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Our Science – Budhu Website

Anuradha S. Budhu, Ph.D.

Selected Publications

1)  Budhu A, Roessler S, Zhao X, Yu Z, Forgues M, Ji J, Karoly E, Qin LX, Ye QH, Jia HL, Fan J, Sun HC, Tang ZY, Wang XW.
Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.
Gastroenterology. 144: 1066-1075.e1, 2013.
2)  Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW.
MicroRNA expression, survival, and response to interferon in liver cancer.
N. Engl. J. Med. 361: 1437-47, 2009.
3)  Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, Zanetti KA, Ye QH, Qin LX, Croce CM, Tang ZY, Wang XW.
Identification of metastasis-related microRNAs in hepatocellular carcinoma.
Hepatology. 47: 897-907, 2008.
4)  Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US, Chen Y, Qin LX, Tang ZY, Wang XW.
Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment.
Cancer Cell. 10: 99-111, 2006.
5)  Wang W, Budhu A, Forgues M, Wang XW.
Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication.
Nat. Cell Biol. 7: 823-30, 2005.
6)  Dang HT, Budhu A, Wang XW.
The origin of cancer stem cells.
J. Hepatol. [Epub ahead of print], 2014.
7)  Henrich CJ, Budhu A, Yu Z, Evans JR, Goncharova EI, Ransom TT, Wang XW, McMahon JB.
High-throughput screening for identification of inhibitors of EpCAM-dependent growth of hepatocellular carcinoma cells.
Chem Biol Drug Des. 82: 131-9, 2013.
8)  Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, Hanna N, Alexander HR, Hussain SP.
Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.
Clin. Cancer Res. 19: 4983-93, 2013.
9)  Budhu A, Wang XW.
At the cancer steering wheel: defining key genomic drivers of liver cancer with next generation sequencing.
J. Hepatol. 56: 1412-4, 2012.
10)  Roessler S, Long EL, Budhu A, Chen Y, Zhao X, Ji J, Walker R, Jia HL, Ye QH, Qin LX, Tang ZY, He P, Hunter KW, Thorgeirsson SS, Meltzer PS, Wang XW.
Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.
Gastroenterology. 142: 957-966.e12, 2012.
11)  Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Woo HG, Kim YJ, Kaneko S, Tang ZY, Thorgeirsson SS, Wang XW.
Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma.
Hepatology. 56: 1792-803, 2012.
12)  Budhu A, Wang XW.
Transforming the microenvironment: a trick of the metastatic cancer cell.
Cancer Cell. 22: 279-80, 2012.
13)  Woo HG, Wang XW, Budhu A, Kim YH, Kwon SM, Tang ZY, Sun Z, Harris CC, Thorgeirsson SS.
Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma.
Gastroenterology. 140: 1063-70, 2011.
14)  Budhu A, Wang XW.
MicroRNAs and Gastroenterological Cancers.
Drug Discov Today Dis Mech. 8: e95-e102, 2011.
15)  Budhu A, Wang XW.
Power play: scoring our goals for liver cancer with better GWAS study design.
J. Hepatol. 54: 823-4, 2011.
16)  Roessler S, Jia HL, Budhu A, Forgues M, Ye QH, Lee JS, Thorgeirsson SS, Sun Z, Tang ZY, Qin LX, Wang XW.
A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients.
Cancer Res. 70: 10202-12, 2010.
17)  Nguyen GH, Schetter AJ, Chou DB, Bowman ED, Zhao R, Hawkes JE, Mathé EA, Kumamoto K, Zhao Y, Budhu A, Hagiwara N, Wang XW, Miyashita M, Casson AG, Harris CC.
Inflammatory and microRNA gene expression as prognostic classifier of Barrett"s-associated esophageal adenocarcinoma.
Clin. Cancer Res. 16: 5824-34, 2010.
18)  Budhu A, Ji J, Wang XW.
The clinical potential of microRNAs.
J Hematol Oncol. 3: 37, 2010.
19)  Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, Jia H, Ye Q, Qin LX, Wauthier E, Reid LM, Minato H, Honda M, Kaneko S, Tang ZY, Wang XW.
EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.
Gastroenterology. 136: 1012-24, 2009.
20)  Ji J, Yamashita T, Budhu A, Forgues M, Jia HL, Li C, Deng C, Wauthier E, Reid LM, Ye QH, Qin LX, Yang W, Wang HY, Tang ZY, Croce CM, Wang XW.
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells.
Hepatology. 50: 472-80, 2009.
21)  Mathé EA, Nguyen GH, Bowman ED, Zhao Y, Budhu A, Schetter AJ, Braun R, Reimers M, Kumamoto K, Hughes D, Altorki NK, Casson AG, Liu CG, Wang XW, Yanaihara N, Hagiwara N, Dannenberg AJ, Miyashita M, Croce CM, Harris CC.
MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival.
Clin. Cancer Res. 15: 6192-200, 2009.
22)  Dong F, Budhu AS, Wang XW.
Translating the metastasis paradigm from scientific theory to clinical oncology.
Clin. Cancer Res. 15: 2588-93, 2009.
23)  Yamashita T, Forgues M, Wang W, Kim JW, Ye Q, Jia H, Budhu A, Zanetti KA, Chen Y, Qin LX, Tang ZY, Wang XW.
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma.
Cancer Res. 68: 1451-61, 2008.
24)  Yamashita T, Budhu A, Forgues M, Wang XW.
Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma.
Cancer Res. 67: 10831-9, 2007.
25)  Roessler S, Budhu A, Wang XW.
Future of molecular profiling of human hepatocellular carcinoma.
Future oncology (London, England). 3: 429-39, 2007.
26)  Jia HL, Ye QH, Qin LX, Budhu A, Forgues M, Chen Y, Liu YK, Sun HC, Wang L, Lu HZ, Shen F, Tang ZY, Wang XW.
Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma.
Clin. Cancer Res. 13: 1133-9, 2007.
27)  Budhu A, Chen Y, Kim JW, Forgues M, Valerie K, Harris CC, Wang XW.
Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteins.
Carcinogenesis. 28: 1552-60, 2007.
28)  Seike M, Yanaihara N, Bowman ED, Zanetti KA, Budhu A, Kumamoto K, Mechanic LE, Matsumoto S, Yokota J, Shibata T, Sugimura H, Gemma A, Kudoh S, Wang XW, Harris CC.
Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier.
J. Natl. Cancer Inst. 99: 1257-69, 2007.
29)  Wu CG, Budhu A, Chen S, Zhou X, Popescu NC, Valerie K, Wang XW.
Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocytes.
Mol. Med. 12: 47-53, 2006.
30)  Budhu A, Wang XW.
The role of cytokines in hepatocellular carcinoma.
J. Leukoc. Biol. 80: 1197-213, 2006.
31)  Budhu AS, Wang XW.
Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1.
Cell Cycle. 4: 1510-4, 2005.
32)  Budhu AS, Zipser B, Forgues M, Ye QH, Sun Z, Wang XW.
The molecular signature of metastases of human hepatocellular carcinoma.
Oncology. 69 Suppl 1: 23-7, 2005.
33)  Kim JW, Ye Q, Forgues M, Chen Y, Budhu A, Sime J, Hofseth LJ, Kaul R, Wang XW.
Cancer-associated molecular signature in the tissue samples of patients with cirrhosis.
Hepatology. 39: 518-27, 2004.
34)  Manor D, Shmidt EN, Budhu A, Flesken-Nikitin A, Zgola M, Page R, Nikitin AY, Noy N.
Mammary carcinoma suppression by cellular retinoic acid binding protein-II.
Cancer Res. 63: 4426-33, 2003.
35)  Budhu AS, Noy N.
Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest.
Mol. Cell. Biol. 22: 2632-41, 2002.
36)  Budhu A, Gillilan R, Noy N.
Localization of the RAR interaction domain of cellular retinoic acid binding protein-II.
J. Mol. Biol. 305: 939-49, 2001.
37)  Budhu AS, Noy N.
On the role of the carboxyl-terminal helix of RXR in the interactions of the receptor with ligand.
Biochemistry. 39: 4090-5, 2000.
38)  Manseau L, Baradaran A, Brower D, Budhu A, Elefant F, Phan H, Philp AV, Yang M, Glover D, Kaiser K, Palter K, Selleck S.
GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of Drosophila.
Dev. Dyn. 209: 310-22, 1997.
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This page was last updated on 7/11/2014.