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Our Science – Chiang Website

Yungping (Jeffrey) Chiang, Ph.D.

Selected Publications

1)  Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG.
c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-ß type II receptor.
Mol. Cell. 49: 499-510, 2013.
2)  Lu J, Frerich JM, Turtzo LC, Li S, Chiang J, Yang C, Wang X, Zhang C, Wu C, Sun Z, Niu G, Zhuang Z, Brady RO, Chen X.
Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury.
Proc. Natl. Acad. Sci. U.S.A. 110: 10747-52, 2013.
3)  Chiang YJ, Difilippantonio MJ, Tessarollo L, Morse HC, Hodes RJ.
Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas.
PLoS ONE. 7: e49305, 2012.
4)  Chiang J, Hodes RJ.
Cbl enforces Vav1 dependence and a restricted pathway of T cell development.
PLoS ONE. 6: e18542, 2011.
5)  Martiniova L, Lu J, Chiang J, Bernardo M, Lonser R, Zhuang Z, Pacak K.
Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy.
PLoS ONE. 6: e14678, 2011.
6)  Lu J, Chiang J, Iyer RR, Thompson E, Kaneski CR, Xu DS, Yang C, Chen M, Hodes RJ, Lonser RR, Brady RO, Zhuang Z.
Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.
Proc. Natl. Acad. Sci. U.S.A. 2010.
7)  Jang IK, Zhang J, Chiang YJ, Kole HK, Cronshaw DG, Zou Y, Gu H.
Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection.
Proc. Natl. Acad. Sci. U.S.A. 107: 10620-5, 2010.
8)  Wen J, Chiang YJ, Gao C, Xue H, Xu J, Ning Y, Hodes RJ, Gao X, Chen YG.
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice.
J. Biol. Chem. 285: 11023-30, 2010.
9)  Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS, Hodes RJ.
Telomere length is inherited with resetting of the telomere set-point.
Proc. Natl. Acad. Sci. U.S.A. 107: 10148-53, 2010.
10)  Chiang YJ, Jordan MS, Horai R, Schwartzberg PL, Koretzky GA, Hodes RJ.
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.
J. Biol. Chem. 284: 4429-38, 2009.
11)  Lu J, Kovach JS, Johnson F, Chiang J, Hodes R, Lonser R, Zhuang Z.
Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.
Proc. Natl. Acad. Sci. U.S.A. 106: 11697-702, 2009.
12)  Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM.
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.
Epigenetics Chromatin. 1: 6, 2008.
13)  Chiang YJ, Hsiao SJ, Yver D, Cushman SW, Tessarollo L, Smith S, Hodes RJ.
Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
PLoS ONE. 3: e2639, 2008.
14)  Chiang JY, Jang IK, Hodes R, Gu H.
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.
J. Clin. Invest. 117: 1029-36, 2007.
15)  Song H, Zhang J, Chiang YJ, Siraganian RP, Hodes RJ.
Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.
J. Immunol. 178: 926-35, 2007.
16)  Cheng A, Shin-ya K, Wan R, Tang SC, Miura T, Tang H, Khatri R, Gleichman M, Ouyang X, Liu D, Park HR, Chiang JY, Mattson MP.
Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage.
J. Neurosci. 27: 3722-33, 2007.
17)  Chiang YJ, Nguyen ML, Gurunathan S, Kaminker P, Tessarollo L, Campisi J, Hodes RJ.
Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice.
Mol. Cell. Biol. 26: 2037-43, 2006.
18)  Horikawa I, Chiang YJ, Patterson T, Feigenbaum L, Leem SH, Michishita E, Larionov V, Hodes RJ, Barrett JC.
Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.
Proc. Natl. Acad. Sci. U.S.A. 102: 18437-42, 2005.
19)  Chiang YJ, Hemann MT, Hathcock KS, Tessarollo L, Feigenbaum L, Hahn WC, Hodes RJ.
Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo.
Mol. Cell. Biol. 24: 7024-31, 2004.
20)  Zhang J, Chiang YJ, Hodes RJ, Siraganian RP.
Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.
J. Immunol. 173: 1811-8, 2004.
21)  Chiang YJ, Sommers CL, Jordan MS, Gu H, Samelson LE, Koretzky GA, Hodes RJ.
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.
J. Exp. Med. 200: 25-34, 2004.
22)  Chiang YJ, Kim SH, Tessarollo L, Campisi J, Hodes RJ.
Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.
Mol. Cell. Biol. 24: 6631-4, 2004.
23)  Chiang YJ, Kole HK, Brown K, Naramura M, Fukuhara S, Hu RJ, Jang IK, Gutkind JS, Shevach E, Gu H.
Cbl-b regulates the CD28 dependence of T-cell activation.
Nature. 403: 216-20, 2000.
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This page was last updated on 10/30/2013.