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Valentina M. Factor, Ph.D.

Selected Publications

1)  Marquardt JU, Factor VM, Thorgeirsson SS.
Epigenetic regulation of cancer stem cells in liver cancer: Current concepts and clinical implications.
Journal of hepatology. 2010.
2)  Andersen JB, Loi R, Perra A, Factor VM, Ledda-Columbano GM, Columbano A, Thorgeirsson SS.
Progenitor-derived hepatocellular carcinoma model in the rat.
Hepatology. 51: 1401-9, 2010.
3)  Kaposi-Novak P, Libbrecht L, Woo HG, Lee YH, Sears NC, Coulouarn C, Conner EA, Factor VM, Roskams T, Thorgeirsson SS.
Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.
Cancer Res. 69: 2775-82, 2009.
4)  Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS.
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.
Oncogene. 28: 3526-36, 2009.
5)  Zimonjic DB, Ullmannova-Benson V, Factor VM, Thorgeirsson SS, Popescu NC.
Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.
Cancer Genet. Cytogenet. 191: 17-26, 2009.
6)  Ladu S, Calvisi DF, Conner EA, Farina M, Factor VM, Thorgeirsson SS.
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer.
Gastroenterology. 135: 1322-32, 2008.
7)  Coulouarn C, Factor VM, Thorgeirsson SS.
Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer.
Hepatology. 47: 2059-67, 2008.
8)  del Castillo G, Factor VM, Fernández M, Alvarez-Barrientos A, Fabregat I, Thorgeirsson SS, Sánchez A.
Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro.
Am. J. Pathol. 172: 1238-47, 2008.
9)  Gómez-Quiroz LE, Factor VM, Kaposi-Novak P, Coulouarn C, Conner EA, Thorgeirsson SS.
Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis.
J. Biol. Chem. 283: 14581-9, 2008.
10)  Takami T, Kaposi-Novak P, Uchida K, Gomez-Quiroz LE, Conner EA, Factor VM, Thorgeirsson SS.
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Cancer Res. 67: 9844-51, 2007.
11)  Calvisi DF, Ladu S, Gorden A, Farina M, Lee JS, Conner EA, Schroeder I, Factor VM, Thorgeirsson SS.
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma.
J. Clin. Invest. 117: 2713-22, 2007.
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This page was last updated on 8/17/2010.