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Xuguang Tai, Ph.D.

Selected Publications

1)  Tai X, Cowan M, Feigenbaum L, Singer A.
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.
Nat. Immunol. 6: 152-62, 2005.
2)  Tai X, Van Laethem F, Sharpe AH, Singer A.
Induction of autoimmune disease in CTLA-4 / mice depends on a specific CD28 motif that is required for in vivo costimulation.
Proc. Natl. Acad. Sci. U.S.A. 104: 13756-61, 2007.
3)  Tai X, Van Laethem F, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, Singer A.
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Blood. 119: 5155-63, 2012.
4)  Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A.
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.
Immunity. 38: 1116-28, 2013.
5)  Tai X, Singer A.
Basis of Treg development in the thymus.
Cell Cycle. 13: 501-2, 2014.
6)  Mu J, Tai X, Iyer SS, Weissman JD, Singer A, Singer DS.
Regulation of MHC class I expression by foxp3 and its effect on regulatory T cell function.
J. Immunol. 192: 2892-903, 2014.
7)  Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.
IL-7 signaling must be intermittent, not continuous, during CD8? T cell homeostasis to promote cell survival instead of cell death.
Nat. Immunol. 14: 143-51, 2013.
8)  Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A.
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Cell. 154: 1326-41, 2013.
9)  Linowes BA, Ligons DL, Nam AS, Hong C, Keller HR, Tai X, Luckey MA, Park JH.
Pim1 permits generation and survival of CD4+ T cells in the absence of ?c cytokine receptor signaling.
Eur. J. Immunol. 43: 2283-94, 2013.
10)  Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A.
Coreceptor gene imprinting governs thymocyte lineage fate.
EMBO J. 31: 366-77, 2012.
11)  Hathcock KS, Farrington L, Ivanova I, Livak F, Selimyan R, Sen R, Williams J, Tai X, Hodes RJ.
The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJß rearrangement.
PLoS ONE. 6: e20639, 2011.
12)  Catalfamo M, Tai X, Karpova T, McNally J, Henkart PA.
TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells.
Immunology. 125: 70-9, 2008.
13)  Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A.
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Immunity. 27: 735-50, 2007.
14)  Graham DB, Bell MP, Huntoon CJ, Griffin MD, Tai X, Singer A, McKean DJ.
CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling.
J. Immunol. 177: 6098-107, 2006.
15)  Bhandoola A, Tai X, Eckhaus M, Auchincloss H, Mason K, Rubin SA, Carbone KM, Grossman Z, Rosenberg AS, Singer A.
Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model.
Immunity. 17: 425-36, 2002.
16)  McKean DJ, Huntoon CJ, Bell MP, Tai X, Sharrow S, Hedin KE, Conley A, Singer A.
Maturation versus death of developing double-positive thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation.
J. Immunol. 166: 3468-75, 2001.
17)  Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A.
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.
Science. 290: 1962-5, 2000.
Click Here to View Collapsed Bibliography.

This page was last updated on 7/14/2014.