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Xin Chen, M.D., Ph.D.

Selected Publications

1)  Chen X, Yang Y, Zhou Q, Weiss JM, Howard OZ, McPherson JM, Wakefield LM, Oppenheim JJ.
Effective Chemoimmunotherapy with Anti-TGFß Antibody and Cyclophosphamide in a Mouse Model of Breast Cancer.
PLoS ONE. 9: e85398, 2014.
2)  Zhou Q, Hu Y, Howard OM, Oppenheim JJ, Chen X.
In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.
Cytokine. 65: 56-64, 2014.
3)  Hu Y, Xiao H, Shi T, Oppenheim JJ, Chen X.
Progranulin promotes TNF-induced proliferation of suppressive mouse CD4(+) Foxp3(+) regulatory T cells.
Immunology. 2014.
4)  Chen X, Oppenheim JJ.
Th17 cells and Tregs: unlikely allies.
J. Leukoc. Biol. 2014.
5)  Chen X, Wu X, Zhou Q, Howard OM, Netea MG, Oppenheim JJ.
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
J. Immunol. 190: 1076-84, 2013.
6)  Griessl S, Chen X, Oppenheim J, Maennel D.
THE DUAL ROLE OF TNF ON T CELL ACTIVATION. In: Advances in Experimental Medicine and Biology. Volume 691:692-693.
Berlin: SPRINGER-VERLAG BERLIN; 2011. [Book]
7)  Chen X, Oppenheim JJ.
Comment on "Interplay between TNF and Regulatory T Cells in a TNF-Driven Murine Model of Arthritis".
J. Immunol. 187: 1527, 2011.
8)  Chen X, Oppenheim JJ.
Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity.
FEBS Lett. 585: 3611-8, 2011.
9)  Chertov O, Zhang N, Chen X, Oppenheim JJ, Lubkowski J, McGrath C, Sowder RC, Crise BJ, Malyguine A, Kutzler MA, Steele AD, Henderson EE, Rogers TJ.
Novel Peptides Based on HIV-1 gp120 Sequence with Homology to Chemokines Inhibit HIV Infection in Cell Culture.
PLoS ONE. 6: e14474, 2011.
10)  Chen X, Oppenheim JJ.
Resolving the identity myth: Key markers of functional CD4(+)FoxP3(+) regulatory T cells.
Int. Immunopharmacol. 11: 1489-96, 2011.
11)  Chen X, Oppenheim JJ.
The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+)  FoxP3(+) regulatory T cells.
Immunology. 133: 426-33, 2011.
12)  Hamano R, Huang J, Yoshimura T, Oppenheim JJ, Chen X.
TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40.
Eur. J. Immunol. 41: 2010-20, 2011.
13)  Chen X.
Watson RR, eds.
Maturation and activation of dendritic cells by botanicals used in traditional Chinese medicine: role in immune enhancement. In: Dietary Components and Immune Function.
NY: Humana Press; 2010. p. 497-514 [Book Chapter]
14)  Chen X, Subleski JJ, Hamano R, Howard OM, Wiltrout RH, Oppenheim JJ.
Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.
Eur. J. Immunol. 40: 1099-106, 2010.
15)  Chen X, Hamano R, Subleski JJ, Hurwitz AA, Howard OM, Oppenheim JJ.
Expression of costimulatory TNFR2 induces resistance of CD4(+)FoxP3(-) conventional T cells to suppression by CD4(+)FoxP3(+) regulatory T Cells.
J. Immunol. 185: 174-82, 2010.
16)  Chen X, Oppenheim JJ.
TNF-alpha: An Activator of CD4+FoxP3+TNFR2+ Regulatory T Cells.
Current directions in autoimmunity. 11: 119-134, 2010.
17)  Chen X, Oppenheim JJ.
Regulatory T cells , Th17 cells and TLRs: implication for autoimmunity and cancer (review).
Pathways. 2: 2-5, 2009.
18)  Weiss JM, Back TC, Scarzello AJ, Subleski JJ, Hall VL, Stauffer JK, Chen X, Micic D, Alderson K, Murphy WJ, Wiltrout RH.
Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment.
Proc. Natl. Acad. Sci. U.S.A. 106: 19455-60, 2009.
19)  Chen X, Subleski JJ, Kopf H, Howard OM, Männel DN, Oppenheim JJ.
Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells.
J. Immunol. 180: 6467-71, 2008.
20)  Mazzucchelli R, Hixon JA, Spolski R, Chen X, Li WQ, Hall VL, Willette-Brown J, Hurwitz AA, Leonard WJ, Durum SK.
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Blood. 112: 3283-92, 2008.
21)  Kim JY, Kim HJ, Hurt EM, Chen X, Howard OM, Farrar WL.
Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells.
Biochem. Biophys. Res. Commun. 362: 44-50, 2007.
22)  Chen X, Bäumel M, Männel DN, Howard OM, Oppenheim JJ.
Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.
J. Immunol. 179: 154-61, 2007.
23)  Chen X, Howard OM, Oppenheim JJ.
Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells.
J. Immunol. 178: 6123-9, 2007.
24)  Kopf H, de la Rosa GM, Howard OM, Chen X.
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells.
Int. Immunopharmacol. 7: 1819-24, 2007.
25)  Murakami T, Chen X, Hase K, Sakamoto A, Nishigaki C, Ohno H.
Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation.
Blood. 110: 1215-24, 2007.
26)  Chen X, Yang L, Howard OM, Oppenheim JJ.
Dendritic cells as a pharmacological target of traditional Chinese medicine.
Cell. Mol. Immunol. 3: 401-10, 2006.
27)  Chen X, Oppenheim JJ, Winkler-Pickett RT, Ortaldo JR, Howard OM.
Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE.
Eur. J. Immunol. 36: 2139-49, 2006.
28)  Chen X, Winkler-Pickett RT, Carbonetti NH, Ortaldo JR, Oppenheim JJ, Howard OM.
Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells.
Eur. J. Immunol. 36: 671-80, 2006.
29)  Howard OM, Dong HF, Su SB, Caspi RR, Chen X, Plotz P, Oppenheim JJ.
Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.
Blood. 105: 4207-14, 2005.
30)  Chen X, Oppenheim JJ, Howard OM.
BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57BL/6 mice.
J. Leukoc. Biol. 78: 114-21, 2005.
31)  Krakauer T, Chen X, Howard OM, Young HA.
Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.
Immunopharmacology and immunotoxicology. 27: 53-66, 2005.
32)  Chen X, Murakami T, Oppenheim JJ, Howard OM.
Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.
Blood. 106: 2409-16, 2005.
33)  Chen X, Oppenheim JJ, Howard OM.
Chemokines and chemokine receptors as novel therapeutic targets in rheumatoid arthritis (RA): inhibitory effects of traditional Chinese medicinal components.
Cell. Mol. Immunol. 1: 336-42, 2004.
34)  Chen X, Murakami T, Oppenheim JJ, Howard OM.
Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death.
Eur. J. Immunol. 34: 859-69, 2004.
35)  Chung IY, Dong HF, Zhang X, Hassanein NM, Howard OM, Oppenheim JJ, Chen X.
Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells.
Cell. Immunol. 232: 57-63, 2004.
36)  Chen X, Krakauer T, Oppenheim JJ, Howard OM.
Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation.
Journal of alternative and complementary medicine (New York, N.Y.). 10: 519-26, 2004.
37)  Krakauer T, Chen X, Howard OM, Young HA.
RNase protection assay for the study of the differential effects of therapeutic agents in suppressing staphylococcal enterotoxin B-induced cytokines in human peripheral blood mononuclear cells.
Methods Mol. Biol. 214: 151-64, 2003.
38)  Chen X, Yang L, Zhang N, Turpin JA, Buckheit RW, Osterling C, Oppenheim JJ, Howard OM.
Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1.
Antimicrob. Agents Chemother. 47: 2810-6, 2003.
39)  Chen X, Beutler JA, McCloud TG, Loehfelm A, Yang L, Dong HF, Chertov OY, Salcedo R, Oppenheim JJ, Howard OM.
Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity.
Clin. Cancer Res. 9: 3115-23, 2003.
40)  Chen X, Yang L, Oppenheim JJ, Howard MZ.
Cellular pharmacology studies of shikonin derivatives.
Phytotherapy research : PTR. 16: 199-209, 2002.
41)  Chen X, Howard OM, Yang X, Wang L, Oppenheim JJ, Krakauer T.
Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function.
Life Sci. 70: 2897-913, 2002.
42)  Chen X, Mellon RD, Yang L, Dong H, Oppenheim JJ, Howard OM.
Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants.
Biochem. Pharmacol. 63: 533-41, 2002.
43)  Chen X, Oppenheim J, Howard OM.
Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.
Int. Immunopharmacol. 1: 229-36, 2001.
44)  Chen X, Yang D, Shen W, Dong HF, Wang JM, Oppenheim JJ, Howard MZ.
Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors.
Inflamm. Res. 49: 744-55, 2000.
45)  Yang D, Chen Q, Stoll S, Chen X, Howard OM, Oppenheim JJ.
Differential regulation of responsiveness to fMLP and C5a upon dendritic cell maturation: correlation with receptor expression.
J. Immunol. 165: 2694-702, 2000.
46)  Chen X, Yang L, Zeng G, Shen G.
The regulatory action of the modified Yu Ping Feng Tang on cellular immunity in mice under amputation-induced stress.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine. 20: 302-6, 2000.
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This page was last updated on 2/25/2014.