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Our Science – Factor Website

Valentina M. Factor, Ph.D.

Selected Publications

1)  Marquardt JU, Factor VM, Thorgeirsson SS.
Epigenetic regulation of cancer stem cells in liver cancer: Current concepts and clinical implications.
Journal of hepatology. 2010.
2)  Andersen JB, Loi R, Perra A, Factor VM, Ledda-Columbano GM, Columbano A, Thorgeirsson SS.
Progenitor-derived hepatocellular carcinoma model in the rat.
Hepatology. 51: 1401-9, 2010.
3)  Kaposi-Novak P, Libbrecht L, Woo HG, Lee YH, Sears NC, Coulouarn C, Conner EA, Factor VM, Roskams T, Thorgeirsson SS.
Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.
Cancer Res. 69: 2775-82, 2009.
4)  Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS.
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.
Oncogene. 28: 3526-36, 2009.
5)  Zimonjic DB, Ullmannova-Benson V, Factor VM, Thorgeirsson SS, Popescu NC.
Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.
Cancer Genet. Cytogenet. 191: 17-26, 2009.
6)  Ladu S, Calvisi DF, Conner EA, Farina M, Factor VM, Thorgeirsson SS.
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer.
Gastroenterology. 135: 1322-32, 2008.
7)  Coulouarn C, Factor VM, Thorgeirsson SS.
Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer.
Hepatology. 47: 2059-67, 2008.
8)  del Castillo G, Factor VM, Fernández M, Alvarez-Barrientos A, Fabregat I, Thorgeirsson SS, Sánchez A.
Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro.
Am. J. Pathol. 172: 1238-47, 2008.
9)  Gómez-Quiroz LE, Factor VM, Kaposi-Novak P, Coulouarn C, Conner EA, Thorgeirsson SS.
Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis.
J. Biol. Chem. 283: 14581-9, 2008.
10)  Takami T, Kaposi-Novak P, Uchida K, Gomez-Quiroz LE, Conner EA, Factor VM, Thorgeirsson SS.
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Cancer Res. 67: 9844-51, 2007.
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This page was last updated on 8/17/2010.