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Our Science – Vocke Website

Cathy D. Vocke, Ph.D.

Selected Publications

1)  Vocke CD, Pozzatti RO, Bostwick DG, Florence CD, Jennings SB, Strup SE, Duray PH, Liotta LA, Emmert-Buck MR, Linehan WM.
Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21.
Cancer Res. 56: 2411-6, 1996.
[Journal]
2)  Vocke CD, Yang Y, Pavlovich CP, Schmidt LS, Nickerson ML, Torres-Cabala CA, Merino MJ, Walther MM, Zbar B, Linehan WM.
High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumors.
J. Natl. Cancer Inst. 97: 931-5, 2005.
[Journal]
3)  Yang Y, Padilla-Nash HM, Vira MA, Abu-Asab MS, Val D, Worrell R, Tsokos M, Merino MJ, Pavlovich CP, Ried T, Linehan WM, Vocke CD.
The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dube gene pathway.
Cancer Genet. Cytogenet. 180: 100-9, 2008.
[Journal]
4)  Benhammou JN, Vocke CD, Santani A, Schmidt LS, Baba M, Seyama K, Wu X, Korolevich S, Nathanson KL, Stolle CA, Linehan WM.
Identification of intragenic deletions and duplication in the FLCN gene in Birt-Hogg-Dubé syndrome.
Genes Chromosomes Cancer. 50: 466-77, 2011.
[Journal]
5)  Ricketts CJ, Shuch B, Vocke CD, Metwalli AR, Bratslavsky G, Middelton L, Yang Y, Wei MH, Pautler SE, Peterson J, Stolle CA, Zbar B, Merino MJ, Schmidt LS, Pinto PA, Srinivasan R, Pacak K, Linehan WM.
Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.
J. Urol. 188: 2063-71, 2012.
[Journal]
6)  Shuch B, Agochukwu N, Ricketts CJ, Vocke CD, Gautam R, Merino MJ, Linehan WM, Srinivasan R.
Vascular endothelial growth factor receptor-targeted therapy in succinate dehydrogenase C kidney cancer.
J Clin Oncol. 2013.
In Press. [Journal]
7)  Shuch B, Ricketts CJ, Vocke CD, Valera VA, Chen CC, Gautam R, Gupta GN, Gomez Macias GS, Merino MJ, Bratslavsky G, Linehan WM.
Adrenal nodular hyperplasia in hereditary leiomyomatosis and renal cell cancer.
J. Urol. 189: 430-5, 2013.
[Journal]
8)  Creighton C, Morgan M, Gunaratne P, Wheeler D, Gibbs R, Robertson A, Chu A, Beroukhim R, et al. .
Comprehensive molecular characterization of clear cell renal cell carcinoma.
Nature. 499: 43-9, 2013.
[Journal]
9)  Farley MN, Schmidt LS, Mester JL, Pena-Llopis S, Pavia-Jimenez A, Christie A, Vocke CD, Ricketts CJ, Peterson J, Middelton L, Kinch L, Grishin N, Merino MJ, Metwalli AR, Xing C, Xie X, Dahia PL, Eng C, Linehan WM, Brugarolas J.
Germline BAP1 mutation predisposes to familial clear-cell renal cell carcinoma.
Mol. Cancer Res. 11: 1061-71, 2013.
[Journal]
10)  Shuch B, Ricketts CJ, Vocke CD, Komiya T, Middelton LA, Kauffman EC, Merino MJ, Metwalli AR, Dennis P, Linehan WM.
Germline PTEN Mutation Cowden Syndrome: An Under-Appreciated Form of Hereditary Kidney Cancer.
J. Urol. 190: 1990-8, 2013.
[Journal]
11)  Sanz-Ortega J, Vocke C, Stratton P, Linehan WM, Merino MJ.
Morphologic and molecular characteristics of uterine leiomyomas in hereditary leiomyomatosis and renal cancer (HLRCC) syndrome.
Am. J. Surg. Pathol. 37: 74-80, 2013.
[Journal]
12)  Yang Y, Valera V, Sourbier C, Vocke CD, Wei M, Pike L, Huang Y, Merino MA, Bratslavsky G, Wu M, Ricketts CJ, Linehan WM.
A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer.
Cancer Genet. 205: 377-90, 2012.
[Journal]
13)  Eisenhofer G, Vocke CD, Elkahloun A, Huynh TT, Prodanov T, Lenders JW, Timmers HJ, Benhammou JN, Linehan WM, Pacak K.
Genetic screening for von Hippel-Lindau gene mutations in non-syndromic pheochromocytoma: low prevalence and false-positives or misdiagnosis indicate a need for caution.
Horm. Metab. Res. 44: 343-8, 2012.
[Journal]
14)  Eisenhofer G, Timmers HJ, Lenders JW, Bornstein SR, Tiebel O, Mannelli M, King KS, Vocke CD, Linehan WM, Bratslavsky G, Pacak K.
Age at diagnosis of pheochromocytoma differs according to catecholamine phenotype and tumor location.
J. Clin. Endocrinol. Metab. 96: 375-84, 2011.
[Journal]
15)  Bratslavsky G, Sanford T, Srinivasan R, Aprelikova O, Liu J, Quezado M, Merino M, Linehan WM.
Differential genetic expression in large versus small clear cell renal cell carcinoma: results from microarray analysis.
J Cancer. 2: 271-9, 2011.
[Journal]
16)  Cherkasova E, Malinzak E, Rao S, Takahashi Y, Senchenko VN, Kudryavtseva AV, Nickerson ML, Merino M, Hong JA, Schrump DS, Srinivasan R, Linehan WM, Tian X, Lerman MI, Childs RW.
Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer.
Oncogene. 30: 4697-706, 2011.
[Journal]
17)  Kearney MF, Lee K, Bagni RK, Wiegand A, Spindler J, Maldarelli F, Pinto PA, Linehan WM, Vocke CD, Delviks-Frankenberry KA, Devere White RW, Del Prete GQ, Mellors JW, Lifson JD, Kewalramani VN, Pathak VK, Coffin JM, Le Grice SF.
Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.
Adv Virol. 2011: 272193, 2011.
[Journal]
18)  Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM.
UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.
Cancer Genet. Cytogenet. 196: 45-55, 2010.
[Journal]
19)  Dhanani N, Vocke C, Bratslavsky G, Linehan WM.
Molecular Genetics in Inherited Renal Cell Carcinoma: Identification of Targets in the Hereditary Syndromes. In: Renal Cell Carcinoma: Molecular Targets and Clinical Applications. Volume Second Edition.
New York: Humana Press; 2009. p. 13-33 [Book Chapter]
20)  Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L.
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.
Mol. Cell. Biol. 29: 4080-90, 2009.
[Journal]
21)  Linehan WM.
Genetic basis of bilateral renal cancer: implications for evaluation and management.
J. Clin. Oncol. 27: 3731-3, 2009.
[Journal]
22)  Linehan WM, Pinto PA, Bratslavsky G, Pfaffenroth E, Merino M, Vocke CD, Toro JR, Bottaro D, Neckers L, Schmidt LS, Srinivasan R.
Hereditary kidney cancer: unique opportunity for disease-based therapy.
Cancer. 115: 2252-61, 2009.
[Journal]
23)  Beroukhim R, Brunet JP, Di Napoli A, Mertz KD, Seeley A, Pires MM, Linhart D, Worrell RA, Moch H, Rubin MA, Sellers WR, Meyerson M, Linehan WM, Kaelin WG, Signoretti S.
Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer Res. 69: 4674-81, 2009.
[Journal]
24)  Stewart L, Glenn GM, Stratton P, Goldstein AM, Merino MJ, Tucker MA, Linehan WM, Toro JR.
Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer.
Arch Dermatol. 144: 1584-92, 2008.
[Journal]
25)  Toro JR, Wei M, Glenn GM, Weinreich M, Toure O, Vocke C, Turner M, Choyke P, Merino MJ, Pinto PA, Steinberg SM, Schmidt LS, Linehan WM.
BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dube syndrome: a new series of 50 families and a review of published reports.
J. Med. Genet. 45: 321-31, 2008.
[Journal]
26)  Linehan WM, Pinto PA, Srinivasan R, Merino M, Choyke P, Choyke L, Coleman J, Toro J, Glenn G, Vocke C, Zbar B, Schmidt LS, Bottaro D, Neckers L.
Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics.
Clin. Cancer Res. 13: 671s-679s, 2007.
[Journal]
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This page was last updated on 7/14/2014.