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Our Science – Sommers Website

Connie L. Sommers, Ph.D.

Selected Publications

1)  Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.
A phospholipase C-?1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
J. Immunol. 190: 147-58, 2013.
2)  Schmidt AM, Zou T, Joshi RP, Leichner TM, Pimentel MA, Sommers CL, Kambayashi T.
Diacylglycerol kinase zeta limits the generation of natural regulatory T cells.
Sci Signal. 6: ra101, 2013.
3)  Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.
miRNA signature of mouse helper T cell hyper-proliferation.
PLoS ONE. 8: e66709, 2013.
4)  Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.
The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.
Sci Signal. 6: ra99, 2013.
5)  Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.
Deconstructing Ras signaling in the thymus.
Mol. Cell. Biol. 32: 2748-59, 2012.
6)  Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE.
LAT-independent Erk activation via Bam32-PLC-?1-Pak1 complexes: GTPase-independent Pak1 activation.
Mol. Cell. 48: 298-312, 2012.
7)  Sherman E, Barr V, Manley S, Patterson G, Balagopalan L, Akpan I, Regan CK, Merrill RK, Sommers CL, Lippincott-Schwartz J, Samelson LE.
Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.
Immunity. 35: 705-20, 2011.
8)  Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE.
Targeted Sos1 deletion reveals its critical role in early T-cell development.
Proc. Natl. Acad. Sci. U.S.A. 108: 12407-12, 2011.
9)  Balagopalan L, Coussens NP, Sherman E, Samelson LE, Sommers CL.
The LAT story: a tale of cooperativity, coordination, and choreography.
Cold Spring Harb Perspect Biol. 2: a005512, 2010.
10)  Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Proc. Natl. Acad. Sci. U.S.A. 106: 14502-7, 2009.
11)  Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE.
Bam32: a novel mediator of Erk activation in T cells.
Int Immunol. 20: 811-8, 2008.
12)  Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE.
Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T Cells: Puncta and Distal Caps.
Mol. Biol. Cell. 19: 2802-17, 2008.
13)  Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.
c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
Mol. Cell. Biol. 27: 8622-36, 2007.
14)  Braiman A, Barda-Saad M, Sommers CL, Samelson LE.
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.
EMBO J. 25: 774-84, 2006.
15)  Sommers CL, Lee J, Steiner KL, Gurson JM, Depersis CL, El-Khoury D, Fuller CL, Shores EW, Love PE, Samelson LE.
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.
J. Exp. Med. 201: 1125-34, 2005.
16)  Woodside KJ, Shen H, Muntzel C, Daller JA, Sommers CL, Love PE.
Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.
Gene Expr. Patterns. 4: 315-20, 2004.
17)  Sommers CL, Samelson LE, Love PE.
LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways.
Bioessays. 26: 61-7, 2004.
18)  Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, Lacaná E, Menon RK, Shores EW, Samelson LE, Love PE.
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
Science. 296: 2040-2043, 2002.
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This page was last updated on 4/15/2014.