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Juraj Bies, Ph.D.

Selected Publications

1)  Markus J, Garin MT, Bies J, Galili N, Raza A, Thirman MJ, Le Beau MM, Rowley JD, Liu PP, Wolff L.
Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16).
Cancer Res. 67: 992-1000, 2007.
[Journal]
2)  Slape C, Hartung H, Lin YW, Bies J, Wolff L, Aplan PD.
Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation.
Cancer Res. 67: 5148-55, 2007.
[Journal]
3)  Sramko M, Markus J, Kabát J, Wolff L, Bies J.
Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins.
J. Biol. Chem. 281: 40065-75, 2006.
[Journal]
4)  Hu X, Bies J, Wolff L.
Interferon beta increases c-Myc proteolysis in mouse monocyte/macrophage leukemia cells.
Leuk. Res. 29: 1307-14, 2005.
[Journal]
5)  Wolff L, Garin MT, Koller R, Bies J, Tessarollo L, Anver MR, Powell D, Perella C.
A novel retrovirus provides the cooperating oncogenic event(s) required to demonstrate the tumor suppressor activity of p15Ink4b in myeloid cells in vivo.
Blood Cells Mol. Dis. 32: 226-31, 2004.
[Journal]
6)  Ramirez JM, Houzet L, Koller R, Bies J, Wolff L, Mougel M.
Activation of c-myb by 5' retrovirus promoter insertion in myeloid neoplasms is dependent upon an intact alternative splice donor site (SD') in gag.
Virology. 330: 398-407, 2004.
[Journal]
7)  Schmidt M, Bies J, Tamura T, Ozato K, Wolff L.
The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells.
Blood. 103: 4142-9, 2004.
[Journal]
8)  Wolff L, Garin MT, Koller R, Bies J, Liao W, Malumbres M, Tessarollo L, Powell D, Perella C.
Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice.
Oncogene. 22: 9265-74, 2003.
[Journal]
9)  Markus J, Feiková S, Sramko M, Wolff L, Bies J.
Proliferation-linked expression of the novel murine gene m4mbt encoding a nuclear zinc finger protein with four mbt domains.
Gene. 319: 117-26, 2003.
[Journal]
10)  Bies J, Markus J, Wolff L.
Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity.
J. Biol. Chem. 277: 8999-9009, 2002.
[Journal]
11)  Schmidt M, Koller R, Haviernik P, Bies J, Maciag K, Wolff L.
Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15(INK4b) normally associated with differentiation.
Oncogene. 20: 6205-14, 2001.
[Journal]
12)  Opavsky R, Haviernik P, Jurkovicova D, Garin MT, Copeland NG, Gilbert DJ, Jenkins NA, Bies J, Garfield S, Pastorekova S, Oue A, Wolff L.
Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo.
J. Biol. Chem. 276: 38795-807, 2001.
[Journal]
13)  Bies J, Feiková S, Markus J, Wolff L.
Phosphorylation-dependent conformation and proteolytic stability of c-Myb.
Blood Cells Mol. Dis. 27: 422-8, 2001.
[Journal]
14)  Duraj J, Takacsova X, Sedlak J, Sulikova M, Hunakova L, Bies J, Chorvath B.
PSC 833 induces apoptosis in drug-sensitive human leukemia cell line and modulates resistance to paclitaxel in its multidrug-resistant variant.
Anticancer Res. 20: 4627-32, 2001.
[Journal]
15)  Wolff L, Schmidt M, Koller R, Haviernik P, Watson R, Bies J, Maciag K.
Three genes with different functions in transformation are regulated by c-Myb in myeloid cells.
Blood Cells Mol. Dis. 27: 483-8, 2001.
[Journal]
16)  Feiková S, Wolff L, Bies J.
Constitutive ubiquitination and degradation of c-myb by the 26S proteasome during proliferation and differentiation of myeloid cells.
Neoplasma. 47: 212-8, 2000.
[Journal]
17)  Hunáková L, Bies J, Sedlák J, Duraj J, Jakubíková J, Takácsová X, Novotný L, Chorváth B.
Differential sensitivity of ovarian carcinoma cell lines to apoptosis induced by the IMPDH inhibitor benzamide riboside.
Neoplasma. 47: 274-9, 2000.
[Journal]
18)  Bies J, Feiková S, Bottaro DP, Wolff L.
Hyperphosphorylation and increased proteolytic breakdown of c-Myb induced by the inhibition of Ser/Thr protein phosphatases.
Oncogene. 19: 2846-54, 2000.
[Journal]
19)  Hlavatý J, Tyukosova S, Bies J, Hlubinova K, Altaner C.
Retrovirus vector containing wild type p53 gene and its effect on human glioma cells.
Neoplasma. 47: 204-11, 2000.
[Journal]
20)  Bies J, Nazarov V, Wolff L.
Alteration of proteolytic processing of c-Myb as a consequence of its truncation in murine myeloid leukemia.
Leukemia. 13 Suppl 1: S116-7, 1999.
[Journal]
21)  Hlavatý J, Hlubinová K, Bies J, Altaner C.
Cells producing recombinant retrovirus with thymidine kinase gene from Herpes simplex virus suitable for human cancer gene therapy.
Neoplasma. 46: 329-34, 1999.
[Journal]
22)  Bies J, Nazarov V, Wolff L.
Identification of protein instability determinants in the carboxy-terminal region of c-Myb removed as a result of retroviral integration in murine monocytic leukemias.
J. Virol. 73: 2038-44, 1999.
[Journal]
23)  Bies J, Koller R, Hoffman B, Amanullah A, Mock B, Wolff L.
MuLV-insertional mutagenesis of c-myb and Mml1 in a murine model for promonocytic leukemia.
Leukemia. 11 Suppl 3: 247-50, 1997.
[Journal]
24)  Bies J, Wolff L.
Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway.
Oncogene. 14: 203-12, 1997.
[Journal]
25)  Bies J, Hoffman B, Amanullah A, Giese T, Wolff L.
B-Myb prevents growth arrest associated with terminal differentiation of monocytic cells.
Oncogene. 12: 355-63, 1996.
[Journal]
26)  Koller R, Krall M, Mock B, Bies J, Nazarov V, Wolff L.
Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10.
Virology. 224: 224-34, 1996.
[Journal]
27)  Wolff L, Koller R, Bies J, Nazarov V, Hoffman B, Amanullah A, Krall M, Mock B.
Retroviral insertional mutagenesis in murine promonocytic leukemias: c-myb and Mml1.
Curr. Top. Microbiol. Immunol. 211: 191-9, 1996.
[Journal]
28)  Bies J, Wolff L.
Acceleration of apoptosis in transforming growth factor beta 1-treated M1 cells ectopically expressing B-myb.
Cancer Res. 55: 501-4, 1995.
[Journal]
29)  Bies J, Mukhopadhyaya R, Pierce J, Wolff L.
Only late, nonmitotic stages of granulocyte differentiation in 32Dcl3 cells are blocked by ectopic expression of murine c-myb and its truncated forms.
Cell Growth Differ. 6: 59-68, 1995.
[Journal]
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This page was last updated on 11/9/2007.