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Our Science – Mackem Website

Susan Mackem, M.D., Ph.D.

Selected Publications

1)  Zhu J, Nakamura E, Nguyen MT, Bao X, Akiyama H, Mackem S.
Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.
Dev. Cell. 14: 624-32, 2008.
2)  Chen Y, Knezevic V, Ervin V, Hutson R, Ward Y, Mackem S.
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.
Development. 131: 2339-47, 2004.
3)  Knezevic V, De Santo R, Schughart K, Huffstadt U, Chiang C, Mahon KA, Mackem S.
Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop.
Development. 124: 4523-36, 1997.
4)  Knezevic V, De Santo R, Mackem S.
Two novel chick T-box genes related to mouse Brachyury are expressed in different, non-overlapping mesodermal domains during gastrulation.
Development. 124: 411-19, 1997.
5)  Mackem S, Roizman B.
Differentiation between alpha promoter and regulator regions of herpes simplex virus 1: the functional domains and sequence of a movable alpha regulator.
Proc. Natl. Acad. Sci. U.S.A. 79: 4917-21, 1982.
6)  Huang BL, Mackem S.
Evolutionary developmental biology: Use it or lose it.
Nature. 511: 34-5, 2014.
7)  Huang B, Mackem S.
Evolutionary Developmental Biology: Use It or Lose It.
Nature. 511: 34-5, 2014.
8)  Xu X, Mackem S.
Tracing the evolution of avian wing digits.
Curr. Biol. 23: R538-44, 2013.
9)  Zhu J, Nguyen M, Nakamura E, Yang J, Mackem S.
Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway.
Genesis. 50: 102-111, 2012.
10)  Bowers M, Eng L, Lao Z, Turnbull RK, Bao X, Riedel E, Mackem S, Joyner AL.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Dev. Biol. 370: 110-24, 2012.
Click Here to View Expanded Bibliography.

This page was last updated on 7/9/2014.