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Our Science – Bauer Website

Thomas R. Bauer Jr., Ph.D.

Selected Publications
1)  Hunter MJ, Zhao H, Tuschong LM, Bauer TR, Burkholder TH, Persons DA, Hickstein DD.
Gene Therapy for Canine Leukocyte Adhesion Deficiency with Lentiviral Vectors Using the Murine Stem Cell Virus and Human Phosphoglycerate Kinase Promoters.
Human gene therapy. 2011. [Journal]
2)  Hunter MJ, Tuschong LM, Fowler CJ, Bauer TR, Burkholder TH, Hickstein DD.
Gene therapy of canine leukocyte adhesion deficiency using lentiviral vectors with human CD11b and CD18 promoters driving canine CD18 expression.
Mol. Ther. 19: 113-21, 2011. [Journal]
3)  Ohmine K, Li Y, Bauer TR, Hickstein DD, Russell DW.
Tracking of specific integrant clones in dogs treated with foamy virus vectors.
Hum. Gene Ther. 22: 217-24, 2011. [Journal]
4)  Bauer TR, Olson EM, Huo Y, Tuschong LM, Allen JM, Li Y, Burkholder TH, Russell DW.
Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter.
Gene therapy. 2011. [Journal]
5)  Nelson EJ, Tuschong LM, Hunter MJ, Bauer TR, Burkholder TH, Hickstein DD.
Lentiviral vectors incorporating a human elongation factor 1alpha promoter for the treatment of canine leukocyte adhesion deficiency.
Gene Ther. 17: 672-7, 2010. [Journal]
6)  Peranteau WH, Heaton TE, Gu YC, Volk SW, Bauer TR, Alcorn K, Tuschong LM, Johnson MP, Hickstein DD, Flake AW.
Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model.
Biol. Blood Marrow Transplant. 15: 293-305, 2009. [Journal]
7)  Bauer TR, Adler RL, Hickstein DD.
Potential large animal models for gene therapy of human genetic diseases of immune and blood cell systems.
ILAR J. 50: 168-86, 2009. [Journal]
8)  Hai M, Adler RL, Bauer TR, Tuschong LM, Gu YC, Wu X, Hickstein DD.
Potential genotoxicity from integration sites in CLAD dogs treated successfully with gammaretroviral vector-mediated gene therapy.
Gene Ther. 15: 1067-71, 2008. [Journal]
9)  Bauer TR, Allen JM, Hai M, Tuschong LM, Khan IF, Olson EM, Adler RL, Burkholder TH, Gu YC, Russell DW, Hickstein DD.
Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors.
Nat. Med. 14: 93-7, 2008. [Journal]
10)  Gu YC, Bauer TR, Sokolic RA, Hai M, Tuschong LM, Burkholder T, Bacher J, Starost MF, Hickstein DD.
Conversion of the severe to the moderate disease phenotype with donor leukocyte microchimerism in canine leukocyte adhesion deficiency.
Bone Marrow Transplant. 37: 607-14, 2006. [Journal]
11)  Bauer TR, Hai M, Tuschong LM, Burkholder TH, Gu YC, Sokolic RA, Ferguson C, Dunbar CE, Hickstein DD.
Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy.
Blood. 108: 3313-20, 2006. [Journal]
12)  Engel ME, Hickstein DD, Bauer TR, Calder C, Manes B, Frangoul H.
Matched unrelated bone marrow transplantation with reduced-intensity conditioning for leukocyte adhesion deficiency.
Bone Marrow Transplant. 37: 717-8, 2006. [Journal]
13)  Burkholder TH, Colenda L, Tuschong LM, Starost MF, Bauer TR, Hickstein DD.
Reproductive capability in dogs with canine leukocyte adhesion deficiency treated with nonmyeloablative conditioning prior to allogeneic hematopoietic stem cell transplantation.
Blood. 108: 1767-9, 2006. [Journal]
14)  Sokolic RA, Bauer TR, Gu YC, Hai M, Tuschong LM, Burkholder T, Colenda L, Bacher J, Starost MF, Hickstein DD.
Nonmyeloablative conditioning with busulfan before matched littermate bone marrow transplantation results in reversal of the disease phenotype in canine leukocyte adhesion deficiency.
Biol. Blood Marrow Transplant. 11: 755-63, 2005. [Journal]
15)  Bauer TR, Gu YC, Tuschong LM, Burkholder T, Bacher JD, Starost MF, Donahue RE, Sokolic RA, Hickstein DD.
Nonmyeloablative hematopoietic stem cell transplantation corrects the disease phenotype in the canine model of leukocyte adhesion deficiency.
Exp. Hematol. 33: 706-12, 2005. [Journal]
16)  Bauer TR, Gu YC, Creevy KE, Tuschong LM, Embree L, Holland SM, Sokolic RA, Hickstein DD.
Leukocyte adhesion deficiency in children and Irish setter dogs.
Pediatr. Res. 55: 363-7, 2004. [Journal]
17)  Gu YC, Bauer TR, Ackermann MR, Smith CW, Kehrli ME, Starost MF, Hickstein DD.
The genetic immunodeficiency disease, leukocyte adhesion deficiency, in humans, dogs, cattle, and mice.
Comp. Med. 54: 363-72, 2004. [Journal]
18)  Bauer TR, Creevy KE, Gu YC, Tuschong LM, Donahue RE, Metzger ME, Embree LJ, Burkholder T, Bacher JD, Romines C, Thomas ML, Colenda L, Hickstein DD.
Very low levels of donor CD18+ neutrophils following allogeneic hematopoietic stem cell transplantation reverse the disease phenotype in canine leukocyte adhesion deficiency.
Blood. 103: 3582-9, 2004. [Journal]
19)  Creevy KE, Bauer TR, Tuschong LM, Embree LJ, Colenda L, Cogan K, Starost MF, Haskins ME, Hickstein DD.
Canine leukocyte adhesion deficiency colony for investigation of novel hematopoietic therapies.
Vet. Immunol. Immunopathol. 94: 11-22, 2003. [Journal]
20)  Creevy KE, Bauer TR, Tuschong LM, Embree LJ, Silverstone AM, Bacher JD, Romines C, Garnier J, Thomas ML, Colenda L, Hickstein DD.
Mixed chimeric hematopoietic stem cell transplant reverses the disease phenotype in canine leukocyte adhesion deficiency.
Vet. Immunol. Immunopathol. 95: 113-21, 2003. [Journal]
21)  Kijas JM, Bauer TR, Gäfvert S, Marklund S, Trowald-Wigh G, Johannisson A, Hedhammar A, Binns M, Juneja RK, Hickstein DD, Andersson L.
A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency.
Genomics. 61: 101-7, 1999. [Journal]
Click Here to View Collapsed Bibliography.

This page was last updated on 5/23/2011.