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Our Science – Robles Website

Ana I. Robles, Ph.D.

Selected Publications

1) Zanetti KA, Haznadar M, Welsh JA, Robles AI, Ryan BM, McClary AC, Bowman ED, Goodman JE, Bernig T, Chanock SJ, Harris CC.
3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans.
Cancer Res. 72: 1467-77, 2012. [Journal]

2) Tang Y, Horikawa I, Ajiro M, Robles AI, Fujita K, Mondal AM, Stauffer JK, Zheng ZM, Harris CC.
Downregulation of splicing factor SRSF3 induces p53Î², an alternatively spliced isoform of p53 that promotes cellular senescence.
Oncogene. 2012. [Journal]

3) Du X, Qian X, Papageorge A, Schetter AJ, Vass WC, Liu X, Braverman R, Robles AI, Lowy DR.
Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells.
Cancer research. 2012. [Journal]

4) Ryan BM, Robles AI, Harris CC.
KRAS-LCS6 Genotype as a Prognostic Marker in Early-Stage CRC-Letter.
Clin. Cancer Res. 18: 3487-8, 2012. [Journal]

5) Ryan BM, Calhoun KM, Pine SR, Bowman ED, Robles AI, Ambs S, Harris CC.
MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer.
International journal of cancer. Journal international du cancer. 2012. [Journal]

6) Ryan BM, McClary AC, Valeri N, Robinson D, Paone A, Bowman ED, Robles AI, Croce C, Harris CC.
rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer.
PLoS ONE. 7: e36306, 2012. [Journal]

7) Robles AI, Harris CC.
Clinical outcomes and correlates of TP53 mutations and cancer.
Cold Spring Harb Perspect Biol. 2: a001016, 2010. [Journal]

8) Ryan BM, Robles AI, Harris CC.
Genetic variation in microRNA networks: the implications for cancer research.
Nat. Rev. Cancer. 10: 389-402, 2010. [Journal]

9) Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC.
Microenvironmental modulation of asymmetric cell division in human lung cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 107: 2195-200, 2010. [Journal]

10) Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC.
Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.
PLoS ONE. 5: e15541, 2010. [Journal]

11) Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A.
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.
Nat. Med. 15: 1369-76, 2009. [Journal]

12) Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G.
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
Proc. Natl. Acad. Sci. U.S.A. 106: 8368-73, 2009. [Journal]

13) Binet R, Ythier D, Robles AI, Collado M, Larrieu D, Fonti C, Brambilla E, Brambilla C, Serrano M, Harris CC, Pedeux R.
WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.
Cancer Res. 69: 9183-91, 2009. [Journal]

14) Unoki M, Kumamoto K, Robles AI, Shen JC, Zheng ZM, Harris CC.
A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.
FEBS Lett. 582: 3868-74, 2008. [Journal]

15) Koll TT, Feis SS, Wright MH, Teniola MM, Richardson MM, Robles AI, Bradsher J, Capala J, Varticovski L.
HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair.
Mol. Cancer Ther. 7: 1985-92, 2008. [Journal]

16) Wright MH, Robles AI, Herschkowitz JI, Hollingshead MG, Anver MR, Perou CM, Varticovski L.
Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1.
Mol. Cancer. 7: 29, 2008. [Journal]

17) Varticovski L, Hollingshead MG, Robles AI, Wu X, Cherry J, Munroe DJ, Lukes L, Anver MR, Carter JP, Borgel SD, Stotler H, Bonomi CA, Nunez NP, Hursting SD, Qiao W, Deng CX, Green JE, Hunter KW, Merlino G, Steeg PS, Wakefield LM, Barrett JC.
Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.
Clin. Cancer Res. 13: 2168-77, 2007. [Journal]

18) Robles AI, Varticovski L.
Harnessing genetically engineered mouse models for preclinical testing.
Chem Biol Interact. 2007. [Journal]

19) Antony S, Agama KK, Miao ZH, Takagi K, Wright MH, Robles AI, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y.
Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.
Cancer Res. 67: 10397-405, 2007. [Journal]

20) Robles AI, Wright MH, Gandhi B, Feis SS, Hanigan CL, Wiestner A, Varticovski L.
Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.
Clin. Cancer Res. 12: 6547-56, 2006. [Journal]

21) Hofseth LJ, Robles AI, Espey MG, Harris CC.
Nitric oxide is a signaling molecule that regulates gene expression.
Meth. Enzymol. 396: 326-40, 2005. [Journal]

22) Staib F, Robles AI, Varticovski L, Wang XW, Zeeberg BR, Sirotin M, Zhurkin VB, Hofseth LJ, Hussain SP, Weinstein JN, Galle PR, Harris CC.
The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.
Cancer Res. 65: 10255-64, 2005. [Journal]

23) Li CQ, Robles AI, Hanigan CL, Hofseth LJ, Trudel LJ, Harris CC, Wogan GN.
Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.
Cancer Res. 64: 3022-9, 2004. [Journal]

24) Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC.
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
J. Cell Biol. 166: 801-13, 2004. [Journal]

25) Hussain SP, Amstad P, He P, Robles A, Lupold S, Kaneko I, Ichimiya M, Sengupta S, Mechanic L, Okamura S, Hofseth LJ, Moake M, Nagashima M, Forrester KS, Harris CC.
p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.
Cancer Res. 64: 2350-6, 2004. [Journal]

26) Hofseth LJ, Robles AI, Yang Q, Wang XW, Hussain SP, Harris C.
p53: at the crossroads of molecular carcinogenesis and molecular epidemiology.
Chest. 125: 83S-5S, 2004. [Journal]

27) Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, Simon R, Li Y, Robles AI, Chen Y, Ma ZC, Wu ZQ, Ye SL, Liu YK, Tang ZY, Wang XW.
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning.
Nat. Med. 9: 416-23, 2003. [Journal]

28) Haupt Y, Robles AI, Prives C, Rotter V.
Deconstruction of p53 functions and regulation.
Oncogene. 21: 8223-31, 2002. [Journal]

29) Miura K, Bowman ED, Simon R, Peng AC, Robles AI, Jones RT, Katagiri T, He P, Mizukami H, Charboneau L, Kikuchi T, Liotta LA, Nakamura Y, Harris CC.
Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.
Cancer Res. 62: 3244-50, 2002. [Journal]

30) Robles AI, Linke SP, Harris CC.
The p53 network in lung carcinogenesis.
Oncogene. 21: 6898-907, 2002. [Journal]

31) Robles AI, Bemmels NA, Foraker AB, Harris CC.
APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.
Cancer Res. 61: 6660-4, 2001. [Journal]

32) Wang XW, Tseng A, Ellis NA, Spillare EA, Linke SP, Robles AI, Seker H, Yang Q, Hu P, Beresten S, Bemmels NA, Garfield S, Harris CC.
Functional interaction of p53 and BLM DNA helicase in apoptosis.
J. Biol. Chem. 276: 32948-55, 2001. [Journal]

33) Robles AI, Harris CC.
p53-mediated apoptosis and genomic instability diseases.
Acta oncologica (Stockholm, Sweden). 40: 696-701, 2001. [Journal]

34) Robles AI, Wang XW, Harris CC.
Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.
Oncogene. 18: 4681-8, 1999. [Journal]

35) Spillare EA, Robles AI, Wang XW, Shen JC, Yu CE, Schellenberg GD, Harris CC.
p53-mediated apoptosis is attenuated in Werner syndrome cells.
Genes Dev. 13: 1355-60, 1999. [Journal]

36) Rodriguez-Puebla ML, Robles AI, Conti CJ.
ras activity and cyclin D1 expression: an essential mechanism of mouse skin tumor development.
Mol. Carcinog. 24: 1-6, 1999. [Journal]

37) Robles AI, Rodriguez-Puebla ML, Glick AB, Trempus C, Hansen L, Sicinski P, Tennant RW, Weinberg RA, Yuspa SH, Conti CJ.
Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.
Genes Dev. 12: 2469-74, 1998. [Journal]

38) Rodriguez-Puebla ML, Robles AI, Johnson DG, LaCava M, Conti CJ.
Synchronized proliferation induced by 12-O-tetradecanoylphorbol-13-acetate treatment of mouse skin: an in vivo model for cell cycle regulation.
Cell Growth Differ. 9: 31-9, 1998. [Journal]

39) Robles AI, Larcher F, Whalin RB, Murillas R, Richie E, Gimenez-Conti IB, Jorcano JL, Conti CJ.
Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia.
Proc. Natl. Acad. Sci. U.S.A. 93: 7634-8, 1996. [Journal]

40) Chen Y, Robles AI, Martinez LA, Liu F, Gimenez-Conti IB, Conti CJ.
Expression of G1 cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors in androgen-induced prostate proliferation in castrated rats.
Cell Growth Differ. 7: 1571-8, 1996. [Journal]

41) Larcher F, Robles AI, Duran H, Murillas R, Quintanilla M, Cano A, Conti CJ, Jorcano JL.
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.
Cancer Res. 56: 5391-6, 1996. [Journal]

42) Robles AI, Conti CJ.
Early overexpression of cyclin D1 protein in mouse skin carcinogenesis.
Carcinogenesis. 16: 781-6, 1995. [Journal]

43) Mitsunaga SI, Zhang SY, Ruggeri BA, Gimenez-Conti I, Robles AI, Conti CJ, Klein-Szanto AJ.
Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene.
Carcinogenesis. 16: 1629-35, 1995. [Journal]

44) Filmus J, Robles AI, Shi W, Wong MJ, Colombo LL, Conti CJ.
Induction of cyclin D1 overexpression by activated ras.
Oncogene. 9: 3627-33, 1994. [Journal]

45) Robles AI, Gimenez-Conti IB, Roop D, Slaga TJ, Conti CJ.
Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors.
Mol. Carcinog. 7: 94-8, 1993. [Journal]

46) Bianchi AB, Fischer SM, Robles AI, Rinchik EM, Conti CJ.
Overexpression of cyclin D1 in mouse skin carcinogenesis.
Oncogene. 8: 1127-33, 1993. [Journal]

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This page was last updated on 7/14/2012.