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Our Science – Barr Website

Valarie A. Barr, Ph.D.

Selected Publications

1)  Zvezdova E, Lee J, El-Khoury D, Barr V, Akpan I, Samelson L, Love PE.
In vivo functional mapping of the conserved protein domains within murine Themis1.
Immunol. Cell Biol. 2014.
[Journal]
2)  Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.
Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.
J. Immunol. 190: 3849-53, 2013.
[Journal]
3)  Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.
Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.
Mol. Cell. Biol. 33: 4140-51, 2013.
[Journal]
4)  Sherman E, Barr VA, Samelson LE.
Resolving multi-molecular protein interactions by photoactivated localization microscopy.
Methods. 59: 261-9, 2013.
[Journal]
5)  Sherman E, Barr V, Samelson LE.
Super-resolution characterization of TCR-dependent signaling clusters.
Immunol. Rev. 251: 21-35, 2013.
[Journal]
6)  Clayberger C, Finn MW, Wang T, Saini R, Wilson C, Barr VA, Sabatino M, Castiello L, Stroncek D, Krensky AM.
15 kDa Granulysin Causes Differentiation of Monocytes to Dendritic Cells but Lacks Cytotoxic Activity.
J Immunol. 188: 6119-26, 2012.
[Journal]
7)  Luo R, Akpan IO, Hayashi R, Sramko M, Barr V, Shiba Y, Randazzo PA.
GTP-binding Protein-like Domain of AGAP1 Is Protein Binding Site That Allosterically Regulates ArfGAP Protein Catalytic Activity.
J. Biol. Chem. 287: 17176-85, 2012.
[Journal]
8)  Lesourne R, Zvezdova E, Song K, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE.
Interchangeability of themis1 and themis2 in thymocyte development reveals two related proteins with conserved molecular function.
J. Immunol. 189: 1154-61, 2012.
[Journal]
9)  Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.
Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.
Proc. Natl. Acad. Sci. U.S.A. 108: 2885-90, 2011.
[Journal]
10)  Sherman E, Barr V, Manley S, Patterson G, Balagopalan L, Akpan I, Regan CK, Merrill RK, Sommers CL, Lippincott-Schwartz J, Samelson LE.
Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.
Immunity. 35: 705-20, 2011.
[Journal]
11)  Balagopalan L, Sherman E, Barr VA, Samelson LE.
Imaging techniques for assaying lymphocyte activation in action.
Nat. Rev. Immunol. 11: 21-33, 2011.
[Journal]
12)  Balagopalan L, Barr VA, Samelson LE.
Endocytic events in TCR signaling: focus on adapters in microclusters.
Immunol. Rev. 232: 84-98, 2009.
[Journal]
13)  Barr VA, Bernot KM, Shaffer MH, Burkhardt JK, Samelson LE.
Formation of STIM and Orai complexes: puncta and distal caps.
Immunol. Rev. 231: 148-59, 2009.
[Journal]
14)  Barr VA, Bunnell SC.
Interference reflection microscopy.
Curr Protoc Cell Biol. Chapter 4: Unit 4.23, 2009.
[Journal]
15)  Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE.
Bam32: a novel mediator of Erk activation in T cells.
Int. Immunol. 20: 811-8, 2008.
[Journal]
16)  Kriebel PW, Barr VA, Rericha EC, Zhang G, Parent CA.
Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge.
J. Cell Biol. 183: 949-61, 2008.
[Journal]
17)  Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE.
Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T Cells: Puncta and Distal Caps.
Mol. Biol. Cell. 19: 2802-17, 2008.
[Journal]
18)  Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.
c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
Mol. Cell. Biol. 27: 8622-36, 2007.
[Journal]
19)  Bharti S, Inoue H, Bharti K, Hirsch DS, Nie Z, Yoon HY, Artym V, Yamada KM, Mueller SC, Barr VA, Randazzo PA.
Src-dependent phosphorylation of ASAP1 regulates podosomes.
Mol. Cell. Biol. 27: 8271-83, 2007.
[Journal]
20)  Bunnell SC, Singer AL, Hong DI, Jacque BH, Jordan MS, Seminario MC, Barr VA, Koretzky GA, Samelson LE.
Persistence of cooperatively stabilized signaling clusters drives T-cell activation.
Mol. Cell. Biol. 26: 7155-66, 2006.
[Journal]
21)  Barr VA, Balagopalan L, Barda-Saad M, Polishchuk R, Boukari H, Bunnell SC, Bernot KM, Toda Y, Nossal R, Samelson LE.
T-cell antigen receptor-induced signaling complexes: internalization via a cholesterol-dependent endocytic pathway.
Traffic. 7: 1143-62, 2006.
[Journal]
22)  Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, Samelson LE.
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.
Nat. Immunol. 6: 80-9, 2005.
[Journal]
23)  Aerbajinai W, Lee YT, Wojda U, Barr VA, Miller JL.
Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth.
J. Biol. Chem. 279: 1916-21, 2004.
[Journal]
24)  Kriebel PW, Barr VA, Parent CA.
Adenylyl cyclase localization regulates streaming during chemotaxis.
Cell. 112: 549-60, 2003.
[Journal]
25)  Salazar-Fontana LI, Barr V, Samelson LE, Bierer BE.
CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells.
J. Immunol. 171: 2225-32, 2003.
[Journal]
26)  Bunnell SC, Barr VA, Fuller CL, Samelson LE.
High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates.
Sci. STKE. 2003: PL8, 2003.
[Journal]
27)  Pennisi PA, Barr V, Nunez NP, Stannard B, Le Roith D.
Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype.
Cancer Res. 62: 6529-37, 2002.
[Journal]
28)  Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE.
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.
J. Cell Biol. 158: 1263-75, 2002.
[Journal]
29)  Phillips SA, Barr VA, Haft DH, Taylor SI, Haft CR.
Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking.
J. Biol. Chem. 276: 5074-84, 2001.
[Journal]
30)  Montagnani M, Chen H, Barr VA, Quon MJ.
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).
J. Biol. Chem. 276: 30392-8, 2001.
[Journal]
31)  Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF.
Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain.
J. Biol. Chem. 276: 10284-9, 2001.
[Journal]
32)  Nakae J, Barr V, Accili D.
Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR.
EMBO J. 19: 989-96, 2000.
[Journal]
33)  Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI.
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.
Mol. Biol. Cell. 11: 4105-16, 2000.
[Journal]
34)  Barr VA, Phillips SA, Taylor SI, Haft CR.
Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking.
Traffic. 1: 904-16, 2000.
[Journal]
35)  Barr VA, Lane K, Taylor SI.
Subcellular localization and internalization of the four human leptin receptor isoforms.
J. Biol. Chem. 274: 21416-24, 1999.
[Journal]
36)  Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI.
Identification of a family of sorting nexin molecules and characterization of their association with receptors.
Mol. Cell. Biol. 18: 7278-87, 1998.
[Journal]
37)  Gavrilova O, Barr V, Marcus-Samuels B, Reitman M.
Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor.
J. Biol. Chem. 272: 30546-51, 1997.
[Journal]
38)  Barr VA, Malide D, Zarnowski MJ, Taylor SI, Cushman SW.
Insulin stimulates both leptin secretion and production by rat white adipose tissue.
Endocrinology. 138: 4463-72, 1997.
[Journal]
39)  Taylor SI, Barr V, Reitman M.
Does leptin contribute to diabetes caused by obesity?.
Science. 274: 1151-2, 1996.
[Journal]
40)  Barr VA, Scott LJ, Hubbard AL.
Immunoadsorption of hepatic vesicles carrying newly synthesized dipeptidyl peptidase IV and polymeric IgA receptor.
J. Biol. Chem. 270: 27834-44, 1995.
[Journal]
41)  Barr VA, Hubbard AL.
Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat.
Gastroenterology. 105: 554-71, 1993.
[Journal]
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This page was last updated on 8/14/2014.