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Our Science – Howard Website

O.M. Zack Howard, Ph.D.

Selected Publications

1)  Chen X, Yang Y, Zhou Q, Weiss JM, Howard OZ, McPherson JM, Wakefield LM, Oppenheim JJ.
Effective chemoimmunotherapy with anti-TGFß antibody and cyclophosphamide in a mouse model of breast cancer.
PLoS ONE. 9: e85398, 2014.
2)  Zhou Q, Hu Y, Howard OM, Oppenheim JJ, Chen X.
In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.
Cytokine. 65: 56-64, 2014.
3)  Yang D, Wei F, Tewary P, Howard OM, Oppenheim JJ.
Alarmin-induced cell migration.
Eur. J. Immunol. 43: 1412-8, 2013.
4)  Yoshimura T, Howard OM, Ito T, Kuwabara M, Matsukawa A, Chen K, Liu Y, Liu M, Oppenheim JJ, Wang JM.
Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells.
PLoS ONE. 8: e58791, 2013.
5)  Tewary P, de la Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OM, Shirota H, Steinhagen F, Klinman DM, Yang D, Oppenheim JJ.
ß-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-a production by human plasmacytoid dendritic cells, and promote inflammation.
J. Immunol. 191: 865-74, 2013.
6)  Chen X, Wu X, Zhou Q, Howard OM, Netea MG, Oppenheim JJ.
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
J. Immunol. 190: 1076-84, 2013.
7)  Malik M, Jividen K, Padmakumar VC, Cataisson C, Li L, Lee J, Howard OM, Yuspa SH.
Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.
Proc. Natl. Acad. Sci. U.S.A. 109: 6130-5, 2012.
8)  Kron MA, Wang C, Vodanovic-Jankovic S, Howard OM, Kuhn LA.
Interleukin-8-like activity in a filarial asparaginyl-tRNA synthetase.
Mol. Biochem. Parasitol. 185: 66-9, 2012.
9)  Marton A, Vizler C, Kusz E, Temesfoi V, Szathmary Z, Nagy K, Szegletes Z, Varo G, Siklos L, Katona RL, Tubak V, Howard OM, Duda E, Minarovits J, Nagy K, Buzas K.
Melanoma cell-derived exosomes alter macrophage and dendritic cell functions in vitro.
Immunol. Lett. 148: 34-8, 2011.
10)  Qi J, Buzas K, Fan H, Cohen JI, Wang K, Mont E, Klinman D, Oppenheim JJ, Howard OM.
Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons.
J Immunol. 186: 6417-26, 2011.
11)  Tarasov SG, Gaponenko V, Howard OM, Chen Y, Oppenheim JJ, Dyba MA, Subramaniam S, Lee Y, Michejda C, Tarasova NI.
Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles.
Proc. Natl. Acad. Sci. U.S.A. 108: 9798-803, 2011.
12)  Chen X, Subleski JJ, Hamano R, Howard OM, Wiltrout RH, Oppenheim JJ.
Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.
Eur. J. Immunol. 40: 1099-106, 2010.
13)  Nguyen BD, Roarke MC, Howard OH.
Ethacrynic acid as potential drug for diuretic renography in instance of sulfonamide allergy.
Clin Nucl Med. 35: 547-9, 2010.
14)  Chen X, Hamano R, Subleski JJ, Hurwitz AA, Howard OM, Oppenheim JJ.
Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.
J. Immunol. 185: 174-82, 2010.
15)  Wolf R, Mascia F, Dharamsi A, Howard OM, Cataisson C, Bliskovski V, Winston J, Feigenbaum L, Lichti U, Ruzicka T, Chavakis T, Yuspa SH.
Gene from a psoriasis susceptibility locus primes the skin for inflammation.
Sci Transl Med. 2: 61ra90, 2010.
16)  Huang J, Chen K, Chen J, Gong W, Dunlop NM, Howard OM, Gao Y, Bian XW, Wang JM.
The G-protein-coupled formylpeptide receptor FPR confers a more invasive phenotype on human glioblastoma cells.
Br. J. Cancer. 102: 1052-60, 2010.
17)  Klausmeyer P, Howard OM, Shipley SM, McCloud TG.
An inhibitor of CCL2-induced chemotaxis from the fungus Leptoxyphium sp.
J. Nat. Prod. 72: 1369-72, 2009.
18)  Huang J, Chen K, Huang J, Gong W, Dunlop NM, Howard OM, Bian X, Gao Y, Wang JM.
Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.
Carcinogenesis. 30: 348-55, 2009.
19)  Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH.
Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15.
J. Immunol. 181: 1499-506, 2008.
20)  Chen X, Subleski JJ, Kopf H, Howard OM, Männel DN, Oppenheim JJ.
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.
J. Immunol. 180: 6467-71, 2008.
21)  Kim JY, Kim HJ, Hurt EM, Chen X, Howard OM, Farrar WL.
Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells.
Biochem. Biophys. Res. Commun. 362: 44-50, 2007.
22)  Chen X, Bäumel M, Männel DN, Howard OM, Oppenheim JJ.
Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.
J. Immunol. 179: 154-61, 2007.
23)  Chen X, Howard OM, Oppenheim JJ.
Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells.
J. Immunol. 178: 6123-9, 2007.
24)  Kopf H, de la Rosa GM, Howard OM, Chen X.
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells.
Int. Immunopharmacol. 7: 1819-24, 2007.
25)  Bok J, Brunet LJ, Howard O, Burton Q, Wu DK.
Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice.
Dev. Biol. 311: 69-78, 2007.
26)  Huang J, Hu J, Bian X, Chen K, Gong W, Dunlop NM, Howard OM, Wang JM.
Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells.
Cancer Res. 67: 5906-13, 2007.
27)  Howard OZ.
Autoantigen signalling through chemokine receptors.
Curr Opin Rheumatol. 18: 642-6, 2006.
28)  Ramirez BL, Howard OM, Dong HF, Edamatsu T, Gao P, Hartlein M, Kron M.
Brugia malayi Asparaginyl-Transfer RNA Synthetase Induces Chemotaxis of Human Leukocytes and Activates G-Protein-Coupled Receptors CXCR1 and CXCR2.
J. Infect. Dis. 193: 1164-71, 2006.
29)  Chen X, Yang L, Howard OM, Oppenheim JJ.
Dendritic cells as a pharmacological target of traditional Chinese medicine.
Cell. Mol. Immunol. 3: 401-10, 2006.
30)  Chen X, Oppenheim JJ, Winkler-Pickett RT, Ortaldo JR, Howard OM.
Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE.
Eur. J. Immunol. 36: 2139-49, 2006.
31)  Chen X, Winkler-Pickett RT, Carbonetti NH, Ortaldo JR, Oppenheim JJ, Howard OM.
Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells.
Eur. J. Immunol. 36: 671-80, 2006.
32)  Coppola V, Barrick CA, Bobisse S, Rodriguez-Galan MC, Pivetta M, Reynolds D, Howard OM, Palko ME, Esteban PF, Young HA, Rosato A, Tessarollo L.
The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo.
Mol. Cell. Biol. 26: 5249-58, 2006.
33)  Oppenheim JJ, Dong HF, Plotz P, Caspi RR, Dykstra M, Pierce S, Martin R, Carlos C, Finn O, Koul O, Howard OM.
Autoantigens act as tissue-specific chemoattractants.
J. Leukoc. Biol. 77: 854-61, 2005.
34)  Howard OM, Dong HF, Su SB, Caspi RR, Chen X, Plotz P, Oppenheim JJ.
Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.
Blood. 105: 4207-14, 2005.
35)  Chen X, Oppenheim JJ, Howard OM.
BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57BL/6 mice.
J. Leukoc. Biol. 78: 114-21, 2005.
36)  Zhou Y, Bian X, Le Y, Gong W, Hu J, Zhang X, Wang L, Iribarren P, Salcedo R, Howard OM, Farrar W, Wang JM.
Formylpeptide receptor FPR and the rapid growth of malignant human gliomas.
J. Natl. Cancer Inst. 97: 823-35, 2005.
37)  Carlos CA, Dong HF, Howard OM, Oppenheim JJ, Hanisch FG, Finn OJ.
Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity.
J. Immunol. 175: 1628-35, 2005.
38)  Gao P, Wange RL, Zhang N, Oppenheim JJ, Howard OM.
Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.
Blood. 106: 2619-26, 2005.
39)  Krakauer T, Chen X, Howard OM, Young HA.
Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.
Immunopharmacology and immunotoxicology. 27: 53-66, 2005.
40)  Chen X, Murakami T, Oppenheim JJ, Howard OM.
Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.
Blood. 106: 2409-16, 2005.
41)  Dong HF, Wigmore K, Carrington MN, Dean M, Turpin JA, Howard OM.
Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5.
Genes Immun. 6: 609-19, 2005.
42)  Howard OM, Galligan CL.
An expanding appreciation of the role chemokine receptors play in cancer progression.
Curr. Pharm. Des. 10: 2377-89, 2004.
43)  Chen X, Oppenheim JJ, Howard OM.
Chemokines and chemokine receptors as novel therapeutic targets in rheumatoid arthritis (RA): inhibitory effects of traditional Chinese medicinal components.
Cell. Mol. Immunol. 1: 336-42, 2004.
44)  Chen X, Murakami T, Oppenheim JJ, Howard OM.
Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death.
Eur. J. Immunol. 34: 859-69, 2004.
45)  Chung IY, Dong HF, Zhang X, Hassanein NM, Howard OM, Oppenheim JJ, Chen X.
Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells.
Cell. Immunol. 232: 57-63, 2004.
46)  Howard OM, Turpin JA, Goldman R, Modi WS.
Functional redundancy of the human CCL4 and CCL4L1 chemokine genes.
Biochem. Biophys. Res. Commun. 320: 927-31, 2004.
47)  Yang D, Chen Q, Rosenberg HF, Rybak SM, Newton DL, Wang ZY, Fu Q, Tchernev VT, Wang M, Schweitzer B, Kingsmore SF, Patel DD, Oppenheim JJ, Howard OM.
Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.
J. Immunol. 173: 6134-42, 2004.
48)  Chen S, Howard O.
Images in clinical medicine. Parvovirus B19 infection.
N. Engl. J. Med. 350: 598, 2004.
49)  Felix K, Gerstmeier S, Kyriakopoulos A, Howard OM, Dong HF, Eckhaus M, Behne D, Bornkamm GW, Janz S.
Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice.
Cancer Res. 64: 2910-7, 2004.
50)  Wang LH, Yang XY, Zhang X, Mihalic K, Fan YX, Xiao W, Howard OM, Appella E, Maynard AT, Farrar WL.
Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor.
Nat. Med. 10: 40-7, 2004.
51)  Galligan CL, Matsuyama W, Matsukawa A, Mizuta H, Hodge DR, Howard OM, Yoshimura T.
Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis.
Arthritis Rheum. 50: 1806-14, 2004.
52)  Chen X, Krakauer T, Oppenheim JJ, Howard OM.
Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation.
Journal of alternative and complementary medicine (New York, N.Y.). 10: 519-26, 2004.
53)  Lin J, Dong HF, Oppenheim JJ, Howard OM.
Effects of astragali radix on the growth of different cancer cell lines.
World J. Gastroenterol. 9: 670-3, 2003.
54)  Krakauer T, Chen X, Howard OM, Young HA.
RNase protection assay for the study of the differential effects of therapeutic agents in suppressing staphylococcal enterotoxin B-induced cytokines in human peripheral blood mononuclear cells.
Methods Mol. Biol. 214: 151-64, 2003.
55)  Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, Liu-Chen LY, Bednar F, Henderson EE, Howard OM, Oppenheim JJ, Rogers TJ.
Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization.
J. Leukoc. Biol. 74: 1074-82, 2003.
56)  Chen X, Yang L, Zhang N, Turpin JA, Buckheit RW, Osterling C, Oppenheim JJ, Howard OM.
Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1.
Antimicrob. Agents Chemother. 47: 2810-6, 2003.
57)  Chen X, Beutler JA, McCloud TG, Loehfelm A, Yang L, Dong HF, Chertov OY, Salcedo R, Oppenheim JJ, Howard OM.
Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity.
Clin. Cancer Res. 9: 3115-23, 2003.
58)  Oppenheim JJ, Yang D, Biragyn A, Howard OM, Plotz P.
Chemokine receptors on dendritic cells promote autoimmune reactions.
Arthritis Res. 4 Suppl 3: S183-8, 2002.
59)  Chen X, Howard OM, Yang X, Wang L, Oppenheim JJ, Krakauer T.
Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function.
Life Sci. 70: 2897-913, 2002.
60)  Szabo I, Chen XH, Xin L, Adler MW, Howard OM, Oppenheim JJ, Rogers TJ.
Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain.
Proc. Natl. Acad. Sci. U.S.A. 99: 10276-81, 2002.
61)  Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, Casciola-Rosen L, Härtlein M, Kron M, Yang D, Yiadom K, Dwivedi S, Plotz PH, Oppenheim JJ.
Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.
J. Exp. Med. 196: 781-91, 2002.
62)  Chen X, Mellon RD, Yang L, Dong H, Oppenheim JJ, Howard OM.
Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants.
Biochem. Pharmacol. 63: 533-41, 2002.
63)  Lin TS, Howard OM, Neuberg DS, Kim HH, Shipp MA.
Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma.
Leuk. Lymphoma. 43: 793-7, 2002.
64)  Schneider GP, Salcedo R, Dong HF, Kleinman HK, Oppenheim JJ, Howard OM.
Suradista NSC 651016 inhibits the angiogenic activity of CXCL12-stromal cell-derived factor 1alpha.
Clin. Cancer Res. 8: 3955-60, 2002.
65)  Howard OM, Dong HF, Oppenheim JJ, Insaf S, Santhosh KC, Paul G, Cushman M.
Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds.
Bioorg. Med. Chem. Lett. 11: 59-62, 2001.
66)  Chen X, Oppenheim J, Howard OM.
Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.
Int. Immunopharmacol. 1: 229-36, 2001.
67)  Schneider GP, Salcedo R, Welniak LA, Howard OM, Murphy WJ.
The diverse role of chemokines in tumor progression: prospects for intervention (Review).
Int. J. Mol. Med. 8: 235-44, 2001.
68)  Rogers TJ, Steele AD, Howard OM, Oppenheim JJ.
Bidirectional heterologous desensitization of opioid and chemokine receptors.
Ann. N. Y. Acad. Sci. 917: 19-28, 2000.
69)  Yang D, Chen Q, Stoll S, Chen X, Howard OM, Oppenheim JJ.
Differential regulation of responsiveness to fMLP and C5a upon dendritic cell maturation: correlation with receptor expression.
J. Immunol. 165: 2694-702, 2000.
70)  Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ.
LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Blood. 96: 840-5, 2000.
71)  Chertov O, Yang D, Howard OM, Oppenheim JJ.
Leukocyte granule proteins mobilize innate host defenses and adaptive immune responses.
Immunol. Rev. 177: 68-78, 2000.
72)  Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schröder JM, Wang JM, Howard OM, Oppenheim JJ.
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Science. 286: 525-8, 1999.
73)  Howard OM, Oppenheim JJ, Wang JM.
Chemokines as molecular targets for therapeutic intervention.
J. Clin. Immunol. 19: 280-92, 1999.
74)  Su SB, Ueda H, Howard OM, Grimm MC, Gong W, Ruscetti FW, Oppenheim JJ, Wang JM.
Inhibition of the expression and function of chemokine receptors on human CD4+ leukocytes by HIV-1 envelope protein gp120.
Chem. Immunol. 72: 141-60, 1999.
75)  Dean M, Jacobson LP, McFarlane G, Margolick JB, Jenkins FJ, Howard OM, Dong HF, Goedert JJ, Buchbinder S, Gomperts E, Vlahov D, Oppenheim JJ, O'Brien SJ, Carrington M.
Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation.
Cancer Res. 59: 3561-4, 1999.
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This page was last updated on 4/9/2014.