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Our Science – Huppi Website

Konrad Huppi, Ph.D.

Selected Publications

1)  Barsotti AM, Beckerman R, Laptenko O, Huppi K, Caplen NJ, Prives C.
p53-Dependent induction of PVT1 and miR-1204.
J. Biol. Chem. 287: 2509-19, 2012.
2)  Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beissbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ.
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.
Mol. Cancer. 11: 1, 2012.
3)  Huppi K, Pitt JJ, Wahlberg BM, Caplen NJ.
The 8q24 gene desert: an oasis of non-coding transcriptional activity.
Front Genet. 3: 69, 2012.
4)  Huppi K, Pitt J, Wahlberg B, Caplen NJ.
Genomic instability and mouse microRNAs.
Toxicol. Mech. Methods. 21: 325-33, 2011.
5)  Mackiewicz M, Huppi K, Pitt JJ, Dorsey TH, Ambs S, Caplen NJ.
Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA.
Breast Cancer Res. Treat. 130: 663-79, 2011.
6)  McKean D, Huppi K, Bell M, Staudt L, Gerhard W, Weigert M.
Pillars article: generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA, 81: 3180-3184, May 1984.
J. Immunol. 180: 5765-9, 2008.
7)  Beck-Engeser GB, Lum AM, Huppi K, Caplen NJ, Wang BB, Wabl M.
Pvt1-encoded microRNAs in oncogenesis.
Retrovirology. 5: 4, 2008.
8)  Huppi K, Volfovsky N, Runfola T, Jones TL, Mackiewicz M, Martin SE, Mushinski JF, Stephens R, Caplen NJ.
The identification of microRNAs in a genomically unstable region of human chromosome 8q24.
Mol. Cancer Res. 6: 212-21, 2008.
9)  Raveche ES, Salerno E, Scaglione BJ, Manohar V, Abbasi F, Lin Y, Fredrickson T, Landgraf P, Ramachandra S, Huppi K, Toro JR, Zenger VE, Metcalf RA, Marti GE.
Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice.
Blood. 109: 5079-86, 2007.
10)  Huppi K, Volfovsky N, Mackiewicz M, Runfola T, Jones TL, Martin SE, Stephens R, Caplen NJ.
MicroRNAs and genomic instability.
Semin. Cancer Biol. 17: 65-73, 2007.
11)  Martin SE, Jones TL, Thomas CL, Lorenzi PL, Nguyen DA, Runfola T, Gunsior M, Weinstein JN, Goldsmith PK, Lader E, Huppi K, Caplen NJ.
Multiplexing siRNAs to compress RNAi-based screen size in human cells.
Nucleic Acids Res. 35: e57, 2007.
12)  McGruder BM, Atha DH, Wang W, Huppi K, Wei WQ, Abnet CC, Qiao YL, Dawsey SM, Taylor PR, Jakupciak JP.
Real-time telomerase assay of less-invasively collected esophageal cell samples.
Cancer Lett. 244: 91-100, 2006.
13)  Roth MJ, Hu N, Johnson LL, Quon-Hang W, Ahnen DJ, Iwamoto M, Dawsey SM, Taylor PR, Huppi K.
beta-Catenin splice variants and downstream targets as markers for neoplastic progression of esophageal cancer.
Genes Chromosomes Cancer. 44: 423-8, 2005.
14)  Huppi K, Martin SE, Caplen NJ.
Defining and assaying RNAi in mammalian cells.
Mol. Cell. 17: 1-10, 2005.
15)  Abnet CC, Huppi K, Carrera A, Armistead D, McKenney K, Hu N, Tang ZZ, Taylor PR, Dawsey SM.
Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma.
BMC Cancer. 4: 30, 2004.
16)  Huppi K, Chandramouli GV.
Molecular profiling of prostate cancer.
Curr Urol Rep. 5: 45-51, 2004.
17)  Czarneski J, Lin YC, Chong S, McCarthy B, Fernandes H, Parker G, Mansour A, Huppi K, Marti GE, Raveche E.
Studies in NZB IL-10 knockout mice of the requirement of IL-10 for progression of B-cell lymphoma.
Leukemia. 18: 597-606, 2004.
18)  Diaw L, Siwarski D, Huppi K.
Double light chain producing lymphocytes: an enigma of allelic exclusion.
Immunol. Res. 24: 303-10, 2001.
19)  Diaw L, Siwarski D, DuBois W, Jones G, Huppi K.
Double producers of kappa and lambda define a subset of B cells in mouse plasmacytomas.
Mol. Immunol. 37: 775-81, 2001.
20)  Siwarski D, Kim J, Diaw L, Huppi K.
Identification of a transcriptionally compromised allele of c-MYC in a North American family.
J. Med. Genet. 38: 47-9, 2001.
21)  Huppi K, Henderson D, Siwarski D, Hochman J, Bergel M, Tuchscherer G.
Generation of monospecific peptide antibodies to the DNA binding domain of p53.
BioTechniques. 29: 1100-6, 2000.
22)  Recio JA, Zambrano N, de La Peña L, Powers C, Siwarski D, Huppi K, Notario V.
cDNA isolation, expression, and chromosomal localization of the mouse pcph proto-oncogene.
Mol. Carcinog. 26: 130-6, 1999.
23)  Diaw L, Siwarski D, Coleman A, Kim J, Jones GM, Dighiero G, Huppi K.
Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.
J. Exp. Med. 190: 1405-16, 1999.
24)  Lehrnbecher T, Foster CB, Zhu S, Leitman SF, Goldin LR, Huppi K, Chanock SJ.
Variant genotypes of the low-affinity Fcgamma receptors in two control populations and a review of low-affinity Fcgamma receptor polymorphisms in control and disease populations.
Blood. 94: 4220-32, 1999.
25)  Beecham EJ, Owens JD, Shaughnessy JD, Huppi K, Bohr VA, Mushinski JF.
Decoupling of DNA excision repair and RNA transcription in translocation breaksite regions of plasmacytoma-susceptible BALB/cAnPt mice.
Carcinogenesis. 18: 687-94, 1997.
26)  Eyler YL, Siwarski DF, Huppi KE, Lewis AM.
Downregulation of Waf1, C2, C3, and major histocompatibility complex class I loci within an 18-cM region of chromosome 17 in adenovirus-transformed mouse cells.
Mol. Carcinog. 18: 213-20, 1997.
27)  Kuehl WM, Brents LA, Chesi M, Huppi K, Bergsagel PL.
Dysregulation of c-myc in multiple myeloma.
Curr. Top. Microbiol. Immunol. 224: 277-82, 1997.
28)  Siwarski D, Müller U, Andersson J, Notario V, Melchers F, Rolink A, Huppi K.
Structure and expression of the c-Myc/Pvt 1 megagene locus.
Curr. Top. Microbiol. Immunol. 224: 67-72, 1997.
29)  Miller CE, Karpas A, Schneerson R, Huppi K.
Of four murine, anti-Shigella dysenteriae type 1 O-polysaccharide antibodies, three employ V-genes that differ extensively from those of the fourth.
Mol. Immunol. 33: 1217-22, 1996.
30)  Hori M, Qi CF, Torrey TA, Huppi K, Morse HC.
The Bcl6 locus is not mutated in mouse B-cell lineage lymphomas.
Leuk Res. 26: 739-43, 2002.
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This page was last updated on 4/9/2014.