Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health
CCR - For Our Staff| Home |

Our Science – Durell Website

Stewart R. Durell, Ph.D.

Selected Publications

1)  Tanoue K, Miller Jenkins LM, Durell SR, Debnath S, Sakai H, Tagad HD, Ishida K, Appella E, Mazur SJ.
Binding of a Third Metal Ion by the Human Phosphatases PP2Ca and Wip1 Is Required for Phosphatase Activity.
Biochemistry. 52: 5830-43, 2013.
2)  Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV.
Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
PLoS ONE. 8: e82463, 2013.
3)  Blumenthal R, Durell S, Viard M.
HIV entry and envelope glycoprotein-mediated fusion.
J. Biol. Chem. 287: 40841-9, 2012.
4)  Jenkins LM, Durell SR, Mazur SJ, Appella E.
p53 N-terminal phosphorylation: a defining layer of complex regulation.
Carcinogenesis. 33: 1441-9, 2012.
5)  Englund EA, Wang D, Fujigaki H, Sakai H, Micklitsch CM, Ghirlando R, Martin-Manso G, Pendrak ML, Roberts DD, Durell SR, Appella DH.
Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.
Nat Commun. 3: 614, 2012.
6)  Waki K, Durell SR, Soheilian F, Nagashima K, Butler SL, Freed EO.
Structural and functional insights into the HIV-1 maturation inhibitor binding pocket.
PLoS Pathog. 8: e1002997, 2012.
7)  Ohnuma S, Chufan E, Nandigama K, Jenkins LM, Durell SR, Appella E, Sauna ZE, Ambudkar SV.
Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites.
Biochemistry. 50: 3724-35, 2011.
8)  Hayashi R, Tanoue K, Durell SR, Chatterjee DK, Jenkins LM, Appella DH, Appella E.
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
Biochemistry. 50: 4537-49, 2011.
9)  Shafrir Y, Durell SR, Anishkin A, Guy HR.
Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils.
Proteins. 78: 3458-3472, 2010.
10)  Shafrir Y, Durell SR, Arispe N, Guy HR.
Models of Membrane-bound Alzheimer's Abeta Peptide Assemblies.
Proteins. 78: 3473-3487, 2010.
11)  Arispe N, Diaz J, Durell SR, Shafrir Y, Guy HR.
Polyhistidine Peptide Inhibitor of the Abeta Calcium Channel Potently Blocks the Abeta-Induced Calcium Response in Cells. Theoretical Modeling Suggests a Cooperative Binding Process.
Biochemistry. 49: 7847-53, 2010.
12)  Hayashi R, Wang D, Hara T, Iera JA, Durell SR, Appella DH.
N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.
Bioorg. Med. Chem. 17: 7884-93, 2009.
13)  Feng H, Jenkins LM, Durell SR, Hayashi R, Mazur SJ, Cherry S, Tropea JE, Miller M, Wlodawer A, Appella E, Bai Y.
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation.
Structure. 17: 202-10, 2009.
14)  Bang J, Yamaguchi H, Durell SR, Appella E, Appella DH.
A small molecular scaffold for selective inhibition of Wip1 phosphatase.
ChemMedChem. 3: 230-2, 2008.
15)  Shafrir Y, Durell SR, Guy HR.
Models of the Structure and Gating Mechanisms of the Pore Domain of the NaChBac Ion Channel.
Biophys. J. 95: 3650-62, 2008.
16)  Shafrir Y, Durell SR, Guy HR.
Models of Voltage-dependent Conformational Changes in NaChBac Channels.
Biophys. J. 95: 3663-76, 2008.
17)  Pokorski JK, Jenkins LM, Feng H, Durell SR, Bai Y, Appella DH.
Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution.
Org. Lett. 9: 2381-3, 2007.
18)  Miller Jenkins LM, Hara T, Durell SR, Hayashi R, Inman JK, Piquemal JP, Gresh N, Appella E.
Specificity of acyl transfer from 2-mercaptobenzamide thioesters to the HIV-1 nucleocapsid protein.
J. Am. Chem. Soc. 129: 11067-78, 2007.
19)  Yamaguchi H, Durell SR, Chatterjee DK, Anderson CW, Appella E.
The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases.
Biochemistry. 46: 12594-603, 2007.
20)  Jenkins LM, Durell SR, Maynard AT, Stahl SJ, Inman JK, Appella E, Legault P, Omichinski JG.
Comparison of the specificity of interaction of cellular and viral zinc-binding domains with 2-mercaptobenzamide thioesters.
J. Am. Chem. Soc. 128: 11964-76, 2006.
21)  Yamaguchi H, Durell SR, Feng H, Bai Y, Anderson CW, Appella E.
Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1.
Biochemistry. 45: 13193-202, 2006.
22)  Hara T, Durell SR, Myers MC, Appella DH.
Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions.
J. Am. Chem. Soc. 128: 1995-2004, 2006.
23)  Higashimoto Y, Asanomi Y, Takakusagi S, Lewis MS, Uosaki K, Durell SR, Anderson CW, Appella E, Sakaguchi K.
Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer.
Biochemistry. 45: 1608-19, 2006.
24)  Yamaguchi H, Minopoli G, Demidov ON, Chatterjee DK, Anderson CW, Durell SR, Appella E.
Substrate specificity of the human protein phosphatase 2Cdelta, Wip1.
Biochemistry. 44: 5285-94, 2005.
25)  Shrivastava IH, Durell SR, Guy HR.
A model of voltage gating developed using the KvAP channel crystal structure.
Biophys J. 87: 2255-70, 2004.
26)  Durell SR, Shrivastava IH, Guy HR.
Models of the structure and voltage-gating mechanism of the shaker K+ channel.
Biophys J. 87: 2116-30, 2004.
27)  Wlodawer A, Durell SR, Li M, Oyama H, Oda K, Dunn BM.
A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases.
BMC Struct Biol. 3: 8, 2003.
28)  Blumenthal R, Clague MJ, Durell SR, Epand RM.
Membrane fusion.
Chem Rev. 103: 53-69, 2003.
29)  Gallo SA, Finnegan CM, Viard M, Raviv Y, Dimitrov A, Rawat SS, Puri A, Durell S, Blumenthal R.
The HIV Env-mediated fusion reaction.
Biochim Biophys Acta. 1614: 36-50, 2003.
30)  Keskin O, Durell SR, Bahar I, Jernigan RL, Covell DG.
Relating molecular flexibility to function: a case study of tubulin.
Biophys J. 83: 663-80, 2002.
31)  Durell SR, Guy HR.
A family of putative Kir potassium channels in prokaryotes.
BMC Evol Biol. 1: 14, 2001.
32)  Durell SR, Guy HR.
A putative prokaryote voltage-gated Ca(2+) channel with only one 6TM motif per subunit.
Biochem Biophys Res Commun. 281: 741-6, 2001.
33)  Atilgan AR, Durell SR, Jernigan RL, Demirel MC, Keskin O, Bahar I.
Anisotropy of fluctuation dynamics of proteins with an elastic network model.
Biophys J. 80: 505-15, 2001.
34)  Sukharev S, Durell SR, Guy HR.
Structural models of the MscL gating mechanism.
Biophys J. 81: 917-36, 2001.
35)  Durell SR, Bakker EP, Guy HR.
Does the KdpA subunit from the high affinity K(+)-translocating P-type KDP-ATPase have a structure similar to that of K(+) channels?.
Biophys J. 78: 188-99, 2000.
36)  Lee B, Sharron M, Blanpain C, Doranz BJ, Vakili J, Setoh P, Berg E, Liu G, Guy HR, Durell SR, Parmentier M, Chang CN, Price K, Tsang M, Doms RW.
Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function.
J Biol Chem. 274: 9617-26, 1999.
37)  Durell SR, Hao Y, Nakamura T, Bakker EP, Guy HR.
Evolutionary relationship between K(+) channels and symporters.
Biophys J. 77: 775-88, 1999.
38)  Nagaich AK, Zhurkin VB, Durell SR, Jernigan RL, Appella E, Harrington RE.
p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting.
Proc Natl Acad Sci U S A. 96: 1875-80, 1999.
39)  Durell SR, Guy HR.
Structural models of the KtrB, TrkH, and Trk1,2 symporters based on the structure of the KcsA K(+) channel.
Biophys J. 77: 789-807, 1999.
40)  Muñoz-Barroso I, Durell S, Sakaguchi K, Appella E, Blumenthal R.
Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41.
J Cell Biol. 140: 315-23, 1998.
41)  Durell SR, Hao Y, Guy HR.
Structural models of the transmembrane region of voltage-gated and other K+ channels in open, closed, and inactivated conformations.
J Struct Biol. 121: 263-84, 1998.
42)  Durell SR, Martin I, Ruysschaert JM, Shai Y, Blumenthal R.
What studies of fusion peptides tell us about viral envelope glycoprotein-mediated membrane fusion (review).
Mol Membr Biol. 14: 97-112, 1997.
43)  Durell SR, Wallqvist A.
Atomic-scale analysis of the solvation thermodynamics of hydrophobic hydration.
Biophys J. 71: 1695-706, 1996.
44)  Guy HR, Durell SR.
Developing three-dimensional models of ion channel proteins.
Ion Channels. 4: 1-40, 1996.
45)  Blumenthal R, Sarkar DP, Durell S, Howard DE, Morris SJ.
Dilation of the influenza hemagglutinin fusion pore revealed by the kinetics of individual cell-cell fusion events.
J Cell Biol. 135: 63-71, 1996.
46)  Durell SR, Guy HR.
Structural model of the outer vestibule and selectivity filter of the Shaker voltage-gated K+ channel.
Neuropharmacology. 35: 761-73, 1996.
47)  Tzounopoulos T, Guy HR, Durell S, Adelman JP, Maylie J.
min K channels form by assembly of at least 14 subunits.
Proc Natl Acad Sci U S A. 92: 9593-7, 1995.
48)  Guy HR, Durell SR.
Structural models of Na+, Ca2+, and K+ channels.
Soc Gen Physiol Ser. 50: 1-16, 1995.
49)  Clark DP, Durell S, Maloy WL, Zasloff M.
Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.
J Biol Chem. 269: 10849-55, 1994.
50)  Durell SR, Guy HR, Arispe N, Rojas E, Pollard HB.
Theoretical models of the ion channel structure of amyloid beta-protein.
Biophys J. 67: 2137-45, 1994.
51)  Guy HR, Durell SR.
Using sequence homology to analyze the structure and function of voltage-gated ion channel proteins.
Soc Gen Physiol Ser. 49: 197-212, 1994.
52)  Wehrli SL, Moore KS, Roder H, Durell S, Zasloff M.
Structure of the novel steroidal antibiotic squalamine determined by two-dimensional NMR spectroscopy.
Steroids. 58: 370-8, 1993.
53)  Guy HR, Durell SR, Schoch C, Blumenthal R.
Analyzing the fusion process of influenza hemagglutinin by mutagenesis and molecular modeling.
Biophys J. 62: 95-7, 1992.
54)  Durell SR, Guy HR.
Atomic scale structure and functional models of voltage-gated potassium channels.
Biophys J. 62: 238-47; discussion 247-50, 1992.
55)  Cruciani RA, Barker JL, Durell SR, Raghunathan G, Guy HR, Zasloff M, Stanley EF.
Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes.
Eur J Pharmacol. 226: 287-96, 1992.
56)  Durell SR, Raghunathan G, Guy HR.
Modeling the ion channel structure of cecropin.
Biophys J. 63: 1623-31, 1992.
57)  Guy HR, Durell SR, Warmke J, Drysdale R, Ganetzky B.
Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels.
Science. 254: 730, 1991.
58)  Gross EL, Curtiss A, Durell SR, White D.
Chemical modification of spinach plastocyanin using 4-chloro-3,5-dinitrobenzoic acid: characterization of four singly-modified forms.
Biochim Biophys Acta. 1016: 107-14, 1990.
59)  Durell SR, Lee CH, Ross RT, Gross EL.
Factor analysis of the near-ultraviolet absorption spectrum of plastocyanin using bilinear, trilinear, and quadrilinear models.
Arch Biochem Biophys. 278: 148-60, 1990.
60)  Durell SR, Labanowski JK, Gross EL.
Modeling of the electrostatic potential field of plastocyanin.
Arch Biochem Biophys. 277: 241-54, 1990.
61)  Durell SR, Gross EL, Draheim JE.
Analysis of the near-ultraviolet absorption and circular dichroic spectra of parsley plastocyanin for the effects of pH and copper center conformation changes.
Arch Biochem Biophys. 267: 217-27, 1988.
62)  Anderson GP, Sanderson DG, Lee CH, Durell S, Anderson LB, Gross EL.
The effect of ethylenediamine chemical modification of plastocyanin on the rate of cytochrome f oxidation and P-700+ reduction.
Biochim Biophys Acta. 894: 386-98, 1987.
Click Here to View Collapsed Bibliography.

This page was last updated on 8/4/2014.