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Our Science – Hickstein Website

Dennis D. Hickstein, M.D.

Selected Publications

1)  Sabaawy HE, Azuma M, Embree LJ, Tsai HJ, Starost MF, Hickstein DD.
TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 103: 15166-71, 2006.
2)  Bauer TR, Allen JM, Hai M, Tuschong LM, Khan IF, Olson EM, Adler RL, Burkholder TH, Gu YC, Russell DW, Hickstein DD.
Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors.
Nat. Med. 14: 93-7, 2008.
3)  Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu P, Hickstein DD.
brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis.
Proc. Natl. Acad. Sci. U.S.A. 107: 19350-5, 2010.
4)  Cuellar-Rodriguez J, Gea-Banacloche J, Freeman AF, Hsu AP, Zerbe CS, Calvo KR, Wilder J, Kurlander R, Olivier KN, Holland SM, Hickstein DD.
Successful allogeneic hematopoietic stem cell transplantation for GATA2 deficiency.
Blood. 118: 3715-20, 2011.
5)  West RR, Hsu AP, Holland SM, Cuellar-Rodriguez J, Hickstein DD.
Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation.
Haematologica. 99: 276-81, 2014.
6)  Shive HR, West RR, Embree LJ, Golden CD, Hickstein DD.
BRCA2 and TP53 collaborate in tumorigenesis in zebrafish.
PLoS ONE. 9: e87177, 2014.
7)  Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, Arthur DC, Gu W, Gould CM, Brewer CC, Cowen EW, Freeman AF, Olivier KN, Uzel G, Zelazny AM, Daub JR, Spalding CD, Claypool RJ, Giri NK, Alter BP, Mace EM, Orange JS, Cuellar-Rodriguez J, Hickstein DD, Holland SM.
GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity.
Blood. 123: 809-21, 2014.
8)  Kochenderfer JN, Dudley ME, Carpenter RO, Kassim SH, Rose JJ, Telford WG, Hakim FT, Halverson DC, Fowler DH, Hardy NM, Mato AR, Hickstein DD, Gea-Banacloche JC, Pavletic SZ, Sportes C, Maric I, Feldman SA, Hansen BG, Wilder JS, Blacklock-Schuver B, Jena B, Bishop MR, Gress RE, Rosenberg SA.
Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation.
Blood. 122: 4129-39, 2013.
9)  Hsu AP, Johnson KD, Falcone EL, Sanalkumar R, Sanchez L, Hickstein DD, Cuellar-Rodriguez J, Lemieux JE, Zerbe CS, Bresnick EH, Holland SM.
GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome.
Blood. 121: 3830-7, 2013.
10)  Bhanushali MJ, Kranick SM, Freeman AF, Cuellar-Rodriguez JM, Battiwalla M, Gea-Banacloche JC, Hickstein DD, Pavletic S, Fahle G, Nath A.
Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation.
Neurology. 80: 1494-500, 2013.
11)  Bauer TR, Tuschong LM, Calvo KR, Shive HR, Burkholder TH, Karlsson EK, West RR, Russell DW, Hickstein DD.
Long-Term Follow-up of Foamy Viral Vector-Mediated Gene Therapy for Canine Leukocyte Adhesion Deficiency.
Mol. Ther. 21: 964-72, 2013.
12)  Fowler DH, Mossoba ME, Steinberg SM, Halverson DC, Stroncek D, Khuu HM, Hakim FT, Castiello L, Sabatino M, Leitman SF, Mariotti J, Gea-Banacloche JC, Sportes C, Hardy NM, Hickstein DD, Pavletic SZ, Rowley S, Goy A, Donato M, Korngold R, Pecora A, Levine BL, June CH, Gress RE, Bishop MR.
Phase II clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation.
Blood. 121: 2864-74, 2013.
13)  English MA, Lei L, Blake T, Wincovitch SM, Sood R, Azuma M, Hickstein D, Liu PP.
Incomplete splicing, cell division defects, and hematopoietic blockage in dhx8 mutant zebrafish.
Dev. Dyn. 241: 879-89, 2012.
14)  Kazenwadel J, Secker GA, Liu YJ, Rosenfeld JA, Wildin RS, Cuellar-Rodriguez J, Hsu AP, Dyack S, Fernandez CV, Chong CE, Babic M, Bardy PG, Shimamura A, Zhang MY, Walsh T, Holland SM, Hickstein DD, Horwitz MS, Hahn CN, Scott HS, Harvey NL.
Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.
Blood. 119: 1283-91, 2012.
15)  Hunter MJ, Zhao H, Tuschong LM, Bauer TR, Burkholder TH, Persons DA, Hickstein DD.
Gene Therapy for Canine Leukocyte Adhesion Deficiency with Lentiviral Vectors Using the Murine Stem Cell Virus and Human Phosphoglycerate Kinase Promoters.
Hum Gene Ther. 22: 689-96, 2011.
16)  Hunter MJ, Tuschong LM, Fowler CJ, Bauer TR, Burkholder TH, Hickstein DD.
Gene Therapy of Canine Leukocyte Adhesion Deficiency Using Lentiviral Vectors With Human CD11b and CD18 Promoters Driving Canine CD18 Expression.
Mol Ther. 19: 113-21, 2011.
17)  Donahue RE, Tuschong L, Bauer TR, Yau YY, Leitman SF, Hickstein DD.
Leukocyte integrin activation mediates transient neutropenia after G-CSF administration.
Blood. 118: 4209-14, 2011.
18)  Hsu AP, Sampaio EP, Khan J, Calvo KR, Lemieux JE, Patel SY, Frucht DM, Vinh DC, Auth RD, Freeman AF, Olivier KN, Uzel G, Zerbe CS, Spalding C, Pittaluga S, Raffeld M, Kuhns DB, Ding L, Paulson ML, Marciano BE, Gea-Banacloche JC, Orange JS, Cuellar-Rodriguez J, Hickstein DD, Holland SM.
Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.
Blood. 118: 2653-5, 2011.
19)  Calvo KR, Vinh DC, Maric I, Wang W, Noel P, Stetler-Stevenson M, Arthur DC, Raffeld M, Dutra A, Pak E, Myung K, Hsu AP, Hickstein DD, Pittaluga S, Holland SM.
Myelodysplasia in autosomal dominant and sporadic monocytopenia immunodeficiency syndrome: diagnostic features and clinical implications.
Haematologica. 96: 1221-5, 2011.
20)  Hickstein DD, West RR.
A WHIM-sical zebrafish.
Blood. 116: 2621-2, 2010.
21)  Zweier-Renn LA, Hawley TS, Burkett S, Ramezani A, Riz I, Adler RL, Hickstein DD, Hawley RG.
Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.
Genes Chromosomes Cancer. 49: 119-31, 2010.
22)  Nelson EJ, Tuschong LM, Hunter MJ, Bauer TR, Burkholder TH, Hickstein DD.
Lentiviral vectors incorporating a human elongation factor 1alpha promoter for the treatment of canine leukocyte adhesion deficiency.
Gene Ther. 17: 672-7, 2010.
23)  Ohmine K, Li Y, Bauer Jr TR, Hickstein D, Russell D.
Tracking of Specific Integrant Clones in Dogs Treated with Foamy Virus Vectors.
Hum Gene Ther. 22: 217-24, 2010.
24)  Embree LJ, Azuma M, Hickstein DD.
Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.
Cancer Res. 69: 4363-71, 2009.
25)  Peranteau WH, Heaton TE, Gu YC, Volk SW, Bauer TR, Alcorn K, Tuschong LM, Johnson MP, Hickstein DD, Flake AW.
Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model.
Biol. Blood Marrow Transplant. 15: 293-305, 2009.
26)  Bauer TR, Adler RL, Hickstein DD.
Potential large animal models for gene therapy of human genetic diseases of immune and blood cell systems.
ILAR J. 50: 168-86, 2009.
27)  Hai M, Adler RL, Bauer TR, Tuschong LM, Gu YC, Wu X, Hickstein DD.
Potential genotoxicity from integration sites in CLAD dogs treated successfully with gammaretroviral vector-mediated gene therapy.
Gene Ther. 15: 1067-71, 2008.
28)  Azuma M, Embree LJ, Sabaawy H, Hickstein DD.
Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo.
PLoS ONE. 2: e979, 2007.
29)  Malech HL, Hickstein DD.
Genetics, biology and clinical management of myeloid cell primary immune deficiencies: chronic granulomatous disease and leukocyte adhesion deficiency.
Curr. Opin. Hematol. 14: 29-36, 2007.
30)  Gu YC, Bauer TR, Sokolic RA, Hai M, Tuschong LM, Burkholder T, Bacher J, Starost MF, Hickstein DD.
Conversion of the severe to the moderate disease phenotype with donor leukocyte microchimerism in canine leukocyte adhesion deficiency.
Bone Marrow Transplant. 37: 607-14, 2006.
31)  Bauer Jr TR, Hai M, Tuschong LM, Burkholder TH, Gu Y, Sokolic RA, Ferguson C, Dunbar CE, Hickstein DD.
Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex-vivo hematopoietic stem cell gene therapy.
Blood. [Epub ahead of print], 2006.
32)  Engel ME, Hickstein DD, Bauer TR, Calder C, Manes B, Frangoul H.
Matched unrelated bone marrow transplantation with reduced-intensity conditioning for leukocyte adhesion deficiency.
Bone Marrow Transplant. 37: 717-8, 2006.
33)  Burkholder TH, Colenda L, Tuschong LM, Starost MF, Bauer Jr TR, Hickstein DD.
Reproductive capability in dogs with canine leukocyte adhesion deficiency treated with non-myeloablative conditioning prior to allogeneic hematopoietic stem cell transplantation.
Blood. [Epub ahead of print], 2006.
34)  Bauer TR, Gu YC, Tuschong LM, Burkholder T, Bacher JD, Starost MF, Donahue RE, Sokolic RA, Hickstein DD.
Nonmyeloablative hematopoietic stem cell transplantation corrects the disease phenotype in the canine model of leukocyte adhesion deficiency.
Exp Hematol. 33: 706-12, 2005.
35)  Bauer TR, Creevy KE, Gu YC, Tuschong LM, Donahue RE, Metzger ME, Embree LJ, Burkholder T, Bacher JD, Romines C, Thomas ML, Colenda L, Hickstein DD.
Very low levels of donor CD18+ neutrophils following allogeneic hematopoietic stem cell transplantation reverse the disease phenotype in canine leukocyte adhesion deficiency.
Blood. 103: 3582-9, 2004.
36)  Bauer TR, Gu Y, Creevy KE, Tuschong LM, Embree L, Holland SM, Sokolic RA, Hickstein DD.
Leukocyte adhesion deficiency in children and Irish setter dogs.
Pediatr Res. 55: 363-367, 2003.
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This page was last updated on 6/19/2014.