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Our Science – Aladjem Website

Mirit I. Aladjem, Ph.D.

Selected Publications

1)  Fu H, Maunakea AK, Martin MM, Huang L, Zhang Y, Ryan M, Kim R, Lin CM, Zhao K, Aladjem MI.
Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle.
PLoS Genet. 9: e1003542, 2013.
2)  Martin MM, Ryan M, Kim R, Zakas AL, Fu H, Lin CM, Reinhold WC, Davis SR, Bilke S, Liu H, Doroshow JH, Reimers MA, Valenzuela MS, Pommier Y, Meltzer PS, Aladjem MI.
Genome-wide depletion of replication initiation events in highly transcribed regions.
Genome Res. 21: 1822-32, 2011.
3)  Fu H, Wang L, Lin CM, Singhania S, Bouhassira EE, Aladjem MI.
Preventing gene silencing with human replicators.
Nat. Biotechnol. 24: 572-6, 2006.
4)  Wang L, Lin CM, Brooks S, Cimbora D, Groudine M, Aladjem MI.
The human beta-globin replication initiation region consists of two modular independent replicators.
Mol Cell Biol. 24: 3373-86, 2004.
5)  Aladjem MI, Rodewald LW, Kolman JL, Wahl GM.
Genetic dissection of a mammalian replicator in the human beta-globin locus.
Science. 281: 1005-1009, 1998.
6)  Gindin Y, Valenzuela MS, Aladjem MI, Meltzer PS, Bilke S.
A chromatin structure-based model accurately predicts DNA replication timing in human cells.
Mol. Syst. Biol. 10: 722, 2014.
7)  Aladjem MI, Fu H.
A new light on DNA replication from the inactive X chromosome.
Bioessays. [Epub ahead of print], 2014.
8)  Mukhopadhyay R, Lajugie J, Fourel N, Selzer A, Schizas M, Bartholdy B, Mar J, Lin CM, Martin MM, Ryan M, Aladjem MI, Bouhassira EE.
Allele-specific genome-wide profiling in human primary erythroblasts reveal replication program organization.
PLoS Genet. 10: e1004319, 2014.
9)  Smith OK, Aladjem MI.
Chromatin Structure and Replication Origins: Determinants Of Chromosome Replication And Nuclear Organization.
J. Mol. Biol. [Epub ahead of print], 2014.
10)  Yudkin D, Hayward BE, Aladjem MI, Kumari D, Usdin K.
Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome.
Hum. Mol. Genet. [Epub ahead of print], 2014.
Click Here to View Expanded Bibliography.

This page was last updated on 6/17/2014.