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Xuguang Tai, Ph.D.

Selected Publications

1)  Tai X, Cowan M, Feigenbaum L, Singer A.
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.
Nat. Immunol. 6: 152-62, 2005.
2)  Tai X, Van Laethem F, Sharpe AH, Singer A.
Induction of autoimmune disease in CTLA-4 / mice depends on a specific CD28 motif that is required for in vivo costimulation.
Proc. Natl. Acad. Sci. U.S.A. 104: 13756-61, 2007.
3)  Tai X, Van Laethem F, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, Singer A.
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Blood. 119: 5155-63, 2012.
4)  Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A.
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.
Immunity. 38: 1116-28, 2013.
5)  Tai X, Singer A.
Basis of Treg development in the thymus.
Cell Cycle. 13: 501-2, 2014.
6)  Mu J, Tai X, Iyer SS, Weissman JD, Singer A, Singer DS.
Regulation of MHC class I expression by foxp3 and its effect on regulatory T cell function.
J. Immunol. 192: 2892-903, 2014.
7)  Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.
IL-7 signaling must be intermittent, not continuous, during CD8? T cell homeostasis to promote cell survival instead of cell death.
Nat. Immunol. 14: 143-51, 2013.
8)  Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A.
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Cell. 154: 1326-41, 2013.
9)  Linowes BA, Ligons DL, Nam AS, Hong C, Keller HR, Tai X, Luckey MA, Park JH.
Pim1 permits generation and survival of CD4+ T cells in the absence of ?c cytokine receptor signaling.
Eur. J. Immunol. 43: 2283-94, 2013.
10)  Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A.
Coreceptor gene imprinting governs thymocyte lineage fate.
EMBO J. 31: 366-77, 2012.
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This page was last updated on 7/14/2014.