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Our Science – Lee Website

Kyung S. Lee, Ph.D.

Selected Publications

1)  Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS.
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.
Mol. Cell. 24: 409-22, 2006.
[Journal]
2)  Yun S, Moulaei T, Lim D, Bang JK, Park J, Shenoy SR, Liu F, Kang YH, Liao C, Soung N, Lee S, Yoon D, Lim Y, Lee D, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR, Yaffe MB, Wlodawer A, Lee KS.
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat. Struct. Mol. Biol. 16: 876-82, 2009.
[Journal]
3)  Soung NK, Park JE, Yu LR, Lee KH, Lee JM, Bang JK, Veenstra TD, Rhee K, Lee KS.
Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells.
Dev. Cell. 16: 539-50, 2009.
[Journal]
4)  Liu F, Park J, Qian W, Lim D, Graber M, Berg T, Yaffe MB, Lee KS, Burke TR.
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat. Chem. Biol. 7: 595-601, 2011.
[Journal]
5)  Park S, Park J, Kim T, Kim J, Kwak M, Ku B, Tian L, Murugan R, Ahn M, Komiya S, Hojo H, Kim N, Kim B, Bang J, Erikson R, Lee K, Kim S, Oh B, Yang W, Lee K.
Molecular basis for unidirectional scaffold switching of Plk4 in centriole biogenesis.
Nat Struct Mol Biol. 2014.
In Press. [Journal]
6)  Zou J, Rezvani K, Wang H, Lee KS, Zhang D.
BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress.
Cell Cycle. 12: 2255-65, 2013.
[Journal]
7)  Qian W, Park J, Liu F, Lee KS, Burke TR.
Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.
Bioorg Med Chem. 21: 3996-4003, 2013.
[Journal]
8)  Chang J, Seo SG, Lee KH, Nagashima K, Bang JK, Kim BY, Erikson RL, Lee KW, Lee HJ, Park JE, Lee KS.
Essential role of Cenexin1, but not Odf2, in ciliogenesis.
Cell Cycle. 12: 655-62, 2013.
[Journal]
9)  González-Sancho JM, Greer YE, Abrahams CL, Takigawa Y, Baljinnyam B, Lee KH, Lee KS, Rubin JS, Brown AM.
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling.
J. Biol. Chem. 288: 9428-37, 2013.
[Journal]
10)  Kim TS, Park JE, Shukla A, Choi S, Murugan RN, Lee JH, Ahn M, Rhee K, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS.
Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.
Proc. Natl. Acad. Sci. U.S.A. 110: E4849-57, 2013.
[Journal]
11)  Kim SO, Sakchaisri K, Thimmegowda NR, N R T, Soung NK, Jang JH, Kim YS, Lee KS, Kwon YT, Asami Y, Ahn JS, Erikson RL, Kim BY.
STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.
PLoS ONE. 8: e53908, 2013.
[Journal]
12)  Lee KH, Johmura Y, Yu L, Park J, Gao Y, Bang JK, Zhou M, Veenstra TD, Yeon Kim B, Lee KS.
Identification of a novel Wnt5a-CK1ε-Dvl2-Plk1-mediated primary cilia disassembly pathway.
EMBO J. 31: 3104-17, 2012.
[Journal]
13)  Liu F, Park J, Qian W, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR.
Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification.
ACS Chem. Biol. 7: 805-10, 2012.
[Journal]
14)  Qian WJ, Park JE, Lee KS, Burke TR.
Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).
Bioorg. Med. Chem. Lett. 22: 7306-8, 2012.
[Journal]
15)  Liu F, Park J, Qian W, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR.
Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1.
Chembiochem. 13: 1291-6, 2012.
[Journal]
16)  Park J, Erikson RL, Lee KS.
A self-propelled biological process: Plk1-dependent, product-activated feedforward mechanism.
Cell Cycle. 10: 3411-2, 2011.
[Journal]
17)  Park J, Erikson RL, Lee KS.
Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate.
Proc Natl Acad Sci U S A. 108: 8200-5, 2011.
[Journal]
18)  Kang YH, Park CH, Kim T, Soung N, Bang JK, Kim BY, Park J, Lee KS.
Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.
J Biol Chem. 286: 19744-57, 2011.
[Journal]
19)  Johmura Y, Soung NK, Park JE, Yu LR, Zhou M, Bang JK, Kim BY, Veenstra TD, Erikson RL, Lee KS.
Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1.
Proc. Natl. Acad. Sci. U.S.A. 108: 11446-51, 2011.
[Journal]
20)  Liao C, Park J, Bang JK, Nicklaus MC, Lee KS.
Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1.
ACS Med Chem Lett. 1: 110-114, 2010.
[Journal]
21)  Park JE, Soung NK, Johmura Y, Kang YH, Liao C, Lee KH, Park CH, Nicklaus MC, Lee KS.
Polo-box domain: a versatile mediator of polo-like kinase function.
Cell. Mol. Life Sci. 67: 1957-70, 2010.
[Journal]
22)  Park JE, Li L, Park J, Knecht R, Strebhardt K, Yuspa SH, Lee KS.
Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.
Proc. Natl. Acad. Sci. U.S.A. 106: 1725-30, 2009.
[Journal]
23)  Liu F, Park J, Lee KS, Burke Jr. TR.
Preparation of orthogonally protected (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of polo-box domain-binding peptides.
Tetrahedron. 65 (47): 9673-9679, 2009.
[Journal]
24)  Lee KS, Park JE, Kang YH, Zimmerman W, Soung NK, Seong YS, Kwak SJ, Erikson RL.
Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: self- versus non-self-priming.
Cell Cycle. 7: 141-5, 2008.
[Journal]
25)  Lee KS, Idle JR.
Pinning down the polo-box domain.
Chem. Biol. 15: 415-6, 2008.
[Journal]
26)  Park CJ, Park JE, Karpova TS, Soung NK, Yu LR, Song S, Lee KH, Xia X, Kang E, Dabanoglu I, Oh DY, Zhang JY, Kang YH, Wincovitch S, Huffaker TC, Veenstra TD, McNally JG, Lee KS.
Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamics.
Eukaryotic Cell. 7: 444-53, 2008.
[Journal]
27)  Lee KS, Oh D, Kang YH, Park J.
Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction.
Cell Div. 3: 4, 2008.
[Journal]
28)  Nakashima A, Maruki Y, Imamura Y, Kondo C, Kawamata T, Kawanishi I, Takata H, Matsuura A, Lee KS, Kikkawa U, Ohsumi Y, Yonezawa K, Kamada Y.
The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.
PLoS ONE. 3: e2223, 2008.
[Journal]
29)  Kuriyama R, Terada Y, Lee KS, Wang CL.
Centrosome replication in hydroxyurea-arrested CHO cells expressing GFP-tagged centrin2.
J. Cell. Sci. 120: 2444-53, 2007.
[Journal]
30)  Hara T, Abe M, Inoue H, Yu LR, Veenstra TD, Kang YH, Lee KS, Miki T.
Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase.
Oncogene. 25: 566-78, 2006.
[Journal]
31)  Asano S, Park J, Yu L, Zhou M, Sakchaisri K, Park CJ, Kang YH, Thorner J, Veenstra TD, Lee KS.
Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast.
J. Biol. Chem. 281: 27090-8, 2006.
[Journal]
32)  Niiya F, Tatsumoto T, Lee KS, Miki T.
Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.
Oncogene. 25: 827-37, 2006.
[Journal]
33)  Soung NK, Kang YH, Kim K, Kamijo K, Yoon H, Seong YS, Kuo YL, Miki T, Kim SR, Kuriyama R, Giam CZ, Ahn CH, Lee KS.
Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes.
Mol. Cell. Biol. 26: 8316-35, 2006.
[Journal]
34)  Sung H, Chul Han K, Chul Kim J, Wan Oh K, Su Yoo H, Tae Hong J, Bok Chung Y, Lee CK, Lee KS, Song S.
A set of epitope-tagging integration vectors for functional analysis in Saccharomyces cerevisiae.
FEMS Yeast Res. 5: 943-50, 2005.
[Journal]
35)  Asano S, Park J, Sakchaisri K, Yu L, Song S, Supavilai P, Veenstra TD, Lee KS.
Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast.
EMBO J. 2194, 2005.
[Journal]
36)  Niiya F, Xie X, Lee KS, Inoue H, Miki T.
Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.
J. Biol. Chem. 280: 36502-9, 2005.
[Journal]
37)  Lee KS, Asano S, Park JE, Sakchaisri K, Erikson RL.
Monitoring the cell cycle by multi-kinase-dependent regulation of Swe1/Wee1 in budding yeast.
Cell Cycle. 4: 1346-9, 2005.
[Journal]
38)  Lee KS, Park JE, Asano S, Park CJ.
Yeast polo-like kinases: functionally conserved multitask mitotic regulators.
Oncogene. 24: 217-29, 2005.
[Journal]
39)  Sakchaisri K, Asano S, Yu LR, Shulewitz MJ, Park CJ, Park JE, Cho YW, Veenstra TD, Thorner J, Lee KS.
Coupling morphogenesis to mitotic entry.
Proc Natl Acad Sci U S A. 101: 4124-9, 2004.
[Journal]
40)  Park JE, Park CJ, Sakchaisri K, Karpova T, Asano S, McNally J, Sunwoo Y, Leem SH, Lee KS.
Novel functional dissection of the localization-specific roles of budding yeast polo kinase Cdc5p.
Mol Cell Biol. 24: 9873-86, 2004.
[Journal]
41)  Park CJ, Song S, Giddings TH, Ro HS, Sakchaisri K, Park JE, Seong YS, Winey M, Lee KS.
Requirement for Bbp1p in the Proper Mitotic Functions of Cdc5p in Saccharomyces cerevisiae.
Mol Biol Cell. 15: 1711-23, 2004.
[Journal]
42)  Seong Y, Min C, Li L, Yang JY, Kim S, Cao X, Kim K, Yuspa SH, Chung H, Lee KS.
Characterization of a novel Cdk1 inhibitor, BMI-1026.
Cancer Res. 63: 7384-7391, 2003.
[Journal]
43)  Park CJ, Song S, Lee PR, Shou W, Deshaies RJ, Lee KS.
Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis.
Genetics. 163: 21-33, 2003.
[Journal]
44)  Seong YS, Kamijo K, Lee JS, Fernandez E, Kuriyama R, Miki T, Lee KS.
A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.
J Biol Chem. 277: 32282-93, 2002.
[Journal]
45)  Ro HS, Song S, Lee KS.
Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiae.
Proc Natl Acad Sci U S A. 99: 5436-41, 2002.
[Journal]
46)  Lee PR, Song S, Ro HS, Park CJ, Lippincott J, Li R, Pringle JR, De Virgilio C, Longtine MS, Lee KS.
Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae.
Mol Cell Biol. 22: 6906-20, 2002.
[Journal]
47)  Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M.
Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins.
Mol Cell Biol. 22: 6809-19, 2002.
[Journal]
48)  Sobering AK, Jung US, Lee KS, Levin DE.
Yeast Rpi1 is a putative transcriptional regulator that contributes to preparation for stationary phase.
Eukaryot Cell. 1: 56-65, 2002.
[Journal]
49)  Song S, Lee KS.
A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis.
J Cell Biol. 152: 451-69, 2001.
[Journal]
50)  Elizondo G, Fernandez-Salguero P, Sheikh MS, Kim GY, Fornace AJ, Lee KS, Gonzalez FJ.
Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast.
Mol Pharmacol. 57: 1056-63, 2000.
[Journal]
51)  Song S, Grenfell TZ, Garfield S, Erikson RL, Lee KS.
Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures.
Mol Cell Biol. 20: 286-98, 2000.
[Journal]
52)  Gallina A, Simoncini L, Garbelli S, Percivalle E, Pedrali-Noy G, Lee KS, Erikson RL, Plachter B, Gerna G, Milanesi G.
Polo-like kinase 1 as a target for human cytomegalovirus pp65 lower matrix protein.
J Virol. 73: 1468-78, 1999.
[Journal]
53)  Lee KS, Song S, Erikson RL.
The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae.
Proc Natl Acad Sci U S A. 96: 14360-5, 1999.
[Journal]
54)  Lee KS, Grenfell TZ, Yarm FR, Erikson RL.
Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk.
Proc Natl Acad Sci U S A. 95: 9301-6, 1998.
[Journal]
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This page was last updated on 7/11/2014.