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Our Science – Misteli Website

Tom Misteli, Ph.D.

Selected Publications

1)  Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T.
Spatial dynamics of chromosome translocations in living cells.
Science. 341: 660-4, 2013.
[Journal]
2)  Misteli T.
The cell biology of genomes: bringing the double helix to life.
Cell. 152: 1209-12, 2013.
[Journal]
3)  Scaffidi P, Misteli T.
In vitro generation of human cells with cancer stem cell properties.
Nat Cell Biol. 13: 1051-1061, 2011.
[Journal]
4)  Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB.
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
Nature. 480: 387-90, 2011.
[Journal]
5)  Misteli T.
The inner life of the genome.
Sci. Am. 304: 66-73, 2011.
[Journal]
6)  Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.
Regulation of alternative splicing by histone modifications.
Science. 327: 996-1000, 2010.
[Journal]
7)  Pegoraro G, Kubben N, Wickert U, Göhler H, Hoffmann K, Misteli T.
Ageing-related chromatin defects through loss of the NURD complex.
Nat. Cell Biol. 11: 1261-7, 2009.
[Journal]
8)  Meaburn KJ, Gudla PR, Khan S, Lockett SJ, Misteli T.
Disease-specific gene repositioning in breast cancer.
J. Cell Biol. 187: 801-12, 2009.
[Journal]
9)  Méjat A, Decostre V, Li J, Renou L, Kesari A, Hantaï D, Stewart CL, Xiao X, Hoffman E, Bonne G, Misteli T.
Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy.
J. Cell Biol. 184: 31-44, 2009.
[Journal]
10)  Misteli T, Soutoglou E.
The emerging role of nuclear architecture in DNA repair and genome maintenance.
Nat. Rev. Mol. Cell Biol. 10: 243-54, 2009.
[Journal]
11)  Hager GL, McNally JG, Misteli T.
Transcription dynamics.
Mol. Cell. 35: 741-53, 2009.
[Journal]
12)  Soutoglou E, Misteli T.
Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions.
Science. 320: 1507-10, 2008.
[Journal]
13)  Takizawa T, Gudla PR, Guo L, Lockett S, Misteli T.
Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP.
Genes Dev. 22: 489-98, 2008.
[Journal]
14)  Misteli T.
Cell biology: Nuclear order out of chaos.
Nature. 456: 333-4, 2008.
[Journal]
15)  Efroni S, Duttagupta R, Cheng J, Dehghani H, Hoeppner DJ, Dash C, Bazett-Jones DP, Le Grice S, McKay RD, Buetow KH, Gingeras TR, Misteli T, Meshorer E.
Global transcription in pluripotent embryonic stem cells.
Cell Stem Cell. 2: 437-47, 2008.
[Journal]
16)  Scaffidi P, Misteli T.
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing.
Nat. Cell Biol. 10: 452-9, 2008.
[Journal]
17)  Meaburn KJ, Misteli T.
Locus-specific and activity-independent gene repositioning during early tumorigenesis.
J. Cell Biol. 180: 39-50, 2008.
[Journal]
18)  Gorski SA, Snyder SK, John S, Grummt I, Misteli T.
Modulation of RNA polymerase assembly dynamics in transcriptional regulation.
Mol. Cell. 30: 486-97, 2008.
[Journal]
19)  Takizawa T, Meaburn KJ, Misteli T.
The meaning of gene positioning.
Cell. 135: 9-13, 2008.
[Journal]
20)  Misteli T.
Beyond the Sequence: Cellular Organization of Genome Function.
Cell. 128: 787-800, 2007.
[Journal]
21)  Meaburn KJ, Misteli T.
Cell biology: chromosome territories.
Nature. 445: 379-781, 2007.
[Journal]
22)  Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T.
Positional stability of single double-strand breaks in mammalian cells.
Nat. Cell Biol. 9: 675-82, 2007.
[Journal]
23)  Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R.
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Nature. 447: 730-4, 2007.
[Journal]
24)  Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP.
Ubiquitination regulates PTEN nuclear import and tumor suppression.
Cell. 128: 141-56, 2007.
[Journal]
25)  Meshorer E, Misteli T.
Chromatin in pluripotent embryonic stem cells and differentiation.
Nat. Rev. Mol. Cell Biol. 7: 540-6, 2006.
[Journal]
26)  Meshorer E, Yellajoshula D, George E, Scambler PJ, Brown DT, Misteli T.
Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.
Dev. Cell. 10: 105-16, 2006.
Full Text Article. [Journal]
27)  Scaffidi P, Misteli T.
Lamin A-dependent nuclear defects in human aging.
Science. 312: 1059-63, 2006.
Full Text Article. [Journal]
28)  Brown DT, Izard T, Misteli T.
Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo.
Nat. Struct. Mol. Biol. 13: 250-5, 2006.
[Journal]
29)  Mazumdar M, Lee JH, Sengupta K, Ried T, Rane S, Misteli T.
Tumor formation via loss of a molecular motor protein.
Curr. Biol. 16: 1559-64, 2006.
[Journal]
30)  Scaffidi P, Misteli T.
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome.
Nat Med. 11: 440-5, 2005.
[Journal]
31)  Scaffidi P, Gordon L, Misteli T.
The cell nucleus and aging: tantalizing clues and hopeful promises.
PLoS Biol. 3: e395, 2005.
[Journal]
32)  Misteli T.
Spatial positioning: A new dimension in genome function.
Cell. 119: 153-156, 2004.
[Journal]
33)  Cheutin T, McNairn AJ, Jenuwein T, Gilbert DM, Singh PB, Misteli T.
Maintenance of stable heterochromatin domains by dynamic HP1 binding.
Science. 299: 721-725, 2003.
[Journal]
34)  Roix JJ, McQueen PG, Munson PJ, Parada LA, Misteli T.
Spatial proximity of translocation-prone gene loci in human lymphomas.
Nat. Genet. 34: 287-291, 2003.
[Journal]
35)  Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T.
A kinetic framework for a mammalian RNA polymerase in vivo.
Science. 298: 1623-6, 2002.
[Journal]
36)  Scaffidi P, Misteli T, Bianchi ME.
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.
Nature. 418: 191-5, 2002.
[Journal]
37)  Misteli T.
Protein dynamics: implications for nuclear architecture and gene expression.
Science. 291: 843-7, 2001.
[Journal]
38)  Misteli T, Gunjan A, Hock R, Bustin M, Brown DT.
Dynamic binding of histone H1 to chromatin in living cells.
Nature. 408: 877-81, 2000.
[Journal]
39)  Phair RD, Misteli T.
High mobility of proteins in the mammalian cell nucleus.
Nature. 404: 604-9, 2000.
[Journal]
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This page was last updated on 11/8/2013.