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Our Science – Horikawa Website

Izumi Horikawa, M.D., Ph.D.

Selected Publications

1)  Tang Y, Horikawa I, Ajiro M, Robles AI, Fujita K, Mondal AM, Stauffer JK, Zheng ZM, Harris CC.
Downregulation of splicing factor SRSF3 induces p53ß, an alternatively spliced isoform of p53 that promotes cellular senescence.
Oncogene. 32: 2792-8, 2013.
2)  Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC.
p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.
J. Clin. Invest. 123: 5247-57, 2013.
3)  Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.
Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.
PLoS ONE. 7: e44156, 2012.
4)  Horikawa I, Fujita K, Harris CC.
p53 governs telomere regulation feedback too, via TRF2.
Aging. 3: 26-32, 2011.
5)  Fujita K, Horikawa I, Mondal AM, Jenkins LM, Appella E, Vojtesek B, Bourdon J, Lane DP, Harris CC.
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.
Nat. Cell Biol. 12: 1205-1212, 2010.
6)  Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee T, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC.
Targeted Disruption of Ing2 Results in Defective Spermatogenesis and Development of Soft-Tissue Sarcomas.
PLoS One. 5: e15541, 2010.
7)  Liu S, Qi Y, Ge Y, Duplessis T, Rowan BG, Ip C, Cheng H, Rennie PS, Horikawa I, Lustig AJ, Yu Q, Zhang H, Dong Y.
Telomerase as an important target of androgen signaling blockade for prostate cancer treatment.
Mol. Cancer Ther. 9: 2016-25, 2010.
8)  Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H, Gemma A, Kudoh S, Croce CM, Harris CC.
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
Proc. Natl. Acad. Sci. U.S.A. 106: 12085-90, 2009.
9)  Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR, Ji H, Vojtesek B, Bourdon JC, Lane DP, Harris CC.
p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.
Nat. Cell Biol. 11: 1135-42, 2009.
10)  Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM.
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.
Epigenetics Chromatin. 1: 6, 2008.
11)  Sedelnikova OA, Horikawa I, Redon C, Nakamura A, Zimonjic DB, Popescu NC, Bonner WM.
Delayed kinetics of DNA double-strand break processing in normal and pathological aging.
Aging Cell. 7: 89-100, 2008.
12)  Kumamoto K, Spillare EA, Fujita K, Horikawa I, Yamashita T, Appella E, Nagashima M, Takenoshita S, Yokota J, Harris CC.
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.
Cancer Res. 68: 3193-203, 2008.
13)  Yang Q, Zhang R, Horikawa I, Fujita K, Afshar Y, Kokko A, Laiho P, Aaltonen LA, Harris CC.
Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
Cancer Res. 67: 11677-86, 2007.
14)  Michishita E, Garcés G, Barrett JC, Horikawa I.
Upregulation of the KIAA1199 gene is associated with cellular mortality.
Cancer Lett. 239: 71-7, 2006.
15)  Horikawa I, Chiang YJ, Patterson T, Feigenbaum L, Leem SH, Michishita E, Larionov V, Hodes RJ, Barrett JC.
Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.
Proc. Natl. Acad. Sci. U.S.A. 102: 18437-42, 2005.
16)  Tanaka H, Horikawa I, Barrett JC, Oshimura M.
Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers.
Int. J. Cancer. 115: 653-7, 2005.
17)  Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I.
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.
Mol. Biol. Cell. 16: 4623-35, 2005.
18)  Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE.
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.
EMBO J. 23: 1949-56, 2004.
19)  Horikawa I, Michishita E, Barrett JC.
Regulation of hTERT transcription: a target of cellular and viral mechanisms for immortalization and carcinogenesis.
Cytotechnology. 45: 23-32, 2004.
20)  Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC.
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.
Nat. Cell Biol. 6: 168-70, 2004.
21)  Sinha-Datta U, Horikawa I, Michishita E, Datta A, Sigler-Nicot JC, Brown M, Kazanji M, Barrett JC, Nicot C.
Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells.
Blood. 104: 2523-31, 2004.
22)  Yawata T, Kamino H, Kugoh H, Katoh M, Nomura N, Oishi M, Horikawa I, Barrett JC, Oshimura M.
Identification of a 600-kb region on human chromosome 1q42.3 inducing cellular senescence.
Oncogene. 22: 281-90, 2003.
23)  Xiao X, Athanasiou M, Sidorov IA, Horikawa I, Cremona G, Blair D, Barret JC, Dimitrov DS.
Role of Ets/Id proteins for telomerase regulation in human cancer cells.
Exp. Mol. Pathol. 75: 238-47, 2003.
24)  Horikawa I, Barrett JC.
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms.
Carcinogenesis. 24: 1167-76, 2003.
25)  Horikawa I, Barrett JC.
cDNA cloning of the human polybromo-1 gene on chromosome 3p21.
DNA Seq. 13: 211-5, 2002.
26)  Horikawa I, Cable PL, Mazur SJ, Appella E, Afshari CA, Barrett JC.
Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression.
Mol. Biol. Cell. 13: 2585-97, 2002.
27)  Lee D, Kim HZ, Jeong KW, Shim YS, Horikawa I, Barrett JC, Choe J.
Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoter.
J. Biol. Chem. 277: 27748-56, 2002.
28)  Xiao X, Phogat SK, Sidorov IA, Yang J, Horikawa I, Prieto D, Adelesberger J, Lempicki R, Barrett JC, Dimitrov DS.
Identification and characterization of rapidly dividing U937 clones with differential telomerase activity and gene expression profiles: role of c-Myc/Mad1 and Id/Ets proteins.
Leukemia. 16: 1877-80, 2002.
29)  Leem SH, Londoño-Vallejo JA, Kim JH, Bui H, Tubacher E, Solomon G, Park JE, Horikawa I, Kouprina N, Barrett JC, Larionov V.
The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions.
Oncogene. 21: 769-77, 2002.
30)  Kirch HC, Ruschen S, Brockmann D, Esche H, Horikawa I, Barrett JC, Opalka B, Hengge UR.
Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system.
Oncogene. 21: 7991-8000, 2002.
31)  Horikawa I, Barrett JC.
cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome.
J. Natl. Cancer Inst. 93: 1171-3, 2001.
32)  Nishimoto A, Miura N, Horikawa I, Kugoh H, Murakami Y, Hirohashi S, Kawasaki H, Gazdar AF, Shay JW, Barrett JC, Oshimura M.
Functional evidence for a telomerase repressor gene on human chromosome 10p15.1.
Oncogene. 20: 828-35, 2001.
33)  Veldman T, Horikawa I, Barrett JC, Schlegel R.
Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein.
J. Virol. 75: 4467-72, 2001.
34)  Horikawa I, Parker ES, Solomon GG, Barrett JC.
Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells.
J. Cell. Biochem. 82: 415-21, 2001.
35)  Kugoh H, Fujiwara M, Kihara K, Fukui I, Horikawa I, Schulz TC, Oshimura M.
Cellular senescence of a human bladder carcinoma cell line (JTC-32) induced by a normal chromosome 11.
Cancer Genet. Cytogenet. 116: 158-63, 2000.
36)  Horikawa I, Cable PL, Afshari C, Barrett JC.
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.
Cancer Res. 59: 826-30, 1999.
37)  Devereux TR, Horikawa I, Anna CH, Annab LA, Afshari CA, Barrett JC.
DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.
Cancer Res. 59: 6087-90, 1999.
38)  Tanaka H, Horikawa I, Kugoh H, Shimizu M, Barrett JC, Oshimura M.
Telomerase-independent senescence of human immortal cells induced by microcell-mediated chromosome transfer.
Mol. Carcinog. 25: 249-55, 1999.
39)  Tanaka H, Shimizu M, Horikawa I, Kugoh H, Yokota J, Barrett JC, Oshimura M.
Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region.
Genes Chromosomes Cancer. 23: 123-33, 1998.
40)  Horikawa I, Oshimura M, Barrett JC.
Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence.
Mol. Carcinog. 22: 65-72, 1998.
41)  Choi C, Cho S, Horikawa I, Berchuck A, Wang N, Cedrone E, Jhung SW, Lee JB, Kerr J, Chenevix-Trench G, Kim S, Barrett JC, Koi M.
Loss of heterozygosity at chromosome segment Xq25-26.1 in advanced human ovarian carcinomas.
Genes Chromosomes Cancer. 20: 234-42, 1997.
42)  Miura N, Horikawa I, Nishimoto A, Ohmura H, Ito H, Hirohashi S, Shay JW, Oshimura M.
Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis.
Cancer Genet. Cytogenet. 93: 56-62, 1997.
43)  Honda T, Sadamori N, Oshimura M, Horikawa I, Omura H, Komatsu K, Watanabe M.
Spontaneous immortalization of cultured skin fibroblasts obtained from a high-dose atomic bomb survivor.
Mutat. Res. 354: 15-26, 1996.
44)  Horikawa I, Suzuki M, Oshimura M.
An amino-terminally truncated p53 protein expressed in a human choriocarcinoma cell line, CC1.
Hum. Mol. Genet. 4: 313-4, 1995.
45)  Horikawa I, Tanaka H, Yuasa Y, Suzuki M, Shimizu M, Oshimura M.
Forced expression of YL-1 protein suppresses the anchorage-independent growth of Kirsten sarcoma virus-transformed NIH3T3 cells.
Exp. Cell Res. 220: 11-7, 1995.
46)  Horikawa I, Suzuki M, Yoshida MA, Oshimura M.
Frame-shift mutation and reduced transcript of p53 gene in a renal cell carcinoma cell line, RCC23.
Hum. Mol. Genet. 4: 771-3, 1995.
47)  Horikawa I, Okamoto A, Yokota J, Oshimura M.
Genetic heterogeneity of chromosome 11 associated with tumorigenicity in HeLa D98-OR cells.
Cancer Genet. Cytogenet. 85: 97-100, 1995.
48)  Horikawa I, Tanaka H, Yuasa Y, Suzuki M, Oshimura M.
Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability.
Biochem. Biophys. Res. Commun. 208: 999-1007, 1995.
49)  Uejima H, Mitsuya K, Kugoh H, Horikawa I, Oshimura M.
Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line SiHa.
Genes Chromosomes Cancer. 14: 120-7, 1995.
50)  Horikawa I, Yamada H, Kugoh H, Yuasa Y, Suzuki M, Oshimura M.
Subchromosomal mapping of a putative transformation suppressor gene on human chromosome 1.
Jpn. J. Cancer Res. 86: 444-50, 1995.
51)  Hoshino Y, Horikawa I, Oshimura M, Yuasa Y.
Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity.
Biochem. Biophys. Res. Commun. 174: 298-304, 1991.
52)  Yamada H, Horikawa I, Hashiba H, Oshimura M.
Normal human chromosome 1 carries suppressor activity for various phenotypes of a Kirsten murine sarcoma virus-transformed NIH/3T3 cell line.
Jpn. J. Cancer Res. 81: 1095-100, 1990.
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This page was last updated on 4/9/2014.