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Our Science – Horikawa Website

Izumi Horikawa, M.D., Ph.D.

Selected Publications

1)  Tang Y, Horikawa I, Ajiro M, Robles AI, Fujita K, Mondal AM, Stauffer JK, Zheng ZM, Harris CC.
Downregulation of splicing factor SRSF3 induces p53ß, an alternatively spliced isoform of p53 that promotes cellular senescence.
Oncogene. 32: 2792-8, 2013.
[Journal]
2)  Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC.
p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.
J. Clin. Invest. 123: 5247-57, 2013.
[Journal]
3)  Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.
Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.
PLoS ONE. 7: e44156, 2012.
[Journal]
4)  Horikawa I, Fujita K, Harris CC.
p53 governs telomere regulation feedback too, via TRF2.
Aging. 3: 26-32, 2011.
[Journal]
5)  Fujita K, Horikawa I, Mondal AM, Jenkins LM, Appella E, Vojtesek B, Bourdon J, Lane DP, Harris CC.
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.
Nat. Cell Biol. 12: 1205-1212, 2010.
[Journal]
6)  Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee T, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC.
Targeted Disruption of Ing2 Results in Defective Spermatogenesis and Development of Soft-Tissue Sarcomas.
PLoS One. 5: e15541, 2010.
[Journal]
7)  Liu S, Qi Y, Ge Y, Duplessis T, Rowan BG, Ip C, Cheng H, Rennie PS, Horikawa I, Lustig AJ, Yu Q, Zhang H, Dong Y.
Telomerase as an important target of androgen signaling blockade for prostate cancer treatment.
Mol. Cancer Ther. 9: 2016-25, 2010.
[Journal]
8)  Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H, Gemma A, Kudoh S, Croce CM, Harris CC.
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
Proc. Natl. Acad. Sci. U.S.A. 106: 12085-90, 2009.
[Journal]
9)  Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR, Ji H, Vojtesek B, Bourdon JC, Lane DP, Harris CC.
p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.
Nat. Cell Biol. 11: 1135-42, 2009.
[Journal]
10)  Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM.
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.
Epigenetics Chromatin. 1: 6, 2008.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 4/9/2014.