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Our Science – Yang Website

De Yang, M.D., Ph.D.

Selected Publications

1)  Yang D, Wei F, Tewary P, Howard OM, Oppenheim JJ.
Alarmin-induced cell migration.
Eur. J. Immunol. 43: 1412-8, 2013.
2)  Tewary P, de la Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OM, Shirota H, Steinhagen F, Klinman DM, Yang D, Oppenheim JJ.
ß-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-a production by human plasmacytoid dendritic cells, and promote inflammation.
J. Immunol. 191: 865-74, 2013.
3)  Yang D, Postnikov YV, Li Y, Tewary P, de la Rosa G, Wei F, Klinman D, Gioannini T, Weiss JP, Furusawa T, Bustin M, Oppenheim JJ.
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
J. Exp. Med. 209: 157-71, 2012.
4)  Yang D, Zhao Y, Guo H, Li Y, Tewary P, Xing G, Hou W, Oppenheim JJ, Zhang N.
[Gd@C(82)(OH)(22)](n) nanoparticles induce dendritic cell maturation and activate Th1 immune responses.
ACS Nano. 4: 1178-86, 2010.
5)  Tewary P, Yang D, de la Rosa G, Li Y, Finn MW, Krensky AM, Clayberger C, Oppenheim JJ.
Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.
Blood. 116: 3465-74, 2010.
6)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
J. Immunol. 184: 6688-94, 2010.
7)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.
J. Biol. Chem. 285: 7028-34, 2010.
8)  Yang D, Oppenheim JJ.
Alarmins and antimicrobial immunity.
Med. Mycol. 47 Suppl 1: S146-53, 2009.
9)  Yang D, de la Rosa G, Tewary P, Oppenheim JJ.
Alarmins link neutrophils and dendritic cells.
Trends Immunol. 30: 531-7, 2009.
10)  Yang D, Tewary P, de la Rosa G, Wei F, Oppenheim JJ.
The alarmin functions of high-mobility group proteins.
Biochim. Biophys. Acta. 1799: 157-63, 2009.
11)  Yang D, Chen Q, Su SB, Zhang P, Kurosaka K, Caspi RR, Michalek SM, Rosenberg HF, Zhang N, Oppenheim JJ.
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.
J. Exp. Med. 205: 79-90, 2008.
12)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3.
J. Biol. Chem. 283: 5414-9, 2008.
13)  de la Rosa G, Yang D, Tewary P, Varadhachary A, Oppenheim JJ.
Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses.
J. Immunol. 180: 6868-76, 2008.
14)  Oppenheim JJ, Tewary P, de la Rosa G, Yang D.
Alarmins initiate host defense.
Adv. Exp. Med. Biol. 601: 185-94, 2007.
15)  Yang D, Liu ZH, Tewary P, Chen Q, de la Rosa G, Oppenheim JJ.
Defensin participation in innate and adaptive immunity.
Curr. Pharm. Des. 13: 3131-9, 2007.
16)  Yang D, Chen Q, Yang H, Tracey KJ, Bustin M, Oppenheim JJ.
High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin.
J. Leukoc. Biol. 81: 59-66, 2007.
17)  Zhang N, Yang D, Dong H, Chen Q, Dimitrova DI, Rogers TJ, Sitkovsky M, Oppenheim JJ.
Adenosine A2a receptors induce heterologous desensitization of chemokine receptors.
Blood. 108: 38-44, 2006.
18)  Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ.
Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Exp. Hematol. 34: 1115-24, 2006.
19)  Oppenheim JJ, Yang D.
Alarmins: chemotactic activators of immune responses.
Curr. Opin. Immunol. 17: 359-65, 2005.
20)  Kurosaka K, Chen Q, Yarovinsky F, Oppenheim JJ, Yang D.
Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant.
J. Immunol. 174: 6257-65, 2005.
21)  Yang D, Oppenheim JJ.
Antimicrobial proteins act as.
Arthritis Rheum. 50: 3401-3, 2004.
22)  Chen B, Blair DG, Plisov S, Vasiliev G, Perantoni AO, Chen Q, Athanasiou M, Wu JY, Oppenheim JJ, Yang D.
Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.
J. Immunol. 173: 5914-7, 2004.
23)  Yang D, Chen Q, Rosenberg HF, Rybak SM, Newton DL, Wang ZY, Fu Q, Tchernev VT, Wang M, Schweitzer B, Kingsmore SF, Patel DD, Oppenheim JJ, Howard OM.
Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.
J. Immunol. 173: 6134-42, 2004.
24)  Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ.
Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.
Annu. Rev. Immunol. 22: 181-215, 2004.
25)  Chen Q, Wade D, Kurosaka K, Wang ZY, Oppenheim JJ, Yang D.
Temporin A and related frog antimicrobial peptides use formyl peptide receptor-like 1 as a receptor to chemoattract phagocytes.
J. Immunol. 173: 2652-9, 2004.
26)  Wu Z, Hoover DM, Yang D, Boulègue C, Santamaria F, Oppenheim JJ, Lubkowski J, Lu W.
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
Proc. Natl. Acad. Sci. U.S.A. 100: 8880-5, 2003.
27)  Yang D, Rosenberg HF, Chen Q, Dyer KD, Kurosaka K, Oppenheim JJ.
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells.
Blood. 102: 3396-403, 2003.
28)  Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J, Oppenheim JJ.
Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
J. Leukoc. Biol. 74: 448-55, 2003.
29)  Oppenheim JJ, Biragyn A, Kwak LW, Yang D.
Roles of antimicrobial peptides such as defensins in innate and adaptive immunity.
Ann. Rheum. Dis. 62 Suppl 2: ii17-21, 2003.
30)  Oppenheim JJ, Yang D, Biragyn A, Howard OM, Plotz P.
Chemokine receptors on dendritic cells promote autoimmune reactions.
Arthritis Res. 4 Suppl 3: S183-8, 2002.
31)  Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, Casciola-Rosen L, Härtlein M, Kron M, Yang D, Yiadom K, Dwivedi S, Plotz PH, Oppenheim JJ.
Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.
J. Exp. Med. 196: 781-91, 2002.
32)  Yang D, Chen Q, Gertz B, He R, Phulsuksombati M, Ye RD, Oppenheim JJ.
Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation.
J. Leukoc. Biol. 72: 598-607, 2002.
33)  Yang D, Biragyn A, Kwak LW, Oppenheim JJ.
Mammalian defensins in immunity: more than just microbicidal.
Trends Immunol. 23: 291-6, 2002.
34)  Hoover DM, Boulegue C, Yang D, Oppenheim JJ, Tucker K, Lu W, Lubkowski J.
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
J. Biol. Chem. 277: 37647-54, 2002.
35)  Yang D, Chen Q, Le Y, Wang JM, Oppenheim JJ.
Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages.
J. Immunol. 166: 4092-8, 2001.
36)  Yang D, Chertov O, Oppenheim JJ.
Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37).
J. Leukoc. Biol. 69: 691-7, 2001.
37)  Yang D, Chertov O, Oppenheim JJ.
The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity.
Cell. Mol. Life Sci. 58: 978-89, 2001.
38)  Chen X, Yang D, Shen W, Dong HF, Wang JM, Oppenheim JJ, Howard MZ.
Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors.
Inflamm. Res. 49: 744-55, 2000.
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This page was last updated on 4/16/2014.