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Our Science – Gardner Website

Kevin Gardner, M.D., Ph.D.

Selected Publications

1)  De Luca P, Moiola CP, Zalazar F, Gardner K, Vazquez ES, De Siervi A.
BRCA1 and p53 regulate critical prostate cancer pathways.
Prostate Cancer Prostatic Dis. 16: 233-8, 2013.
2)  Alsarraj J, Faraji F, Geiger TR, Mattaini KR, Williams M, Wu J, Ha NH, Merlino T, Walker RC, Bosley AD, Xiao Z, Andresson T, Esposito D, Smithers N, Lugo D, Prinjha R, Day A, Crawford NP, Ozato K, Gardner K, Hunter KW.
BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.
PLoS ONE. 8: e80746, 2013.
3)  Byun JS, Gardner K.
C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer.
Int J Cell Biol. 2013: 647975, 2013.
4)  Di LJ, Byun JS, Wong MM, Wakano C, Taylor T, Bilke S, Baek S, Hunter K, Yang H, Lee M, Zvosec C, Khramtsova G, Cheng F, Perou CM, Ryan Miller C, Raab R, Olopade OI, Gardner K.
Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer.
Nat Commun. 4: 1449, 2013.
5)  Byun JS, Gardner K.
Wounds That Will Not Heal: Pervasive Cellular Reprogramming in Cancer.
Am. J. Pathol. 182: 1055-64, 2013.
6)  Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A.
Dynamic Coregulatory Complex Containing BRCA1, E2F1 and CtIP Controls ATM Transcription.
Cell Physiol Biochem. 30: 596-608, 2012.
7)  Byun JS, Fufa TD, Wakano C, Fernandez A, Haggerty CM, Sung MH, Gardner K.
ELL facilitates RNA polymerase II pause site entry and release.
Nat Commun. 3: 633, 2012.
8)  Wakano C, Byun JS, Di L, Gardner K.
The dual lives of bidirectional promoters.
Biochim Biophys Acta. 1819: 688-93, 2012.
9)  Li X, Li L, Pandey R, Byun JS, Gardner K, Qin Z, Dou Y.
The Histone Acetyltransferase MOF Is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network.
Cell Stem Cell. 11: 163-78, 2012.
10)  De Luca P, Vazquez ES, Moiola CP, Zalazar F, Cotignola J, Gueron G, Gardner K, De Siervi A.
BRCA1 Loss Induces GADD153-Mediated Doxorubicin Resistance in Prostate Cancer.
Mol. Cancer Res. 9: 1078-90, 2011.
11)  Moiola C, De Luca P, Gardner K, Vazquez E, De Siervi A.
Cyclin T1 overexpression induces malignant transformation and tumor growth.
Cell Cycle. 9: 3119-26, 2010.
12)  De Siervi A, De Luca P, Byun JS, Di LJ, Fufa T, Haggerty CM, Vazquez E, Moiola C, Longo DL, Gardner K.
Transcriptional autoregulation by BRCA1.
Cancer Res. 70: 532-42, 2010.
13)  Di LJ, Fernandez AG, De Siervi A, Longo DL, Gardner K.
Transcriptional regulation of BRCA1 expression by a metabolic switch.
Nat. Struct. Mol. Biol. 17: 1406-13, 2010.
14)  Byun JS, Wong MM, Cui W, Idelman G, Li Q, De Siervi A, Bilke S, Haggerty CM, Player A, Wang YH, Thirman MJ, Kaberlein JJ, Petrovas C, Koup RA, Longo D, Ozato K, Gardner K.
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print], 2009.
15)  De Siervi A, De Luca P, Moiola C, Gueron G, Tongbai R, Chandramouli GV, Haggerty C, Dzekunova I, Petersen D, Kawasaki E, Kil WJ, Camphausen K, Longo D, Gardner K.
Identification of new Rel/NFkappaB regulatory networks by focused genome location analysis.
Cell Cycle. 8, 2009.
16)  Luo X, Li Z, Yan Q, Li X, Tao D, Wang J, Leng Y, Gardner K, Judge SI, Li QQ, Hu J, Gong J.
The human WW45 protein enhances MST1-mediated apoptosis in vivo.
Int. J. Mol. Med. 23: 357-62, 2009.
17)  Ge Y, Byun JS, De Luca P, Gueron G, Li QQ, Yabe IM, Sadiq-Ali SG, Figg WD, Quintero J, Haggerty CM, De Siervi A, Gardner K.
Combinatorial anti-leukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide CPS49 and flavopiridol.
Mol. Pharmacol. Sep;74(3):: 872-83., 2008.
18)  Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Luhasen T, Lee MH, Xiao C, Vassilopoulos A, Chen W, Gardner K, Man YG, Hung MC, Finkel T, Deng CX.
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Mol. Cell. 32: 11-20, 2008.
19)  Yu C, Zhang X, Sun G, Guo X, Li H, You Y, Gardner K, Yuan D, Xu Z, DU Q, Dai C, Qian Z, Jiang K, Zhu Y, Jacobs JL, Li QQ, Miao Y.
RNA Interference-Mediated Silencing of the Polo-like Kinase 1 Gene Enhances Chemosensitivity to Gemcitabine in Pancreatic Adenocarcinoma Cells.
J. Cell. Mol. Med. [Epub ahead of print], 2008.
20)  Tongbai R, Idelman G, Nordgard SH, Cui W, Jacobs JL, Haggerty CM, Chanock SJ, Borresen-Dale A, Livingston G, Shaunessy P, Chiang C, Kristensen VN, Bilke S, Gardner K.
Transcriptional networks inferred from molecular signatures of breast cancer.
Am. J. Pathol. 172: 495-509, 2008.
21)  You Y, Geng X, Zhao P, Fu Z, Wang C, Chao S, Liu N, Lu A, Gardner K, Pu P, Kong C, Ge Y, Judge SI, Li QQ.
Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts.
Cell Mol Life Sci. 64(5):: 621-31, 2007.
22)  Idelman G, Taylor JG, Tongbai R, Chen RA, Haggerty CM, Bilke S, Chanock SJ, Gardner K.
Functional profiling of uncommon VCAM1 promoter polymorphisms prevalent in African American populations.
Hum. Mutat. 28: 824-9, 2007.
23)  Zhao J, Li QQ, Zou B, Wang G, Li X, Kim JE, Cuff CF, Huang L, Reed E, Gardner K.
In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma.
Int. J. Oncol. 31: 241-52, 2007.
24)  Cui W, Taub DD, Gardner K.
qPrimerDepot: a primer database for quantitative real time PCR.
Nucleic Acids Res. 35: D805-9, 2007.
25)  Feng Y, Wu J, Feng X, Tao D, Hu J, Qin J, Li X, Xiao W, Gardner K, Judge SI, Li QQ, Gong J.
Timing of apoptosis onset depends on cell cycle progression in peripheral blood lymphocytes and lymphocytic leukemia cells.
Oncol. Rep. 17: 1437-44, 2007.
26)  Xiao Q, Li L, Xie Y, Tan N, Wang C, Xu J, Xia K, Gardner K, Li QQ.
Transcription factor E2F-1 is upregulated in human gastric cancer tissues and its overexpression suppresses gastric tumor cell proliferation.
Cell. Oncol. 29: 335-49, 2007.
27)  Rustici G, Gardner K.
Transcriptional Networks: From Yeast to Man. Volume Microarrays and Transcriptional Networks.
Georgetown: Landes Bioscience; 2006. [Book]
28)  Xin L, Wang J, Zhang H, Shi W, Yu M, Li Q, Jiang X, Gong F, Gardner K, Li QQ, Li Z.
Dual regulation of soluble tumor necrosis factor-alpha induced activation of human monocytic cells via modulating transmembrane TNF-alpha-mediated 'reverse signaling'.
Int. J. Mol. Med. 18: 885-92, 2006.
29)  Ge Y, Montano I, Rustici G, Freebern WJ, Haggerty CM, Cui W, Ponciano-Jackson D, Chandramouli GV, Gardner ER, Figg WD, Abu-Asab M, Tsokos M, Jackson SH, Gardner K.
Selective leukemic cell killing by a novel functional class of thalidomide analogs.
Blood. 108:: 4126-35, 2006.
30)  Wu J, Feng Y, Xie D, Li X, Xiao W, Tao D, Qin J, Hu J, Gardner K, Judge SI, Li QQ, Gong J.
Unscheduled CDK1 activity in G1 phase of the cell cycle triggers apoptosis in X-irradiated lymphocytic leukemia cells.
Cell. Mol. Life Sci. 63: 2538-45, 2006.
31)  McNutt MC, Tongbai R, Cui W, Collins I, Freebern WJ, Montano I, Haggerty CM, Chandramouli G, Gardner K.
Human Promoter Genomic Composition Demonstrates Non-Random Groupings that Reflect General Cellular Function.
BMC Bioinformatics. 6: 259, 2005.
32)  Freebern WJ, Haggerty CM, Montano I, McNutt MC, Collins I, Graham A, Chandramouli GV, Stewart DH, Biebuyck HA, Taub DD, Gardner K.
Pharmacologic profiling of transcriptional targets deciphers promoter logic.
Pharmacogenomics J. 5:: 305-23, 2005.
33)  Sohn RH, Deming CB, Johns DC, Champion HC, Bian C, Gardner K, Rade JJ.
Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B.
Blood. 105: 3910-7, 2005.
34)  Smith JL, Freebern WJ, Collins I, De Siervi A, Montano I, Haggerty CM, McNutt MC, Butscher WG, Dzekunova I, Petersen DW, Kawasaki E, Merchant JL, Gardner K.
Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment.
Proc Natl Acad Sci U S A. 101(32): 11554-9, 2004.
35)  Galperin MM, Traicoff JL, Ramesh A, Freebern WJ, Haggerty CM, Hartmann DP, Emmert-Buck MR, Gardner K, Knezevic V.
Multimembrane dot-blotting: a cost-effective tool for proteome analysis.
Biotechniques. 36: 1046-51, 2004.
36)  Traicoff JL, Galperin MM, Ramesh A, Freebern WJ, Haggerty CM, Gardner K, Knezevic V.
Profiling the expression of mitogen-induced T-cell proteins by using multi-membrane dot-blotting.
Biochem Biophys Res Commun. 323: 355-60, 2004.
37)  Cannons JL, Yu LJ, Hill B, Mijares LA, Dombroski D, Nichols KE, Antonellis A, Koretzky GA, Gardner K, Schwartzberg PL.
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.
Immunity. 21: 693-706, 2004.
38)  Smith JL, Collins I, Chandramouli GV, Butscher WG, Zaitseva E, Freebern WJ, Haggerty CM, Doseeva V, Gardner K.
Targeting combinatorial transcriptional complex assembly at specific modules within the interleukin-2 promoter by the immunosuppressant SB203580.
J Biol Chem. 278: 41034-46, 2003.
39)  Chaudhry S, Freebern WJ, Smith JL, Butscher WG, Haggerty CM, Gardner K.
Cross-regulation of T cell growth factor expression by p53 and the Tax oncogene.
J Immunol. 169: 6767-78, 2002.
40)  Freebern WJ, Smith JL, Chaudhry SS, Haggerty CM, Gardner K.
Novel Cell Specific and Dominant Negative Anti-apoptotic Roles of p73 in Transformed Leukemia Cells.
J. Biol. Chem. 278: 2249-2255, 2002.
41)  Gardner K, Liu ET.
BRCA1 function in T lymphocytes: a cellular specificity of a different kind.
Breast Cancer Res. 3: 11-3, 2001.
42)  Butscher WG, Haggerty CM, Chaudhry S, Gardner K.
Targeting of p300 to the interleukin-2 promoter via CREB-Rel cross-talk during mitogen and oncogenic molecular signaling in activated T-cells.
J Biol Chem. 276: 27647-56, 2001.
43)  Okamoto Y, Chaves A, Chen J, Kelley R, Jones K, Weed HG, Gardner KL, Gangi L, Yamaguchi M, Klomkleaw W, Nakayama T, Hamlin RL, Carnes C, Altschuld R, Bauer J, Hai T.
Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction.
Am J Pathol. 159: 639-50, 2001.
44)  Wilson KE, Li Z, Kara M, Gardner KL, Roberts DD.
Beta 1 integrin- and proteoglycan-mediated stimulation of T lymphoma cell adhesion and mitogen-activated protein kinase signaling by thrombospondin-1 and thrombospondin-1 peptides.
J Immunol. 163: 3621-8, 1999.
45)  Li Q, Zhang L, Tsang B, Gardner K, Bostick-Bruton F, Reed E.
Phorbol ester exposure activates an AP-1-mediated increase in ERCC-1 messenger RNA expression in human ovarian tumor cells.
Cell Mol Life Sci. 55: 456-66, 1999.
46)  Butscher WG, Powers C, Olive M, Vinson C, Gardner K.
Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2.
J Biol Chem. 273: 552-60, 1998.
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This page was last updated on 4/28/2014.