Our Science – Misteli Website
Tom Misteli, Ph.D.
Selected Publications |
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| 1)
Misteli T, Warren G. 25 years of Current Opinion in Cell Biology. Curr. Opin. Cell Biol. 25: 1-2, 2013. [Journal] |
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| 2)
Cavalli G, Misteli T. Functional implications of genome topology. Nat. Struct. Mol. Biol. 20: 290-9, 2013. [Journal] |
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| 3)
Misteli T. The cell biology of genomes: bringing the double helix to life. Cell. 152: 1209-12, 2013. [Journal] |
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| 4)
Roukos V, Burman B, Misteli T. The cellular etiology of chromosome translocations. Curr. Opin. Cell Biol. 2013. [Journal] |
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| 5)
Nandy K, Gudla PR, Amundsen R, Meaburn KJ, Misteli T, Lockett SJ. Automatic segmentation and supervised learning-based selection of nuclei in cancer tissue images. Cytometry A. 81: 743-54, 2012. [Journal] |
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| 6)
Budde PP, Williams EH, Misteli T. Cell biology: at the center of modern biomedicine. J. Cell Biol. 199: 7-8, 2012. [Journal] |
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| 7)
Burgess RC, Misteli T, Oberdoerffer P. DNA damage, chromatin, and transcription: the trinity of aging. Curr. Opin. Cell Biol. 2012. [Journal] |
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| 8)
Pegoraro G, Voss TC, Martin SE, Tuzmen P, Guha R, Misteli T. Identification of mammalian protein quality control factors by high-throughput cellular imaging. PLoS ONE. 7: e31684, 2012. [Journal] |
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| 9)
Kubben N, Adriaens M, Meuleman W, Voncken JW, van Steensel B, Misteli T. Mapping of lamin A- and progerin-interacting genome regions. Chromosoma. 121: 447-64, 2012. [Journal] |
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| 10)
Williams EH, Carpentier PA, Misteli T. Minimizing the "re" in review. J. Cell Biol. 197: 345-6, 2012. [Journal] |
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| 11)
Misteli T. Parallel genome universes. Nat. Biotechnol. 30: 55-6, 2012. [Journal] |
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| 12)
Cukierski WJ, Nandy K, Gudla P, Meaburn KJ, Misteli T, Foran DJ, Lockett SJ. Ranked retrieval of segmented nuclei for objective assessment of cancer gene repositioning. BMC Bioinformatics. 13: 232, 2012. [Journal] |
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| 13)
Hakim O, Misteli T. SnapShot: Chromosome confirmation capture. Cell. 148: 1068.e1-2, 2012. [Journal] |
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| 14)
Williams EH, Carpentier P, Misteli T. The JCB DataViewer scales up. J. Cell Biol. 198: 271-2, 2012. [Journal] |
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| 15)
Mazumdar M, Sung MH, Misteli T. Chromatin maintenance by a molecular motor protein. Nucleus. 2: 591-600, 2011. [Journal] |
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| 16)
Luco RF, Allo M, Schor IE, Kornblihtt AR, Misteli T. Epigenetics in alternative pre-mRNA splicing. Cell. 144: 16-26, 2011. [Journal] |
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| 17)
Misteli T. HGPS-derived iPSCs for the ages. Cell Stem Cell. 8: 4-6, 2011. [Journal] |
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| 18)
Scaffidi P, Misteli T. In vitro generation of human cells with cancer stem cell properties. Nat Cell Biol. 13: 1051-1061, 2011. [Journal] |
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| 19)
Luco RF, Misteli T. More than a splicing code: integrating the role of RNA, chromatin and non-coding RNA in alternative splicing regulation. Curr. Opin. Genet. Dev. 21: 366-72, 2011. [Journal] |
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| 20)
Williams EH, Misteli T. New tools for JCB. J. Cell Biol. 194: 663-4, 2011. [Journal] |
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| 21)
Kubben N, Voncken JW, Konings G, van Weeghel M, van den Hoogenhof MM, Gijbels M, van Erk A, Schoonderwoerd K, van den Bosch B, Dahlmans V, Calis C, Houten SM, Misteli T, Pinto YM. Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins. Nucleus. 2: 195-207, 2011. [Journal] |
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| 22)
Rosenthal AS, Tanega C, Shen M, Mott BT, Bougie JM, Nguyen DT, Misteli T, Auld DS, Maloney DJ, Thomas CJ. Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg. Med. Chem. Lett. 21: 3152-8, 2011. [Journal] |
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| 23)
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 480: 387-90, 2011. [Journal] |
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| 24)
Nandy K, Gudla PR, Amundsen R, Meaburn KJ, Misteli T, Lockett SJ. Supervised learning framework for screening nuclei in tissue sections. Conf Proc IEEE Eng Med Biol Soc. 2011: 5989-92, 2011. [Journal] |
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| 25)
Misteli T. The inner life of the genome. Sci. Am. 304: 66-73, 2011. [Journal] |
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| 26)
Dittmer TA, Misteli T. The lamin protein family. Genome Biol. 12: 222, 2011. [Journal] |
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| 27)
Dundr M, Misteli T. Biogenesis of nuclear bodies. Cold Spring Harb Perspect Biol. 2: a000711, 2010. [Journal] |
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| 28)
Scaffidi P, Misteli T. Cancer Epigenetics: From Disruption of Differentiation Programs to the Emergence of Cancer Stem Cells. Cold Spring Harb. Symp. Quant. Biol. 2010. [Journal] |
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| 29)
Budde PP, Misteli T. Cell biology beyond the cell. J. Cell Biol. 190: 7, 2010. [Journal] |
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| 30)
Roukos V, Misteli T, Schmidt CK. Descriptive no more: the dawn of high-throughput microscopy. Trends Cell Biol. 20: 503-6, 2010. [Journal] |
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| 31)
DeCathelineau A, Williams EH, Misteli T, Rossner M. Friends, colleagues, authors, lend us your data. J. Cell Biol. 191: 231-2, 2010. [Journal] |
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| 32)
Misteli T. Higher-order genome organization in human disease. Cold Spring Harb Perspect Biol. 2: a000794, 2010. [Journal] |
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| 33)
Kubben N, Voncken JW, Demmers J, Calis C, van Almen G, Pinto Y, Misteli T. Identification of differential protein interactors of lamin A and progerin. Nucleus. 1: 513-525, 2010. [Journal] |
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| 34)
Méjat A, Misteli T. LINC complexes in health and disease. Nucleus. 1: 40-52, 2010. [Journal] |
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| 35)
Kubben N, Voncken JW, Misteli T. Mapping of protein- and chromatin-interactions at the nuclear lamina. Nucleus. 1: 460-471, 2010. [Journal] |
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| 36)
Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T. Regulation of alternative splicing by histone modifications. Science. 327: 996-1000, 2010. [Journal] |
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| 37)
Pegoraro G, Kubben N, Wickert U, Göhler H, Hoffmann K, Misteli T. Ageing-related chromatin defects through loss of the NURD complex. Nat. Cell Biol. 11: 1261-7, 2009. [Journal] |
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| 38)
Meaburn KJ, Gudla PR, Khan S, Lockett SJ, Misteli T. Disease-specific gene repositioning in breast cancer. J. Cell Biol. 187: 801-12, 2009. [Journal] |
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| 39)
Mott BT, Tanega C, Shen M, Maloney DJ, Shinn P, Leister W, Marugan JJ, Inglese J, Austin CP, Misteli T, Auld DS, Thomas CJ. Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg. Med. Chem. Lett. 19: 6700-5, 2009. [Journal] |
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| 40)
Mathas S, Kreher S, Meaburn KJ, Jöhrens K, Lamprecht B, Assaf C, Sterry W, Kadin ME, Daibata M, Joos S, Hummel M, Stein H, Janz M, Anagnostopoulos I, Schrock E, Misteli T, Dörken B. Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc. Natl. Acad. Sci. U.S.A. 106: 5831-6, 2009. [Journal] |
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| 41)
Méjat A, Decostre V, Li J, Renou L, Kesari A, Hantaï D, Stewart CL, Xiao X, Hoffman E, Bonne G, Misteli T. Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. J. Cell Biol. 184: 31-44, 2009. [Journal] |
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| 42)
Misteli T. Self-organization in the genome. Proc. Natl. Acad. Sci. U.S.A. 106: 6885-6, 2009. [Journal] |
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| 43)
Mathas S, Misteli T. The dangers of transcription. Cell. 139: 1047-9, 2009. [Journal] |
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| 44)
Misteli T, Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat. Rev. Mol. Cell Biol. 10: 243-54, 2009. [Journal] |
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| 45)
Hager GL, McNally JG, Misteli T. Transcription dynamics. Mol. Cell. 35: 741-53, 2009. [Journal] |
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| 46)
Soutoglou E, Misteli T. Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions. Science. 320: 1507-10, 2008. [Journal] |
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| 47)
Takizawa T, Gudla PR, Guo L, Lockett S, Misteli T. Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP. Genes Dev. 22: 489-98, 2008. [Journal] |
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| 48)
Misteli T. Cell biology: Nuclear order out of chaos. Nature. 456: 333-4, 2008. [Journal] |
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| 49)
Efroni S, Duttagupta R, Cheng J, Dehghani H, Hoeppner DJ, Dash C, Bazett-Jones DP, Le Grice S, McKay RD, Buetow KH, Gingeras TR, Misteli T, Meshorer E. Global transcription in pluripotent embryonic stem cells. Cell Stem Cell. 2: 437-47, 2008. [Journal] |
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| 50)
Scaffidi P, Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat. Cell Biol. 10: 452-9, 2008. [Journal] |
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| 51)
Meaburn KJ, Misteli T. Locus-specific and activity-independent gene repositioning during early tumorigenesis. J. Cell Biol. 180: 39-50, 2008. [Journal] |
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| 52)
Gorski SA, Snyder SK, John S, Grummt I, Misteli T. Modulation of RNA polymerase assembly dynamics in transcriptional regulation. Mol. Cell. 30: 486-97, 2008. [Journal] |
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| 53)
Takizawa T, Meaburn KJ, Misteli T. The meaning of gene positioning. Cell. 135: 9-13, 2008. [Journal] |
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| 54)
Misteli T. Beyond the Sequence: Cellular Organization of Genome Function. Cell. 128: 787-800, 2007. [Journal] |
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| 55)
Meaburn KJ, Misteli T. Cell biology: chromosome territories. Nature. 445: 379-781, 2007. [Journal] |
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| 56)
Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T. Positional stability of single double-strand breaks in mammalian cells. Nat. Cell Biol. 9: 675-82, 2007. [Journal] |
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| 57)
Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R. The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature. 447: 730-4, 2007. [Journal] |
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| 58)
Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell. 128: 141-56, 2007. [Journal] |
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| 59)
Meshorer E, Misteli T. Chromatin in pluripotent embryonic stem cells and differentiation. Nat. Rev. Mol. Cell Biol. 7: 540-6, 2006. [Journal] |
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| 60)
Meshorer E, Yellajoshula D, George E, Scambler PJ, Brown DT, Misteli T. Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev. Cell. 10: 105-16, 2006. Full Text Article. [Journal] |
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| 61)
Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science. 312: 1059-63, 2006. Full Text Article. [Journal] |
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| 62)
Brown DT, Izard T, Misteli T. Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo. Nat. Struct. Mol. Biol. 13: 250-5, 2006. [Journal] |
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| 63)
Mazumdar M, Lee JH, Sengupta K, Ried T, Rane S, Misteli T. Tumor formation via loss of a molecular motor protein. Curr. Biol. 16: 1559-64, 2006. [Journal] |
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| 64)
Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med. 11: 440-5, 2005. [Journal] |
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| 65)
Scaffidi P, Gordon L, Misteli T. The cell nucleus and aging: tantalizing clues and hopeful promises. PLoS Biol. 3: e395, 2005. [Journal] |
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| 66)
Misteli T. Spatial positioning: A new dimension in genome function. Cell. 119: 153-156, 2004. [Journal] |
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| 67)
Cheutin T, McNairn AJ, Jenuwein T, Gilbert DM, Singh PB, Misteli T. Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science. 299: 721-725, 2003. [Journal] |
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| 68)
Roix JJ, McQueen PG, Munson PJ, Parada LA, Misteli T. Spatial proximity of translocation-prone gene loci in human lymphomas. Nat. Genet. 34: 287-291, 2003. [Journal] |
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| 69)
Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T. A kinetic framework for a mammalian RNA polymerase in vivo. Science. 298: 1623-6, 2002. [Journal] |
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| 70)
Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 418: 191-5, 2002. [Journal] |
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| 71)
Misteli T. Protein dynamics: implications for nuclear architecture and gene expression. Science. 291: 843-7, 2001. [Journal] |
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| 72)
Misteli T, Gunjan A, Hock R, Bustin M, Brown DT. Dynamic binding of histone H1 to chromatin in living cells. Nature. 408: 877-81, 2000. [Journal] |
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| 73)
Phair RD, Misteli T. High mobility of proteins in the mammalian cell nucleus. Nature. 404: 604-9, 2000. [Journal] |
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This page was last updated on 4/19/2013.
