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Jung-Hyun Park, Ph.D.

Selected Publications

1)  Hong C, Luckey MA, Ligons DL, Waickman AT, Park JY, Kim GY, Keller HR, Etzensperger R, Tai X, Lazarevic V, Feigenbaum L, Catalfamo M, Walsh ST, Park JH.
Activated T Cells Secrete an Alternatively Spliced Form of Common ?-Chain that Inhibits Cytokine Signaling and Exacerbates Inflammation.
Immunity. 2014.
[Journal]
2)  Luckey MA, Kimura MY, Waickman AT, Feigenbaum L, Singer A, Park JH.
The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.
Nat. Immunol. 2014.
[Journal]
3)  Tinsley KW, Hong C, Luckey MA, Park J, Kim GY, Yoon H, Keller HR, Sacks AJ, Feigenbaum L, Park J.
Ikaros is required to survive positive selection and to maintain clonal diversity during T cell development in the thymus.
Blood. 122: 2358-68, 2013.
[Journal]
4)  Linowes BA, Ligons DL, Nam AS, Hong C, Keller HR, Tai X, Luckey MA, Park J.
Pim1 permits generation and survival of CD4(+) T cells in the absence of ?c cytokine receptor signaling.
Eur. J. Immunol. 43: 2283-94, 2013.
[Journal]
5)  Kim GY, Ligons DL, Hong C, Luckey MA, Keller HR, Tai X, Lucas PJ, Gress RE, Park J.
An In Vivo IL-7 Requirement for Peripheral Foxp3+ Regulatory T Cell Homeostasis.
J Immunol. 188: 5859-66, 2012.
[Journal]
6)  Le Saout C, Hasley RB, Imamichi H, Tcheung L, Hu Z, Luckey MA, Park JH, Durum SK, Smith M, Rupert AW, Sneller MC, Lane HC, Catalfamo M.
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
PLoS Pathog. 10: e1003976, 2014.
[Journal]
7)  Luckey MA, Park JH.
?c Cytokine signaling: graduate school in thymic education.
Blood. 121: 4-6, 2013.
[Journal]
8)  Hasley RB, Hong C, Li W, Friesen T, Nakamura Y, Kim GY, Park JH, Hixon JA, Durum S, Hu Z, Sneller MC, Oguariri R, Imamichi T, Lane HC, Catalfamo M.
HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.
AIDS. 27: 1867-77, 2013.
[Journal]
9)  Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.
IL-7 signaling must be intermittent, not continuous, during CD8? T cell homeostasis to promote cell survival instead of cell death.
Nat. Immunol. 14: 143-51, 2013.
[Journal]
10)  Hong C, Nam AS, Keller HR, Ligons DL, Park J, Yoon H, Park JJ, Luckey MA, Park J.
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine. 64: 532-40, 2013.
[Journal]
11)  Um JH, Brown AL, Singh SK, Chen Y, Gucek M, Lee BS, Luckey MA, Kim MK, Park JH, Sleckman BP, Gellert M, Chung JH.
Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.
Proc. Natl. Acad. Sci. U.S.A. 110: 9873-8, 2013.
[Journal]
12)  Tikhonova AN, Van Laethem F, Hanada K, Lu J, Pobezinsky LA, Hong C, Guinter TI, Jeurling SK, Bernhardt G, Park J, Yang JC, Sun PD, Singer A.
abT cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.
Immunity. 36: 79-91, 2012.
[Journal]
13)  Ligons DL, Tuncer C, Linowes BA, Akcay IM, Kurtulus S, Deniz E, Atasever Arslan B, Cevik SI, Keller HR, Luckey MA, Feigenbaum L, Möröy T, Ersahin T, Atalay R, Erman B, Park J.
CD8 lineage specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.
J. Biol. Chem. 287: 34386-99, 2012.
[Journal]
14)  Pobezinsky LA, Angelov GS, Tai X, Jeurling S, Van Laethem F, Feigenbaum L, Park JH, Singer A.
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.
Nat. Immunol. 13: 569-78, 2012.
[Journal]
15)  McCaughtry TM, Etzensperger R, Alag A, Tai X, Kurtulus S, Park JH, Grinberg A, Love P, Feigenbaum L, Erman B, Singer A.
Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.
J. Exp. Med. 209: 2263-76, 2012.
[Journal]
16)  Adoro S, Park JH, Singer A.
Coreceptor gene 'imprinting': A genetic solution to a developmental dillema in T cells.
Cell Cycle. 11: 833-834, 2012.
[Journal]
17)  Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A.
Coreceptor gene imprinting governs thymocyte lineage fate.
EMBO J. 31: 366-77, 2012.
[Journal]
18)  Hong C, Luckey MA, Park JH.
Intrathymic IL-7: The where, when, and why of IL-7 signaling during T cell development.
Semin. Immunol. 24: 151-8, 2012.
[Journal]
19)  Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A.
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
Immunity. 37: 971-85, 2012.
[Journal]
20)  Catalfamo M, Wilhelm C, Tcheung L, Proschan M, Friesen T, Park JH, Adelsberger J, Baseler M, Maldarelli F, Davey R, Roby G, Rehm C, Lane C.
CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7.
J. Immunol. 186: 2106-16, 2011.
[Journal]
21)  Kim GY, Hong C, Park JH.
Seeing is believing: illuminating the source of in vivo interleukin-7.
Immune Netw. 11: 1-10, 2011.
[Journal]
22)  Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L, Singer A.
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.
Nat. Immunol. 11: 257-64, 2010.
[Journal]
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This page was last updated on 6/17/2014.