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Our Science – Mackem Website

Susan Mackem, M.D., Ph.D.

Selected Publications

1)  Zhu J, Nguyen M, Nakamura E, Yang J, Mackem S.
Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway.
Genesis. 50: 102-111, 2012.
[Journal]
2)  Bowers M, Eng L, Lao Z, Turnbull RK, Bao X, Riedel E, Mackem S, Joyner AL.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Dev. Biol. 370: 110-24, 2012.
[Journal]
3)  Gegonne A, Tai X, Zhang J, Wu G, Zhu J, Yoshimoto A, Hanson J, Cultraro C, Chen QR, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer DS.
The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells.
Mol. Cell. Biol. 32: 1984-97, 2012.
[Journal]
4)  Zhu J, Mackem S.
Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen.
Dev. Dyn. 240: 1303-10, 2011.
[Journal]
5)  Suh YH, Yoshimoto-Furusawa A, Weih KA, Tessarollo L, Roche KW, Mackem S, Roche PA.
Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice.
PLoS ONE. 6: e18444, 2011.
[Journal]
6)  Mackem S, Lewandoski M.
Development. Limb cells don't tell time.
Science. 332: 1038-9, 2011.
[Journal]
7)  Lewandoski M, Mackem S.
Developmental biology: extending the limb and body with vectors and scalars.
Curr. Biol. 21: R34-6, 2011.
[Journal]
8)  Sebastian A, Matsushita T, Kawanami A, Mackem S, Landreth G, Murakami S.
Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal.
J Ortho Res. 29: 375-379, 2011.
[Journal]
9)  Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen M, Mackem S, Clemens TL, Bikle DD, Chang W.
IGF-1R Signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway.
J. Bone Miner Res. 26: 1437-46, 2011.
[Journal]
10)  Hirai T, Chagin AS, Kobayashi T, Mackem S, Kronenberg HM.
Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life.
Proc. Natl. Acad. Sci. U.S.A. 108: 191-6, 2011.
[Journal]
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This page was last updated on 4/19/2013.