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Our Science – Mittelstadt Website

Paul R. Mittelstadt, Ph.D.

Selected Publications

1)  Presman DM, Ogara MF, Stortz M, Alvarez LD, Pooley JR, Schiltz RL, Grøntved L, Johnson TA, Mittelstadt PR, Ashwell JD, Ganesan S, Burton G, Levi V, Hager GL, Pecci A.
Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor.
PLoS Biol. 12: e1001813, 2014.
2)  Guo L, Zheng Z, Ai J, Howatt DA, Mittelstadt PR, Thacker S, Daugherty A, Ashwell JD, Remaley AT, Li XA.
Scavenger Receptor BI and High-Density Lipoprotein Regulate Thymocyte Apoptosis in Sepsis.
Arterioscler. Thromb. Vasc. Biol. 2014.
3)  Kugler DG, Mittelstadt PR, Ashwell JD, Sher A, Jankovic D.
CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection.
J. Exp. Med. 210: 1919-27, 2013.
4)  Mittelstadt PR, Monteiro JP, Ashwell JD.
Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness.
J. Clin. Invest. 122: 2384-94, 2012.
5)  Jirmanova L, Giardino Torchia ML, Sarma ND, Mittelstadt PR, Ashwell JD.
Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.
Blood. 118: 3280-9, 2011.
6)  Jirmanova L, Sarma DN, Jankovic D, Mittelstadt PR, Ashwell JD.
Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.
Blood. 113: 2229-37, 2009.
7)  Mittelstadt PR, Yamaguchi H, Appella E, Ashwell JD.
T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity.
J. Biol. Chem. 284: 15469-74, 2009.
8)  Mittelstadt PR, Salvador JM, Fornace AJ, Ashwell JD.
Activating p38 MAPK: new tricks for an old kinase.
Cell Cycle. 4: 1189-92, 2005.
9)  Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ, Ashwell JD.
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
Nat. Immunol. 6: 390-5, 2005.
10)  Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ, Ashwell JD.
The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
Nat. Immunol. 6: 396-402, 2005.
11)  Mittelstadt PR, Ashwell JD.
Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression.
Mol. Endocrinol. 17: 1534-42, 2003.
12)  Mittelstadt PR, Galon J, Franchimont D, O'Shea JJ, Ashwell JD.
Glucocorticoid-inducible genes that regulate T-cell function.
Ernst Schering Res. Found. Workshop. 319-39, 2002.
13)  Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD.
HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.
J. Biol. Chem. 277: 19482-7, 2002.
14)  Mittelstadt PR, Ashwell JD.
Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.
J. Biol. Chem. 276: 29603-10, 2001.
15)  Rengarajan J, Mittelstadt PR, Mages HW, Gerth AJ, Kroczek RA, Ashwell JD, Glimcher LH.
Sequential involvement of NFAT and Egr transcription factors in FasL regulation.
Immunity. 12: 293-300, 2000.
16)  Mittelstadt PR, Ashwell JD.
Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells.
J. Biol. Chem. 274: 3222-7, 1999.
17)  Mittelstadt PR, Ashwell JD.
Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression.
Mol. Cell. Biol. 18: 3744-51, 1998.
18)  DeFranco AL, Mittelstadt PR, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L.
Mechanism of B cell antigen receptor function: transmembrane signaling and triggering of apoptosis.
Adv. Exp. Med. Biol. 365: 9-22, 1994.
19)  Mittelstadt PR, DeFranco AL.
Induction of early response genes by cross-linking membrane Ig on B lymphocytes.
J. Immunol. 150: 4822-32, 1993.
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This page was last updated on 4/10/2014.