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Our Science – Mackem Website

Susan Mackem, M.D., Ph.D.

Selected Publications

1)  Zhu J, Nakamura E, Nguyen MT, Bao X, Akiyama H, Mackem S.
Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.
Dev. Cell. 14: 624-32, 2008.
2)  Chen Y, Knezevic V, Ervin V, Hutson R, Ward Y, Mackem S.
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.
Development. 131: 2339-47, 2004.
3)  Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S, Zeller R.
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.
PLoS Genet. 6: e1000901, 2010.
4)  Bowers M, Eng L, Lao Z, Turnbull RK, Bao X, Riedel E, Mackem S, Joyner AL.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Dev. Biol. 370: 110-24, 2012.
5)  Zhu J, Mackem S.
Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen.
Dev. Dyn. 240: 1303-10, 2011.
6)  Xu X, Mackem S.
Tracing the evolution of avian wing digits.
Curr. Biol. 23: R538-44, 2013.
7)  Zhu J, Nguyen M, Nakamura E, Yang J, Mackem S.
Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway.
Genesis. 50: 102-111, 2012.
8)  Gegonne A, Tai X, Zhang J, Wu G, Zhu J, Yoshimoto A, Hanson J, Cultraro C, Chen QR, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer DS.
The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells.
Mol. Cell. Biol. 32: 1984-97, 2012.
9)  Suh YH, Yoshimoto-Furusawa A, Weih KA, Tessarollo L, Roche KW, Mackem S, Roche PA.
Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice.
PLoS ONE. 6: e18444, 2011.
10)  Mackem S, Lewandoski M.
Development. Limb cells don't tell time.
Science. 332: 1038-9, 2011.
Click Here to View Expanded Bibliography.

This page was last updated on 11/20/2013.