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Our Science – St. Croix Website

Brad St. Croix, Ph.D.

Selected Publications

1)  Xu L, Stevens J, Hilton MB, Seaman S, Conrads TP, Veenstra TD, Logsdon D, Morris H, Swing DA, Patel NL, Kalen J, Haines DC, Zudaire E, St Croix B.
COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models.
Sci Transl Med. 6: 242ra84, 2014.
[Journal]
2)  Kuo F, Histed S, Xu B, Bhadrasetty V, Szajek LP, Williams MR, Wong K, Wu H, Lane K, Coble V, Vasalatiy O, Griffiths GL, Paik CH, Elbuluk O, Szot C, Chaudhary A, St Croix B, Choyke P, Jagoda EM.
Immuno-PET Imaging of Tumor Endothelial Marker 8 (TEM8).
Mol. Pharm. 2014.
[Journal]
3)  Tang Z, Feng M, Gao W, Phung Y, Chen W, Chaudhary A, St Croix B, Qian M, Dimitrov DS, Ho M.
A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin close to the cancer cell surface.
Mol. Cancer Ther. 12: 416-26, 2013.
[Journal]
4)  Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B.
Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.
Cell Rep. 3: 1457-64, 2013.
[Journal]
5)  Stránecký V, Hoischen A, Hartmannová H, Zaki MS, Chaudhary A, Zudaire E, Nosková L, Barešová V.
Mutations in ANTXR1 Cause GAPO Syndrome.
Am. J. Hum. Genet. 92: 792-9, 2013.
[Journal]
6)  Chaudhary A, St Croix B.
Selective blockade of tumor angiogenesis.
Cell Cycle. 11: 2253-9, 2012.
[Journal]
7)  Chaudhary A, Hilton MB, Seaman S, Haines DC, Stevenson S, Lemotte PK, Tschantz WR, Zhang XM, Saha S, Fleming T, St Croix B.
TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types.
Cancer Cell. 21: 212-26, 2012.
[Journal]
8)  Langenkamp E, Zwiers PJ, Moorlag HE, Leenders WP, St Croix B, Molema G.
Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296.
Anticancer Drugs. 23: 161-72, 2012.
[Journal]
9)  Meehan B, Appu S, St Croix B, Rak-Poznanska K, Klotz L, Rak J.
Age-related properties of the tumour vasculature in renal cell carcinoma.
BJU Int. 107: 416-24, 2011.
[Journal]
10)  Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B.
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Proc. Natl. Acad. Sci. U.S.A. 108: 5759-64, 2011.
[Journal]
11)  Yang MY, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad MK, Frankel AE, St Croix B.
The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton.
Biochim. Biophys. Acta. 1813: 39-49, 2011.
[Journal]
12)  Cullen M, Seaman S, Chaudhary A, Yang MY, Hilton MB, Logsdon D, Haines DC, Tessarollo L, St Croix B.
Host-derived tumor endothelial marker 8 promotes the growth of melanoma.
Cancer Res. 69: 6021-6, 2009.
[Journal]
13)  Dang DT, Chun SY, Burkitt K, Abe M, Chen S, Havre P, Mabjeesh NJ, Heath EI, Vogelzang NJ, Cruz-Correa M, Blayney DW, Ensminger WD, St Croix B, Dang NH, Dang LH.
Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition.
Cancer Res. 68: 1872-80, 2008.
[Journal]
14)  Klement H, St Croix B, Milsom C, May L, Guo Q, Yu JL, Klement P, Rak J.
Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy.
Am. J. Pathol. 171: 1342-51, 2007.
[Journal]
15)  Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B.
Genes that distinguish physiological and pathological angiogenesis.
Cancer Cell. 11: 539-54, 2007.
[Journal]
16)  Peters BA, St Croix B, Sjoblom T, Cummins JM, Silliman N, Ptak J, Saha S, Kinzler KW, Hatzis C, Velculescu VE.
Large-scale identification of novel transcripts in the human genome.
Genome Res. 17: 287-92, 2007.
[Journal]
17)  Blackshaw S, St Croix B, Polyak K, Kim JB, Cai L.
Serial analysis of gene expression (SAGE): experimental method and data analysis.
Curr. Protoc. Hum. Genet. Chapter 11: Unit 11.7, 2007.
[Journal]
18)  St. Croix B.
Vaccines targeting tumor vasculature: a new approach for cancer immunotherapy.
Cytotherapy. 9 (1): 1-3, 2007.
[Journal]
19)  Nanda A, Karim B, Peng Z, Liu G, Qiu W, Gan C, Vogelstein B, St Croix B, Kinzler KW, Huso DL.
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.
Proc. Natl. Acad. Sci. U.S.A. 103: 3351-6, 2006.
[Journal]
20)  Nanda A, Buckhaults P, Seaman S, Agrawal N, Boutin P, Shankara S, Nacht M, Teicher B, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B.
Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R.
Cancer Res. 64: 8507-11, 2004.
[Journal]
21)  Nanda A, Carson-Walter EB, Seaman S, Barber TD, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B.
TEM8 Interacts with the Cleaved C5 Domain of Collagen alpha3(VI).
Cancer Res. 64: 817-820, 2004.
[Journal]
22)  Nanda A, St Croix B.
Tumor endothelial markers: new targets for cancer therapy.
Curr Opin Oncol. 16 (1): 44-49., 2004.
[Journal]
23)  Buckhaults P, Zhang Z, Chen YC, Wang TL, St Croix B, Saha S, Bardelli A, Morin PJ, Polyak K, Hruban RH, Velculescu VE, Shih IeM.
Identifying tumor origin using a gene expression-based classification map.
Cancer Res. 63: 4144-9, 2003.
[Journal]
24)  Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B.
A phosphatase associated with metastasis of colorectal cancer.
Science. 294: 1343-6, 2001.
[Journal]
25)  Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B.
Cell surface tumor endothelial markers are conserved in mice and humans.
Cancer Res. 61: 6649-6655, 2001.
[Journal]
26)  Buckhaults P, Rago C, St Croix B, Romans KE, Saha S, Zhang L, Vogelstein B, Kinzler KW.
Secreted and cell surface genes expressed in benign and malignant colorectal tumors.
Cancer Res. 61: 6996-7001, 2001.
[Journal]
27)  Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL, Kaanders JH, van der Kogel AJ, Riggins GJ.
Transcriptional response to hypoxia in human tumors.
J Natl Cancer Inst. 93: 1337-43, 2001.
[Journal]
28)  St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW.
Genes expressed in human tumor endothelium.
Science. 289: 1197-1202, 2000.
[Journal]
Click Here to View Collapsed Bibliography.

This page was last updated on 7/21/2014.