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Our Science – Zudaire Ubani Website

Enrique Zudaire Ubani, Ph.D.

Selected Publications

1)  Stránecký V, Hoischen A, Hartmannová H, Zaki MS, Chaudhary A, Zudaire E, Nosková L, Barešová V.
Mutations in ANTXR1 Cause GAPO Syndrome.
Am. J. Hum. Genet. 92: 792-9, 2013.
2)  Portal-Nuñez S, Shankavaram UT, Rao M, Datrice N, Atay S, Aparicio M, Camphausen KA, Fernández-Salguero PM, Chang H, Lin P, Schrump DS, Garantziotis S, Cuttitta F, Zudaire E.
Aryl hydrocarbon receptor-induced adrenomedullin mediates cigarette smoke carcinogenicity in humans and mice.
Cancer Res. 72: 5790-800, 2012.
3)  Zudaire E, Gambardella L, Kurcz C, Vermeren S.
A computational tool for quantitative analysis of vascular networks.
PLoS ONE. 6: e27385, 2011.
4)  Collins J, Kurcz C, Lisle C, Liu Y, Zudaire E.
Assessment of vascular network segmentation.
International Journal of Image Processing. 4: 584-599, 2011.
Full Text Article. [Journal]
5)  Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, Croix BS.
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Proceedings of the National Academy of Sciences of the United States of America. 2011.
6)  Lisboa FA, Warren J, Sulkowski G, Aparicio M, David G, Zudaire E, Dveksler GS.
Pregnancy-specific Glycoprotein 1 Induces Endothelial Tubulogenesis through Interaction with Cell Surface Proteoglycans.
J. Biol. Chem. 286: 7577-86, 2011.
7)  Tauler J, Zudaire E, Liu H, Shih J, Mulshine JL.
hnRNP A2/B1 modulates epithelial-mesenchymal transition in lung cancer cell lines.
Cancer Res. 70: 7137-47, 2010.
8)  Gambardella L, Hemberger M, Hughes B, Zudaire E, Andrews S, Vermeren S.
PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.
Sci Signal. 3: ra76, 2010.
9)  El-Chemaly S, Malide D, Zudaire E, Ikeda Y, Weinberg BA, Pacheco-Rodriguez G, Rosas IO, Aparicio M, Ren P, MacDonald SD, Wu HP, Nathan SD, Cuttitta F, McCoy JP, Gochuico BR, Moss J.
Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms.
Proc. Natl. Acad. Sci. U.S.A. 106: 3958-63, 2009.
10)  Fang C, Miguel MA, Avis I, Martinez A, Zudaire E, Cuttitta F.
Non-peptide small molecule regulators of lymphangiogenesis.
Lymphat Res Biol. 7: 189-96, 2009.
11)  Kandalaft LE, Zudaire E, Portal-Núñez S, Cuttitta F, Jakowlew SB.
Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis.
Carcinogenesis. 29: 1282-9, 2008.
12)  Kwon M, Hanna E, Lorang D, He M, Quick JS, Adem A, Stevenson C, Chung JY, Hewitt SM, Zudaire E, Esposito D, Cuttitta F, Libutti SK.
Functional characterization of filamin a interacting protein 1-like, a novel candidate for antivascular cancer therapy.
Cancer Res. 68: 7332-41, 2008.
13)  Sackett DL, Ozbun L, Zudaire E, Wessner L, Chirgwin JM, Cuttitta F, Martínez A.
Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function.
Endocrinology. 149: 2888-98, 2008.
14)  Gonzalez N, Hocart SJ, Portal-Nuñez S, Mantey SA, Nakagawa T, Zudaire E, Coy DH, Jensen RT.
Molecular basis for agonist selectivity and activation of the orphan bombesin receptor subtype 3 receptor.
J. Pharmacol. Exp. Ther. 324: 463-74, 2008.
15)  Garantziotis S, Zudaire E, Trempus CS, Hollingsworth JW, Jiang D, Lancaster LH, Richardson E, Zhuo L, Cuttitta F, Brown KK, Noble PW, Kimata K, Schwartz DA.
Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury.
Am. J. Respir. Crit. Care Med. 178: 939-47, 2008.
16)  Zudaire E, Cuesta N, Murty V, Woodson K, Adams L, Gonzalez N, Martínez A, Narayan G, Kirsch I, Franklin W, Hirsch F, Birrer M, Cuttitta F.
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.
J. Clin. Invest. 118: 640-50, 2008.
17)  Cuesta N, Nhu QM, Zudaire E, Polumuri S, Cuttitta F, Vogel SN.
IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism.
J. Immunol. 178: 3602-11, 2007.
18)  Zudaire E, Martínez A, Garayoa M, Pío R, Kaur G, Woolhiser MR, Metcalfe DD, Hook WA, Siraganian RP, Guise TA, Chirgwin JM, Cuttitta F.
Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis.
Am. J. Pathol. 168: 280-91, 2006.
19)  Zudaire E, Portal-Núñez S, Cuttitta F.
The central role of adrenomedullin in host defense.
J. Leukoc. Biol. 80: 237-44, 2006.
20)  Martínez A, Zudaire E, Julián M, Moody TW, Cuttitta F.
Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo.
Oncogene. 24: 4106-13, 2005.
21)  Avis I, Martínez A, Tauler J, Zudaire E, Mayburd A, Abu-Ghazaleh R, Ondrey F, Mulshine JL.
Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.
Cancer Res. 65: 4181-90, 2005.
22)  Moore DF, Li H, Jeffries N, Wright V, Cooper RA, Elkahloun A, Gelderman MP, Zudaire E, Blevins G, Yu H, Goldin E, Baird AE.
Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: a pilot investigation.
Circulation. 111: 212-21, 2005.
23)  Ajona D, Castaño Z, Garayoa M, Zudaire E, Pajares MJ, Martinez A, Cuttitta F, Montuenga LM, Pio R.
Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement.
Cancer Res. 64: 6310-8, 2004.
24)  Martínez A, Zudaire E, Portal-Núñez S, Guédez L, Libutti SK, Stetler-Stevenson WG, Cuttitta F.
Proadrenomedullin NH2-terminal 20 peptide is a potent angiogenic factor, and its inhibition results in reduction of tumor growth.
Cancer Res. 64: 6489-94, 2004.
25)  Zudaire E, Martínez A, Cuttitta F.
Adrenomedullin and cancer.
Regul. Pept. 112: 175-83, 2003.
26)  Martínez A, Saldise L, Ramírez MJ, Belzunegui S, Zudaire E, Luquin MR, Cuttitta F.
Adrenomedullin expression and function in the rat carotid body.
J. Endocrinol. 176: 95-102, 2003.
27)  Zudaire E, Cuttitta F, Martínez A.
Regulation of pancreatic physiology by adrenomedullin and its binding protein.
Regul. Pept. 112: 121-30, 2003.
28)  Cuttitta F, Pío R, Garayoa M, Zudaire E, Julián M, Elsasser TH, Montuenga LM, Martínez A.
Adrenomedullin functions as an important tumor survival factor in human carcinogenesis.
Microsc. Res. Tech. 57: 110-9, 2002.
29)  Castilla-Cortazar I, Prieto J, Urdaneta E, Pascual M, Nuñez M, Zudaire E, Garcia M, Quiroga J, Santidrian S.
Impaired intestinal sugar transport in cirrhotic rats: correction by low doses of insulin-like growth factor I.
Gastroenterology. 113: 1180-7, 1997.
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This page was last updated on 3/31/2014.