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Our Science – Mackem Website

Susan Mackem, M.D., Ph.D.

Selected Publications

1)  Zhu J, Nakamura E, Nguyen MT, Bao X, Akiyama H, Mackem S.
Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.
Dev. Cell. 14: 624-32, 2008.
2)  Chen Y, Knezevic V, Ervin V, Hutson R, Ward Y, Mackem S.
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.
Development. 131: 2339-47, 2004.
3)  Knezevic V, De Santo R, Schughart K, Huffstadt U, Chiang C, Mahon KA, Mackem S.
Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop.
Development. 124: 4523-36, 1997.
4)  Knezevic V, De Santo R, Mackem S.
Two novel chick T-box genes related to mouse Brachyury are expressed in different, non-overlapping mesodermal domains during gastrulation.
Development. 124: 411-19, 1997.
5)  Mackem S, Roizman B.
Differentiation between alpha promoter and regulator regions of herpes simplex virus 1: the functional domains and sequence of a movable alpha regulator.
Proc. Natl. Acad. Sci. U.S.A. 79: 4917-21, 1982.
6)  Huang BL, Mackem S.
Evolutionary developmental biology: Use it or lose it.
Nature. 511: 34-5, 2014.
7)  Huang B, Mackem S.
Evolutionary Developmental Biology: Use It or Lose It.
Nature. 511: 34-5, 2014.
8)  Yun K, Ajima R, Sharma N, Costantini F, Mackem S, Lewandoski M, Yamaguchi TP, Perantoni AO.
Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.
Hum. Mol. Genet. 2014.
9)  Xu X, Mackem S.
Tracing the evolution of avian wing digits.
Curr. Biol. 23: R538-44, 2013.
10)  Zhu J, Nguyen M, Nakamura E, Yang J, Mackem S.
Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway.
Genesis. 50: 102-111, 2012.
11)  Bowers M, Eng L, Lao Z, Turnbull RK, Bao X, Riedel E, Mackem S, Joyner AL.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Dev. Biol. 370: 110-24, 2012.
12)  Gegonne A, Tai X, Zhang J, Wu G, Zhu J, Yoshimoto A, Hanson J, Cultraro C, Chen QR, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer DS.
The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells.
Mol. Cell. Biol. 32: 1984-97, 2012.
13)  Zhu J, Mackem S.
Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen.
Dev. Dyn. 240: 1303-10, 2011.
14)  Suh YH, Yoshimoto-Furusawa A, Weih KA, Tessarollo L, Roche KW, Mackem S, Roche PA.
Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice.
PLoS ONE. 6: e18444, 2011.
15)  Mackem S, Lewandoski M.
Development. Limb cells don't tell time.
Science. 332: 1038-9, 2011.
16)  Lewandoski M, Mackem S.
Developmental biology: extending the limb and body with vectors and scalars.
Curr. Biol. 21: R34-6, 2011.
17)  Sebastian A, Matsushita T, Kawanami A, Mackem S, Landreth G, Murakami S.
Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal.
J Ortho Res. 29: 375-379, 2011.
18)  Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen M, Mackem S, Clemens TL, Bikle DD, Chang W.
IGF-1R Signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway.
J. Bone Miner Res. 26: 1437-46, 2011.
19)  Hirai T, Chagin AS, Kobayashi T, Mackem S, Kronenberg HM.
Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life.
Proc. Natl. Acad. Sci. U.S.A. 108: 191-6, 2011.
20)  Gildea DE, Luetkemeier ES, Bao X, Loftus SK, Mackem S, Yang Y, Pavan WJ, Biesecker LG.
The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.
FASEB J. 25: 1596-605, 2011.
21)  Matsumoto K, Irie F, Mackem S, Yamaguchi Y.
A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses.
Proc. Natl. Acad. Sci. U.S.A. 107: 10932-7, 2010.
22)  Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S, Zeller R.
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.
PLoS Genet. 6: e1000901, 2010.
23)  Maes C, Kobayashi T, Selig MK, Torrekens S, Roth SI, Mackem S, Carmeliet G, Kronenberg HM.
Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels.
Dev Cell. 19: 329-344, 2010.
24)  Nagao K, Zhu J, Heneghan MB, Hanson JC, Morasso MI, Tessarollo L, Mackem S, Udey MC.
Abnormal placental development and early embryonic lethality in EpCAM-null mice.
PLoS ONE. 4: e8543, 2009.
25)  Mackem S, Lewandoski M.
Limb development takes a measured step toward systems analysis.
Sci Signal. 2: pe33, 2009.
26)  Lewandoski M, Mackem S.
Limb development: the rise and fall of retinoic acid.
Curr. Biol. 19: R558-61, 2009.
27)  Nguyen MT, Zhu J, Nakamura E, Bao X, Mackem S.
Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud.
Dev. Dyn. 238: 467-74, 2009.
28)  Yuasa T, Kondo N, Yasuhara R, Shimono K, Mackem S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.
Transient Activation of Wnt/β-catenin Signaling Induces Abnormal Growth Plate Closure and Articular Cartilage Thickening in Postnatal Mice.
Am J Pathol. 175: 1993-2003, 2009.
29)  Ohtola J, Myers J, Akhtar-Zaidi B, Zuzindlak D, Sandesara P, Yeh K, Mackem S, Atit R.
{beta}-Catenin has sequential roles in the survival and specification of ventral dermis.
Development. 135: 2321-9, 2008.
30)  Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y.
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.
Development. 135: 1947-56, 2008.
31)  Maeda Y, Nakamura E, Nguyen MT, Suva LJ, Swain FL, Razzaque MS, Mackem S, Lanske B.
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone.
Proc. Natl. Acad. Sci. U.S.A. 104: 6382-7, 2007.
32)  Mackem S.
Unsicker K, Krieglstein K, eds.
Limb Development. In: Cell signaling and growth factors in development: from molecules to organogenesis. Volume 2.
Weinheim: Wiley-VCH Verlag GmbH & Co.; 2006. p. Ch. 15, 523-618 [Book Chapter]
33)  Furusawa T, Lim JH, Catez F, Birger Y, Mackem S, Bustin M.
Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes.
Mol. Cell. Biol. 26: 592-604, 2006.
34)  Nakamura E, Nguyen MT, Mackem S.
Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton.
Dev. Dyn. 235: 2603-12, 2006.
35)  Mackem S.
Stern C, eds.
Not-Homeobox Gene Function in Axial Mesoderm Development. In: Gastrulation: from Cells to Embryo.
Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 2004. p. 599-607 [Book Chapter]
36)  Liu C, Knezevic V, Mackem S.
Ventral tail bud mesenchyme is a signaling center for tail paraxial mesoderm induction.
Dev. Dyn. 229: 600-606, 2004.
37)  Liu C, Nakamura E, Knezevic V, Hunter S, Thompson K, Mackem S.
A role for the mesenchymal T-box gene Brachyury in AER formation during limb development.
Development. 130: 1327-1337, 2003.
38)  Mackem S, Baumann CT, Hager GL.
A glucocorticoid/retinoic acid receptor chimera that displays cytoplasmic/nuclear translocation in response to retinoic acid. A real time sensing assay for nuclear receptor ligands.
J Biol Chem. 276: 45501-45504, 2001.
39)  Knezevic V, Mackem S.
Activation of epiblast gene expression by the hypoblast layer in the prestreak chick embryo.
Genesis. 30: 264-273, 2001.
40)  Mackem S, Knezevic V.
Do 5'Hoxd genes play a role in initiating or maintaining A-P polarizing signals in the limb?.
Cell Tissue Res. 296: 27-31, 1999.
41)  Knezevic V, De Santo R, Mackem S.
Continuing organizer function during chick tail development.
Development. 125: 1791-1801, 1998.
42)  Celli G, LaRochelle WJ, Mackem S, Sharp R, Merlino G.
Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.
EMBO J. 17: 1642-1655, 1998.
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This page was last updated on 8/5/2014.