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Our Science – Tai Website

Xuguang Tai, Ph.D.

Selected Publications

1)  Tai X, Singer A.
Basis of Treg development in the thymus.
Cell Cycle. 13: 501-2, 2014.
[Journal]
2)  Mu J, Tai X, Iyer SS, Weissman JD, Singer A, Singer DS.
Regulation of MHC class I expression by foxp3 and its effect on regulatory T cell function.
J. Immunol. 192: 2892-903, 2014.
[Journal]
3)  Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A.
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.
Immunity. 38: 1116-28, 2013.
[Journal]
4)  Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.
IL-7 signaling must be intermittent, not continuous, during CD8? T cell homeostasis to promote cell survival instead of cell death.
Nat. Immunol. 14: 143-51, 2013.
[Journal]
5)  Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A.
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Cell. 154: 1326-41, 2013.
[Journal]
6)  Linowes BA, Ligons DL, Nam AS, Hong C, Keller HR, Tai X, Luckey MA, Park JH.
Pim1 permits generation and survival of CD4+ T cells in the absence of ?c cytokine receptor signaling.
Eur. J. Immunol. 43: 2283-94, 2013.
[Journal]
7)  Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A.
Coreceptor gene imprinting governs thymocyte lineage fate.
EMBO J. 31: 366-77, 2012.
[Journal]
8)  Hathcock KS, Farrington L, Ivanova I, Livak F, Selimyan R, Sen R, Williams J, Tai X, Hodes RJ.
The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJß rearrangement.
PLoS ONE. 6: e20639, 2011.
[Journal]
9)  Catalfamo M, Tai X, Karpova T, McNally J, Henkart PA.
TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells.
Immunology. 125: 70-9, 2008.
[Journal]
10)  Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A.
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Immunity. 27: 735-50, 2007.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 4/16/2014.