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Wenqing Li, Ph.D.

Selected Publications

1)  Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y.
IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis.
Cell Death Differ. 19: 1139-51, 2012.
2)  Ruppert SM, Li W, Zhang G, Carlson AL, Limaye A, Durum SK, Khaled AR.
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.
Biochim. Biophys. Acta. 1823: 1877-93, 2012.
3)  Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT.
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Nat. Genet. 43: 932-9, 2011.
4)  Brooks AD, Jacobsen KM, Li W, Shanker A, Sayers TJ.
Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex.
Mol. Cancer Res. 8: 729-38, 2010.
5)  Kittipatarin C, Li W, Durum SK, Khaled AR.
Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.
Exp. Hematol. 38: 1143-56, 2010.
6)  Li WQ, Guszczynski T, Hixon JA, Durum SK.
Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.
Mol. Cell. Biol. 30: 590-600, 2010.
7)  Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, Cherry J, Naf D, Sternberg LR, McVicar DW, Farr AG, Germain RN, Rogers K, Jenkins NA, Copeland NG, Durum SK.
Visualization and identification of IL-7 producing cells in reporter mice.
PLoS ONE. 4: e7637, 2009.
8)  Mazzucchelli R, Hixon JA, Spolski R, Chen X, Li WQ, Hall VL, Willette-Brown J, Hurwitz AA, Leonard WJ, Durum SK.
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Blood. 112: 3283-92, 2008.
9)  Jiang Q, Huang J, Li WQ, Cavinato T, Keller JR, Durum SK.
Role of the intracellular domain of IL-7 receptor in T cell development.
J. Immunol. 178: 228-34, 2007.
10)  Kittipatarin C, Li WQ, Bulavin DV, Durum SK, Khaled AR.
Cell cycling through Cdc25A: transducer of cytokine proliferative signals.
Cell Cycle. 5: 907-12, 2006.
11)  Li WQ, Jiang Q, Aleem E, Kaldis P, Khaled AR, Durum SK.
IL-7 promotes T cell proliferation through destabilization of p27Kip1.
J. Exp. Med. 203: 573-82, 2006.
12)  Jiang Q, Li WQ, Aiello FB, Mazzucchelli R, Asefa B, Khaled AR, Durum SK.
Cell biology of IL-7, a key lymphotrophin.
Cytokine Growth Factor Rev. 16: 513-33, 2005.
13)  Khaled AR, Bulavin DV, Kittipatarin C, Li WQ, Alvarez M, Kim K, Young HA, Fornace AJ, Durum SK.
Cytokine-driven cell cycling is mediated through Cdc25A.
J. Cell Biol. 169: 755-63, 2005.
14)  Jiang Q, Li WQ, Aiello FB, Klarmann KD, Keller JR, Durum SK.
Retroviral transduction of IL-7Ralpha into IL-7Ralpha-/- bone marrow progenitors: correction of lymphoid deficiency and induction of neutrophilia.
Gene Ther. 12: 1761-8, 2005.
15)  Jiang Q, Li WQ, Hofmeister RR, Young HA, Hodge DR, Keller JR, Khaled AR, Durum SK.
Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members.
Mol. Cell. Biol. 24: 6501-13, 2004.
16)  Li WQ, Jiang Q, Khaled AR, Keller JR, Durum SK.
Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival.
J. Biol. Chem. 279: 29160-6, 2004.
17)  Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK.
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Immunity. 17: 561-73, 2002.
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This page was last updated on 12/19/2012.