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Our Science – Hager Website

Gordon L. Hager, Ph.D.

Selected Publications

1)  Voss TC, Schiltz RL, Sung MH, Yen PM, Stamatoyannopoulos JA, Biddie SC, Johnson TA, Miranda TB, John S, Hager GL.
Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism.
Cell. 146: 544-54, 2011.
2)  Biddie SC, John S, Sabo PJ, Thurman RE, Johnson TA, Schiltz RL, Miranda TB, Sung MH, Trump S, Lightman SL, Vinson C, Stamatoyannopoulos JA, Hager GL.
Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding.
Mol. Cell. 43: 145-55, 2011.
3)  Stavreva DA, Wiench M, John S, Conway-Campbell BL, McKenna MA, Pooley JR, Johnson TA, Voss TC, Lightman SL, Hager GL.
Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription.
Nat. Cell Biol. 11: 1093-102, 2009.
4)  McNally JG, Müller WG, Walker D, Wolford R, Hager GL.
The glucocorticoid receptor: rapid exchange with regulatory sites in living cells.
Science. 287: 1262-5, 2000.
5)  Archer TK, Lefebvre P, Wolford RG, Hager GL.
Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation.
Science. 255: 1573-6, 1992.
6)  Stavreva DA, Varticovski L, Hager GL.
A quantitative high-throughput assay for detection of biologically active endocrine-disrupting chemicals in water. In: Aquananotechnology: Global Prospects. Volume 35.
CRC Press; 2014. p. 721-733 In Press. [Book Chapter]
7)  Voss TC, Hager GL.
Dynamic regulation of transcriptional states by chromatin and transcription factors.
Nat. Rev. Genet. 15: 69-81, 2014.
8)  Dull AB, George AA, Goncharova EI, Evans JR, Wamiru A, Cartner LK, Hager GL, McMahon JB.
Identification of compounds by high-content screening that induce cytoplasmic to nuclear localization of a fluorescent estrogen receptor a chimera and exhibit agonist or antagonist activity in vitro.
J Biomol Screen. 19: 242-52, 2014.
9)  Presman DM, Ogara MF, Stortz M, Alvarez LD, Pooley JR, Schiltz RL, Grøntved L, Johnson TA, Mittelstadt PR, Ashwell JD, Ganesan S, Burton G, Levi V, Hager GL, Pecci A.
Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor.
PLoS Biol. 12: e1001813, 2014.
10)  Siersbæk R, Baek S, Rabiee A, Nielsen R, Traynor S, Clark N, Sandelin A, Jensen ON, Sung MH, Hager GL, Mandrup S.
Molecular Architecture of Transcription Factor Hotspots in Early Adipogenesis.
Cell Rep. 2014.
11)  Morris SA, Baek S, Sung MH, John S, Wiench M, Johnson TA, Schiltz RL, Hager GL.
Overlapping chromatin-remodeling systems collaborate genome-wide at dynamic chromatin transitions.
Nat. Struct. Mol. Biol. 21: 73-81, 2014.
12)  Sung MH, Li N, Lao Q, Gottschalk RA, Hager GL, Fraser ID.
Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-?B signaling.
Sci Signal. 7: ra6, 2014.
13)  Nakahashi H, Kwon KR, Resch W, Vian L, Dose M, Stavreva D, Hakim O, Pruett N, Nelson S, Yamane A, Qian J, Dubois W, Welsh S, Phair RD, Pugh BF, Lobanenkov V, Hager GL, Casellas R.
A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code.
Cell Rep. 3: 1678-89, 2013.
14)  Grøntved L, John S, Baek S, Liu Y, Buckley JR, Vinson C, Aguilera G, Hager GL.
C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements.
EMBO J. 32: 1568-83, 2013.
15)  Miranda TB, Morris SA, Hager GL.
Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor.
Mol. Cell. Endocrinol. 380: 16-24, 2013.
16)  He X, Chatterjee R, John S, Bravo H, Sathyanarayana BK, Biddie SC, FitzGerald PC, Stamatoyannopoulos JA, Hager GL, Vinson C.
Contribution of nucleosome binding preferences and co-occurring DNA sequences to transcription factor binding.
BMC Genomics. 14: 428, 2013.
17)  Aguilar-Arnal L, Hakim O, Patel VR, Baldi P, Hager GL, Sassone-Corsi P.
Cycles in spatial and temporal chromosomal organization driven by the circadian clock.
Nat. Struct. Mol. Biol. 20: 1206-13, 2013.
18)  Mousavi K, Zare H, Dell'orso S, Grontved L, Gutierrez-Cruz G, Derfoul A, Hager GL, Sartorelli V.
eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci.
Mol. Cell. 51: 606-17, 2013.
19)  Miranda TB, Voss TC, Hager GL.
High-throughput fluorescence-based screen to identify factors involved in nuclear receptor recruitment to response elements.
Methods Mol. Biol. 1042: 3-12, 2013.
20)  Lalmansingh AS, Arora K, Demarco RA, Hager GL, Nagaich AK.
High-throughput RNA FISH analysis by imaging flow cytometry reveals that pioneer factor Foxa1 reduces transcriptional stochasticity.
PLoS ONE. 8: e76043, 2013.
21)  Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R.
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
Cell. 155: 1507-20, 2013.
22)  Miranda TB, Voss TC, Sung M, Baek S, John S, Hawkins M, Grontved L, Schiltz RL, Hager GL.
Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level.
Cancer Res. 73: 5130-9, 2013.
23)  Hakim O, Sung MH, Nakayamada S, Voss TC, Baek S, Hager GL.
Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.
Genome Res. 23: 462-72, 2013.
24)  Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, Mathe E, Liang G, Cobell J, Nakahashi H, Robbiani DF, Nussenzweig A, Hager GL, Nussenzweig MC, Casellas R.
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Nature. 484: 69-74, 2012.
25)  Grøntved L, Hager GL.
Impact of chromatin structure on PR signaling: Transition from local to global analysis.
Mol. Cell. Endocrinol. 357: 30-6, 2012.
26)  Mandrup S, Hager GL.
Modulation of chromatin access during adipocyte differentiation.
Nucleus. 3: 12-5, 2012.
27)  Baek S, Sung MH, Hager GL.
Quantitative analysis of genome-wide chromatin remodeling.
Methods Mol. Biol. 833: 433-41, 2012.
28)  Grøntved L, Bandle R, John S, Baek S, Chung HJ, Liu Y, Aguilera G, Oberholtzer C, Hager GL, Levens D.
Rapid Genome-Scale Mapping of Chromatin Accessibility in Tissue.
Epigenetics & chromatin. 5: 10, 2012.
29)  Romero OA, Setien F, John S, Gimenez-Xavier P, Gómez-López G, Pisano D, Condom E, Villanueva A, Hager GL, Sanchez-Cespedes M.
The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer.
EMBO Mol Med. 4: 603-16, 2012.
30)  John S, Sabo PJ, Thurman RE, Sung MH, Biddie SC, Johnson TA, Hager GL, Stamatoyannopoulos JA.
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns.
Nat. Genet. 43: 264-8, 2011.
31)  Hakim O, Sung MH, Voss TC, Splinter E, John S, Sabo PJ, Thurman RE, Stamatoyannopoulos JA, de Laat W, Hager GL.
Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements.
Genome Res. 21: 697-706, 2011.
32)  Wiench M, John S, Baek S, Johnson TA, Sung MH, Escobar T, Simmons CA, Pearce KH, Biddie SC, Sabo PJ, Thurman RE, Stamatoyannopoulos JA, Hager GL.
DNA methylation status predicts cell type-specific enhancer activity.
EMBO J. 30: 3028-39, 2011.
33)  Qiu Y, Stavreva DA, Luo Y, Indrawan A, Chang M, Hager GL.
Dynamic interaction of HDAC1 with a glucocorticoid receptor-regulated gene is modulated by the activity state of the promoter.
J. Biol. Chem. 286: 7641-7, 2011.
34)  Hakim O, Sung MH, Hager GL.
3D shortcuts to gene regulation.
Curr. Opin. Cell Biol. 22: 305-13, 2010.
35)  Voss TC, Schiltz RL, Sung MH, Johnson TA, John S, Hager GL.
Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity.
J. Cell. Sci. 122: 345-56, 2009.
36)  Hager GL, McNally JG, Misteli T.
Transcription dynamics.
Mol. Cell. 35: 741-53, 2009.
37)  John S, Sabo PJ, Johnson TA, Sung MH, Biddie SC, Lightman SL, Voss TC, Davis SR, Meltzer PS, Stamatoyannopoulos JA, Hager GL.
Interaction of the glucocorticoid receptor with the chromatin landscape.
Mol. Cell. 29: 611-24, 2008.
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This page was last updated on 6/18/2014.