Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health
CCR - For Our Staff| Home |

Our Science – Marquez Website

Victor E. Marquez, Ph.D.

Selected Publications

1)  Ciarapica R, Carcarino E, Adesso L, De Salvo M, Bracaglia G, Leoncini PP, Dall Agnese A, Verginelli F, Milano GM, Boldrini R, Inserra A, Stifani S, Screpanti I, Marquez VE, Valente S, Mai A, Puri PL, Locatelli F, Palacios D, Rota R.
Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS.
BMC Cancer. 14: 139, 2014.
2)  Lad N, Sharma R, Marquez VE, Mascarenhas M.
A new synthesis of sultams from amino alcohols.
Tetrahedron Letters. 54: 6307-6309, 2013.
3)  Zhao X, Lwin T, Zhang X, Huang A, Wang J, Marquez VE, Chen-Kiang S, Dalton WS, Sotomayor E, Tao J.
Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity.
Leukemia. 27: 2341-50, 2013.
4)  Kirby KA, Michailidis E, Fetterly TL, Steinbach MA, Singh K, Marchand B, Leslie MD, Hagedorn AN, Kodama EN, Marquez VE, Hughes SH, Mitsuya H, Parniak MA, Sarafianos SG.
Effects of substitutions at the 4" and 2 positions on the bioactivity of 4"-ethynyl-2-fluoro-2"-deoxyadenosine.
Antimicrob. Agents Chemother. 57: 6254-64, 2013.
5)  Li CH, To KF, Tong JH, Xiao Z, Xia T, Lai PB, Chow SC, Zhu YX, Chan SL, Marquez VE, Chen Y.
Enhancer of Zeste Homolog 2 Silences miR-218 in Human Pancreatic Ductal Adenocarcinoma Cells by Inducing Formation of Heterochromatin.
Gastroenterology. 2013.
6)  Vella S, Gnani D, Crudele A, Ceccarelli S, De Stefanis C, Gaspari S, Nobili V, Locatelli F, Marquez VE, Rota R, Alisi A.
EZH2 Down-Regulation Exacerbates Lipid Accumulation and Inflammation in in Vitro and in Vivo NAFLD.
Int J Mol Sci. 14: 24154-68, 2013.
7)  Hartsough EJ, Meyer RD, Chitalia V, Jiang Y, Marquez VE, Zhdanova IV, Weinberg J, Costello CE, Rahimi N.
Lysine methylation promotes VEGFR-2 activation and angiogenesis.
Sci Signal. 6: ra104, 2013.
8)  Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H.
PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer.
Sci Rep. 3: 1911, 2013.
9)  Ciarapica R, De Salvo M, Carcarino E, Bracaglia G, Adesso L, Leoncini PP, Dall'agnese A, Walters ZS, Verginelli F, De Sio L, Boldrini R, Inserra A, Bisogno G, Rosolen A, Alaggio R, Ferrari A, Collini P, Locatelli M, Stifani S, Screpanti I, Rutella S, Yu Q, Marquez VE, Shipley J, Valente S, Mai A, Miele L, Puri PL, Locatelli F, Palacios D, Rota R.
The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx).
Oncogene. 2013.
10)  Thompson A, Marquez VE.
Current Protocols in Nucleic Acid Chemistry: Synthesis of a North-Methanocarba-Thymidine (N-MCT) Analog. In: Wiley Online Library. Volume 1.29.
Hoboken, NJ: John Wiley & Sons; 2012. p. 1-13 [Book Chapter]
11)  Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL.
A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota.
J. Am. Chem. Soc. 134: 10698-705, 2012.
12)  Zhang X, Zhao X, Fiskus W, Lin J, Lwin T, Rao R, Zhang Y, Chan JC, Fu K, Marquez VE, Chen-Kiang S, Moscinski LC, Seto E, Dalton WS, Wright KL, Sotomayor E, Bhalla K, Tao J.
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas.
Cancer Cell. 22: 506-23, 2012.
13)  Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL.
Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide Analogues.
Biochemistry. 51: 9234-9244, 2012.
14)  Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Marquez VE, Nishimura M, Dosaka-Akita H.
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.
Lung Cancer. 78: 138-43, 2012.
15)  Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, Ge K, Thiele CJ.
EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR.
Cancer Res. 72: 315-24, 2012.
16)  Ren SX, Cheng AS, To KF, Tong JH, Li MS, Shen J, Wong CC, Zhang L, Chan RL, Wang XJ, Ng SS, Chiu LC, Marquez VE, Gallo RL, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH.
Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer.
Cancer Res. 72: 6512-23, 2012.
17)  Svedlund J, Koskinen Edblom S, Marquez VE, Åkerström G, Björklund P, Westin G.
Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modification.
J. Clin. Endocrinol. Metab. 97: E1307-15, 2012.
18)  Alimova I, Birks DK, Harris PS, Knipstein JA, Venkataraman S, Marquez VE, Foreman NK, Vibhakar R.
Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells.
Neuro-oncology. 2012.
19)  Krämer M, Dees C, Huang J, Schlottmann I, Palumbo-Zerr K, Zerr P, Gelse K, Beyer C, Distler A, Marquez VE, Distler O, Schett G, Distler JH.
Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.
Ann. Rheum. Dis. 2012.
20)  Reuland SN, Smith SM, Bemis LT, Goldstein NB, Almeida AR, Partyka KA, Marquez VE, Zhang Q, Norris DA, Shellman YG.
MicroRNA-26a Is Strongly Downregulated in Melanoma and Induces Cell Death through Repression of Silencer of Death Domains (SODD).
J. Invest. Dermatol. 2012.
21)  Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang JH, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM.
Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.
J. Biol. Chem. 287: 13137-58, 2012.
22)  Avan A, Crea F, Paolicchi E, Funel N, Galvani E, Marquez VE, Honeywell RJ, Danesi R, Peters GJ, Giovannetti E.
Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells.
Mol. Cancer Ther. 11: 1735-46, 2012.
23)  Kemp CD, Rao M, Xi S, Inchauste S, Mani H, Fetsch P, Filie A, Zhang M, Hong JA, Walker RL, Zhu YJ, Ripley RT, Mathur A, Liu F, Yang M, Meltzer PA, Marquez VE, De Rienzo A, Bueno R, Schrump DS.
Polycomb repressor complex-2 is a novel target for mesothelioma therapy.
Clin. Cancer Res. 18: 77-90, 2012.
24)  He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT.
PRC2 directly methylates GATA4 and represses its transcriptional activity.
Genes Dev. 26: 37-42, 2012.
25)  Ott M, Litzenburger UM, Sahm F, Rauschenbach KJ, Tudoran R, Hartmann C, Marquez VE, von Deimling A, Wick W, Platten M.
Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase.
PLoS ONE. 7: e47663, 2012.
26)  Taniguchi H, Jacinto FV, Villanueva A, Fernandez AF, Yamamoto H, Carmona FJ, Puertas S, Marquez VE, Shinomura Y, Imai K, Esteller M.
Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer.
Oncogene. 31: 1988-1994, 2012.
27)  Fiskus W, Rao R, Balusu R, Ganguly S, Tao J, Sotomayor E, Mudunuru U, Smith JE, Hembruff SL, Atadja P, Marquez VE, Bhalla K.
Superior efficacy of a combined epigenetic therapy against human mantle cell lymphoma cells.
Clin. Cancer Res. 18: 6227-38, 2012.
28)  Momparler RL, Idaghdour Y, Marquez VE, Momparler LF.
Synergistic antileukemic action of a combination of inhibitors of DNA methylation and histone methylation.
Leuk. Res. 36: 1049-54, 2012.
29)  Thompson A, Marquez VE.
Synthesis of a North-methanocarba-thymidine (N-MCT) analog.
Curr Protoc Nucleic Acid Chem. Chapter 1: Unit1.29, 2012.
30)  Alimova I, Venkataraman S, Harris P, Marquez VE, Northcott PA, Dubuc A, Taylor MD, Foreman NK, Vibhakar R.
Targeting the enhancer of zeste homologue 2 in medulloblastoma.
Int. J. Cancer. 131: 1800-9, 2012.
31)  Pallan PS, Marquez VE, Egli M.
The conformationally constrained N-methanocarba-dT analogue adopts an unexpected C4'-exo sugar pucker in the structure of a DNA hairpin.
Biochemistry. 51: 2639-41, 2012.
32)  Aviñó A, Mazzini S, Ferreira R, Gargallo R, Marquez VE, Eritja R.
The effect on quadruplex stability of North-nucleoside derivatives in the loops of the thrombin-binding aptamer.
Bioorg. Med. Chem. 20: 4186-93, 2012.
33)  Choudhury SR, Balasubramanian S, Chew YC, Han B, Marquez VE, Eckert RL.
(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells.
Carcinogenesis. 32: 1525-32, 2011.
34)  Vu BC, Boyer PL, Siddiqui MA, Marquez VE, Hughes SH.
4'-C-Methyl-2'-Deoxyadenosine and 4'-C-Ethyl-2'-Deoxyadenosine Inhibit HIV-1 Replication.
Antimicrob. Agents Chemother. 55: 2379-89, 2011.
35)  Terrazas M, Aviñó A, Siddiqui MA, Marquez VE, Eritja R.
A Direct, Efficient Method for the Preparation of siRNAs Containing Ribo-like North Bicyclo[3.1.0]hexane Pseudosugars.
Organic letters. 13: 2888-2891, 2011.
36)  Diaz Perez SV, Kim R, Li Z, Marquez VE, Patel S, Plath K, Clark AT.
Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin.
Hum. Mol. Genet. 2011.
37)  Chen M, Shabashvili D, Nawab A, Yang SX, Dyer L, Brown KD, Hollingshead M, Hunter KW, Kaye FJ, Hochwald SN, Marquez VE, Steeg PS, Zajac-Kaye M.
DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer.
Molecular cancer therapeutics. 2011.
38)  Smits M, Mir SE, Nilsson RJ, van der Stoop PM, Niers JM, Marquez VE, Cloos J, Breakefield XO, Krichevsky AM, Noske DP, Tannous BA, Würdinger T.
Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2.
PLoS ONE. 6: e16282, 2011.
39)  Terrazas M, Ocampo SM, Perales JC, Marquez VE, Eritja R.
Effect of North Bicyclo[3.1.0]hexane 2'-Deoxy-pseudosugars on RNA Interference: A Novel Class of siRNA Modification.
Chembiochem. 12: 1056-65, 2011.
40)  Wierda RJ, Kuipers HF, van Eggermond MC, Benard A, van Leeuwen JC, Carluccio S, Geutskens SB, Jukema JW, Marquez VE, Quax PH, van den Elsen PJ.
Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors.
J. Cell. Mol. Med. 2011.
41)  van Eggermond MC, Boom DR, Klous P, Schooten E, Marquez VE, Wierda RJ, Holling TM, van den Elsen PJ.
Epigenetic regulation of CIITA expression in human T-cells.
Biochem. Pharmacol. 82: 1430-7, 2011.
42)  Ohtani K, Vlachojannis GJ, Koyanagi M, Boeckel JN, Urbich C, Farcas R, Bonig H, Marquez VE, Zeiher AM, Dimmeler S.
Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells.
Circ. Res. 109: 1219-29, 2011.
43)  Damaraju VL, Mowles D, Smith KM, Yao SY, Young JD, Marquez VE, Cass CE.
Influence of sugar ring conformation on the transportability of nucleosides by human nucleoside transporters.
Chembiochem. 12: 2774-8, 2011.
44)  Rao M, Chinnasamy N, Hong JA, Zhang Y, Zhang M, Xi S, Liu F, Marquez VE, Morgan RA, Schrump DS.
Inhibition of Histone Lysine Methylation Enhances the Expression of Cancer-Testis Genes in Lung Cancer Cells: Implications for Adoptive Immunotherapy of Cancer.
Cancer research. 2011.
45)  He S, Wang J, Kato K, Xie F, Varambally S, Mineishi S, Kuick R, Mochizuki K, Liu Y, Nieves E, Mani RS, Chinnaiyan AM, Marquez VE, Zhang Y.
Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells.
Blood. 2011.
46)  Sandovici I, Smith NH, Nitert MD, Ackers-Johnson M, Uribe-Lewis S, Ito Y, Jones RH, Marquez VE, Cairns W, Tadayyon M, O'Neill LP, Murrell A, Ling C, Constância M, Ozanne SE.
Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.
Proc. Natl. Acad. Sci. U.S.A. 108: 5449-54, 2011.
47)  Huang WY, Yang PM, Chang YF, Marquez VE, Chen CC.
Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2.
Biochem. Pharmacol. 81: 510-7, 2011.
48)  Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y.
Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy.
Haematologica. 96: 712-9, 2011.
49)  Crea F, Hurt EM, Mathews LA, Cabarcas SM, Sun L, Marquez VE, Danesi R, Farrar WL.
Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer.
Molecular cancer. 10: 40, 2011.
50)  Crea F, Paolicchi E, Marquez VE, Danesi R.
Polycomb genes and cancer: Time for clinical application?.
Crit. Rev. Oncol. Hematol. 2011.
51)  Zoabi M, Sadeh R, de Bie P, Marquez VE, Ciechanover A.
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins.
Biochem. Biophys. Res. Commun. 408: 393-8, 2011.
52)  Ludek OR, Marquez VE.
Synthesis of Conformationally North-Locked Pyrimidine Nucleosides Built on an Oxabicyclo[3.1.0]hexane Scaffold.
J. Org. Chem. 2011.
53)  Rao RC, Tchedre KT, Malik MT, Coleman N, Fang Y, Marquez VE, Chen DF.
Dynamic patterns of histone lysine methylation in the developing retina.
Invest. Ophthalmol. Vis. Sci. 51: 6784-92, 2010.
54)  Stumpel DJ, Schotte D, Lange-Turenhout EA, Schneider P, Seslija L, de Menezes RX, Marquez VE, Pieters R, den Boer ML, Stam RW.
Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale.
Leukemia. 2010.
55)  Smits M, Nilsson J, Mir SE, van der Stoop PM, Hulleman E, Niers JM, de Witt Hamer PC, Marquez VE, Cloos J, Krichevsky AM, Noske DP, Tannous BA, Würdinger T.
miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis.
Oncotarget. 1: 710-20, 2010.
56)  Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA.
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Blood. 2010.
57)  Saneyoshi H, Deschamps JR, Marquez VE.
Synthesis of Conformationally Locked l-Deoxythreosyl Phosphonate Nucleosides Built on a Bicyclo[3.1.0]hexane Template.
J. Org. Chem. 2010.
58)  Palacios D, Mozzetta C, Consalvi S, Caretti G, Saccone V, Proserpio V, Marquez VE, Valente S, Mai A, Forcales SV, Sartorelli V, Puri PL.
TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.
Cell Stem Cell. 7: 455-69, 2010.
59)  Kim T, Barchi JJ, Marquez VE, Shapiro BA.
Understanding the effects of carbocyclic sugars constrained to north and south conformations on RNA nanodesign.
Journal of molecular graphics & modelling. 2010.
60)  Moon HR, Siddiqui MA, Sun G, Filippov IV, Landsman NA, Lee YC, Adams KM, Barchi JJ, Deschamps JR, Nicklaus MC, Kelley JA, Marquez VE.
Using conformationally locked nucleosides to calibrate the anomeric effect: Implications for glycosyl bond stability.
Tetrahedron. 66: 6707-6717, 2010.
61)  Suvà ML, Riggi N, Janiszewska M, Radovanovic I, Provero P, Stehle JC, Baumer K, Le Bitoux MA, Marino D, Cironi L, Marquez VE, Clément V, Stamenkovic I.
EZH2 is essential for glioblastoma cancer stem cell maintenance.
Cancer Res. 69: 9211-8, 2009.
62)  Menigatti M, Cattaneo E, Sabates-Bellver J, Ilinsky VV, Went P, Buffoli F, Marquez VE, Jiricny J, Marra G.
The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis.
Mol. Cancer. 8: 124, 2009.
63)  Moon HR, Siddiqui MA, Sun G, Filippov IV, Landsman NA, Lee Y, Adams K, Barchi, Jr. JJ, Deschamps JR, Nicklaus MC, Kelley JA, Marquez VE.
Using conformationally locked nucleosides to calibrate the anomeric effect: implications for glycosyl bond stability.
Tetrahedron. 66: 6707-6717, 2010.
64)  Chen M, Voeller D, Marquez VE, Kaye FJ, Steeg PS, Giaccone G, Zajac-Kaye M.
Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.
Int. J. Oncol. 37: 963-71, 2010.
65)  Teider N, Scott DK, Neiss A, Weeraratne SD, Amani VM, Wang Y, Marquez VE, Cho YJ, Pomeroy SL.
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncology. 2010.
66)  Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M.
Selective Modulation of DNA Polymerase Activity by Fixed-Conformation Nucleoside Analogues.
Angewandte Chemie (International ed. in English). 2010.
67)  Toth Z, Maglinte DT, Lee SH, Lee HR, Wong LY, Brulois KF, Lee S, Buckley JD, Laird PW, Marquez VE, Jung JU.
Epigenetic analysis of KSHV latent and lytic genomes.
PLoS Pathog. 6: e1001013, 2010.
68)  Raifman O, Kolusheva S, El Kazzouli S, Sigano DM, Kedei N, Lewin NE, Lopez-Nicolas R, Ortiz-Espin A, Gomez-Fernandez JC, Blumberg PM, Marquez VE, Corbalan-Garcia S, Jelinek R.
Membrane-Surface Anchoring of Charged Diacylglycerol-Lactones Correlates with Biological Activities.
Chembiochem : a European journal of chemical biology. 2010.
69)  Kwon MJ, Kim SS, Choi YL, Jung HS, Balch C, Kim SH, Song YS, Marquez VE, Nephew KP, Shin YK.
Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications.
Carcinogenesis. 31: 974-83, 2010.
70)  Raifman O, Kolusheva S, Comin MJ, Kedei N, Lewin NE, Blumberg PM, Marquez VE, Jelinek R.
Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities.
FEBS J. 277: 233-43, 2010.
71)  Nagel S, Venturini L, Marquez VE, Meyer C, Kaufmann M, Scherr M, Macleod RA, Drexler HG.
Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines.
Molecular cancer. 9: 151, 2010.
72)  Betham B, Shalhout S, Marquez VE, Bhagwat AS.
Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli.
DNA Repair (Amst.). 9: 153-60, 2010.
73)  Sun F, Chan E, Wu Z, Yang X, Marquez VE, Yu Q.
Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.
Mol. Cancer Ther. 8: 3191-202, 2009.
74)  Marquez VE, Schroeder GK, Ludek OR, Siddiqui MA, Ezzitouni A, Wolfenden R.
Contrasting behavior of conformationally locked carbocyclic nucleosides of adenosine and cytidine as substrates for deaminases.
Nucleosides Nucleotides Nucleic Acids. 28: 614-32, 2009.
75)  Saneyoshi H, Mazzini S, Aviñó A, Portella G, González C, Orozco M, Marquez VE, Eritja R.
The use of conformationally rigid nucleoside probes to study the role of sugar pucker and nucleobase orientation in the thrombin binding aptamer.
Nucleic Acids Symp Ser (Oxf). 109-10, 2009.
76)  Marquez VE, Schroeder GK, Ludek OR, Siddiqui M, Ezzitouni A, Wolfenden R.
Contrasting Behavior of Conformationally Locked Carbocyclic Nucleosides of Adenosine and Cytidine as Substrates for Deaminases.
Nucleosides Nucleotides Nucleic Acids. 28: 614-632, 2009.
77)  Boyer PL, Vu BC, Ambrose Z, Julias JG, Warnecke S, Liao C, Meier C, Marquez VE, Hughes SH.
The Nucleoside Analogue D-carba T Blocks HIV-1 Reverse Transcription.
J. Med. Chem. 2009.
78)  Ludek OR, Schroeder GK, Liao C, Russ PL, Wolfenden R, Marquez VE.
Synthesis and Conformational Analysis of Locked Carbocyclic Analogues of 1,3-Diazepinone Riboside, a High-Affinity Cytidine Deaminase Inhibitor.
J. Org. Chem. 74: 6212-6223, 2009.
79)  Fiskus W, Wang Y, Sreekumar A, Buckley KM, Shi H, Jillella A, Ustun C, Rao R, Fernandez P, Chen J, Balusu R, Koul S, Atadja P, Marquez VE, Bhalla KN.
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.
Blood. 114: 2733-43, 2009.
80)  van Bemmel DM, Brank AS, Eritja R, Marquez VE, Christman JK.
DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site.
Biochem. Pharmacol. 2009.
81)  Miranda TB, Cortez CC, Yoo CB, Liang G, Abe M, Kelly TK, Marquez VE, Jones PA.
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
Mol. Cancer Ther. 8: 1579-88, 2009.
82)  Russ PL, Gonzalez-Moa MJ, Vu BC, Sigano DM, Kelley JA, Lai CC, Deschamps JR, Hughes SH, Marquez VE.
North- and South-Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti-HIV Activity.
ChemMedChem. 2009.
83)  Aviñó A, Pérez-Rentero S, Garibotti AV, Siddiqui MA, Márquez VE, Eritja R.
Synthesis and hybridization properties of modified oligodeoxynucleotides carrying non-natural bases.
Chem. Biodivers. 6: 117-26, 2009.
84)  Comin MJ, Czifra G, Kedei N, Telek A, Lewin NE, Kolusheva S, Velasquez JF, Kobylarz R, Jelinek R, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol (DAG). 31. Modulation of the Biological Properties of Diacylgycerol Lactones (DAG-lactones) Containing Rigid-Rod Acyl Groups Separated from the Core Lactone by Spacer Units of Different Lengths.
J. Med. Chem. 2009.
85)  Ludek OR, Marquez VE.
A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-D-ribose.
Tetrahedron. 65: 8461-8467, 2009.
86)  Saneyoshi H, Mazzini S, Avino A, Portella G, Gonzalez C, Orozco M, Marquez VE, Eritja R.
Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer.
Nucleic Acids Res. 37: 5589-601, 2009.
87)  Philosof-Mazor L, Volinsky R, Jopp J, Blumberg P, Rapaport H, Marquez VE, Jelinek R.
Lipid-Modulated Pharmacophore Nanorods Assembled at the Air/Water Interface.
Chemphyschem : a European journal of chemical physics and physical chemistry. 2009.
88)  Kang JH, Garg H, Sigano DM, Francella N, Blumenthal R, Marquez VE.
Ceramides: Branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency.
Bioorg. Med. Chem. 2009.
89)  Truman JP, Rotenberg SA, Kang JH, Lerman G, Fuks Z, Kolesnick R, Marquez VE, Haimovitz-Friedman A.
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.
Cancer Biol. Ther. 8, 2009.
90)  Yoo CB, Valente R, Congiatu C, Gavazza F, Angel A, Siddiqui MA, Jones PA, McGuigan C, Marquez VE.
Activation of p16 Gene Silenced by DNA Methylation in Cancer Cells by Phosphoramidate Derivatives of 2'-Deoxyzebularine.
J. Med. Chem. 51: 7593-7601, 2008.
91)  Saneyoshi H, Michel BY, Choi Y, Strazewski P, Marquez VE.
Synthesis of Conformationally Locked Versions of Puromycin Analogues.
J. Org. Chem. 73: 9435-9438, 2008.
92)  Melman A, Zhong M, Marquez VE, Jacobson KA.
Synthesis of Enantiomerically Pure (S)-Methanocarbaribo Uracil Nucleoside Derivatives for Use as Antiviral Agents and P2Y Receptor Ligands.
J. Org. Chem. 73: 8085-8088, 2008.
93)  Yoo CB, Chuang JC, Byun HM, Egger G, Yang AS, Dubeau L, Long T, Laird PW, Marquez VE, Jones PA.
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.
Cancer prevention research (Philadelphia, Pa.). 1: 233-40, 2008.
94)  Marquez VE.
Herewijn P, eds.
The Properties of Locked Methanocarba Nucleosides in Biochemistry, Biotechnology, and Medicinal Chemistry. In: Modified Nucleosides: in Biochemistry, Biotechnology and Medicine.
Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA; 2008. p. 307-341 [Book Chapter]
95)  Philosof-Mazor L, Volinsky R, Comin MJ, Lewin NE, Kedei N, Blumberg PM, Marquez VE, Jelinek R.
Self-Assembly and Lipid Interactions of Diacylglycerol Lactone Derivatives Studied at the Air/Water Interface.
Langmuir : the ACS journal of surfaces and colloids. 24: 11043-11052, 2008.
96)  Ludek OR, Schroeder GK, Wolfenden R, Marquez VE.
Synthesis of conformationally locked carbocyclic 1,3-diazepinone nucleosides as inhibitors of cytidine deaminase.
Nucleic Acids Symp Ser (Oxf). 659-60, 2008.
97)  Saneyoshi H, Vu BC, Hughes SH, Boyer PL, Sarafianos SG, Marquez VE.
Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.
Nucleic Acids Symp Ser (Oxf). 623-4, 2008.
98)  Marquez VE, Sun G, Siddiqui MA, Lee YC, Barchi JJ, Filippov IV, Landsman NA, Kelley JA.
What are the consequences of freezing the anomeric effect in nucleosides?.
Nucleic Acids Symp Ser (Oxf). 543-4, 2008.
99)  El Kazzouli S, Lewin NE, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol. 30. An Investigation of Diacylglycerol-lactones Containing Heteroaryl Groups Reveals Compounds with High Selectivity for Ras Guanyl Nucleotide-Releasing Proteins.
J. Med. Chem. 2008.
100)  Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, Kazzouli SE, Chung JU, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman JP, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol. 29. Cells Sort Diacylglycerol-Lactone Chemical Zip Codes to Produce Diverse and Selective Biological Activities.
J. Med. Chem. 2008.
101)  Blumberg PM, Kedei N, Lewin NE, Yang D, Czifra G, Pu Y, Peach ML, Marquez VE.
Wealth of opportunity - the C1 domain as a target for drug development.
Current drug targets. 9: 641-52, 2008.
102)  Barchi JJ, Karki RG, Nicklaus MC, Siddiqui MA, George C, Mikhailopulo IA, Marquez VE.
Comprehensive Structural Studies of 2',3'-Difluorinated Nucleosides: Comparison of Theory, Solution, and Solid State.
J. Am. Chem. Soc. 130: 9048-9057, 2008.
103)  Byun H, Choi SH, Laird PW, Trinh B, Siddiqui MA, Marquez VE, Yang AS.
2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: A novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1.
Cancer Lett. 266: 238-248, 2008.
104)  Tsuge H, Nagahama M, Oda M, Iwamoto S, Utsunomiya H, Marquez VE, Katunuma N, Nishizawa M, Sakurai J.
Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens {iota}-toxin.
Proc. Natl. Acad. Sci. U.S.A. 105: 7399-7404, 2008.
105)  Comin MJ, Vu BC, Boyer PL, Liao C, Hughes SH, Marquez VE.
D-(+)-iso-Methanocarbathymidine: a High-Affinity Substrate for Herpes Simplex Virus 1 Thymidine Kinase.
ChemMedChem. 3: 1129-1134, 2008.
106)  Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM.
Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42-binding kinase) alpha/beta.
J. Biol. Chem. 283: 10543-10549, 2008.
107)  Dowd CL, Sutch BT, Haworth IS, Eritja R, Marquez VE, Yang AS.
Incorporation of zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase.
Nucleosides Nucleotides Nucleic Acids. 27: 131-45, 2008.
108)  Marquez VE, Comin MJ.
Rearranging the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve binding recognition by kinases.
Nucleosides Nucleotides Nucleic Acids. 26: 585-8, 2007.
109)  Ludek OR, Marquez VE.
Convergent or linear? A challenging question in carbocyclic nucleoside chemistry.
Synthesis. 22: 3451-3460, 2007.
Full Text Article. [Journal]
110)  Yu J, Cao Q, Mehra R, Laxman B, Yu J, Tomlins SA, Creighton CJ, Dhanasekaran SM, Shen R, Chen G, Morris DS, Marquez VE, Shah RB, Ghosh D, Varambally S, Chinnaiyan AM.
Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer.
Cancer Cell. 12: 419-31, 2007.
111)  Boyer PL, Julias JG, Ambrose Z, Siddiqui MA, Marquez VE, Hughes SH.
The Nucleoside Analogs 4'C-Methyl Thymidine and 4'C-Ethyl Thymidine Block DNA Synthesis by Wild-type HIV-1 RT and Excision Proficient NRTI Resistant RT Variants.
J. Mol. Biol. 371: 873-82, 2007.
112)  Choi Y, Pu Y, Peach ML, Kang JH, Lewin NE, Sigano DM, Garfield SH, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol (DAG). 28. DAG-dioxolanones Reveal a New Additional Interaction Site in the C1b Domain of PKCdelta.
J Med Chem. 50: 3465-3481, 2007.
113)  Comin MJ, Agbaria R, Ben-Kasus T, Huleihel M, Liao C, Sun G, Nicklaus MC, Deschamps JR, Parrish DA, Marquez VE.
Sculpting the Bicyclo[3.1.0]hexane Template of Carbocyclic Nucleosides to Improve Recognition by Herpes Thymidine Kinase.
J Am Chem Soc. 129: 6216-6222, 2007.
114)  Maderia M, Shenoy S, Van QN, Marquez VE, Barchi JJ.
Biophysical studies of DNA modified with conformationally constrained nucleotides: comparison of 2'-exo (north) and 3'-exo (south) 'locked' templates.
Nucleic Acids Res. 35: 1978-91, 2007.
115)  Malolanarasimhan K, Kedei N, Sigano DM, Kelley JA, Lai CC, Lewin NE, Surawski RJ, Pavlyukovets VA, Garfield SH, Wincovitch S, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol (DAG). 27. Modulation of Membrane Translocation of Protein Kinase C (PKC) Isozymes alpha and delta by Diacylglycerol Lactones (DAG-lactones) Containing Rigid-Rod Acyl Groups.
J Med Chem. 50: 962-978, 2007.
116)  Marquez VE.
Combinatorial Synthesis of Natural Product-Based Libraries. Edited by Armen M. Boldi. CRC Press, Taylor & Francis Group, Boca Raton, FL. 2006. xii + 347 pp. 18 x 26 cm. ISBN 0-8493-4000-4. $198.95.
J. Med. Chem. 50: 1083-4, 2007.
117)  Siddiqui MA, Marquez VE.
The triphosphate of beta-d-4'-C-ethynyl-2',3'-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase.
Bioorg. Med. Chem. 15: 283-7, 2007.
118)  Pu Y, Peach ML, Garfield SH, Wincovitch S, Marquez VE, Blumberg PM.
Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms.
J. Biol. Chem. 281: 33773-88, 2006.
119)  Johnson AA, Sayer JM, Yagi H, Patil SS, Debart F, Maier MA, Corey DR, Vasseur JJ, Burke TR, Marquez VE, Jerina DM, Pommier Y.
Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
J. Biol. Chem. 281: 32428-38, 2006.
120)  Marquez VE, Hughes SH, Sei S, Agbaria R.
The history of N-methanocarbathymidine: The investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent.
Antiviral Res. 71: 268-75, 2006.
121)  Young HA, Marquez VE, Kelley JA.
Designing a Chemical Probe to Find a Molecular Target.
CCR Frontiers in Science. 5: March, 2006.
Full Text Article. [Journal]
122)  Kang JH, Benzaria S, Sigano DM, Lewin NE, Pu Y, Peach ML, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.
J. Med. Chem. 49: 3185-203, 2006.
123)  Lee J, Kang JH, Han KC, Kim Y, Kim SY, Youn HS, Mook-Jung I, Kim H, Lo Han JH, Ha HJ, Kim YH, Marquez VE, Lewin NE, Pearce LV, Lundberg DJ, Blumberg PM.
Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.
J Med Chem. 49: 2028-36, 2006.
124)  Comin MJ, Parrish DA, Deschamps JR, Marquez VE.
Synthesis of bicyclo[3.1.0]hexanes functionalized at the tip of the cyclopropane ring. Application to the synthesis of carbocyclic nucleosides.
Org Lett. 8: 705-8, 2006.
125)  Herranz M, Martin-Caballero J, Fraga MF, Ruiz-Cabello J, Flores JM, Desco M, Marquez VE, Esteller M.
The novel DNAmethylation inhibitor zebularine is effective against the development of murine T-cell lymphoma.
Blood. 107: 1174-1177, 2006.
126)  Marquez VE, Kelley JA, Agbaria R, Ben-Kasus T, Cheng JC, Yoo CB, Jones PA.
Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy.
Ann N Y Acad Sci. 1058: 246-54, 2005.
127)  Costanzi S, Joshi BV, Maddileti S, Mamedova L, Gonzalez-Moa MJ, Marquez VE, Harden TK, Jacobson KA.
Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
J Med Chem. 48: 8108-11, 2005.
128)  Zhu W, Burnette A, Dorjsuren D, Roberts PE, Huleihel M, Shoemaker RH, Marquez VE, Agbaria R, Sei S.
Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.
Antimicrob Agents Chemother. 49: 4965-73, 2005.
129)  Marquez VE, Choi Y, Comin MJ, Russ P, George C, Huleihel M, Ben-Kasus T, Agbaria R.
Understanding How the Herpes Thymidine Kinase Orchestrates Optimal Sugar and Nucleobase Conformations To Accommodate Its Substrate at the Active Site: A Chemical Approach.
J Am Chem Soc. 127: 15145-15150, 2005.
130)  Sun G, Voigt JH, Marquez VE, Nicklaus MC.
Prosit, an online service to calculate pseudorotational parameters of nucleosides and nucleotides.
Nucleosides Nucleotides Nucleic Acids. 24: 1029-32, 2005.
131)  Maderia M, Wu J, Bax A, Shenoy S, O'Keefe B, Marquez VE, Barchi JJ.
Engineering DNA topology with locked nucleosides: a structural study.
Nucleosides Nucleotides Nucleic Acids. 24: 687-90, 2005.
132)  Marquez VE, Barchi JJ, Kelley JA, Rao KV, Agbaria R, Ben-Kasus T, Cheng JC, Yoo CB, Jones PA.
Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology.
Nucleosides Nucleotides Nucleic Acids. 24: 305-18, 2005.
133)  Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.
J Med Chem. 48: 5738-48, 2005.
134)  Marquez VE.
Flores-Herrera O, Rendón-Huerta E, Riveros-Rojas H, Sosa-Peinado A, Vázquez-Contreras E, Velázquez-López I, eds.
Diseño molecular de lactonas de diacilglicerol (DAG-lactonas) como activadores específicos de isozimas de la proteína cinasa C y de otras proteínas con receptores similares. In: Mensaje Bioquímico. Volume XXIX.
Mexico City: Universidad Nacional Autónoma de México; 2005. p. 43-63 [Book Chapter]
135)  Jørgensen R, Merrill AR, Yates SP, Marquez VE, Schwan AL, Boesen T, Andersen GR.
Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature. 436: 979-84, 2005.
136)  Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE.
A Novel Diacylglycerol-lactone Shows Marked Selectivity in Vitro among C1 Domains of Protein Kinase C (PKC) Isoforms {alpha} and {delta} as Well as Selectivity for RasGRP Compared with PKC{alpha}.
J Biol Chem. 280: 27329-38, 2005.
137)  Hodge DR, Peng B, Pompeia C, Thomas S, Cho E, Clausen PA, Marquez VE, Farrar WL.
Epigenetic Silencing of Manganese Superoxide Dismutase (SOD-2) in KAS 6/1 Human Multiple Myeloma Cells Increases Cell Proliferation.
Cancer Biol Ther. 4: 585-92, 2005.
138)  Ben-Kasus T, Ben-Zvi Z, Marquez VE, Kelley JA, Agbaria R.
Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
Biochem Pharmacol. 70: 121-33, 2005.
139)  Huleihel M, Talishanisky M, Ford H, Marquez VE, Kelley JA, Johns DG, Agbaria R.
Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture.
Int J Antimicrob Agents. 25: 427-432, 2005.
140)  Malolanarasimhan K, Lai CC, Kelley JA, Iaccarino L, Reynolds D, Young HA, Marquez VE.
Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe.
Bioorg Med Chem. 13: 2717-22, 2005.
141)  Lemaire M, Momparler LF, Bernstein ML, Marquez VE, Momparler RL.
Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia.
Anticancer Drugs. 16: 301-8, 2005.
142)  Joshi BV, Moon HR, Fettinger JC, Marquez VE, Jacobson KA.
A New Synthetic Route to (North)-Methanocarba Nucleosides Designed as A(3) Adenosine Receptor Agonists.
J Org Chem. 70: 439-447, 2005.
143)  Wu Z, Maderia M, Barchi JJ, Marquez VE, Bax A.
Changes in DNA bending induced by restricting nucleotide ring pucker studied by weak alignment NMR spectroscopy.
Proc Natl Acad Sci U S A. 102: 24-8, 2005.
144)  Boyer PL, Julias JG, Marquez VE, Hughes SH.
Fixed Conformation Nucleoside Analogs Effectively Inhibit Excision-proficient HIV-1 Reverse Transcriptases.
J Mol Biol. 345: 441-50, 2005.
145)  Borchers CH, Marquez VE, Schroeder GK, Short SA, Snider MJ, Speir JP, Wolfenden R.
Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex.
Proc Natl Acad Sci U S A. 101: 15341-5, 2004.
146)  Marquez V.
Chemical and biological consequences of locking the conformation of nucleosides at the two antipodal extremes of the pseudorotational cycle.
Nucleic Acids Symposium Series. 48: 11-12, 2004.
147)  Siddiqui MA, Hughes SH, Boyer PL, Mitsuya H, Van QN, George C, Sarafinanos SG, Marquez VE.
A 4'-C-Ethynyl-2',3'-Dideoxynucleoside Analogue Highlights the Role of the 3'-OH in Anti-HIV Active 4'-C-Ethynyl-2'-deoxy Nucleosides.
J Med Chem. 47: 5041-5048, 2004.
148)  Sun G, Voigt JH, Filippov IV, Marquez VE, Nicklaus MC.
PROSIT: Pseudo-Rotational Online Service and Interactive Tool, Applied to a Conformational Survey of Nucleosides and Nucleotides.
J Chem Inf Comput Sci. 44: 1752-62, 2004.
149)  Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).
J Med Chem. 47: 4858-64, 2004.
150)  Cheng JC, Yoo CB, Weisenberger DJ, Chuang J, Wozniak C, Liang G, Marquez VE, Greer S, Orntoft TF, Thykjaer T, Jones PA.
Preferential response of cancer cells to zebularine.
Cancer Cell. 6: 151-8, 2004.
151)  Horton JR, Ratner G, Banavali NK, Huang N, Choi Y, Maier MA, Marquez VE, MacKerell AD, Cheng X.
Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase.
Nucleic Acids Res. 32: 3877-86, 2004.
152)  Kang JH, Kim SY, Lee J, Marquez VE, Lewin NE, Pearce LV, Blumberg PM.
Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. interactions with protein kinase C.
J Med Chem. 47: 4000-7, 2004.
153)  Maier MA, Choi Y, Gaus H, Barchi JJ, Marquez VE, Manoharan M.
Synthesis and characterization of oligonucleotides containing conformationally constrained bicyclo[3.1.0]hexane pseudosugar analogs.
Nucleic Acids Res. 32: 3642-50, 2004.
154)  Kang JH, Siddiqui MA, Sigano DM, Krajewski K, Lewin NE, Pu Y, Blumberg PM, Lee J, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones.
Org Lett. 6: 2413-6, 2004.
155)  Schelling P, Claus MT, Johner R, Marquez VE, Schulz GE, Scapozza L.
Biochemical and Structural Characterization of (South)-Methanocarbathymidine That Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-transduced Osteosarcoma Cells.
J Biol Chem. 279: 32832-8, 2004.
156)  Duan D, Lewin NE, Sigano DM, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands.
J Med Chem. 47: 3248-54, 2004.
157)  Pompeia C, Hodge DR, Plass C, Wu YZ, Marquez VE, Kelley JA, Farrar WL.
Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line.
Cancer Res. 64: 3465-73, 2004.
158)  Lee J, Kim SY, Kang JH, Acs G, Acs P, Blumberg PM, Marquez VE.
Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands.
Eur J Med Chem. 39: 69-77, 2004.
159)  Marquez VE, Eritja R, Kelley JA, Vanbemmel D, Christman JK.
Potent inhibition of HhaI DNA methylase by the aglycon of 2-(1H)-pyrimidinone riboside (zebularine) at the GCGC recognition domain.
Ann N Y Acad Sci. 1002: 154-64, 2003.
160)  Cheng JC, Weisenberger DJ, Gonzales FA, Liang G, Xu GL, Hu YG, Marquez VE, Jones PA.
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells.
Mol Cell Biol. 24: 1270-8, 2004.
161)  Tamamura H, Sigano DM, Lewin NE, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.
J Med Chem. 47: 644-55, 2004.
162)  Marquez VE, Ben-Kasus T, Barchi JJ, Green KM, Nicklaus MC, Agbaria R.
Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.
J Am Chem Soc. 126: 543-9, 2004.
163)  Marquez VE.
Chemical and biological consequences of locking the conformation of nucleosides at the two antipodal extremes of the pseudorotational cycle.
Nucleic acids symposium series (2004). 11-2, 2004.
164)  Vives M, Eritja R, Tauler R, Marquez VE, Gargallo R.
Synthesis, stability, and protonation studies of a self-complementary dodecamer containing the modified nucleoside 2'-deoxyzebularine.
Biopolymers. 73: 27-43, 2004.
165)  Choi Y, Sun G, George C, Nicklaus MC, Kelley JA, Marquez VE.
Synthesis and conformational analysis of a locked analogue of carbovir built on a bicyclo[3.1.0]hex-2-enyl template.
Nucleosides Nucleotides Nucleic Acids. 22: 2077-91, 2003.
166)  Marquez VE, Eritja R, Kelley JA, Vanbemmel D, Christman JK.
Potent Inhibition of HhaI DNA Methylase by the Aglycon of 2-(1H)-Pyrimidinone Riboside (Zebularine) at the GCGC Recognition Domain.
Ann N Y Acad Sci. 1002: 154-164, 2003.
167)  Wang QJ, Fang TW, Yang D, Lewin NE, Van Lint J, Marquez VE, Blumberg PM.
Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase d.
Mol Pharmacol. 64: 1342-8, 2003.
168)  Russ P, Schelling P, Scapozza L, Folkers G, Clercq ED, Marquez VE.
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
J Med Chem. 46: 5045-54, 2003.
169)  Kim HS, Ohno M, Xu B, Kim HO, Choi Y, Ji XD, Maddileti S, Marquez VE, Harden TK, Jacobson KA.
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.
J Med Chem. 46: 4974-87, 2003.
170)  Choi Y, Moon HR, Yoshimura Y, Marquez VE.
Recent advances in the synthesis of confortnationally locked nucleosides and their success in probing the critical question of conformational preferences by their biological targets.
Nucleosides Nucleotides Nucleic Acids. 22: 547-558, 2003.
171)  Hamer DH, Bocklandt S, McHugh L, Chun TW, Blumberg PM, Sigano DM, Marquez VE.
Rational Design of Drugs That Induce Human Immunodeficiency Virus Replication.
J Virol. 77: 10227-10236, 2003.
172)  Ritter H, Koch-Nolte F, Marquez VE, Schulz GE.
Substrate Binding and Catalysis of Ecto-ADP-ribosyltransferase 2.2 from Rat.
Biochemistry. 42: 10155-10162, 2003.
173)  Choi Y, Kang JH, Lewin NE, Blumberg PM, Lee J, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.
J Med Chem. 46: 2790-3, 2003.
174)  Choi Y, George C, Comin MJ, Barchi JJ, Kim HS, Jacobson KA, Balzarini J, Mitsuya H, Boyer PL, Hughes SH, Marquez VE.
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
J Med Chem. 46: 3292-9, 2003.
175)  Kang JH, Chung HE, Kim SY, Kim Y, Lee J, Lewin NE, Pearce LV, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.
Bioorg Med Chem. 11: 2529-39, 2003.
176)  Marquez VE, Blumberg PM.
Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C).
Acc Chem Res. 36: 434-43, 2003.
177)  Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE.
Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).
J Med Chem. 46: 1571-9, 2003.
178)  Cheng JC, Matsen CB, Gonzales FA, Ye W, Greer S, Marquez VE, Jones PA, Selker EU.
Inhibition of DNA methylation and reactivation of silenced genes by zebularine.
J Natl Cancer Inst. 95: 399-409, 2003.
179)  Comin MJ, Rodriguez JB, Russ P, Marquez VE.
Sythesis of Conformationally Locked Carbocyclic Nucleosides Built on an Oxabicyclo[3.3.0]hexane System.
Tetrahedron. 59: 295-301, 2003.
180)  Zhu J, Song X, Lin HP, Young DC, Yan S, Marquez VE, Chen CS.
Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents.
J Natl Cancer Inst. 94: 1745-57, 2002.
181)  Noy R, Ben-Zvi Z, Elezra M, Candotti F, Ford Jr H, Morris JC, Marquez VE, Johns DG, Agbaria R.
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Cancer Chemother Pharmacol. 50: 360-6, 2002.
182)  Brank AS, Eritja R, Garcia RG, Marquez VE, Christman JK.
Inhibition of HhaI DNA (Cytosine-C5) methyltransferase by oligodeoxyribonucleotides containing 5-aza-2'-deoxycytidine: examination of the intertwined roles of co-factor, target, transition state structure and enzyme conformation.
J Mol Biol. 323: 53-67, 2002.
183)  Noy R, Ben-Zvi Z, Manor E, Candotti F, Morris JC, Ford H, Marquez VE, Johns DG, Agbaria R.
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Mol Cancer Ther. 1: 585-93, 2002.
184)  Yoshimura Y, Moon HR, Choi Y, Marquez VE.
Enantioselective synthesis of bicyclo[3.1.0]hexane carbocyclic nucleosides via a lipase-catalyzed asymmetric acetylation. Characterization of an unusual acetal byproduct.
J Org Chem. 67: 5938-45, 2002.
185)  Hernandez S, Ford H, Marquez VE.
Is the anomeric effect an important factor in the rate of adenosine deaminase catalyzed hydrolysis of purine nucleosides? A direct comparison of nucleoside analogues constructed on ribose and carbocyclic templates with equivalent heterocyclic bases selected to promote hydration.
Bioorg Med Chem. 10: 2723-30, 2002.
186)  Zalah L, Huleihel M, Manor E, Konson A, Ford H, Marquez VE, Johns DG, Agbaria R.
Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent, in native and herpes simplex virus type 1 infected Vero cells.
Antiviral Res. 55: 63-75, 2002.
187)  Nacro K, Lee J, Lewin NE, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol (DAG). 19. Asymmetric Syntheses of (3R)- and 3(S)-3-Hydroxy-4,4-disubstituted Heptonon-1,4-lactones as Protein Kinase C (PK-C) Ligands with Increased Hydrophilicity.
Tetrahedron. 58: 5335-5345, 2002.
188)  Zhou T, Kurnasov O, Tomchick DR, Binns DD, Grishin NV, Marquez VE, Osterman AL, Zhang H.
Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J Biol Chem. 277: 13148-54, 2002.
189)  Choi Y, George C, Strazewski P, Marquez VE.
Synthesis of a conformationally locked version of puromycin amino nucleoside.
Org Lett. 4: 589-92, 2002.
190)  Garcia-Bermejo ML, Leskow FC, Fujii T, Wang Q, Blumberg PM, Ohba M, Kuroki T, Han KC, Lee J, Marquez VE, Kazanietz MG.
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.
J Biol Chem. 277: 645-55, 2002.
191)  Kim HS, Ravi RG, Marquez VE, Maddileti S, Wihlborg AK, Erlinge D, Malmsjö M, Boyer JL, Harden TK, Jacobson KA.
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
J Med Chem. 45: 208-18, 2002.
192)  Güimil García R, Brank AS, Christman JK, Marquez VE, Eritja R.
Synthesis of oligonucleotide inhibitors of DNA (Cytosine-C5) methyltransferase containing 5-azacytosine residues at specific sites.
Antisense Nucleic Acid Drug Dev. 11: 369-78, 2001.
193)  Lee J, Han KC, Kang JH, Pearce LL, Lewin NE, Yan S, Benzaria S, Nicklaus MC, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
J Med Chem. 44: 4309-12, 2001.
194)  Ravi G, Lee K, Ji X, Kim HS, Soltysiak KA, Marquez VE, Jacobson KA.
Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings.
Bioorg Med Chem Lett. 11: 2295-300, 2001.
195)  Marquez VE, Wang P, Nicklaus MC, Maier M, Manoharan M, Christman JK, Banavali NK, Mackerell AD.
Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites.
Nucleosides Nucleotides Nucleic Acids. 20: 451-9, 2001.
196)  Jacobson KA, Ravi RG, Nandanan E, Kim HS, Moro S, Kim YC, Lee K, Barak D, Marquez VE, Ji XD.
Ribose modified nucleosides and nucleotides as ligands for purine receptors.
Nucleosides Nucleotides Nucleic Acids. 20: 333-41, 2001.
197)  Nacro K, Sigano DM, Yan S, Nicklaus MC, Pearce LL, Lewin NE, Garfield SH, Blumberg PM, Marquez VE.
An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).
J Med Chem. 44: 1892-904, 2001.
198)  Wang QJ, Fang TW, Nacro K, Marquez VE, Wang S, Blumberg PM.
Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions.
J Biol Chem. 276: 19580-7, 2001.
199)  Lee K, Ravi G, Ji XD, Marquez VE, Jacobson KA.
Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.
Bioorg Med Chem Lett. 11: 1333-7, 2001.
200)  Lee J, Han KC, Lee SY, Kim SY, Kang JH, Lewin NE, Best LS, Blumberg PM, Marquez VE.
5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding.
Farmaco. 56: 203-10, 2001.
201)  Lee J, Lee J, Kim J, Kim SY, Chun MW, Cho H, Hwang SW, Oh U, Park YH, Marquez VE, Beheshti M, Szabo T, Blumberg PM.
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics.
Bioorg Med Chem. 9: 19-32, 2001.
202)  Wang P, Brank AS, Banavali NK, Nicklaus MC, Marquez VE, Christman JK, MacKerell Jr AD.
Use of Oligodeoxyribonucleotides with Conformationally Constrained Abasic Sugar Targets to Probe the Mechanism of Base Flipping by HhaI DNA (Cytosine C5)-methyltransferase.
J Am Chem Soc. 122: 12422-12434, 2000.
203)  Moon HR, Ford H, Marquez VE.
A remarkably simple chemicoenzymatic approach to structurally complex bicyclo[3.1.0]hexane carbocyclic nucleosides.
Org Lett. 2: 3793-6, 2000.
204)  Mu L, Sarafianos SG, Nicklaus MC, Russ P, Siddiqui MA, Ford H, Mitsuya H, Le R, Kodama E, Meier C, Knispel T, Anderson L, Barchi JJ, Marquez VE.
Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.
Biochemistry. 39: 11205-15, 2000.
205)  Tamamura H, Bienfait B, Nacro K, Lewin NE, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C.
J Med Chem. 43: 3209-17, 2000.
206)  Prota A, Vogt J, Pilger B, Perozzo R, Wurth C, Marquez VE, Russ P, Schulz GE, Folkers G, Scapozza L.
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine.
Biochemistry. 39: 9597-603, 2000.
207)  Nacro K, Bienfait B, Lewin NE, Blumberg PM, Marquez VE.
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones.
Bioorg Med Chem Lett. 10: 653-5, 2000.
208)  Jacobson KA, Ji X, Li AH, Melman N, Siddiqui MA, Shin KJ, Marquez VE, Ravi RG.
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
J Med Chem. 43: 2196-203, 2000.
209)  Siddiqui MA, Driscoll JS, Abushanab E, Kelley JA, Barchi JJ, Marquez VE.
The "beta-fluorine effect" in the non-metal hydride radical deoxygenation of fluorine-containing nucleoside xanthates.
Nucleosides Nucleotides Nucleic Acids. 19: 1-12, 2000.
210)  Wang QJ, Fang TW, Fenick D, Garfield S, Bienfait B, Marquez VE, Blumberg PM.
The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein.
J Biol Chem. 275: 12136-46, 2000.
211)  Shin KJ, Moon HR, George C, Marquez VE.
Construction of the bicyclo[3.1.0]hexane template of a conformationally locked carbocyclic adenosine via an olefin keto-carbene cycloaddition.
J Org Chem. 65: 2172-8, 2000.
212)  Nacro K, Bienfait B, Lee J, Han KC, Kang JH, Benzaria S, Lewin NE, Bhattacharyya DK, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?.
J Med Chem. 43: 921-44, 2000.
213)  Ford H, Dai F, Mu L, Siddiqui MA, Nicklaus MC, Anderson L, Marquez VE, Barchi JJ.
Adenosine deaminase prefers a distinct sugar ring conformation for binding and catalysis: kinetic and structural studies.
Biochemistry. 39: 2581-92, 2000.
214)  Nandanan E, Jang SY, Moro S, Kim HO, Siddiqui MA, Russ P, Marquez VE, Busson R, Herdewijn P, Harden TK, Boyer JL, Jacobson KA.
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.
J Med Chem. 43: 829-42, 2000.
215)  Marquez VE, Russ P, Alonso R, Siddiqui MA, Hernandez S, George C, Nicklau MC, Dai F, Ford H.
Synthesis of Conformationally Restricted Carbocyclic Nucleosides: The Role of the O(4')-Atom in the Key Hydration Step of Adenosine Deaminase.
Helv Chim Acta. 82: 2119-2129, 1999.
216)  Wang QJ, Bhattacharyya D, Garfield S, Nacro K, Marquez VE, Blumberg PM.
Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein.
J Biol Chem. 274: 37233-9, 1999.
217)  Ikeda H, Abushanab E, Marquez VE.
The assembly of beta-methylene-TAD, a metabolically stable analogue of the antitumor agent TAD, by the stepwise esterification of monodeprotected methylenebis-(phosphonate) benzyl esters under Mitsunobu conditions.
Bioorg Med Chem Lett. 9: 3069-74, 1999.
218)  Lee J, Park SU, Kim JY, Kim JK, Lee J, Oh U, Marquez VE, Beheshti M, Wang QJ, Modarres S, Blumberg PM.
3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists.
Bioorg Med Chem Lett. 9: 2909-14, 1999.
219)  Caloca MJ, Garcia-Bermejo ML, Blumberg PM, Lewin NE, Kremmer E, Mischak H, Wang S, Nacro K, Bienfait B, Marquez VE, Kazanietz MG.
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.
Proc Natl Acad Sci U S A. 96: 11854-9, 1999.
220)  Lee J, Kang JH, Lee SY, Han KC, Torres CM, Bhattacharyya DK, Blumberg PM, Marquez VE.
Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores.
J Med Chem. 42: 4129-39, 1999.
221)  Marquez VE, Goddard A, Alvarez E, Ford H, Christman JK, Sheikhnejad G, Brank A, Marasco CJ, O'Gara M, Cheng X.
Oligonucleotides containing 5,6-dihydro-5-azacytosine at CpG sites can produce potent inhibition of DNA cytosine-C5-methyltransferase without covalently binding to the enzyme.
Antisense & Nucleic Acid Drug Dev. 9: 415-421, 1999.
222)  Marquez VE, Russ P, Alonso R, Siddiqui MA, Shin KJ, George C, Nicklaus MC, Dai F, Ford H.
Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template.
Nucleosides Nucleotides. 18: 521-30, 1999.
223)  Meier C, Knispel T, Marquez VE, De Clercq E, Balzarini J.
CycloSal-2'-ara(ribo)-fluoro-2',3'-dideoxyadenosine monophosphates--an effort to solve the structure-activity relationship of 2'-fluoro-ddA.
Nucleosides Nucleotides. 18: 907-12, 1999.
224)  Moon HR, Kim HO, Chun MW, Jeong LS, Marquez VE.
Synthesis of Cyclopropyl-Fused Carbocyclic Nucleosides via the Regioselective Opening of Cyclic Sulfites.
J Org Chem. 64: 4733-4741, 1999.
225)  Marquez VE, Nacro K, Benzaria S, Lee J, Sharma R, Teng K, Milne GW, Bienfait B, Wang S, Lewin NE, Blumberg PM.
The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.
Pharmacol Ther. 82: 251-61, 1999.
226)  Meier C, Knispel T, Marquez VE, Siddiqui MA, De Clercq E, Balzarini J.
cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade.
J Med Chem. 42: 1615-24, 1999.
227)  Sheikhnejad G, Brank A, Christman JK, Goddard A, Alvarez E, Ford H, Marquez VE, Marasco CJ, Sufrin JR, O'gara M, Cheng X.
Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.
J Mol Biol. 285: 2021-34, 1999.
228)  Benzaria S, Bienfait B, Nacro K, Wang S, Lewin NE, Beheshti M, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).
Bioorg Med Chem Lett. 8: 3403-8, 1998.
229)  Marquez VE, Sharma R, Wang S, Lewin NE, Blumberg PM, Kim IS, Lee J.
Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement.
Bioorg Med Chem Lett. 8: 1757-62, 1998.
230)  Thibaudeau C, Kumar A, Bekiroglu S, Matsuda A, Marquez VE, Chattopadhyaya J.
NMR conformation of (-)-beta-D-aristeromycin and its 2'-deoxy and 3'-deoxy counterparts in aqueous solution.
J Org Chem. 63: 5447-5462, 1998.
231)  Jeong LS, Buenger G, McCormack JJ, Cooney DA, Hao Z, Marquez VE.
Carbocyclic analogues of the potent cytidine deaminase inhibitor 1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine).
J Med Chem. 41: 2572-8, 1998.
232)  Berger I, Tereshko V, Ikeda H, Marquez VE, Egli M.
Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability.
Nucleic Acids Res. 26: 2473-80, 1998.
233)  Ikeda H, Fernandez R, Wilk A, Barchi JJ, Huang X, Marquez VE.
The effect of two antipodal fluorine-induced sugar puckers on the conformation and stability of the Dickerson-Drew dodecamer duplex [d(CGCGAATTCGCG)]2.
Nucleic Acids Res. 26: 2237-44, 1998.
234)  Lee J, Lewin NE, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol having a perhydrofuro[3,4-c]furan-1,4-dione bis-gamma-butyrolactone skeleton.
Arch Pharm Res. 21: 164-7, 1998.
235)  Marquez VE, Ezzitouni A, Russ P, Siddiqui MA, Ford H, Feldman RJ, Mitsuya H, George C, Barchi JJ.
HIV-1 Reverse Transcriptase Can Discriminate Between Two Conformationally Locked Carbocyclic AZT Triphosphate Analogues.
J Am Chem Soc. 120: 2780-2789, 1998.
236)  Siddiqui M, Driscoll J, Marquez V.
A new synthetic approach to the clinically useful, anti-HIV-active nucleoside, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine (beta FddA). Introduction of a 2'-beta-fluoro substituent via inversion of a readily obtainable 2'-alpha-fluoro isomer.
Tetrahedron Lett. 39: 1657-1660, 1998.
237)  Marquez VE, Nacro K, Benzaria S, Lee J, Milne GW, Bienfair B, Wang S, Lewin N, Blumberg PM.
The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.
Cell. Mol. Biol. Lett. 3: 318-319, 1998.
238)  Marquez VE, Ezzitouni A, Siddiqui MA, Russ P, Ikeda H, George C.
Conformational analysis of nucleosides constructed on a bicyclo[3.1.0]hexane template. Structure-antiviral activity analysis for the northern and southern hemispheres of the pseudorotational cycle.
Nucleosides & Nucleotides. 15: 1431-1434, 1997.
239)  Eritja R, Marquez VE, Garcia RG.
Synthesis and properties of oligonucleotides containing 5'-aza-2'-deoxycytidine.
Nucleosides & Nucleotides. 16: 1111-1114, 1997.
240)  Jeong LS, Bae M, Chun MW, Marquez VE.
Synthesis and anti-HIV activity of carbocyclic ring-enlarged 4',1'a-methano oxetanocin analogues.
Nucleosides & Nucleotides. 16: 1059-1062, 1997.
241)  Avila JL, Avila A, Polegre MA, Marquez VE.
Specific inhibitory effect of 3-deazaneplanocin A against several Leishmania mexicana and L. braziliensis strains.
Am J Trop Med Hyg. 57: 407-12, 1997.
242)  Eritja R, Adam V, Avino A, Diaz AR, Fabrega C, Ferrer E, Grotli M, Garcia RG, Hoffman M, Marquez VE, Wiersma M.
Preparation of oligonucleotides containing nonnatural base analogs.
Nucleosides & Nucleotides. 16: 697-702, 1997.
243)  Ezzitouni A, Russ P, Marquez VE.
(1S,2R)-[(benzyloxy)methyl]cyclopent-3-enol. A versatile synthon for the preparation of 4',1'a-methano- and 1',1'a-methanocarbocyclic nucleosides.
J Org Chem. 62: 4870-4873, 1997.
244)  Ezzitouni A, Marquez VE.
Conformationally locked carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template with a fixed southern conformation. Synthesis and antiviral activity.
J Chem Soc Perkin Trans 1. Iss 7: 1073-1078, 1997.
245)  Russ P, Ezzitouni A, Marquez V.
Hydroxyl- versus amid-directed cyclopropanation from teh allylic position in 1-hydroxy-4-N-acyl-cyclopentenes under modified Simmons-Smith conditions.
Tetrahedron Lett. 38: 723-726, 1997.
246)  Barchi JJ, Jeong LS, Siddiqui MA, Marquez VE.
Conformational analysis of the complete series of 2' and 3' monofluorinated dideoxyuridines.
J Biochem Biophys Methods. 34: 11-29, 1997.
247)  Lee J, Kim SH, Chun MW, Lewin NE, Blumberg PM, Marquez VE.
Conformationally constrained analogs of diacylglycerol: Protein kinase C (PK-C) ligands based on a 5-disubstituted tetrahydro-2-furanone template having an (R)-hydroxyethyl group.
Carbohydrate Letters. 2: 1997, .
248)  Lee J, Lewin NE, Acs P, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 13. Protein kinase C ligands based on templates derived from 2,3-dideoxy-L-erythro(threo)-hexono-1,4-lactone and 2-deoxyapiolactone.
J Med Chem. 39: 4912-9, 1996.
249)  Marquez VE, Siddiqui MA, Ezzitouni A, Russ P, Wang J, Wagner RW, Matteucci MD.
Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?.
J Med Chem. 39: 3739-47, 1996.
250)  Lee J, Lewin NE, Blumberg PM, Marquez VE.
Synthesis of bis-gamma-butyrolactones containing conformationally constrained (S)- and (R)-diacylglycerol structures.
Bioorg Med Chem. 4: 1299-305, 1996.
251)  Wang S, Kazanietz MG, Blumberg PM, Marquez VE, Milne GW.
Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C.
J Med Chem. 39: 2541-53, 1996.
252)  Driscoll JS, Siddiqui MA, Ford H, Kelley JA, Roth JS, Mitsuya H, Tanaka M, Marquez VE.
Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 3. 6-Amino prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
J Med Chem. 39: 1619-25, 1996.
253)  Jeong L, Marquez V.
Use of a cyclic sulfite as an epoxide surrogate in the regioselective synthesis of a carbocyclic ring-enlarged 4',1'a-methano oxetanocin analogue.
Tetrahedron Lett. 37: 2353-2356, 1996.
254)  Siddiqui MA, Ford H, George C, Marquez VE.
Synthesis, conformational analysis, and biological activity of a rigid carbocyclic analogue of 2'-deoxyaristeromycin built on a bicyclo[3.1.0]hexane template.
Nucleosides & Nucleotides. 25: 235-250, 1996.
255)  Acs G, Lee J, Marquez VE, Blumberg PM.
Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes.
Brain Res Mol Brain Res. 35: 173-82, 1996.
256)  Lee J, Sharma R, Wang S, Milne GW, Lewin NE, Szallasi Z, Blumberg PM, George C, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template.
J Med Chem. 39: 36-45, 1996.
257)  Lee J, Wang S, Milne GW, Sharma R, Lewin NE, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 11. Ultrapotent protein kinase C ligands based on a chiral 5-disubstituted tetrahydro-2-furanone template.
J Med Chem. 39: 29-35, 1996.
258)  Sharma R, Lee J, Wang S, Milne GW, Lewin NE, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 10. Ultrapotent protein kinase C ligands based on a racemic 5-disubstituted tetrahydro-2-furanone template.
J Med Chem. 39: 19-28, 1996.
259)  Jeong LS, Marquez VE, Yuan CS, Borchardt RT.
4',1'a-methanocarbacyclic adenosine analogues as potential inhibitors of S-adenosylhomocysteine hydrolase.
Heterocycles. 41: 2651-2656, 1995.
260)  Avino A, Garcia RG, Marquez VE, Eritja R.
Preparation and properties of oligodeoxynucleotides containing 4-O-butylthymine,2-fluorohypoxanthine and 5-azacytosine.
Bioorg Med Chem Lett. 5: 2331-2336, 1995.
261)  Acs G, Lee J, Marquez VE, Wang S, Milne GW, Du L, Lewin NE, Blumberg PM.
Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids.
J Neurochem. 65: 301-18, 1995.
262)  Sharma R, Voynov GH, Ovaska TV, Marquez VE.
Facile reduction of carboxylic-acid imidazolides to primary alcohols in the presence of water.
Synlett. Iss 8: 839-840, 1995.
263)  Jeong LS, Marquez VE.
First Synthesis of a dideoxydifluoro nucleoside with a beta-D-lyxo configuration - an unprecedented effect of the cis-fluorines on the reactivity of aglycon.
J Org Chem. 60: 4276-4279, 1995.
264)  Lee JW, Acs G, Blumberg PM, Marquez VE.
Thiourea analogs of resiniferatoxin as ligands for the vanilloid receptor.
Bioorg Med Chem Lett. 5: 1331-1334, 1995.
265)  Ezzitouni A, Barchi JJ, Marquez VE.
A Simple Approach to 1',1'A-Methano Carbocyclic Thymidine.
J Chem Soc Chem Comm. Iss 13: 1345-1346, 1995.
266)  Marquez VE, Jeong LS, Nicklaus MC, George C.
Synthesis and Biological-Activity of Sugar-Fluorinated 2',2'-Dideoxy-4'-thioribofuranosyl Nucleosides.
Nucleosides & Nucleotides. 14: 555-558, 1995.
267)  Barchi JJ, Cooney DA, Hao Z, Weinberg ZH, Taft C, Marquez VE, Ford H.
Improved synthesis of zebularine [1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one] nucleotides as inhibitors of human deoxycytidylate deaminase.
J Enzyme Inhib. 9: 147-62, 1995.
268)  Jeong LS, Marquez VE.
The stereochemical outcome of the DAST fluorination of 4'-thiopyrimiden nucleosides with up hydroxyl groups is controlled by the oxidation stae of the sulfur atom.
Chem Lett. Iss 4: 301-302, 1995.
269)  Lee J, Barchi JJ, Marquez VE.
Synthesis of a Rigid Diacylglycerol Analog Having a Bis-gamma-butyrolactone Skeleton Separated by a Cyclopentane Ring.
Chem Lett. Iss 4: 299-300, 1995.
270)  Lee J, Sharma R, Marquez VE.
Synthesis of chiral doubly C-4 branched gamma-lactones. An efficient synthesis of 4-C-hydroxymethyl-2,3-dideoxy-hexono-1,4-lactones.
Carbohydrate Lett. 1: 285-290, 1995.
271)  Ford H, Siddiqui MA, Driscoll JS, Marquez VE, Kelley JA, Mitsuya H, Shirasaka T.
Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 2. 6-Halo and 6-alkoxy prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
J Med Chem. 38: 1189-95, 1995.
272)  Cysyk RL, Malinowski N, Marquez V, Zaharevitz D, August EM, Moyer JD.
Cyclopentenyl uracil: An effective inhibitor of uridine salvage in vivo.
Biochem Pharmacol. 49: 203-207, 1995.
273)  Wang S, Zaharevitz DW, Sharma R, Marquez VE, Lewin NE, Du L, Blumberg PM, Milne GW.
The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies.
J Med Chem. 37: 4479-89, 1994.
274)  Lee JW, Lewin NE, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol. 9. The Effect of Side-Chain Orientation on the Protein Kinase C (PK-C) Binding Affinity of delta-Lactones.
Bioorg & Med Chem Lett. 4: 2405-2410, 1994.
275)  Sharma R, Marquez VE.
A Concise Synthesis of 8-Phenyloctadecanoic Acid.
Org Prep Proc Intl. 26: 611-614, 1994.
276)  Jeong L, Nicklaus M, George C, Marquez V.
Facile fluorination of deoxy-4'-thiopyrimidine nucleosides with down hydroxyl groups - retention of configuration after fluoride opening of the quaternized N-3-MEM anhydronucleosides.
Tetrahedron Lett. 35: 7573-7576, 1994.
277)  Jeong L, Nicklaus M, George C, Marquez V.
Unanticipated Retention of Configuration in the Dast Fluorination of Deoxy-4'-Thiopyrimidine Nucleosides with Up Hydroxyl Groups.
Tetrahedron Lett. 35: 7569-7572, 1994.
278)  Rodriguez JB, Marquez VE, Nicklaus MC, Mitsuya H, Barchi JJ.
Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.
J Med Chem. 37: 3389-99, 1994.
279)  Jeong LS, Lim BB, Marquez VE.
Synthesis of a 2,3-dideoxy-2,3-difluorofuranose with the D-lyxo configuration. An intramolecular rearrangement of methyl 5-O-benzoyl-2,3-dideoxy-2,3-difluoro-D-lyxofuranoside observed during the attempted synthesis of 1-(2,3-dideoxy-2,3-difluoro-beta-D-lyxofuranosyl)thymine.
Carbohydr Res. 262: 103-14, 1994.
280)  Li H, Hallows WH, Punzi JS, Marquez VE, Carrell HL, Pankiewicz KW, Watanabe KA, Goldstein BM.
Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry. 33: 23-32, 1994.
281)  Lee JW, Sharma R, Teng K, Lewin NE, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of DAG. 8. Changes in PK-C Binding Affinity Produced by Isosteric Groups of the 3-O-Acyl Function in 2-Deoxy-L-Ribonolactones.
Bioorg Med Chem Lett. 4: 1369-1374, 1994.
282)  Sharma R, Marquez VE.
Rapid synthesis of 5-O-(tert-butyldiphenylsilyl)-2-deoxy-L-ribonolactone.
Syn Comm. 24: 1937-1945, 1994.
283)  Marquez VE, Lim BB, Driscoll JS, Snoek R, Balzarini J, Ikeda S, Andrei G, DeClercq E.
Cyclopentene Carbocyclic Nucleosides Related to the Antitumor Nucleoside Clitocine and their Conversion to 8-Azaneoplanocin Analogs - Synthesis and Antiviral Activity.
J Heterocycl Chem. 30: 1393-1398, 1993.
284)  Siddiqui M, Marquez V, Driscoll J, Barchi J.
A Diastereoselective Synthesis of (S,S)-alpha-Fluoro-2,2-dimethyl-1,3,-dioxolane-4-propanoic Acid Methyl Ester, a Key Intermediate for the Preparation of Anti-HIV Effective Fluorodideoxynucleosides.
Tetrahedron Lett. 35: 3263-3266, 1994.
285)  Sharma R, Marquez VE, Milne GWA, Lewin NE, Blumberg PM.
Conformationally Constrained Analogs of Diacylglycerols. 5. 2,5-Dideoxy-3-O-Tetradecanoyl-D-Galactono-1,4-lactone - A Superior Homolog of 3-O-Tetradecanoyl-2-deoxy-L-Ribonolactone with PK-C Binding Affinity.
Bioorg & Med Chem Lett. 3: 1993-1998, 1993.
286)  Wang S, Milne GW, Nicklaus MC, Marquez VE, Lee J, Blumberg PM.
Protein kinase C. Modeling of the binding site and prediction of binding constants.
J Med Chem. 37: 1326-38, 1994.
287)  Bodenteich M, Marquez VE, Barchi JJ, Hallows WH, Goldstein BM, Driscoll JS.
Synthesis of Carbocyclic Analogs of 1-beta-D-Psicofuranosyl Nucleosides - Psico-cyclopentenyladenosine (Psicoplanocin-A) and Psico-cyclopentenylcytosine.
J Org Chem. 58: 6009-6015, 1993.
288)  Ford H, Driscoll JS, Siddiqui M, Kelley JA, Mitsuya H, Shirasaka T, Johns DG, Marquez VE.
Chemistry and anti-HIV activity of 2'-beta-bluoro-2',3'-dideoxyguanosine.
Nucleosides & Nucleotides. 13: 213-234, 1994.
289)  Rodriguez JB, Marquez VE, Nicklaus MC, Mitsuya H, Barchi JJ.
Synthesis of Cyclopropane-fused Dideoxycarbocyclic Nucleosides Structurally Related to Neplanocin-C.
Tetrahedron Lett. 34: 6233-6236, 1993.
290)  Lee JW, Marquez VE, Lewin NE, Blumberg PM.
Conformationally Constrained Analogues of DAG. 7. Interaction of a medium size epsilon lactone with protein kinase C (PK-C).
Bioorg Med Chem Lett. 4: 543-548, 1994.
291)  Agbaria R, Ford H, Kelley JA, Xie F, Politi P, Grem JL, Cooney DA, Marquez VE, Allegra CJ, Johns DG.
Measurement of cyclopentenyl cytosine 5'-triphosphate in vitro and in vivo by multidimensional high-performance liquid chromatography.
Anal Biochem. 213: 90-6, 1993.
292)  Gharehbaghi K, Paull KD, Kelley JA, Barchi JJ, Marquez VE, Cooney DA, Monks A, Scudiero D, Krohn K, Jayaram HN.
Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase.
Int J Cancer. 56: 892-9, 1994.
293)  Lee J, Marquez V, Bahador A, Kazanietz M, Blumberg P.
Synthesis of 2 rigid diacylglycerol analogs having a perhydrofuro[3,2-B] furan bis-gamma-butyrolactone skeleton. 3.
Tetrahedron Lett. 34: 4317-4320, 1993.
294)  Lee J, Marquez V, Lewin N, Blumberg P.
Synthesis of 2 rigid diacylglycerol analogs having a perhydrofuro[3,4-b]furan bis -gamma-butyrolactone skeleton. 2.
Tetrahedron Lett. 34: 4313-4316, 1993.
295)  Lee J, Marquez VE, Lewin NE, Blumberg PM.
Synthesis of 2 rigid diacylglycerol analogs having a 1,7-dioxaspiro[4.4]nonane bis-gamma-butyrolactone skeleton. 4.
Synlett. Iss 3: 206-208, 1994.
296)  Marquez VE, Lee JW, Sharma R, Teng K, Wang SM, Lewin NE, Bahador A, Kazanietz MG, Blumberg PM.
Conformationally Constrained Analogues of DAG. 6. Changes in PK-C binding affinity for 3-O-acyl-2-deoxy-L-ribonolactones bearing different acyl chains.
Bioorg Med Chem Lett. 4: 355-360, 1994.
297)  Lee J, Marquez VE, Blumberg PM, Krausz KW, Kazanietz MG.
Conformationally constrained analogues of diacylglycerol (DAG)--II. Differential interaction of delta-lactones and gamma-lactones with protein kinase C (PK-C).
Bioorg Med Chem. 1: 119-23, 1993.
298)  Driscoll JS, Marquez VE.
The design and synthesis of a new anticancer drug based on a natural product lead compound: from neplanocin A to cyclopentenyl cytosine (CPE-C).
Stem Cells. 12: 7-12, 1994.
299)  Lee JW, Marquez VE, Lewin NE, Bahador A, Kazanietz MG, Blumberg PM.
Conformationally Constrained Analogs of Diacylglycerols. 4. Interaction of alpha-alkylidene-gamma-lactones with protein kinase C (PK-C).
Bioorg Med Chem Lett. 3: 1107-1110, 1993.
300)  Li H, Hallows WH, Punzi JS, Marquez VE, Goldstein BM.
Nonbonded interactions in alcohol dehydrogenase-bound beta-methylene selenazole-4-carboxamide adenine dinucleotide.
Biophysical Journal. 64: A57-A57, 1993.
301)  Lee J, Marquez VE, Lewin NE, Kazanietz MG, Bahador A, Blumberg PM.
Conformationally constrained analogues of diacylglycerol (DAG). 3. Interaction of alpha-alkyl-gamma-lactones with protein kinase C (PK-C).
Bioorg & Med Chem Lett. 3: 1101-1106, 1993.
302)  Burke TR, Lim B, Marquez VE, Li ZH, Bolen JB, Stefanova I, Horak ID.
Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck.
J Med Chem. 36: 425-32, 1993.
303)  Barchi JJ, Haces A, Marquez VE, McCormack JJ.
Inhibition of Cytidine Deaminase by Derivatives of 1-(beta-D-Ribofuranosyl)-dihydropropyrimidin-2-one (Zebularine).
Nucleosides & Nucleotides. 11: 1781-1793, 1992.
304)  Burke TR, Ford H, Osherov N, Levitzki A, Stefanova I, Horak ID, Marquez VE.
Arylamides of Hydroxylated Isoquinolines as Protien Tyrosine Kinase Inhibitors.
Bioorg Med Chem Lett. 2: 1771-1774, 1992.
305)  Bodenteich M, Marquez VE.
Synthesis of protected (+/-)-alpha-carba-psicofuranose and beta-carba-psicofuranose.
Tetrahedron. 48: 5961-5968, 1992.
306)  Buenger G, Marquez V.
Carbocyclic ring-enlarged oxetanocin analogs.
Tetrahedron Lett. 33: 3707-3710, 1992.
307)  Lim BB, Marquez VE, Dobyns KA, Cooney DA, DeClercq E.
Synthesis and biological activity of the cyclopentenyl carbocyclic nucleoside analog of 5-azacytidine.
Nucleosides & Nucleotides. 11: 1123-1135, 1992.
308)  Siddiqui MA, Driscoll JS, Marquez VE, Roth JS, Shirasaka T, Mitsuya H, Barchi JJ, Kelley JA.
Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines.
J Med Chem. 35: 2195-201, 1992.
309)  Russ PL, Hegedus L, Kelley JA, Barchi JJ, Marquez VE.
The Controlled Stereospecific Reduction of Cyclopentenyl Cytosine (CPE-C) to Carbodine and Isocarbodine.
Nucleosides & Nucleotides. 11: 351-363, 1992.
310)  Burke TR, Russ PL, Marquez VE.
A New Synthetic Method for the Synthesis of Hydroxylated Isoquinolines - Preparation of Methyl 6,7-Dihydroxy-isoquinoline-3-carboxylate and 7,8-Dihydroxy-isoquinoline-3-carboxylate, Potential Protein Tyrosine Kinase Inhibitors.
Heterocycles. 34: 757-764, 1992.
311)  Laliberté J, Marquez VE, Momparler RL.
Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
Cancer Chemother Pharmacol. 30: 7-11, 1992.
312)  Bodenteich M, Marquez VE, Hallows WH, Goldstein BM.
Synthesis and structural determination of (+/-)-neplanocin-F.
J Org Chem. 57: 2071-2076, 1992.
313)  Lee JW, Teng K, Marquez VE.
Synthesis of 2 rigid diacylglycerol analogs having a bis-butyrolactone skeleton.
Tet Lett. 33: 1539-1542, 1992.
314)  Liaw YC, Gao YG, Marquez VE, Wang AH.
Molecular structures of two new anti-HIV nucleoside analogs: 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine and 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)hypoxanthine.
Nucleic Acids Res. 20: 459-65, 1992.
315)  Teng K, Marquez VE, Milne GWA, Barchi JJ, Kazanietz MG, Lewin NE, Blumberg PM, Abushanab E.
Conformationally constrained analogs of diacylglycerol - interaction of gamma-lactones with the phorbol ester receptor of protein kinase C.
J Am Chem Soc. 114: 1059-1070, 1992.
316)  Barchi JJ, Musser S, Marquez VE.
The Decomposition of 1-(beta-D-Ribofuranosyl)-1,2-Dihydropyrimidin-2-one (Zebularine) in Alkali - Mechanism and Products.
J Org Chem. 57: 536-541, 1992.
317)  Wysocki RJ, Siddiqui MA, Barchi JJ, Driscoll JS, Marquez VE.
A More Expedient Approach to the Synthesis of Anti-HIV-Active 2,3-Dideoxy-2-fluoro-beta-D-threo-pentafuranosyl Nucleosides.
Synthesis-Stuttgart. Iss 11: 1005-1008, 1991.
318)  Driscoll JS, Marquez VE, Plowman J, Liu PS, Kelley JA, Barchi JJ.
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
J Med Chem. 34: 3280-4, 1991.
319)  Zhen W, Jayaram HN, Marquez VE, Goldstein BM, Cooney DA, Weber G.
Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells.
Biochem Biophys Res Commun. 180: 933-8, 1991.
320)  Burke TR, Li ZH, Bolen JB, Marquez VE.
Structural Influences of Styryl-based Inhibitors on Epidermal Growth Factor Receptor and P56LCK Tyrosine Specific Protein Kinases.
Bioorg & Med Chem Lett. 1: 165-168, 1991.
321)  Goldstein BM, Leary JF, Farley BA, Marquez VE, Levy PC, Rowley PT.
Induction of HL60 cell differentiation by tiazofurin and its analogues: characterization and efficacy.
Blood. 78: 593-8, 1991.
322)  Marquez VE, Bodenteich M.
Psicoplanocin-A - A synthetic carbocyclic nucleoside with the combined structural features of neplanocin-A and psicofuranine.
Nucleosides & Nucleotides. 10: 311-314, 1991.
323)  De Clercq E, Murase J, Marquez VE.
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase.
Biochem Pharmacol. 41: 1821-9, 1991.
324)  Burke TR, Li ZH, Bolen JB, Marquez VE.
Phosphonate-containing inhibitors of tyrosine-specific protein kinases.
J Med Chem. 34: 1577-81, 1991.
325)  Barchi JJ, Marquez VE, Driscoll JS, Ford H, Mitsuya H, Shirasaka T, Aoki S, Kelley JA.
Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs.
J Med Chem. 34: 1647-55, 1991.
326)  Burke TR, Li ZH, Bolen JB, Chapekar M, Gang Y, Glazer RI, Rice KC, Marquez VE.
Examination of the possible mediation of antineoplastic effects of opiates through the inhibition of tyrosine-specific protein kinases.
Biochem Pharmacol. 41: R17-20, 1991.
327)  Tseng CK, Marquez VE, Milne GW, Wysocki RJ, Mitsuya H, Shirasaki T, Driscoll JS.
A ring-enlarged oxetanocin A analogue as an inhibitor of HIV infectivity.
J Med Chem. 34: 343-9, 1991.
328)  Copp RR, Marquez VE.
Synthesis of two cyclopentenyl-3-deazapyrimidine carbocyclic nucleosides related to cytidine and uridine.
J Med Chem. 34: 208-12, 1991.
329)  Fridland A, Johnson MA, Cooney DA, Ahluwalia G, Marquez VE, Driscoll JS, Johns DG.
Metabolism in human leukocytes of anti-HIV dideoxypurine nucleosides.
Ann N Y Acad Sci. 616: 205-16, 1990.
330)  Chwang TL, Fridland A, Avery TL.
Synthesis and biological activity of ara and 2'-deoxycyclopentenyl cytosine nucleoside analogs.
Nucleosides & Nucleotides. 9: 663-677, 1990.
331)  Bodenteich M, Marquez V.
Synthesis of (+/-)-psicoplanocin-A - A carbocyclic nucleoside combining the structural features of psicofuranine and neplanocin-A.
Tetrahedron Lett. 31: 5977-5980, 1990.
332)  Masood R, Ahluwalia GS, Cooney DA, Fridland A, Marquez VE, Driscoll JS, Hao Z, Mitsuya H, Perno CF, Broder S.
2'-Fluoro-2',3'-dideoxyarabinosyladenine: a metabolically stable analogue of the antiretroviral agent 2',3'-dideoxyadenosine.
Mol Pharmacol. 37: 590-6, 1990.
333)  Goldstein BM, Bell JE, Marquez VE.
Dehydrogenase binding by tiazofurin anabolites.
J Med Chem. 33: 1123-7, 1990.
334)  Marquez VE, Tseng CK, Mitsuya H, Aoki S, Kelley JA, Ford H, Roth JS, Broder S, Johns DG, Driscoll JS.
Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIV.
J Med Chem. 33: 978-85, 1990.
335)  Marquez VE.
Effect of fluorine substitution on the anti-HIV activity of dideoxynucleosides.
NIDA Res Monogr. 96: 61-79, 1990.
336)  Marquez VE, Bodenteich M, Copp RR, Lim BB.
Synthesis and biological activity of novel carbocyclic nucleosides.
Nucleic Acids Symp Ser. 35-6, 1990.
337)  Frick L, Yang C, Marquez VE, Wolfenden R.
Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity.
Biochemistry. 28: 9423-30, 1989.
338)  Bodenteich M, Marquez V.
Total synthesis of (+/-)-neplanocin F.
Tetrahedron Lett. 30: 4909-4912, 1989.
339)  Goddard AJ, Marquez VE.
Synthesis of oligonucleotides containing 5,6-dihydro-5-azacytosine and 5-azacytosine at specific CPG sites.
Nucleosides & Nucleotides. 8: 1015-1018, 1989.
340)  Driscoll JS, Marquez VE, Plowman J.
Cyclopentenyl cytosine (CPE-C). A carbocyclic nucleoside with antitumor and antiviral properties.
Nucleosides & Nucleotides. 8: 1131-1133, 1989.
341)  De Clercq E, Cools M, Balzarini J, Marquez VE, Borcherding DR, Borchardt RT, Drach JC, Kitaoka S, Konno T.
Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives.
Antimicrob Agents Chemother. 33: 1291-7, 1989.
342)  Tseng CK, Marquez VE, Fuller RW, Goldstein BM, Haines DR, McPherson H, Parsons JL, Shannon WM, Arnett G, Hollingshead M.
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
J Med Chem. 32: 1442-6, 1989.
343)  Kang GJ, Cooney DA, Moyer JD, Kelley JA, Kim HY, Marquez VE, Johns DG.
Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase.
J Biol Chem. 264: 713-8, 1989.
344)  Marquez VE, Lim MI, Tseng CKH, Markovac A, Priest MA, Khan MS, Kaskar B.
Total synthesis of (+/-)-neplanocin A.
J Org Chem. 53: 5709-5714, 1988.
345)  Goldstein BM, Mao DT, Marquez VE.
Ara-tiazofurin: conservation of structural features in an unusual thiazole nucleoside.
J Med Chem. 31: 1026-31, 1988.
346)  Marquez VE, Lim MI, Treanor SP, Plowman J, Priest MA, Markovac A, Khan MS, Kaskar B, Driscoll JS.
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
J Med Chem. 31: 1687-94, 1988.
347)  Goddard A, Marquez V.
Synthesis of a phoshoramidite of 2'-deoxy-5,6-dihydro-5-azacytidine - its potential application in the synthesis of DNA containing dihydro-5-azacytosine and 5-azacytosine bases.
Tetrahedron Lett. 29: 1767-1770, 1988.
348)  Marquez VE, Tseng CK, Kelley JA, Mitsuya H, Broder S, Roth JS, Driscoll JS.
2',3'-Dideoxy-2'-fluoro-ara-A. An acid-stable purine nucleoside active against human immunodeficiency virus (HIV).
Biochem Pharmacol. 36: 2719-22, 1987.
349)  Sutton PA, Cody V, Marquez VE.
Structures of 2 7-membered ring pyrimidine nucleoside derivatives.
Nucleosides & Nucleotides. 6: 613-620, 1987.
350)  Kim CH, Marquez VE.
Synthesis of ring-expanded cytidine - homocytidine.
J Org Chem. 52: 1979-1983, 1987.
351)  Kim CH, Marquez VE, Broder S, Mitsuya H, Driscoll JS.
Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogues.
J Med Chem. 30: 862-6, 1987.
352)  Haines DR, Tseng CK, Marquez VE.
Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogues.
J Med Chem. 30: 943-7, 1987.
353)  Haines DR, Fuller RW, Ahmad S, Vistica DT, Marquez VE.
Selective cytotoxicity of a system L specific amino acid nitrogen mustard.
J Med Chem. 30: 542-7, 1987.
354)  Cooney DA, Hamel E, Cohen M, Kang GJ, Dalal M, Marquez VE.
A simple method for teh rapid determination of the stereospecificity of NAD-dependent dehydrogenases applied to mammalian IMP dehydrogenase and bacterial NADH peroxidase.
Biochem Biophys Acta. 916: 89-93, 1987.
355)  Marquez VE, Tseng CKH, Treanor SP, Driscoll JS.
Synthesis of 2',3'-dideoxycyclopentenyl carbocyclic nucleosides as potential drugs for the treatment of AIDS.
Nucleosides & Nucleotides. 6: 239-244, 1987.
356)  Glazer RI, Knode MC, Tseng CK, Haines DR, Marquez VE.
3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells.
Biochem Pharmacol. 35: 4523-7, 1986.
357)  Kelley JA, Driscoll JS, McCormack JJ, Roth JS, Marquez VE.
Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides.
J Med Chem. 29: 2351-8, 1986.
358)  Ahluwalia GS, Cooney DA, Marquez VE, Jayaram HN, Johns DG.
Studies on the mechanism of action of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide). VI. Biochemical and pharmacological studies on the degradation of thiazole-4-carboxamide adenine dinucleotide (TAD).
Biochem Pharmacol. 35: 3783-90, 1986.
359)  Marquez VE, Tseng CK, Gebeyehu G, Cooney DA, Ahluwalia GS, Kelley JA, Dalal M, Fuller RW, Wilson YA, Johns DG.
Thiazole-4-carboxamide adenine dinucleotide (TAD). Analogues stable to phosphodiesterase hydrolysis.
J Med Chem. 29: 1726-31, 1986.
360)  Kim CH, Marquez VE, Mao DT, Haines DR, McCormack JJ.
Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase.
J Med Chem. 29: 1374-80, 1986.
361)  Moyer JD, Malinowski NM, Treanor SP, Marquez VE.
Antitumor activity and biochemical effects of cyclopentenyl cytosine in mice.
Cancer Res. 46: 3325-9, 1986.
362)  Glazer RI, Cohen MB, Hartman KD, Knode MC, Lim MI, Marquez VE.
Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine.
Biochem Pharmacol. 35: 1841-8, 1986.
363)  Glazer RI, Hartman KD, Knode MC, Richard MM, Chiang PK, Tseng CK, Marquez VE.
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
Biochem Biophys Res Commun. 135: 688-94, 1986.
364)  Marquez VE, Lim MI.
Carbocyclic nucleosides.
Med Res Rev. 6: 1-40, 1986.
365)  Moyer JD, Karle JM, Malinowski N, Marquez VE, Salam MA, Malspeis L, Cysyk RL.
Inhibition of uridine kinase and the salvage of uridine by modified pyrimidine nucleosides.
Mol Pharmacol. 28: 454-60, 1985.
366)  Monks A, Marquez VE, Mao DT, Cysyk RL.
Uptake of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) and analogues by the facilitated transport mechanism of erythrocytes.
Cancer Lett. 28: 1-8, 1985.
367)  Kelley JA, Tseng C, Marquez VE.
Applications of FAB/MS in the synthesis of NAD analogues and the structure determination of oligoribonucleotides.
Adv Mass Spectrometry. Part B: 1571-1572, 1985.
368)  Tseng C, Marquez V.
An improved method of synthesis of neplanocin and related cyclopentenyl-containing nucleosides.
Tetrahedron Lett. 31: 3669-3672, 1985.
369)  Glazer RI, Knode MC, Lim MI, Marquez VE.
Cyclopentenyl cytidine analogue. An inhibitor of cytidine triphosphate synthesis in human colon carcinoma cells.
Biochem Pharmacol. 34: 2535-9, 1985.
370)  Tonooka S, Tone Y, Marquez VE, Cooney DA, Sekikawa I, Azuma I.
Enzymatic synthesis and biochemical activity of various indazole adenine dinucleotides.
Bull Chem Soc Jpn. 58: 309-315, 1985.
371)  Gebeyehu G, Marquez VE, Van Cott A, Cooney DA, Kelley JA, Jayaram HN, Ahluwalia GS, Dion RL, Wilson YA, Johns DG.
Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.
J Med Chem. 28: 99-105, 1985.
372)  Lim MI, Moyer JD, Cysyk RI, Marquez VE.
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
J Med Chem. 27: 1536-8, 1984.
373)  Mao DT, Driscoll JS, Marquez VE.
Synthesis of 3-hydroxy-2- and -4-pyridone nucleosides as potential antitumor agents.
J Med Chem. 27: 160-4, 1984.
374)  Marquez VE, Rao KVB, Silverton JV, Kelley JA.
A ring expansion approach to 1,3-diazepin-2-one nucleosides.
J Org Chem. 49: 912-919, 1984.
375)  Mao DT, Driscoll JS, Marquez VE.
Synthesis of 3-hydroxy-2-pyridone and 3-hydroxy-4-pyridone.
Nucleosides & Nucleotides. 27: 160-164, 1984.
376)  Lim M, Marquez V.
Total synthesis of (+/-)-neplanocin A1.
Tetrahedron Lett. 24: 5559-5562, 1983.
377)  Marquez VE.
Anti-neoplastic agents.
Annu Rep Med Chem. 18: 129-138, 1983.
378)  Jayaram HN, Ahluwalia GS, Dion RL, Gebeyehu G, Marquez VE, Kelley JA, Robins RK, Cooney DA, Johns DG.
Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
Biochem Pharmacol. 32: 2633-6, 1983.
379)  Lim M, Marquez V.
A synthetic approach towards neplanocin-A - Preparation of the optically active cyclopentene moiety from D-ribose.
Tetrahedron Lett. 38: 4051-4054, 1983.
380)  Cooney DA, Jayaram HN, Glazer RI, Kelley JA, Marquez VE, Gebeyehu G, Van Cott AC, Zwelling LA, Johns DG.
Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.
Adv Enzyme Regul. 21: 271-303, 1983.
381)  Marquez VE.
Mechanisms of formation of cyclic urea nucleosides. 2. Direct N-glycosylation versus O-transglycosylation to N-transglycosylation.
Nucleosides & Nucleotides. 2: 1983, .
382)  Gebeyehu G, Marquez VE, Kelley JA, Cooney DA, Jayaram HN, Johns DG.
Synthesis of thiazole-4-carboxamide adenine dinucleotide. A powerful inhibitor of IMP dehydrogenase.
J Med Chem. 26: 922-5, 1983.
383)  Rao KVB, Marquez VE, Kelley JA, Corcoran MT.
A new synthesis of 3-(beta-D-ribofuranosyl)uracil (isouridine) via the intermediacy of an O-6,5'-cyclotetrahydropyrimidinone nucleoside.
J Chem Soc Perkin Trans 1. Iss 1: 127-130, 1983.
384)  Marquez VE.
Anti-neoplastic agents.
Annu Rep Med Chem. 17: 163-174, 1982.
385)  Cooney DA, Jayaram HN, Gebeyehu G, Betts CR, Kelley JA, Marquez VE, Johns DG.
The conversion of 2-beta-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
Biochem Pharmacol. 31: 2133-6, 1982.
386)  Marquez VE, Liu PA, Linevsky JK.
Mechanism of formation of cyclic urea nucleosides - evidence for an O-transglycosylation to N-transglycosylation.
J Org Chem. 47: 1712-1717, 1982.
387)  Liu PS, Marquez VE, Driscoll JS, Fuller RW, McCormack JJ.
Cyclic urea nucleosides. Cytidine deaminase activity as a function of aglycon ring size.
J Med Chem. 24: 662-6, 1981.
388)  Di Parsia MT, Suárez C, Vítolo MJ, Márquez VE, Beyer B, Urbina C, Hurtado I.
Synthesis and study of the potential antiallergic activity of some pyrazole derivatives.
J Med Chem. 24: 117-9, 1981.
389)  Marquez VE, Kelley JA, Driscoll JS.
1,3-Diazepinones. 2. The correct structure of squamolone as 1-carbamoyl-2-pyrrolidinone and synthesis of authentic perhydro-1,3-diazepine-2,4-dione.
J Org Chem. 45: 5308-5312, 1980.
390)  Marquez VE, Liu PS, Kelley JA, Driscoll JS, McCormack JJ.
Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase.
J Med Chem. 23: 713-5, 1980.
391)  Liu PS, Marquez VE, Kelley JA, Driscoll JS.
Synthesis of 1,3-diazepin-2-one nucleosides as transition state inhibitors of cytidine deaminase. 2.
J Org Chem. 45: 5225-5227, 1980.
392)  McCormack JJ, Marquez VE, Liu PS, Vistica DT, Driscoll JS.
Inhibition of cytidine deaminase by 2-Oxopyrimidine riboside and related compounds.
Biochem Pharmacol. 29: 830-832, 1980.
393)  Marquez VE, Liu PS, Kelley JA, Driscoll JS.
1,3-Diazepinones. 1. Synthesis of 5-hydroxyperhydro-1,3-diazepin-2-one.
J Org Chem. 45: 485-489, 1980.
394)  Hurtado I, Márquez VE, Vítolo MJ.
Inhibition of allergic reactions by a new antiallergic drug, LC-6 (trans-2,3b,4,5,7,8b,9,10-octahydronaphthol[1,2-c:5,6-c'] dipyrazole). I. Inhibition of the rat reaginic passive cutaneous anaphylaxis.
Int Arch Allergy Appl Immunol. 57: 507-13, 1978.
395)  Vítolo MJ, Márquez VE, Hurtado I.
trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound.
J Med Chem. 21: 692-4, 1978.
396)  Suarez C, DiParsia MT, Marquez VE.
Synthesis of pyridyloxadizaoles 2. 2-(oxadiazolyl)pyridines and 2,6-bis(oxadiazolyl)-pyridines as analogues of pyridinolcarbamate.
J Heterocycl Chem. 15: 1093-1096, 1978.
397)  Nakano T, Marquez VE, DiParsia MR, Suarez C.
Mass spectra of some oxadiazole derivatives.
Org Mass Spec. 13: 236-242, 1978.
398)  Marquez VE, DiParsia MT, Kelley JA.
Synthesis of pyridyloxadiazoles 1. Characterization and thermal rearrangement of an unexpected 1,2,4-oxadizol-5(4H)-one.
J Heterocycl Chem. 14: 1427-1429, 1977.
399)  Vitolo MJ, Marquez VE.
Synthesis of hexahydroquino[8,7,h]-quinolines. Cis and trans isomers of 3,9-dimethyl-4b,5,6,10b,11,12-hexahydroquino[8,7-h]-quinoline.
J Org Chem. 42: 2187-2190, 1977.
400)  Peng GW, Marquez VE, Driscoll JS.
Potential central nervous system antitumor agents. Hydantoin derivatives.
J Med Chem. 18: 846-9, 1975.
401)  Márquez VE, Cranston JW, Ruddon RW, Burckhalter JH.
Binding to deoxyribonucleic acid and inhibition of ribonucleic acid polymerase by analogs of chloroquine.
J Med Chem. 17: 856-62, 1974.
402)  Marquez VE, Twanmoh LM, Wood HB, Driscoll JS.
Two modes of reductive ring opening in 2,3-dihydro-6,6-diphenylimidazo-[2,1-b]-oxazole-5(6H)-one.
J Heterocycl Chem. 9: 1145-1146, 1972.
403)  Marquez VE, Twanmoh LM, Wood HB, Driscoll JS.
Intramolecular cyclizations leading to N-bridgehead bicyclics. 5,5-Diphenylhydantoin derivatives.
J Org Chem. 37: 2558-61, 1972.
404)  Marquez VE, Cranston JW, Ruddon RW, Kier LB, Burckhalter JH.
Mechanism of action of amodiaquine. Synthesis of its indoloquinoline analog.
J Med Chem. 15: 36-9, 1972.
405)  Saneyoshi H, Deschamps JR, Marquez VE.
Synthesis of Conformationally Locked L-Deoxythreosyl Phosphonate Nucleosides Built on a Bicyclo[3.1.0]hexane Template.
Journal of Organic Chemistry. 2010.
In Press. [Journal]
Click Here to View Collapsed Bibliography.

This page was last updated on 3/12/2014.