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Our Science – Waugh Website

David S. Waugh, Ph.D.

Selected Publications

1)  Kapust RB, Waugh DS.
Escherichia coli maltose-binding protein is uncommonly effective at promoting the solubility of polypeptides to which it is fused.
Protein Sci. 8: 1668-74, 1999.
2)  Kapust RB, Tözsér J, Fox JD, Anderson DE, Cherry S, Copeland TD, Waugh DS.
Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency.
Protein Eng. 14: 993-1000, 2001.
3)  Schubot FD, Jackson MW, Penrose KJ, Cherry S, Tropea JE, Plano GV, Waugh DS.
Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis.
J Mol Biol. 346: 1147-61, 2005.
4)  Lountos GT, Tropea JE, Zhang D, Jobson AG, Pommier Y, Shoemaker RH, Waugh DS.
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor.
Protein Sci. 18: 92-100, 2009.
5)  Bahta M, Lountos GT, Dyas B, Kim SE, Ulrich RG, Waugh DS, Burke TR.
Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase.
J. Med. Chem. 54: 2933-43, 2011.
6)  Needle D, Waugh DS.
Rescuing Aggregation-Prone Proteins in Escherichia coli with a Dual His6-MBP Tag.
Methods Mol. Biol. 1177: 81-94, 2014.
7)  Shaw GX, Li Y, Shi G, Wu Y, Cherry S, Needle D, Zhang D, Tropea JE, Waugh DS, Yan H, Ji X.
Structural enzymology and inhibition of the bifunctional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.
FEBS J. 2014.
8)  Raran-Kurussi S, Waugh DS.
Unrelated solubility-enhancing fusion partners MBP and NusA utilize a similar mode of action.
Biotechnol. Bioeng. 2014.
9)  Hogan M, Bahta M, Cherry S, Lountos GT, Tropea JE, Zhao BM, Burke TR, Waugh DS, Ulrich RG.
Biomolecular Interactions of small-molecule inhibitors affecting the YopH protein tyrosine phosphatase.
Chem Biol Drug Des. 81: 323-33, 2013.
10)  Raran-Kurussi S, Tözsér J, Cherry S, Tropea JE, Waugh DS.
Differential temperature dependence of tobacco etch virus and rhinovirus 3C proteases.
Anal. Biochem. 436: 142-4, 2013.
Click Here to View Expanded Bibliography.

This page was last updated on 7/18/2014.