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Our Science – McMahon Website

James B. McMahon, Ph.D.

Selected Publications

1)  Woldemichael GM, Vasselli JR, Gardella RS, McKee TC, Linehan WM, McMahon JB.
Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression.
J Biomol Screen. 11: 678-87, 2006.
2)  Henrich CJ, Robey RW, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, Dean M, McMahon JB.
New inhibitors of ABCG2 identified by high-throughput screening.
Mol. Cancer Ther. 6: 3271-8, 2007.
3)  Kang MI, Henrich CJ, Bokesch HR, Gustafson KR, McMahon JB, Baker AR, Young MR, Colburn NH.
A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for.
Mol. Cancer Ther. 8: 571-81, 2009.
4)  Woldemichael GM, Turbyville TJ, Linehan WM, McMahon JB.
Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells.
Cancer Res. 71: 134-42, 2011.
5)  Woldemichael GM, Turbyville TJ, Vasselli JR, Linehan WM, McMahon JB.
Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A.
Neoplasia. 14: 771-7, 2012.
6)  Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.
Biochem. Pharmacol. 88: 313-21, 2014.
7)  Devkota KP, Wilson JA, Henrich CJ, McMahon JB, Reilly KM, Beutler JA.
Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells.
Phytochem Lett. 7: 42-45, 2014.
8)  Dull AB, George AA, Goncharova EI, Evans JR, Wamiru A, Cartner LK, Hager GL, McMahon JB.
Identification of compounds by high-content screening that induce cytoplasmic to nuclear localization of a fluorescent estrogen receptor a chimera and exhibit agonist or antagonist activity in vitro.
J Biomol Screen. 19: 242-52, 2014.
9)  Beutler J.
Koehn F, eds.
Natural Products as Tools for Discovering New Cancer Targets. In: Natural Products and Cancer Drug Discovery.
New York: Humana Press; 2013. p. 213-237 [Book Chapter]
10)  Kanduluru AK, Banerjee P, Beutler JA, Fuchs PL.
A Convergent Total Synthesis of the Potent Cephalostatin/Ritterazine Hybrid -25-epi Ritterostatin GN1N.
J. Org. Chem. 78: 9085-92, 2013.
11)  Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, O'Keefe BR.
Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.
PLoS ONE. 8: e64449, 2013.
12)  Dossou KS, Devkota KP, Kavanagh PV, Beutler JA, Egan JM, Moaddel R.
Development and preliminary validation of a plate-based CB1/CB2 receptor functional assay.
Anal. Biochem. 437: 138-43, 2013.
13)  Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, Porco JA.
Enantioselective total synthesis and biological evaluation of (+)-kibdelone a and a tetrahydroxanthone analogue.
J. Org. Chem. 78: 7617-26, 2013.
14)  Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee MJ, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L.
Englerin A stimulates PKC? to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.
Cancer Cell. 23: 228-37, 2013.
15)  Masaoka T, Chung S, Caboni P, Rausch JW, Wilson JA, Taskent-Sezgin H, Beutler JA, Tocco G, Le Grice SF.
Exploiting Drug-Resistant Enzymes as Tools To Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.
J. Med. Chem. 56: 5436-45, 2013.
16)  Devkota KP, Covell D, Ransom T, McMahon JB, Beutler JA.
Growth Inhibition of Human Colon Carcinoma Cells by Sesquiterpenoids and Tetralones of Zygogynum calothyrsum.
J. Nat. Prod. 76: 710-4, 2013.
17)  Henrich CJ, Budhu A, Yu Z, Evans JR, Goncharova EI, Ransom TT, Wang XW, McMahon JB.
High-throughput Screening for Identification of Inhibitors of EpCAM-Dependent Growth of Hepatocellular Carcinoma Cells.
Chem Biol Drug Des. 82: 131-9, 2013.
18)  Devkota KP, Wilson J, Henrich CJ, McMahon JB, Reilly KM, Beutler JA.
Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth.
J. Nat. Prod. 76: 59-63, 2013.
19)  Henrich CJ, Beutler JA.
Matching the power of high throughput screening to the chemical diversity of natural products.
Nat Prod Rep. 30: 1284-98, 2013.
20)  Alexandre KB, Moore PL, Nonyane M, Gray ES, Ranchobe N, Chakauya E, McMahon JB, O'Keefe BR, Chikwamba R, Morris L.
Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN.
Virology. 446: 66-76, 2013.
21)  Beutler J, Cragg G, Newman D.
Chibale K, Davies-Coleman M, Masimirembwa C, eds.
The National Cancer Institute and Natural Product Based Drug Discovery in Africa. In: Drug Discovery in Africa.
New York: Springer; 2012. p. 29-51 [Book Chapter]
22)  Giubellino A, Woldemichael GM, Sourbier C, Lizak MJ, Powers JF, Tischler AS, Pacak K.
Characterization of two mouse models of metastatic pheochromocytoma using bioluminescence imaging.
Cancer Lett. 316: 46-52, 2012.
23)  Akee RK, Ransom T, Ratnayake R, McMahon JB, Beutler JA.
Chlorinated englerins with selective inhibition of renal cancer cell growth.
J. Nat. Prod. 75: 459-63, 2012.
24)  Henrich CJ, Thomas CL, Brooks AD, Booth NL, Lowery EM, Pompei RJ, McMahon JB, Sayers TJ.
Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.
Apoptosis. 17: 79-89, 2012.
25)  Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase ß-TrCP1.
PLoS ONE. 7: e46567, 2012.
26)  Diyabalanage T, Ratnayake R, Bokesch HR, Ransom TT, Henrich CJ, Beutler JA, McMahon JB, Gustafson KR.
Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera.
J. Nat. Prod. 75: 1490-4, 2012.
27)  Hatanaka T, Ohzono S, Park M, Sakamoto K, Tsukamoto S, Sugita R, Ishitobi H, Mori T, Ito O, Sorajo K, Sugimura K, Ham S, Ito Y.
Human IgA-binding peptides selected from random peptide libraries: affinity maturation and application in IgA purification.
J. Biol. Chem. 287: 43126-36, 2012.
28)  McKee TC, Rabe D, Bokesch HR, Grkovic T, Whitson EL, Diyabalanage T, Van Wyk AW, Marcum SR, Gardella RS, Gustafson KR, Linehan WM, McMahon JB, Bottaro DP.
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
J. Nat. Prod. 75: 1632-6, 2012.
29)  Whitson EL, Sun H, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, Griesinger C, McKee TC.
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
J. Nat. Prod. 75: 394-9, 2012.
30)  Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Bermingam A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.
Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
J. Med. Chem. 55: 4457-78, 2012.
31)  Dong S, Qin T, Hamel E, Beutler JA, Porco JA.
Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation.
J. Am. Chem. Soc. 134: 19782-7, 2012.
32)  Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.
The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells.
Virology. 423: 175-86, 2012.
33)  Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, McKee TC.
A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum.
Chem. Pharm. Bull. 59: 1178-9, 2011.
34)  Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B.
Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.
J. Nat. Prod. 74: 1990-5, 2011.
35)  Tai BH, Nhut ND, Nhiem NX, Quang TH, Thanh Ngan NT, Thuy Luyen BT, Huong TT, Wilson J, Beutler JA, Ban NK, Cuong NM, Kim YH.
An evaluation of the RNase H inhibitory effects of Vietnamese medicinal plant extracts and natural compounds.
Pharm. Biol. 49: 1046-51, 2011.
36)  Alexandre KB, Gray ES, Pantophlet R, Moore PL, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.
Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site.
J Virol. 85: 9039-50, 2011.
37)  Grkovic T, Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, Gustafson KR.
Cryptocaryols A-H, α-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4.
J. Nat. Prod. 74: 1015-20, 2011.
38)  Versiani MA, Diyabalanage T, Ratnayake R, Henrich CJ, Bates SE, McMahon JB, Gustafson KR.
Flavonoids from Eight Tropical Plant Species That Inhibit the Multidrug Resistance Transporter ABCG2.
J. Nat. Prod. 74: 262-6, 2011.
39)  Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC.
Grassypeptolides F and G, Cyanobacterial Peptides from Lyngbya majuscula.
J. Nat. Prod. 74: 1686-91, 2011.
40)  Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, McMahon JB, Gustafson KR, McKee TC.
Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression.
Bioorg. Med. Chem. Lett. 21: 2113-5, 2011.
41)  Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ.
Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening.
J. Natl. Cancer Inst. 103: 962-78, 2011.
42)  Best AM, Chang J, Dull AB, Beutler JA, Martinez ED.
Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay.
J. Biomed. Biotechnol. 2011: 868095, 2011.
43)  Devkota KP, Ratnayake R, Colburn NH, Wilson JA, Henrich CJ, McMahon JB, Beutler JA.
Inhibitors of the Oncogenic Transcription Factor AP-1 from Podocarpus latifolius.
J. Nat. Prod. 74: 374-7, 2011.
44)  Van Wyk AW, Zuck KM, McKee TC.
Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum.
J. Nat. Prod. 74: 1275-80, 2011.
45)  Whitson EL, Pluchino KM, Hall MD, McMahon JB, McKee TC.
New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth.
Org. Lett. 13: 3518-21, 2011.
46)  Kim JA, Yang SY, Wamiru A, McMahon JB, Le Grice SF, Beutler JA, Kim YH.
New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H.
Bioorg. Med. Chem. Lett. 21: 2840-4, 2011.
47)  Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR.
Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.
Bioorg. Med. Chem. Lett. 21: 4397-9, 2011.
48)  Sloman DL, Mitasev B, Scully SS, Beutler JA, Porco JA.
Synthesis and biological evaluation of ABCD ring fragments of the kibdelones.
Angew. Chem. Int. Ed. Engl. 50: 2511-5, 2011.
49)  Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF.
Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.
J. Med. Chem. 54: 4462-73, 2011.
50)  O'Keefe BR, Giomarelli B, Barnard DL, Shenoy SR, Chan PK, McMahon JB, Palmer KE, Barnett BW, Meyerholz DK, Wohlford-Lenane CL, McCray PB.
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae.
J. Virol. 84: 2511-21, 2010.
51)  Whitson EL, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, McKee TC.
Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.
J. Nat. Prod. 73: 2013-8, 2010.
52)  Blees JS, Schmid T, Thomas CL, Baker AR, Benson L, Evans JR, Goncharova EI, Colburn NH, McMahon JB, Henrich CJ.
Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4.
J Biomol Screen. 15: 21-9, 2010.
53)  Dull A, Goncharova E, Hager G, McMahon JB.
Development of an image analysis screen for estrogen receptor alpha (ER-alpha) ligands through measurement of nuclear translocation dynamics.
J. Steroid Biochem. Mol. Biol. 122: 341-51, 2010.
54)  Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.
Bioorg. Med. Chem. Lett. 20: 3848-50, 2010.
55)  Oku N, Takada K, Fuller RW, Wilson JA, Peach ML, Pannell LK, McMahon JB, Gustafson KR.
Isolation, structural elucidation, and absolute stereochemistry of enigmazole A, a cytotoxic phosphomacrolide from the Papua New Guinea marine sponge Cinachyrella enigmatica.
J. Am. Chem. Soc. 132: 10278-85, 2010.
56)  Alexandre KB, Gray ES, Lambson BE, Moore PL, Choge IA, Mlisana K, Karim SS, McMahon J, O'Keefe B, Chikwamba R, Morris L.
Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin.
Virology. 402: 187-96, 2010.
57)  Moulaei T, Shenoy SR, Giomarelli B, Thomas C, McMahon JB, Dauter Z, O'Keefe BR, Wlodawer A.
Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity.
Structure. 18: 1104-15, 2010.
58)  Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H.
Peptide HIV-1 integrase inhibitors from HIV-1 gene products.
J. Med. Chem. 53: 5356-60, 2010.
59)  Turbyville TJ, Gürsel DB, Tuskan RG, Walrath JC, Lipschultz CA, Lockett SJ, Wiemer DF, Beutler JA, Reilly KM.
Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.
Mol. Cancer Ther. 9: 1234-43, 2010.
60)  Klausmeyer P, Van QN, Jato J, McCloud TG, Beutler JA.
Schweinfurthins I and J from Macaranga schweinfurthii.
J. Nat. Prod. 73: 479-81, 2010.
61)  Ulrich NC, Kodet JG, Mente NR, Kuder CH, Beutler JA, Hohl RJ, Wiemer DF.
Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.
Bioorg. Med. Chem. 18: 1676-83, 2010.
62)  Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF.
Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.
Antimicrob. Agents Chemother. 54: 3913-21, 2010.
63)  Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J.
Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii.
Eukaryotic Cell. 9: 228-41, 2010.
64)  Takada K, Imamura N, Gustafson KR, Henrich CJ.
Synthesis and structure-activity relationship of botryllamides that block the ABCG2 multidrug transporter.
Bioorg. Med. Chem. Lett. 20: 1330-3, 2010.
65)  Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J.
The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites.
Eukaryotic Cell. 9: 1661-8, 2010.
66)  Moulaei T, Stuchlik O, Reed M, Yuan W, Pohl J, Lu W, Haugh-Krumpe L, O'Keefe BR, Wlodawer A.
Topology of the disulfide bonds in the antiviral lectin scytovirin.
Protein Sci. 19: 1649-61, 2010.
67)  Booth NL, Sayers TJ, Brooks AD, Thomas CL, Jacobsen K, Goncharova EI, McMahon JB, Henrich CJ.
A cell-based high-throughput screen to identify synergistic TRAIL sensitizers.
Cancer Immunol. Immunother. 58: 1229-44, 2009.
68)  Henrich CJ, Robey RW, Takada K, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, McMahon JB, Gustafson KR.
Botryllamides: natural product inhibitors of ABCG2.
ACS Chem. Biol. 4: 637-47, 2009.
69)  Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA.
Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor.
Angew. Chem. Int. Ed. Engl. 48: 1494-7, 2009.
70)  Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.
Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.
Org. Lett. 11: 57-60, 2009.
71)  Wendeler W, Beilhartz G, Gotte M, Beutler J, LeGrice S.
Human immunodeficiency virus ribonuclease H: continuing the search for small molecular antagonists.
HIV Ther. 3: 39-53, 2009.
72)  Liu Y, Carroll JR, Holt LA, McMahon J, Giomarelli B, Ghirlanda G.
Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin.
Biopolymers. 92: 194-200, 2009.
73)  Beutler JA, Kang MI, Robert F, Clement JA, Pelletier J, Colburn NH, McKee TC, Goncharova E, McMahon JB, Henrich CJ.
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
J. Nat. Prod. 72: 503-6, 2009.
74)  O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE.
Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
Proc. Natl. Acad. Sci. U.S.A. 106: 6099-104, 2009.
75)  Yun SM, Moulaei T, Lim D, Bang JK, Park JE, Shenoy SR, Liu F, Kang YH, Liao C, Soung NK, Lee S, Yoon DY, Lim Y, Lee DH, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR, Yaffe MB, Wlodawer A, Lee KS.
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat. Struct. Mol. Biol. 16: 876-82, 2009.
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This page was last updated on 6/17/2014.