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Our Science – Hussain Website

S. Perwez Hussain, Ph.D.

Selected Publications

1)  Zhang G, He P, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Hanna N, Alexander HR, Hussain SP.
FOXL1, a Novel Candidate Tumor Suppressor, Inhibits Tumor Aggressiveness and Predicts Outcome in Human Pancreatic Cancer.
Cancer Res. 2013.
[Journal]
2)  Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, Hanna N, Alexander HR, Hussain SP.
Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.
Clin. Cancer Res. 19: 4983-93, 2013.
[Journal]
3)  Zhang G, Schetter A, He P, Funamizu N, Gaedcke J, Ghadimi BM, Ried T, Hassan R, Yfantis HG, Lee DH, Lacy C, Maitra A, Hanna N, Alexander HR, Hussain SP.
DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.
PLoS ONE. 7: e31507, 2012.
[Journal]
4)  Funamizu N, Hu C, Lacy C, Schetter A, Zhang G, He P, Gaedcke J, Ghadimi BM, Ried T, Yffantis HG, Lee DH, Subleski J, Chan T, Weiss JM, Back TC, Yanaga K, Hanna N, Alexander HR, Maitra A, Hussain SP.
Macrophage Migration Inhibitory Factor (MIF) induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma.
Int J Cancer. [Epub ahead of print], 2012.
[Journal]
5)  Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.
Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.
PLoS ONE. 7: e44156, 2012.
[Journal]
6)  Okayama H, Saito M, Oue N, Weiss JM, Stauffer J, Takenoshita S, Wiltrout RH, Hussain SP, Harris CC.
NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression.
Int J Cancer. [Epub ahead of print], 2012.
[Journal]
7)  Mathé E, Nguyen GH, Funamizu N, He P, Moake M, Croce CM, Hussain SP.
Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide.
Int. J. Cancer. [Epub ahead of print], 2011.
[Journal]
8)  Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC, Wink DA, Wiltrout RH.
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy.
J. Exp. Med. 207: 2455-67, 2010.
[Journal]
9)  Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC.
Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.
PLoS ONE. 5: e15541, 2010.
[Journal]
10)  Jiang W, Wang XW, Unger T, Forgues M, Kim JW, Hussain SP, Bowman E, Spillare EA, Lipsky MM, Meck JM, Cavalli LR, Haddad BR, Harris CC.
Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line.
Int J Cancer. 127: 1011-20, 2009.
[Journal]
11)  Hussain SP.
Inflammation and cancer: is AID aiding?.
Gastroenterology. 135: 736-7, 2008.
[Journal]
12)  Hussain SP, He P, Subleski J, Hofseth LJ, Trivers GE, Mechanic L, Hofseth AB, Bernard M, Schwank J, Nguyen G, Mathe E, Djurickovic D, Haines D, Weiss J, Back T, Gruys E, Laubach VE, Wiltrout RH, Harris CC.
Nitric oxide is a key component in inflammation-accelerated tumorigenesis.
Cancer Res. 68: 7130-6, 2008.
[Journal]
13)  Wink DA, Ridnour LA, Hussain SP, Harris CC.
The reemergence of nitric oxide and cancer.
Nitric Oxide. 19: 65-7, 2008.
[Journal]
14)  Hussain SP, Harris CC.
Inflammation and cancer: an ancient link with novel potentials.
Int. J. Cancer. 121: 2373-80, 2007.
[Journal]
15)  Hussain SP, Schwank J, Staib F, Wang XW, Harris CC.
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer.
Oncogene. 26: 2166-76, 2007.
[Journal]
16)  Hussain SP, Harris CC.
p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis.
J Nippon Med Sch. 73: 54-64, 2006.
[Journal]
17)  Hagiwara N, Mechanic LE, Trivers GE, Cawley HL, Taga M, Bowman ED, Kumamoto K, He P, Bernard M, Doja S, Miyashita M, Tajiri T, Sasajima K, Nomura T, Makino H, Takahashi K, Hussain SP, Harris CC.
Quantitative detection of p53 mutations in plasma DNA from tobacco smokers.
Cancer Res. 66: 8309-17, 2006.
[Journal]
18)  Du Q, Park KS, Guo Z, He P, Nagashima M, Shao L, Sahai R, Geller DA, Hussain SP.
Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling.
Cancer Res. 66: 7024-31, 2006.
[Journal]
19)  Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, DeGraff W, Roberts DD, Mitchell JB, Wink DA.
Superoxide fluxes limit nitric oxide-induced signaling.
J. Biol. Chem. 281: 25984-93, 2006.
[Journal]
20)  Ying L, Marino J, Hussain SP, Khan MA, You S, Hofseth AB, Trivers GE, Dixon DA, Harris CC, Hofseth LJ.
Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation.
Cancer Res. 65: 9132-6, 2005.
[Journal]
21)  Staib F, Robles AI, Varticovski L, Wang XW, Zeeberg BR, Sirotin M, Zhurkin VB, Hofseth LJ, Hussain SP, Weinstein JN, Galle PR, Harris CC.
The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.
Cancer Res. 65: 10255-64, 2005.
[Journal]
22)  Goodman JE, Hofseth LJ, Hussain SP, Harris CC.
Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.
Environ. Mol. Mutagen. 44: 3-9, 2004.
[Journal]
23)  Hussain SP, Trivers GE, Hofseth LJ, He P, Shaikh I, Mechanic LE, Doja S, Jiang W, Subleski J, Shorts L, Haines D, Laubach VE, Wiltrout RH, Djurickovic D, Harris CC.
Nitric oxide, a mediator of inflammation, suppresses tumorigenesis.
Cancer Res. 64: 6849-53, 2004.
[Journal]
24)  Hussain SP, Amstad P, He P, Robles A, Lupold S, Kaneko I, Ichimiya M, Sengupta S, Mechanic L, Okamura S, Hofseth LJ, Moake M, Nagashima M, Forrester KS, Harris CC.
p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.
Cancer Res. 64: 2350-6, 2004.
[Journal]
25)  Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol. Sci. 25: 177-81, 2004.
[Journal]
26)  Hofseth LJ, Robles AI, Yang Q, Wang XW, Hussain SP, Harris C.
p53: at the crossroads of molecular carcinogenesis and molecular epidemiology.
Chest. 125: 83S-5S, 2004.
[Journal]
27)  Zurer I, Hofseth LJ, Cohen Y, Xu-Welliver M, Hussain SP, Harris CC, Rotter V.
The role of p53 in base excision repair following genotoxic stress.
Carcinogenesis. 25: 11-9, 2004.
[Journal]
28)  Olivier M, Hussain SP, Caron de Fromentel C, Hainaut P, Harris CC.
TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer.
IARC Sci. Publ. 247-70, 2004.
[Journal]
29)  Hofseth LJ, Hussain SP, Wogan GN, Harris CC.
Nitric oxide in cancer and chemoprevention.
Free Radic. Biol. Med. 34: 955-68, 2003.
[Journal]
30)  Hofseth LJ, Saito S, Hussain SP, Espey MG, Miranda KM, Araki Y, Jhappan C, Higashimoto Y, He P, Linke SP, Quezado MM, Zurer I, Rotter V, Wink DA, Appella E, Harris CC.
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Proc. Natl. Acad. Sci. U.S.A. 100: 143-8, 2003.
[Journal]
31)  Hussain SP, Hofseth LJ, Harris CC.
Radical causes of cancer.
Nat. Rev. Cancer. 3: 276-85, 2003.
[Journal]
32)  Araki Y, Okamura S, Hussain SP, Nagashima M, He P, Shiseki M, Miura K, Harris CC.
Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.
Cancer Res. 63: 728-34, 2003.
[Journal]
33)  Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I, Rotter V, Samson LD, Harris CC.
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.
J. Clin. Invest. 112: 1887-94, 2003.
[Journal]
34)  Staib F, Hussain SP, Hofseth LJ, Wang XW, Harris CC.
TP53 and liver carcinogenesis.
Hum. Mutat. 21: 201-16, 2003.
[Journal]
35)  Wang XW, Hussain SP, Huo TI, Wu CG, Forgues M, Hofseth LJ, Brechot C, Harris CC.
Molecular pathogenesis of human hepatocellular carcinoma.
Toxicology. 181-182: 43-7, 2002.
[Journal]
36)  Hussain SP, Amstad P, Raja K, Sawyer M, Hofseth L, Shields PG, Hewer A, Phillips DH, Ryberg D, Haugen A, Harris CC.
Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung.
Cancer Res. 61: 6350-5, 2001.
[Journal]
37)  Marrogi AJ, Khan MA, van Gijssel HE, Welsh JA, Rahim H, Demetris AJ, Kowdley KV, Hussain SP, Nair J, Bartsch H, Okby N, Poirier MC, Ishak KG, Harris CC.
Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma.
J. Natl. Cancer Inst. 93: 1652-5, 2001.
[Journal]
38)  Hussain SP, Hofseth LJ, Harris CC.
Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment.
Lung Cancer. 34 Suppl 2: S7-15, 2001.
[Journal]
39)  Hussain SP, Amstad P, Raja K, Ambs S, Nagashima M, Bennett WP, Shields PG, Ham AJ, Swenberg JA, Marrogi AJ, Harris CC.
Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease.
Cancer Res. 60: 3333-7, 2000.
[Journal]
40)  Hussain SP, Raja K, Amstad PA, Sawyer M, Trudel LJ, Wogan GN, Hofseth LJ, Shields PG, Billiar TR, Trautwein C, Hohler T, Galle PR, Phillips DH, Markin R, Marrogi AJ, Harris CC.
Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases.
Proc. Natl. Acad. Sci. U.S.A. 97: 12770-5, 2000.
[Journal]
41)  Zhou X, Espey MG, Chen JX, Hofseth LJ, Miranda KM, Hussain SP, Wink DA, Harris CC.
Inhibitory effects of nitric oxide and nitrosative stress on dopamine-beta-hydroxylase.
J. Biol. Chem. 275: 21241-6, 2000.
[Journal]
42)  Hussain SP, Harris CC.
Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens.
Mutat. Res. 462: 311-22, 2000.
[Journal]
43)  Hussain SP, Hollstein MH, Harris CC.
p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment.
Ann. N. Y. Acad. Sci. 919: 79-85, 2000.
[Journal]
44)  Ambs S, Hussain SP, Marrogi AJ, Harris CC.
Cancer-prone oxyradical overload disease.
IARC Sci. Publ. 295-302, 1999.
[Journal]
45)  Bennett WP, Hussain SP, Vahakangas KH, Khan MA, Shields PG, Harris CC.
Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer.
J. Pathol. 187: 8-18, 1999.
[Journal]
46)  Hussain SP, Harris CC.
p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer.
Mutat. Res. 428: 23-32, 1999.
[Journal]
47)  Ambs S, Bennett WP, Merriam WG, Ogunfusika MO, Oser SM, Harrington AM, Shields PG, Felley-Bosco E, Hussain SP, Harris CC.
Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer.
J. Natl. Cancer Inst. 91: 86-8, 1999.
[Journal]
48)  Hussain SP, Harris CC.
Molecular epidemiology of human cancer.
Recent Results Cancer Res. 154: 22-36, 1998.
[Journal]
49)  Hussain SP, Harris CC.
Molecular epidemiology of human cancer.
Toxicol. Lett. 102-103: 219-25, 1998.
[Journal]
50)  Hussain SP, Harris CC.
Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes.
Cancer Res. 58: 4023-37, 1998.
[Journal]
51)  Ambs S, Merriam WG, Ogunfusika MO, Bennett WP, Ishibe N, Hussain SP, Tzeng EE, Geller DA, Billiar TR, Harris CC.
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells.
Nat. Med. 4: 1371-6, 1998.
[Journal]
52)  Ambs S, Hussain SP, Harris CC.
Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression.
FASEB J. 11: 443-8, 1997.
[Journal]
53)  Hussain SP, Kennedy CH, Amstad P, Lui H, Lechner JF, Harris CC.
Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to 238Pu alpha-particles in human bronchial epithelial cells.
Carcinogenesis. 18: 121-5, 1997.
[Journal]
54)  Rusin MR, Okamoto A, Chorazy M, Czyzewski K, Harasim J, Spillare EA, Hagiwara K, Hussain SP, Xiong Y, Demetrick DJ, Harris CC.
Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers.
Int. J. Cancer. 65: 734-9, 1996.
[Journal]
55)  Gemma A, Takenoshita S, Hagiwara K, Okamoto A, Spillare EA, McMemamin MG, Hussain SP, Forrester K, Zariwala M, Xiong Y, Harris CC.
Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines.
Int. J. Cancer. 68: 605-11, 1996.
[Journal]
56)  Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ, Serrano M, Hannon GJ, Shiseki M, Zariwala M.
Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer.
Cancer Res. 55: 1448-51, 1995.
[Journal]
57)  Hussain SP, Aguilar F, Cerutti P.
Mutagenesis of codon 248 of the human p53 tumor suppressor gene by N-ethyl-N-nitrosourea.
Oncogene. 9: 13-8, 1994.
[Journal]
58)  Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH.
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91: 11045-9, 1994.
[Journal]
59)  Hussain SP, Aguilar F, Amstad P, Cerutti P.
Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene.
Oncogene. 9: 2277-81, 1994.
[Journal]
60)  Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Greenblatt MS, Serrano M.
p16INK4 mutations and altered expression in human tumors and cell lines.
Cold Spring Harb. Symp. Quant. Biol. 59: 49-57, 1994.
[Journal]
61)  Amstad P, Hussain SP, Cerutti P.
Ultraviolet B light-induced mutagenesis of p53 hotspot codons 248 and 249 in human skin fibroblasts.
Mol. Carcinog. 10: 181-8, 1994.
[Journal]
62)  Aguilar F, Hussain SP, Cerutti P.
Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.
Proc. Natl. Acad. Sci. U.S.A. 90: 8586-90, 1993.
[Journal]
63)  Hussain SP, Rao AR.
Chemopreventive action of selenium on methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse.
Oncology. 49: 237-40, 1992.
[Journal]
64)  Hussain SP, Rao AR.
Modulatory influence of injectable contraceptive steroid medroxyprogesterone acetate on methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse.
Cancer Lett. 61: 187-93, 1992.
[Journal]
65)  Hussain SP, Rao AR.
Modulatory influence of oral contraceptive pills Ovral and Noracycline on 3-methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse.
Jpn. J. Cancer Res. 83: 576-83, 1992.
[Journal]
66)  Jannu LN, Hussain SP, Rao AR.
Chemopreventive action of mace (Myristica fragrans, Houtt) on DMBA-induced papillomagenesis in the skin of mice.
Cancer Lett. 56: 59-63, 1991.
[Journal]
67)  Hussain SP, Rao AR.
Chemopreventive action of mace (Myristica fragrans, Houtt) on methylcholanthrene-induced carcinogenesis in the uterine cervix in mice.
Cancer Lett. 56: 231-4, 1991.
[Journal]
68)  Hussain SP, Chhabra SK, Rao AR.
Effects of oral contraceptive pills on drug metabolizing enzymes and acid soluble sulfhydryl level in mouse liver.
Biochem. Int. 25: 973-84, 1991.
[Journal]
69)  Ramesha A, Rao N, Rao AR, Jannu LN, Hussain SP.
Chemoprevention of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in rat by the combined actions of selenium, magnesium, ascorbic acid and retinyl acetate.
Jpn. J. Cancer Res. 81: 1239-46, 1990.
[Journal]
70)  Hussain SP, Jannu LN, Rao AR.
Chemopreventive action of garlic on methylcholanthrene-induced carcinogenesis in the uterine cervix of mice.
Cancer Lett. 49: 175-80, 1990.
[Journal]
71)  Rao AR, Hussain SP, Jannu LN, Kumari MV.
Modulatory influences of tamoxifen, tocopherol, retinyl acetate, aminoglutethimide, ergocryptine and selenium on DMBA-induced initiation of mammary carcinogenesis in rats.
Indian J. Exp. Biol. 28: 409-16, 1990.
[Journal]
72)  Rao AR, Hussain SP, Jannu L.
Modulation of 7,12-dimethylbenz[a]anthracene-induced transmammary carcinogenesis by disulfiram and butylated hydroxyanisole in mice.
Jpn. J. Cancer Res. 80: 1171-5, 1989.
[Journal]
73)  Rao AR, Hussain SP.
Modulation of methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse by indomethacin.
Cancer Lett. 43: 15-9, 1988.
[Journal]
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This page was last updated on 11/25/2013.