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Our Science – Ambs Website

Stefan Ambs, Ph.D., M.P.H.

Selected Publications

1)  Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S.
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
J. Clin. Invest. 124: 398-412, 2014.
[Journal]
2)  Hudson RS, Yi M, Esposito D, Watkins SK, Hurwitz AA, Yfantis HG, Lee DH, Borin JF, Naslund MJ, Alexander RB, Dorsey TH, Stephens RM, Croce CM, Ambs S.
MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer.
Nucleic Acids Res. 40: 3689-3703, 2012.
[Journal]
3)  Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH, Hudson RS, Wink DA, Lee DH, Stephens RM, Ambs S.
Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.
J. Clin. Invest. 120: 3843-54, 2010.
[Journal]
4)  Wallace TA, Prueitt RL, Yi M, Howe TM, Gillespie JW, Yfantis HG, Stephens RM, Caporaso NE, Loffredo CA, Ambs S.
Tumor immunobiological differences in prostate cancer between African-American and European-American men.
Cancer Res. 68: 927-36, 2008.
[Journal]
5)  Ambs S, Merriam WG, Ogunfusika MO, Bennett WP, Ishibe N, Hussain SP, Tzeng EE, Geller DA, Billiar TR, Harris CC.
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells.
Nat Med. 4: 1371-6, 1998.
[Journal]
6)  Subramanian M, Francis P, Bilke S, Li XL, Hara T, Lu X, Jones MF, Walker RL, Zhu Y, Pineda M, Lee C, Varanasi L, Yang Y, Martinez LA, Luo J, Ambs S, Sharma S, Wakefield LM, Meltzer PS, Lal A.
A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis.
Oncogene. [Epub ahead of print], 2014.
[Journal]
7)  Wallace TA, Downey RF, Seufert CJ, Schetter A, Dorsey TM, Johnson CA, Goldman R, Loffredo CA, Yan P, Sullivan FJ, Giles FJ, Wang-Johanning F, Ambs S, Glynn SA.
Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers.
Carcinogenesis. 2014.
[Journal]
8)  Downey RF, Sullivan FJ, Wang-Johanning F, Ambs S, Giles FJ, Glynn SA.
Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?.
Int. J. Cancer. 2014.
[Journal]
9)  Wang-Johanning F, Li M, Esteva FJ, Hess KR, Yin B, Rycaj K, Plummer JB, Garza JG, Ambs S, Johanning GL.
Human endogenous retrovirus type K antibodies and mRNA as serum biomarkers of early-stage breast cancer.
Int. J. Cancer. 134: 587-95, 2014.
[Journal]
10)  Heinecke JL, Ridnour LA, Cheng RY, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP, Young HA, Ambs S, Wink DA.
Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print], 2014.
[Journal]
11)  Chen F, Chen GK, Stram DO, Millikan RC, Ambrosone CB, John EM, Bernstein L, Zheng W, Palmer JR, Hu JJ, Rebbeck TR, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Ruiz-Narvaez EA, Deming SL, Rodriguez-Gil JL, Demichele A, Chanock SJ, Blot W, Signorello L, Cai Q, Li G, Long J, Huo D, Zheng Y, Cox NJ, Olopade OI, Ogundiran TO, Adebamowo C, Nathanson KL, Domchek SM, Simon MS, Hennis A, Nemesure B, Wu SY, Leske MC, Ambs S, Hutter CM, Young A, Kooperberg C, Peters U, Rhie SK, Wan P, Sheng X, Pooler LC, Van Den Berg DJ, Le Marchand L, Kolonel LN, Henderson BE, Haiman CA.
A genome-wide association study of breast cancer in women of African ancestry.
Hum. Genet. 132: 39-48, 2013.
[Journal]
12)  Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV, Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X, Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD, Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A, Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA, Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL, Nayak U, N'diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL, Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S, Speliotes EK, Spitz MR, Sucheston L, Taylor H, Tayo BO, Tucker MA, Van Den Berg DJ, Edwards DR, Wang Z, Wiencke JK, Winkler TW, Witte JS, Wrensch M, Wu X, Yang JJ, Levin AM, Young TR, Zakai NA, Cushman M, Zanetti KA, Zhao JH, Zhao W, Zheng Y, Zhou J, Ziegler RG, Zmuda JM, Fernandes JK, Gilkeson GS, Kamen DL, Hunt KJ, Spruill IJ, Ambrosone CB, Ambs S, Arnett DK, Atwood L, Becker DM, Berndt SI, Bernstein L, Blot WJ, Borecki IB, Bottinger EP, Bowden DW, Burke G, Chanock SJ, Cooper RS, Ding J, Duggan D, Evans MK, Fox C, Garvey WT, Bradfield JP, Hakonarson H, Grant SF, Hsing A, Chu L, Hu JJ, Huo D, Ingles SA, John EM, Jordan JM, Kabagambe EK, Kardia SL, Kittles RA, Goodman PJ, Klein EA, Kolonel LN, Le Marchand L, Liu S, McKnight B, Millikan RC, Mosley TH, Padhukasahasram B, Williams LK, Patel SR, Peters U, Pettaway CA, Peyser PA, Psaty BM, Redline S, Rotimi CN, Rybicki BA, Sale MM, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Strom SS, Thun MJ, Vitolins M, Zheng W, Moore JH, Williams SM, Ketkar S, Zhu X, Zonderman AB, Kooperberg C, Papanicolaou GJ, Henderson BE, Reiner AP, Hirschhorn JN, Loos RJ, North KE, Haiman CA.
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Nat. Genet. 45: 690-6, 2013.
[Journal]
13)  Soliman H, Rawal B, Fulp J, Lee J, Lopez A, Bui MM, Khalil F, Antonia S, Yfantis HG, Lee DH, Dorsey TH, Ambs S.
Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry.
Cancer Immunol. Immunother. 62: 829-37, 2013.
[Journal]
14)  Martin DN, Starks AM, Ambs S.
Biological determinants of health disparities in prostate cancer.
Curr Opin Oncol. 25: 235-41, 2013.
[Journal]
15)  Zheng Y, Ogundiran TO, Falusi AG, Nathanson KL, John EM, Hennis AJ, Ambs S, Domchek SM, Rebbeck TR, Simon MS, Nemesure B, Wu S, Leske MC, Odetunde A, Niu Q, Zhang J, Afolabi C, Gamazon ER, Cox NJ, Olopade CO, Olufunmilayo OI, Huo D.
Fine-mapping of Breast Cancer Genome-wide Association Studies Loci in Women of African Ancestry Identifies Novel Susceptibility Markers.
Carcinogenesis. 34: 1520-8, 2013.
[Journal]
16)  Starks AM, Martin DN, Dorsey TH, Boersma BJ, Wallace TA, Ambs S.
Household Income Is Associated with the p53 Mutation Frequency in Human Breast Tumors.
PLoS ONE. 8: e57361, 2013.
[Journal]
17)  Ridnour LA, Cheng RY, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G, Wink DA.
Molecular Pathways: Toll-like Receptors in the Tumor Microenvironment--Poor Prognosis or New Therapeutic Opportunity.
Clin. Cancer Res. 19: 1340-6, 2013.
[Journal]
18)  Hudson RS, Yi M, Volfovsky N, Prueitt RL, Esposito D, Volinia S, Liu CG, Schetter AJ, Roosbroeck K, Stephens RM, Calin GA, Croce CM, Ambs S.
Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer.
Mol. Cancer. 12: 13, 2013.
[Journal]
19)  Ambs S.
Analysis of stromal gene expression for the identification of prognostic and predictive molecular markers in cancer therapy.
Int J Cancer. 131: 2213-4, 2012.
[Journal]
20)  Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA.
Dithiolethiones Inhibit NF-kappaB Activity via Covalent Modification in Human Estrogen Receptor-Negative Breast Cancer.
Cancer Res. 72: 2394-404, 2012.
[Journal]
21)  Switzer CH, Cheng RY, Ridnour LA, Glynn SA, Ambs S, Wink DA.
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer.
Breast Cancer Res. 14: R125, 2012.
[Journal]
22)  Huo D, Zheng Y, Ogundiran TO, Adebamowo C, Nathanson KL, Domchek SM, Rebbeck TR, Simon MS, John EM, Hennis A, Nemesure B, Wu SY, Leske MC, Ambs S, Niu Q, Zhang J, Cox NJ, Olopade OI.
Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry.
Carcinogenesis. 33: 835-40, 2012.
[Journal]
23)  Hou N, Zheng Y, Gamazon ER, Ogundiran TO, Adebamowo C, Nathanson KL, Domchek SM, Rebbeck TR, Simon MS, John EM, Hennis A, Nemesure B, Wu SY, Leske MC, Ambs S, Niu Q, Zhang J, Pierce B, Cox NJ, Olopade OI, Huo D.
Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.
Cancer Epidemiol. Biomarkers Prev. 21: 552-6, 2012.
[Journal]
24)  Wang-Johanning F, Rycaj K, Plummer JB, Li M, Yin B, Frerich K, Garza JG, Shen J, Lin K, Yan P, Glynn SA, Dorsey TH, Hunt KK, Ambs S, Johanning GL.
Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors.
J. Natl. Cancer Inst. 104: 189-210, 2012.
[Journal]
25)  Zheng Y, Ogundiran TO, Adebamowo C, Nathanson KL, Domchek SM, Rebbeck TR, Simon MS, John EM, Hennis A, Nemesure B, Wu SY, Leske MC, Ambs S, Niu Q, Zhang J, Cox NJ, Olopade OI, Huo D.
Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry.
Breast Cancer Res. Treat. 132: 341-5, 2012.
[Journal]
26)  Ryan BM, Calhoun KM, Pine SR, Bowman ED, Robles AI, Ambs S, Harris CC.
MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer.
Int J Cancer. 131: 2710-6, 2012.
[Journal]
27)  Hudson RS, Yi M, Esposito D, Glynn SA, Starks AM, Yang Y, Schetter AJ, Watkins SK, Hurwitz AA, Dorsey TH, Stephens RM, Croce CM, Ambs S.
MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer.
Oncogene. 32: 4139-47, 2012.
[Journal]
28)  Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RY, Heinecke JL, Brueggemann E, Hines HB, Khanna C, Glynn SA, Ambs S, Wink DA.
Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation.
PLoS ONE. 7: e44081, 2012.
[Journal]
29)  Wang S, Dorsey TH, Terunuma A, Kittles RA, Ambs S, Kwabi-Addo B.
Relationship between Tumor DNA Methylation Status and Patient Characteristics in African-American and European-American Women with Breast Cancer.
PLoS ONE. 7: e37928, 2012.
[Journal]
30)  Switzer CH, Glynn SA, Cheng RY, Ridnour LA, Green JE, Ambs S, Wink DA.
S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer.
Mol. Cancer Res. 10: 1203-15, 2012.
[Journal]
31)  Meyer KB, Maia AT, O'Reilly M, Ghoussaini M, Prathalingam R, Porter-Gill P, Ambs S, Prokunina-Olsson L, Carroll J, Ponder BA.
A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression.
PLoS Genet. 7: e1002165, 2011.
[Journal]
32)  Ambs S, Glynn SA.
Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer.
Cell Cycle. 10: 619-24, 2011.
[Journal]
33)  Zhao J, Rycaj K, Geng S, Li M, Plummer JB, Yin B, Liu H, Xu X, Zhang Y, Yan Y, Glynn SA, Dorsey TH, Ambs S, Johanning GL, Gu L, Wang-Johanning F.
Expression of Human Endogenous Retrovirus Type K Envelope Protein is a Novel Candidate Prognostic Marker for Human Breast Cancer.
Genes Cancer. 2: 914-22, 2011.
[Journal]
34)  Watkins SK, Zhu Z, Riboldi E, Shafer-Weaver KA, Stagliano KE, Sklavos MM, Ambs S, Yagita H, Hurwitz AA.
FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer.
J. Clin. Invest. 121: 1361-72, 2011.
[Journal]
35)  Mackiewicz M, Huppi K, Pitt JJ, Dorsey TH, Ambs S, Caplen NJ.
Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA.
Breast Cancer Res. Treat. 130: 663-79, 2011.
[Journal]
36)  Wallace TA, Martin DN, Ambs S.
Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale.
Carcinogenesis. 32: 1107-21, 2011.
[Journal]
37)  Switzer CH, Glynn SA, Ridnour LA, Cheng RY, Vitek MP, Ambs S, Wink DA.
Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.
Trends Pharmacol. Sci. 32: 644-51, 2011.
[Journal]
38)  Glynn SA, Prueitt RL, Ridnour LA, Boersma BJ, Dorsey TM, Wink DA, Goodman JE, Yfantis HG, Lee DH, Ambs S.
COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer.
BMC Cancer. 10: 626, 2010.
[Journal]
39)  Fu Y, Edvardsen H, Kaushiva A, Arhancet JP, Howe TM, Kohaar I, Porter-Gill P, Shah A, Landmark-Hoyvik H, Fossa SD, Ambs S, Naume B, Borresen-Dale A, Kristensen VN, Prokunina-Olsson L.
NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations.
Mol Cancer. 9: 113, 2010.
[Journal]
40)  Ambs S.
Prognostic significance of subtype classification for short- and long-term survival in breast cancer: survival time holds the key.
PLoS Med. 7: e1000281, 2010.
[Journal]
41)  Volinia S, Galasso M, Costinean S, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Sana ME, Abu Jarour R, Desponts C, Teitell M, Baffa R, Aqeilan R, Iorio MV, Taccioli C, Garzon R, Di Leva G, Fabbri M, Catozzi M, Previati M, Ambs S, Palumbo T, Garofalo M, Veronese A, Bottoni A, Gasparini P, Harris CC, Visone R, Pekarsky Y, de la Chapelle A, Bloomston M, Dillhoff M, Rassenti LZ, Kipps TJ, Huebner K, Pichiorri F, Lenze D, Cairo S, Buendia MA, Pineau P, Dejean A, Zanesi N, Rossi S, Calin GA, Liu CG, Palatini J, Negrini M, Vecchione A, Rosenberg A, Croce CM.
Reprogramming of miRNA networks in cancer and leukemia.
Genome Res. 20: 589-99, 2010.
[Journal]
42)  Glynn SA, Boersma BJ, Howe TM, Edvardsen H, Geisler SB, Goodman JE, Ridnour LA, Lønning PE, Børresen-Dale AL, Naume B, Kristensen VN, Chanock SJ, Wink DA, Ambs S.
A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.
Clin. Cancer Res. 15: 4165-73, 2009.
[Journal]
43)  Martin DN, Boersma BJ, Yi M, Reimers M, Howe TM, Yfantis HG, Tsai YC, Williams EH, Lee DH, Stephens RM, Weissman AM, Ambs S.
Differences in the tumor microenvironment between African-American and European-American breast cancer patients.
PLoS ONE. 4: e4531, 2009.
[Journal]
44)  Jones LE, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD.
Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.
Carcinogenesis. 30: 2123-9, 2009.
[Journal]
45)  Tahara H, Sato M, Thurin M, Wang E, Butterfield LH, Disis ML, Fox BA, Lee PP, Khleif SN, Wigginton JM, Ambs S, Akutsu Y, Chaussabel D, Doki Y, Eremin O, Fridman WH, Hirohashi Y, Imai K, Jacobson J, Jinushi M, Kanamoto A, Kashani-Sabet M, Kato K, Kawakami Y, Kirkwood JM, Kleen TO, Lehmann PV, Liotta L, Lotze MT, Maio M, Malyguine A, Masucci G, Matsubara H, Mayrand-Chung S, Nakamura K, Nishikawa H, Palucka AK, Petricoin EF, Pos Z, Ribas A, Rivoltini L, Sato N, Shiku H, Slingluff CA, Streicher H, Stroncek DF, Takeuchi H, Toyota M, Wada H, Wu X, Wulfkuhle J, Yaguchi T, Zeskind B, Zhao Y, Zocca MB, Marincola FM.
Emerging concepts in biomarker discovery; The US-Japan workshop on immunological molecular markers in oncology.
Journal of translational medicine. 7: 45, 2009.
[Journal]
46)  Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW.
MicroRNA expression, survival, and response to interferon in liver cancer.
N. Engl. J. Med. 361: 1437-47, 2009.
[Journal]
47)  Boersma BJ, Reimers M, Yi M, Ludwig JA, Luke BT, Stephens RM, Yfantis HG, Lee DH, Weinstein JN, Ambs S.
A stromal gene signature associated with inflammatory breast cancer.
Int. J. Cancer. 122: 1324-32, 2008.
[Journal]
48)  Prueitt RL, Yi M, Hudson RS, Wallace TA, Howe TM, Yfantis HG, Lee DH, Stephens RM, Liu CG, Calin GA, Croce CM, Ambs S.
Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer.
Prostate. 68: 1152-64, 2008.
[Journal]
49)  Ambs S, Prueitt RL, Yi M, Hudson RS, Howe TM, Petrocca F, Wallace TA, Liu CG, Volinia S, Calin GA, Yfantis HG, Stephens RM, Croce CM.
Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer.
Cancer Res. 68: 6162-70, 2008.
[Journal]
50)  Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA.
Molecular mechanisms for discrete nitric oxide levels in cancer.
Nitric Oxide. 2008.
[Journal]
51)  Ambs S, Marincola FM, Thurin M.
Profiling of immune response to guide cancer diagnosis, prognosis, and prediction of therapy.
Cancer Res. 68: 4031-3, 2008.
[Journal]
52)  Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C, Paolocci N, Ambs S, Colton CA, Harris CC, Roberts DD, Wink DA.
The chemical biology of nitric oxide: Implications in cellular signaling.
Free Radic. Biol. Med. 45: 18-31, 2008.
[Journal]
53)  Pine S, Mechanic L, Ambs S, Bowman E, Chanock S, Loffredo C, Shields P, Harris C.
Association of lung cancer outcome with functional polymorphisms in mannose-binding lectin 2, an innate immunity gene.
J Natl Cancer Inst. 99: 1401-9, 2007.
[Journal]
54)  Prueitt RL, Boersma BJ, Howe TM, Goodman JE, Thomas DD, Ying L, Pfiester CM, Yfantis HG, Cottrell JR, Lee DH, Remaley AT, Hofseth LJ, Wink DA, Ambs S.
Inflammation and IGF-I activate the Akt pathway in breast cancer.
Int. J. Cancer. 120: 796-805, 2007.
[Journal]
55)  Crawford NP, Qian X, Ziogas A, Papageorge AG, Boersma BJ, Walker RC, Lukes L, Rowe WL, Zhang J, Ambs S, Lowy DR, Anton-Culver H, Hunter KW.
Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis.
PLoS Genet. 3: e214, 2007.
[Journal]
56)  Bernig T, Boersma BJ, Howe TM, Welch R, Yadavalli S, Staats B, Mechanic LE, Chanock SJ, Ambs S.
The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women.
Carcinogenesis. 28: 828-36, 2007.
[Journal]
57)  Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM.
A microRNA expression signature of human solid tumors defines cancer gene targets.
Proc Natl Acad Sci U S A. 103: 2257-61, 2006.
[Journal]
58)  Boersma BJ, Howe TM, Goodman JE, Yfantis HG, Lee DH, Chanock SJ, Ambs S.
Association of breast cancer outcome with status of p53 and MDM2 SNP309.
J. Natl. Cancer Inst. 98: 911-9, 2006.
[Journal]
59)  Martin DN, Boersma BJ, Howe TM, Goodman JE, Mechanic LE, Chanock SJ, Ambs S.
Association of MTHFR gene polymorphisms with breast cancer survival.
BMC Cancer. 6: 257, 2006.
[Journal]
60)  Goodman JE, Mechanic LE, Luke BT, Ambs S, Chanock S, Harris CC.
Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis.
Int J Cancer. 118: 1790-7, 2006.
[Journal]
61)  Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, Degraff W, Roberts DD, Mitchell JB, Wink DA.
Superoxide fluxes limit nitric oxide-induced signaling.
J Biol Chem. 281: 25984-93, 2006.
[Journal]
62)  Hussain SP, Amstad P, Raja K, Ambs S, Nagashima M, Bennett WP, Shields PG, Ham AJ, Swenberg JA, Marrogi AJ, Harris CC.
Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease.
Cancer Res. 60: 3333-7, 2000.
[Journal]
63)  Ambs S, Dennis S, Fairman J, Wright M, Papkoff J.
Inhibition of tumor growth correlates with the expression level of a human angiostatin transgene in transfected B16F10 melanoma cells.
Cancer Res. 59: 5773-7, 1999.
[Journal]
64)  Ambs S, Bennett WP, Merriam WG, Ogunfusika MO, Oser SM, Harrington AM, Shields PG, Felley-Bosco E, Hussain SP, Harris CC.
Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer.
J Natl Cancer Inst. 91: 86-8, 1999.
[Journal]
65)  Ambs S, Merriam WG, Bennett WP, Felley-Bosco E, Ogunfusika MO, Oser SM, Klein S, Shields PG, Billiar TR, Harris CC.
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.
Cancer Res. 58: 334-41, 1998.
[Journal]
66)  Ambs S, Ogunfusika MO, Merriam WG, Bennett WP, Billiar TR, Harris CC.
Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice.
Proc Natl Acad Sci U S A. 95: 8823-8, 1998.
[Journal]
67)  Ambs S, Hussain SP, Harris CC.
Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression.
FASEB J. 11: 443-8, 1997.
[Journal]
68)  Forrester K, Ambs S, Lupold SE, Kapust RB, Spillare EA, Weinberg WC, Felley-Bosco E, Wang XW, Geller DA, Tzeng E, Billiar TR, Harris CC.
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.
Proc Natl Acad Sci U S A. 93: 2442-7, 1996.
[Journal]
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This page was last updated on 6/16/2014.