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Our Science – Pommier Website

Yves Pommier, M.D., Ph.D.

Selected Publications

1)  Zhang H, Zhang Y, Yasukawa T, Rosa ID, Khiati S, Pommier Y.
Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIa and IIß in vertebrate mitochondria.
Nucleic Acids Res. [Epub ahead of print], 2014.
[Journal]
2)  Zoppoli G, Regairaz M, Leo E, Reinhold WC, Varma S, Ballestrero A, Doroshow JH, Pommier Y.
Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents.
Proc. Natl. Acad. Sci. U.S.A. 109: 15030-5, 2012.
[Journal]
3)  Murai J, Huang SY, Das BB, Renaud A, Zhang Y, Doroshow JH, Ji J, Takeda S, Pommier Y.
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.
Cancer Res. 72: 5588-99, 2012.
[Journal]
4)  Huang SN, Murai J, Dalla Rosa I, Dexheimer TS, Naumova A, Gmeiner WH, Pommier Y.
TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.
Nucleic Acids Res. 41: 7793-803, 2013.
[Journal]
5)  Métifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR, Hughes SH, Cherepanov P, Pommier Y.
Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.
ACS Chem. Biol. 8: 209-17, 2013.
[Journal]
6)  Costi R, Métifiot M, Chung S, Cuzzucoli Crucitti G, Maddali K, Pescatori L, Messore A, Madia VN, Pupo G, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Marinelli L, Novellino E, Le Grice SF, Corona A, Pommier Y, Marchand C, Di Santo R.
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase.
J. Med. Chem. 57: 3223-34, 2014.
[Journal]
7)  Zhao XZ, Smith SJ, Métifiot M, Johnson BC, Marchand C, Pommier Y, Hughes SH, Burke TR.
Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.
J. Med. Chem. 57: 1573-82, 2014.
[Journal]
8)  Lv P, Agama K, Marchand C, Pommier Y, Cushman M.
Design, Synthesis, and Biological Evaluation of O-2-Modified Indenoisoquinolines as Dual Topoisomerase I-Tyrosyl-DNA Phosphodiesterase I Inhibitors.
J. Med. Chem. [Epub ahead of print], 2014.
[Journal]
9)  Maede Y, Shimizu H, Fukushima T, Kogame T, Nakamura T, Miki T, Takeda S, Pommier Y, Murai J.
Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel.
Mol. Cancer Ther. 13: 214-20, 2014.
[Journal]
10)  Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ.
Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
Clin. Cancer Res. 20: 1190-203, 2014.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 6/17/2014.