131: 2339-47, 2004.
27)  Ward Y, Spinelli B, Quon MJ, Chen H, Ikeda SR, Kelly K.
Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.
Mol. Cell. Biol. 24: 651-61, 2004.
28)  Oh J, Seo DW, Diaz T, Wei B, Ward Y, Ray JM, Morioka Y, Shi S, Kitayama H, Takahashi C, Noda M, Stetler-Stevenson WG.
Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK.
Cancer Res. 64: 9062-9, 2004.
29)  Zhang H, Merchant MS, Chua KS, Khanna C, Helman LJ, Telford B, Ward Y, Summers J, Toretsky J, Thomas EK, June CH, Mackall CL.
Tumor expression of 4-1BB ligand sustains tumor lytic T cells.
Cancer Biol. Ther. 2: 579-86, 2003.
30)  Topalian SL, Gonzales MI, Ward Y, Wang X, Wang RF.
Revelation of a cryptic major histocompatibility complex class II-restricted tumor epitope in a novel RNA-processing enzyme.
Cancer Res. 62: 5505-9, 2002.
31)  Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K.
The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.
J. Cell Biol. 157: 291-302, 2002.
32)  Poruchynsky MS, Giannakakou P, Ward Y, Bulinski JC, Telford WG, Robey RW, Fojo T.
Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.
Biochem. Pharmacol. 62: 1469-80, 2001.
33)  Topalian SL, Kaneko S, Gonzales MI, Bond GL, Ward Y, Manley JL.
Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors.
Mol. Cell. Biol. 21: 5614-23, 2001.
34)  Leone A, Mitsiades N, Ward Y, Spinelli B, Poulaki V, Tsokos M, Kelly K.
The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma.
Oncogene. 20: 3217-25, 2001.
35)  Martínez A, Kapas S, Miller MJ, Ward Y, Cuttitta F.
Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells.
Endocrinology. 141: 406-11, 2000.
36)  Giannakakou P, Sackett DL, Ward Y, Webster KR, Blagosklonny MV, Fojo T.
p53 is associated with cellular microtubules and is transported to the nucleus by dynein.
Nat. Cell Biol. 2: 709-17, 2000.
37)  Vance BA, Bennett MJ, Ward Y, Gress RG, Kearse KP.
Distinct but dispensable N-glycosylation of human CD69 proteins.
Arch. Biochem. Biophys. 368: 214-20, 1999.
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This page was last updated on 7/22/2014.