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Our Science – Roschke Website

Anna V. Roschke, Ph.D.

Selected Publications

1)  Affer M, Chesi M, Chen WD, Keats JJ, Demchenko YN, Roschke AV, Van Wier S, Fonseca R, Bergsagel PL, Kuehl WM.
Promiscuous rearrangements of the MYC locus hijack enhancers and super-enhancers to dysregulate MYC expression in multiple myeloma.
Leukemia. 2014.
2)  Kim GY, Gabrea A, Demchenko YN, Bergsagel L, Roschke AV, Kuehl WM.
Complex IGH rearrangements in multiple myeloma: Frequent detection discrepancies among three different probe sets.
Genes Chromosomes Cancer. 2014.
3)  Roschke AV, Rozenblum E.
Multi-Layered Cancer Chromosomal Instability Phenotype.
Front Oncol. 3: 302, 2013.
4)  Klorin G, Rozenblum E, Glebov O, Walker RL, Park Y, Meltzer PS, Kirsch IR, Kaye FJ, Roschke AV.
Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.
Cancer Genet. 206: 191-205, 2013.
5)  Cheng Y, Zhang Z, Keenan B, Roschke AV, Nakahara K, Aplan PD.
Efficient repair of DNA double-strand breaks in malignant cells with structural instability.
Mutat. Res. 683: 115-22, 2010.
6)  Roschke AV, Kirsch IR.
Targeting karyotypic complexity and chromosomal instability of cancer cells.
Curr Drug Targets. 11: 1341-50, 2010.
7)  Roschke AV, Glebov OK, Lababidi S, Gehlhaus KS, Weinstein JN, Kirsch IR.
Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance.
Neoplasia. 10: 1222-30, 2008.
8)  Gabrea A, Martelli ML, Qi Y, Roschke A, Barlogie B, Shaughnessy JD, Sawyer JR, Kuehl WM.
Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors.
Genes Chromosomes Cancer. 47: 573-90, 2008.
9)  Lenz G, Nagel I, Siebert R, Roschke AV, Sanger W, Wright GW, Dave SS, Tan B, Zhao H, Rosenwald A, Muller-Hermelink HK, Gascoyne RD, Campo E, Jaffe ES, Smeland EB, Fisher RI, Kuehl WM, Chan WC, Staudt LM.
Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma.
J. Exp. Med. 204: 633-43, 2007.
10)  Bussey KJ, Chin K, Lababidi S, Reimers M, Reinhold WC, Kuo WL, Gwadry F, Kouros-Mehr H, Fridlyand J, Jain A, Collins C, Nishizuka S, Tonon G, Roschke A, Gehlhaus K, Kirsch I, Scudiero DA, Gray JW, Weinstein JN.
Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel.
Mol. Cancer Ther. 5: 853-67, 2006.
Click Here to View Expanded Bibliography.

This page was last updated on 3/21/2014.