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Our Science – Choksi Website

Swati S. Choksi, Ph.D.

Selected Publications

1)  Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG.
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Nat. Cell Biol. 16: 55-65, 2014.
[Journal]
2)  Zhang Y, Choksi S, Liu ZG.
Butylated hydroxyanisole blocks the occurrence of tumor associated macrophages in tobacco smoke carcinogen-induced lung tumorigenesis.
Cancers (Basel). 5: 1643-54, 2013.
[Journal]
3)  Zhang Y, Choksi S, Chen K, Pobezinskaya Y, Linnoila I, Liu ZG.
ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages.
Cell Res. 23: 898-914, 2013.
[Journal]
4)  Zhang Y, Morgan MJ, Chen K, Choksi S, Liu ZG.
Induction of autophagy is essential for monocyte-macrophage differentiation.
Blood. 119: 2895-905, 2012.
[Journal]
5)  Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG.
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.
Proc. Natl. Acad. Sci. U.S.A. 109: 5322-7, 2012.
[Journal]
6)  Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, Morgan M, Li T, Jitkaew S, Cao X, Kim YS, Kim HS, Levitt P, Shih G, Birre M, Deng CX, Liu ZG.
A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2.
Mol. Cell. 42: 597-609, 2011.
[Journal]
7)  Pobezinskaya YL, Choksi S, Morgan MJ, Cao X, Liu ZG.
The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling.
J. Immunol. 186: 5212-6, 2011.
[Journal]
8)  Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS, Liu ZG.
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation.
Nat. Immunol. 11: 799-805, 2010.
[Journal]
9)  Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, Liu C, Liu Z.
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors.
Nat. Immunol. 9: 1047-54, 2008.
[Journal]
10)  Kim YS, Morgan MJ, Choksi S, Liu ZG.
TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.
Mol. Cell. 26: 675-87, 2007.
[Journal]
11)  Hur GM, Kim YS, Won M, Choksi S, Liu ZG.
The death domain kinase RIP has an important role in DNA damage-induced, p53-independent cell death.
J. Biol. Chem. 281: 25011-7, 2006.
[Journal]
12)  Choksi S, Kim JC, Whitaker-Menezes D, Murphy GF, Friedman TM, Korngold R.
A CD8 DE loop peptide analog prevents graft-versus-host disease in a multiple minor histocompatibility antigen-mismatched bone marrow transplantation model.
Biol. Blood Marrow Transplant. 10: 669-80, 2004.
[Journal]
13)  Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG.
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death.
Mol. Cell. Biol. 24: 5914-22, 2004.
[Journal]
14)  Lin Y, Choksi S, Shen HM, Yang QF, Hur GM, Kim YS, Tran JH, Nedospasov SA, Liu ZG.
Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation.
J. Biol. Chem. 279: 10822-8, 2004.
[Journal]
15)  Edling AE, Choksi S, Huang Z, Korngold R.
An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis.
J. Autoimmun. 18: 169-79, 2002.
[Journal]
16)  Edling AE, Choksi S, Huang Z, Korngold R.
Effect of a cyclic heptapeptide based on the human CD4 domain 1 CC" loop region on murine experimental allergic encephalomyelitis: inhibition of both primary and secondary responses.
J. Neuroimmunol. 112: 115-28, 2001.
[Journal]
17)  Wang JL, Zhang ZJ, Choksi S, Shan S, Lu Z, Croce CM, Alnemri ES, Korngold R, Huang Z.
Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells.
Cancer Res. 60: 1498-502, 2000.
[Journal]
18)  Choksi S, Jameson BA, Korngold R.
A structure-based approach to designing synthetic CD8alpha peptides that can inhibit cytotoxic T-lymphocyte responses.
Nat. Med. 4: 309-14, 1998.
[Journal]
19)  Koch U, Choksi S, Marcucci L, Korngold R.
A synthetic CD4-CDR3 peptide analog enhances skin allograft survival across a MHC class II barrier.
J. Immunol. 161: 421-9, 1998.
[Journal]
20)  Li S, Choksi S, Shan S, Hu X, Gao J, Korngold R, Huang Z.
Identification of the CD8 DE loop as a surface functional epitope. Implications for major histocompatibility complex class I binding and CD8 inhibitor design.
J. Biol. Chem. 273: 16442-5, 1998.
[Journal]
21)  Li S, Gao J, Satoh T, Friedman TM, Edling AE, Koch U, Choksi S, Han X, Korngold R, Huang Z.
A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics.
Proc. Natl. Acad. Sci. U.S.A. 94: 73-8, 1997.
[Journal]
22)  Satoh T, Aramini JM, Li S, Friedman TM, Gao J, Edling AE, Townsend R, Koch U, Choksi S, Germann MW, Korngold R, Huang Z.
Bioactive peptide design based on protein surface epitopes. A cyclic heptapeptide mimics CD4 domain 1 CC" loop and inhibits CD4 biological function.
J. Biol. Chem. 272: 12175-80, 1997.
[Journal]
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This page was last updated on 4/8/2014.