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Our Science – Garfield Website

Susan H. Garfield, M.S.

Selected Publications

1)  Zhang Y, Calado R, Rao M, Hong JA, Meeker AK, Dumitriu B, Atay S, McCormick PJ, Garfield SH, Wangsa D, Padilla-Nash HM, Burkett S, Zhang M, Kunst TF, Peterson NR, Xi S, Inchauste S, Altorki NK, Casson AG, Beer DG, Harris CC, Ried T, Young NS, Schrump DS.
Telomerase Variant A279T Induces Telomere Dysfunction and Inhibits Non-Canonical Telomerase Activity in Esophageal Carcinomas.
PLoS ONE. 9: e101010, 2014.
2)  Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, Keck GE.
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
ACS Chem. Biol. 8: 767-77, 2013.
3)  Pandey GS, Yanover C, Miller-Jenkins LM, Garfield S, Cole SA, Curran JE, Moses EK, Rydz N, Simhadri V, Kimchi-Sarfaty C, Lillicrap D, Viel KR, Przytycka TM, Pierce GF, Howard TE, Sauna ZE.
Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A.
Nat. Med. 19: 1318-24, 2013.
4)  Xin HW, Ambe CM, Ray S, Kim BK, Koizumi T, Wiegand GW, Hari D, Mullinax JE, Jaiswal KR, Garfield SH, Stojadinovic A, Rudloff U, Thorgeirsson SS, Avital I.
Wnt and the cancer niche: paracrine interactions with gastrointestinal cancer cells undergoing asymmetric cell division.
J Cancer. 4: 447-57, 2013.
5)  Weng MT, Lee JH, Wei SC, Li Q, Shahamatdar S, Hsu D, Schetter AJ, Swatkoski S, Mannan P, Garfield S, Gucek M, Kim MK, Annunziata CM, Creighton CJ, Emanuele MJ, Harris CC, Sheu JC, Giaccone G, Luo J.
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 109: E3659-67, 2012.
6)  Mineo M, Garfield SH, Taverna S, Flugy A, De Leo G, Alessandro R, Kohn EC.
Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion.
Angiogenesis. 15: 33-45, 2012.
7)  Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang J, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM.
Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.
J. Biol. Chem. 287: 13137-58, 2012.
8)  Xin HW, Hari DM, Mullinax JE, Ambe CM, Koizumi T, Ray S, Anderson AJ, Wiegand GW, Garfield SH, Thorgeirsson SS, Avital I.
Tumor-initiating label-retaining cancer cells in human gastrointestinal cancers undergo asymmetric cell division.
Stem Cells. 30: 591-8, 2012.
9)  Shukla S, Fujita K, Xiao Q, Liao Z, Garfield S, Srinivasula SM.
A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface.
Apoptosis. 16: 162-73, 2011.
10)  Hunt RC, Geetha S, Allen CE, Hershko K, Fathke R, Kong PL, Plum E, Struble EB, Soejima K, Friedman S, Garfield S, Balaji S, Kimchi-Sarfaty C.
Detection of a secreted metalloprotease within the nuclei of liver cells.
Mol Biosyst. 7: 2012-8, 2011.
11)  Hari D, Xin H, Jaiswal K, Wiegand G, Kim B, Ambe C, Burka D, Koizumi T, Ray S, Garfield S, Thorgeirsson S, Avital I.
Isolation of Live Label-Retaining Cells and Cells Undergoing Asymmetric Cell Division via Nonrandom Chromosomal Cosegregation from Human Cancers.
Stem Cells Dev. 20: 1649-58, 2011.
12)  Gal N, Kolusheva S, Kedei N, Telek A, Naeem TA, Lewin NE, Lim L, Mannan P, Garfield SH, El Kazzouli S, Sigano DM, Marquez VE, Blumberg PM, Jelinek R.
N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activity.
Chembiochem. 12: 2331-40, 2011.
13)  Motegi S, Garfield S, Feng X, Sárdy M, Udey MC.
Potentiation of platelet-derived growth factor receptor-β signaling mediated by integrin-associated MFG-E8.
Arterioscler. Thromb. Vasc. Biol. 31: 2653-64, 2011.
14)  Kedei N, Lubart E, Lewin NE, Telek A, Lim L, Mannan P, Garfield SH, Kraft MB, Keck GE, Kolusheva S, Jelinek R, Blumberg PM.
Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells.
Chembiochem. 12: 1242-51, 2011.
15)  Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, Blumberg PM.
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.
Biochem. Pharmacol. 81: 1296-308, 2011.
16)  Mendoza A, Hong SH, Osborne T, Khan MA, Campbell K, Briggs J, Eleswarapu A, Buquo L, Ren L, Hewitt SM, Dakir el-H, Garfield S, Walker R, Merlino G, Green JE, Hunter KW, Wakefield LM, Khanna C.
Modeling metastasis biology and therapy in real time in the mouse lung.
J. Clin. Invest. 120: 2979-88, 2010.
17)  Li L, Shukla S, Lee A, Garfield SH, Maloney DJ, Ambudkar SV, Yuspa SH.
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
Cancer Res. 70: 4509-19, 2010.
18)  Kaur S, Martin-Manso G, Pendrak ML, Garfield SH, Isenberg JS, Roberts DD.
Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.
J. Biol. Chem. 285: 38923-32, 2010.
19)  Pu Y, Garfield SH, Kedei N, Blumberg PM.
Characterization of the differential roles of the twin C1a and C1b domains of protein kinase C-delta.
J. Biol. Chem. 284: 1302-12, 2009.
20)  Geetha S, Allen CE, Hunt RC, Plum E, Garfield S, Friedman SL, Soejima K, Sauna ZE, Kimchi-Sarfaty C.
Detection of intracellular ADAMTS13, a secreted zinc-metalloprotease, via flow cytometry.
Cytometry A. 75: 675-81, 2009.
21)  Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y.
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
EMBO J. 28: 3667-80, 2009.
22)  Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Conze D, El-Deiry WS, Schütze S, Srinivasula SM.
CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation.
Curr. Biol. 18: 641-9, 2008.
23)  Liang X, Yin J, Taylor B, Winkovitch SM, Garfield SH, Shen D, Gottesman MM, Aszalos A.
Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines.
Cancer Chemother. Pharmacol. 62: 977-84, 2008.
24)  Chu YW, Schmitz S, Choudhury B, Telford W, Kapoor V, Garfield S, Howe D, Gress RE.
Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion.
Blood. 112: 2836-46, 2008.
25)  Sengupta K, Upender MB, Barenboim-Stapleton L, Nguyen QT, Wincovitch SM, Garfield SH, Difilippantonio MJ, Ried T.
Artificially introduced aneuploid chromosomes assume a conserved position in colon cancer cells.
PLoS ONE. 2: e199, 2007.
26)  Malolanarasimhan K, Kedei N, Sigano DM, Kelley JA, Lai CC, Lewin NE, Surawski RJ, Pavlyukovets VA, Garfield SH, Wincovitch S, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.
J. Med. Chem. 50: 962-78, 2007.
27)  Choi Y, Pu Y, Peach ML, Kang JH, Lewin NE, Sigano DM, Garfield SH, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.
J. Med. Chem. 50: 3465-81, 2007.
28)  Paterson JK, Shukla S, Black CM, Tachiwada T, Garfield S, Wincovitch S, Ernst DN, Agadir A, Li X, Ambudkar SV, Szakacs G, Akiyama S, Gottesman MM.
Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.
Biochemistry. 46: 9443-52, 2007.
29)  Lu G, Chen J, Espinoza LA, Garfield S, Toshiyuki S, Akiko H, Huppler A, Wang QJ.
Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2.
Cell. Signal. 19: 867-79, 2007.
30)  Pu Y, Peach ML, Garfield SH, Wincovitch S, Marquez VE, Blumberg PM.
Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms.
J. Biol. Chem. 281: 33773-88, 2006.
31)  Lazar J, Braun DC, Tóth A, Wang Y, Pearce LV, Pavlyukovets VA, Blumberg PM, Garfield SH, Wincovitch S, Choi HK, Lee J.
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1.
Mol. Pharmacol. 69: 1166-73, 2006.
32)  Chen KG, Valencia JC, Lai B, Zhang G, Paterson JK, Rouzaud F, Berens W, Wincovitch SM, Garfield SH, Leapman RD, Hearing VJ, Gottesman MM.
Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas.
Proc. Natl. Acad. Sci. U.S.A. 103: 9903-7, 2006.
33)  Fountaine TJ, Wincovitch SM, Geho DH, Garfield SH, Pittaluga S.
Multispectral imaging of clinically relevant cellular targets in tonsil and lymphoid tissue using semiconductor quantum dots.
Mod. Pathol. 19: 1181-91, 2006.
34)  Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS.
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.
Mol. Cell. 24: 409-22, 2006.
35)  Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE.
A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.
J Biol Chem. 280: 27329-38, 2005.
36)  Goucher DR, Wincovitch SM, Garfield SH, Carbone KM, Malik TH.
A quantitative determination of multi-protein interactions by the analysis of confocal images using a pixel-by-pixel assessment algorithm.
Bioinformatics. 21: 3248-54, 2005.
37)  Braun DC, Garfield SH, Blumberg PM.
Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell.
J Biol Chem. 280: 8164-71, 2005.
38)  Liang XJ, Taylor B, Cardarelli C, Yin JJ, Annereau JP, Garfield S, Wincovitch S, Szakács G, Gottesman MM, Aszalos A.
Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance.
Anticancer Res. 25: 4113-22, 2005.
39)  Kimchi-Sarfaty C, Brittain S, Garfield S, Caplen NJ, Tang Q, Gottesman MM.
Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions.
Hum Gene Ther. 16: 1110-5, 2005.
40)  Berman DM, Wincovitch S, Garfield S, Romeo MJ.
Grading melanocytic dysplasia in paraffin wax embedded tissue by the nucleic acid index.
J Clin Pathol. 58: 1206-10, 2005.
41)  Pedeux R, Sengupta S, Shen JC, Demidov ON, Saito S, Onogi H, Kumamoto K, Wincovitch S, Garfield SH, McMenamin M, Nagashima M, Grossman SR, Appella E, Harris CC.
ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation.
Mol Cell Biol. 25: 6639-48, 2005.
42)  Braun DC, Cao Y, Wang S, Garfield SH, Hur GM, Blumberg PM.
Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: real-time analysis using fluorescent ligands and proteins.
Mol Cancer Ther. 4: 141-50, 2005.
43)  Liang XJ, Shen DW, Chen KG, Wincovitch SM, Garfield SH, Gottesman MM.
Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum.
J Cell Physiol. 202: 635-41, 2005.
44)  Tanaka T, Dancheck BL, Trifiletti LC, Birnkrant RE, Taylor BJ, Garfield SH, Thorgeirsson U, De Luca LM.
Altered localization of retinoid X receptor alpha coincides with loss of retinoid responsiveness in human breast cancer MDA-MB-231 cells.
Mol Cell Biol. 24: 3972-82, 2004.
45)  Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM.
Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Cancer Res. 64: 3243-55, 2004.
46)  Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM.
PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.
Mol Pharmacol. 66: 76-84, 2004.
47)  Suh KS, Mutoh M, Nagashima K, Fernandez-Salas E, Edwards LE, Hayes DD, Crutchley JM, Marin KG, Dumont RA, Levy JM, Cheng C, Garfield S, Yuspa SH.
The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis.
J Biol Chem. 279: 4632-41, 2004.
48)  Liang XJ, Shen DW, Garfield S, Gottesman MM.
Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines.
Cancer Res. 63: 5909-16, 2003.
49)  Linke SP, Sengupta S, Khabie N, Jeffries BA, Buchhop S, Miska S, Henning W, Pedeux R, Wang XW, Hofseth LJ, Yang Q, Garfield SH, Stürzbecher HW, Harris CC.
p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination.
Cancer Res. 63: 2596-605, 2003.
50)  Seker H, Rubbi C, Linke SP, Bowman ED, Garfield S, Hansen L, Borden KL, Milner J, Harris CC.
UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML.
Oncogene. 22: 1620-8, 2003.
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This page was last updated on 8/5/2014.