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Our Science – Kimura Website

Shioko Kimura, Ph.D.

Selected Publications

1)  Mizuno K, Gonzalez FJ, Kimura S.
Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1.
Mol. Cell. Biol. 11: 4927-33, 1991.
2)  Kimura S, Hara Y, Pineau T, Fernandez-Salguero P, Fox CH, Ward JM, Gonzalez FJ.
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
Genes Dev. 10: 60-9, 1996.
3)  Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC, Kimura S.
UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor.
Mol. Endocrinol. 15: 2021-36, 2001.
4)  Kusakabe T, Kawaguchi A, Hoshi N, Kawaguchi R, Hoshi S, Kimura S.
Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid.
Mol. Endocrinol. 20: 1796-809, 2006.
5)  Hoshi N, Kusakabe T, Taylor BJ, Kimura S.
Side population cells in the mouse thyroid exhibit stem/progenitor cell-like characteristics.
Endocrinology. 148: 4251-8, 2007.
6)  Katagiri N, Uemae Y, Sakamoto J, Hidaka Y, Susa T, Kato Y, Kimura S, Suzuki M.
Molecular cloning and functional characterization of two forms of Pax8 in the rainbow trout, Oncorhynchus mykiss.
Gen. Comp. Endocrinol. 198: 22-31, 2014.
7)  Cai Y, Winn ME, Zehmer JK, Gillette WK, Lubkowski JT, Pilon AL, Kimura S.
Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung development and fibrosis.
Am. J. Physiol. Lung Cell Mol. Physiol. 306: L10-22, 2014.
8)  Miyano Y, Tahara S, Sakata I, Sakai T, Abe H, Kimura S, Kurotani R.
Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.
Cell Tissue Res. 356: 253-60, 2014.
9)  Kimura S.
Thyroid regeneration: how stem cells play a role?.
Front Endocrinology. 5: 55, 2014.
10)  Snyder EL, Watanabe H, Magendantz M, Hoersch S, Chen TA, Wang DG, Crowley D, Whittaker CA, Meyerson M, Kimura S, Jacks T.
Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma.
Mol. Cell. 50: 185-99, 2013.
11)  Cai Y, Kimura S.
Noninvasive intratracheal intubation to study the pathology and physiology of mouse lung.
J Vis Exp. e50601, 2013.
12)  Cai Y, Zhu L, Zhang F, Niu G, Lee S, Kimura S, Chen X.
Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs).
Mol. Pharm. 10: 2237-47, 2013.
13)  Shimamura M, Nakahara M, Orim F, Kurashige T, Mitsutake N, Nakashima M, Kondo S, Yamada M, Taguchi R, Kimura S, Nagayama Y.
Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma.
Endocrinology. 154: 4423-4430, 2013.
14)  Okamoto M, Hayase S, Miyakoshi M, Murata T, Kimura S.
Stem cell antigen 1-positive mesenchymal cells are the origin of follicular cells during thyroid regeneration.
PLoS ONE. 8: e80801, 2013.
15)  Kimura S, Paiz J, Yoneda M, Kido T, Vinson C, Ward JM.
Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse.
Mol. Cancer. 11: 90, 2012.
16)  Guha A, Vasconcelos M, Cai Y, Yoneda M, Hinds A, Qian J, Li G, Dickel L, Johnson JE, Kimura S, Guo J, McMahon J, McMahon AP, Cardoso WV.
Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.
Proc. Natl. Acad. Sci. U.S.A. 109: 12592-7, 2012.
17)  Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.
Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy.
Invest Ophthalmol Vis Sci. 53: 4055-62, 2012.
18)  Ozaki T, Matsubara T, Seo D, Okamoto M, Nagashima K, Sasaki Y, Hayase S, Murata T, Liao XH, Hanson J, Rodriguez-Canales J, Thorgeirsson SS, Kakudo K, Refetoff S, Kimura S.
Thyroid regeneration: characterization of clear cells after partial thyroidectomy.
Endocrinology. 153: 2514-25, 2012.
19)  Ock S, Lee SH, Ahn J, Lee TJ, Cho CH, Abel ED, Kimura S, Kim J.
Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function.
Endocr. J. 58: 1013-9, 2011.
20)  Dranovsky A, Picchini AM, Moadel T, Sisti AC, Yamada A, Kimura S, Leonardo ED, Hen R.
Experience dictates stem cell fate in the adult hippocampus.
Neuron. 70: 908-23, 2011.
21)  Kido T, Tomita T, Okamoto M, Cai Y, Matsumoto Y, Vinson C, Maru Y, Kimura S.
FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo.
Am. J. Physiol. Lung Cell Mol. Physiol. 300: L441-52, 2011.
22)  Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S.
Secretoglobin 3A2 Suppresses Bleomycin-induced Pulmonary Fibrosis by Transforming Growth Factor {beta} Signaling Down-regulation.
J. Biol. Chem. 286: 19682-92, 2011.
23)  Magno L, Kretz O, Bert B, Ersözlü S, Vogt J, Fink H, Kimura S, Vogt A, Monyer H, Nitsch R, Naumann T.
The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1.
Eur. J. Neurosci. 34: 1767-82, 2011.
24)  Lin CI, Barletta JA, Nehs MA, Morris ZS, Donner DB, Whang EE, Jeong JW, Kimura S, Moore FD, Ruan DT.
Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activity.
Surgery. 150: 1295-302, 2011.
25)  Kimura S.
Thyroid-specific transcription factors and their roles in thyroid cancer.
J Thyroid Res. 2011: 710213, 2011.
26)  Franco AT, Malaguarnera R, Refetoff S, Liao XH, Lundsmith E, Kimura S, Pritchard C, Marais R, Davies TF, Weinstein LS, Chen M, Rosen N, Ghossein R, Knauf JA, Fagin JA.
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
Proc. Natl. Acad. Sci. U.S.A. 108: 1615-20, 2011.
27)  Gilbert-Sirieix M, Makoukji J, Kimura S, Talbot M, Caillou B, Massaad C, Massaad-Massade L.
Wnt/β-Catenin Signaling Pathway Is a Direct Enhancer of Thyroid Transcription Factor-1 in Human Papillary Thyroid Carcinoma Cells.
PLoS ONE. 6: e22280, 2011.
28)  Chiba Y, Tanabe M, Sakai H, Kimura S, Misawa M.
A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells.
Biochem. Biophys. Res. Commun. 401: 487-90, 2010.
29)  Ozaki T, Nagashima K, Kusakabe T, Kakudo K, Kimura S.
Development of thyroid gland and ultimobranchial body cyst is independent of p63.
Laboratory investigation; a journal of technical methods and pathology. 2010.
30)  Chiba Y, Goto K, Matsusue K, Kimura S, Misawa M.
Identification and characterization of rat RhoA gene promoter.
J. Pharmacol. Sci. 112: 467-72, 2010.
31)  Kurotani R, Kumaki N, Naizhen X, Ward JM, Linnoila RI, Kimura S.
Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans.
Lung cancer (Amsterdam, Netherlands). 2010.
32)  Flandin P, Kimura S, Rubenstein JL.
The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons.
J. Neurosci. 30: 2812-23, 2010.
33)  Goto K, Chiba Y, Matsusue K, Hattori Y, Maitani Y, Sakai H, Kimura S, Misawa M.
The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and TNF-alpha-induced RhoA transcriptions in human bronchial smooth muscle cells.
Pharmacol. Res. 61: 466-72, 2010.
34)  Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R.
IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
Biochem. Biophys. Res. Commun. 379: 964-8, 2009.
35)  Tomita T, Yamada A, Miyakoshi M, Kido T, Sheikh F, Srisodsai A, Miyajima A, Donnelly RP, Kimura S.
Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.
Am. J. Respir. Cell Mol. Biol. 40: 620-30, 2009.
36)  Hoshi S, Hoshi N, Okamoto M, Paiz J, Kusakabe T, Ward JM, Kimura S.
Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice.
Carcinogenesis. 30: 1614-9, 2009.
37)  Tomita T, Kido T, Kurotani R, Iemura S, Sterneck E, Natsume T, Vinson C, Kimura S.
CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression.
J. Biol. Chem. 283: 25617-27, 2008.
38)  Tachihara-Yoshikawa M, Ishida T, Watanabe K, Sugawara A, Kanazawa K, Kanno R, Suzuki T, Niimi T, Kimura S, Munakata M.
Expression of secretoglobin3A2 (SCGB3A2) in primary pulmonary carcinomas.
Fukushima journal of medical science. 54: 61-72, 2008.
39)  Inoue K, Wang X, Saito J, Tanino Y, Ishida T, Iwaki D, Fujita T, Kimura S, Munakata M.
Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma.
Allergol Int. 57: 57-64, 2008.
40)  Nóbrega-Pereira S, Kessaris N, Du T, Kimura S, Anderson SA, Marín O.
Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors.
Neuron. 59: 733-45, 2008.
41)  Tomita T, Kimura S.
Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression.
BMC Mol. Biol. 9: 5, 2008.
42)  Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S.
Role of Secretoglobin (SCGB) 3A2 in Lung Development.
Am. J. Respir. Crit. Care Med. 178(4): 389-98, 2008.
43)  Butt SJ, Sousa VH, Fuccillo MV, Hjerling-Leffler J, Miyoshi G, Kimura S, Fishell G.
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes.
Neuron. 59: 722-32, 2008.
44)  Chen C, Ma X, Malfatti MA, Krausz KW, Kimura S, Felton JS, Idle JR, Gonzalez FJ.
A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.
Chem. Res. Toxicol. 20: 531-42, 2007.
45)  Zhang Y, Rath N, Hannenhalli S, Wang Z, Cappola T, Kimura S, Atochina-Vasserman E, Lu MM, Beers MF, Morrisey EE.
GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo.
Development. 134: 189-98, 2007.
46)  Yeager N, Klein-Szanto A, Kimura S, Di Cristofano A.
Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.
Cancer Res. 67: 959-66, 2007.
47)  Ueda R, Iketaki H, Nagata K, Kimura S, Gonzalez FJ, Kusano K, Yoshimura T, Yamazoe Y.
A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes.
Mol. Pharmacol. 69: 1924-30, 2006.
48)  Yang Q, Yamada A, Kimura S, Peters JM, Gonzalez FJ.
Alterations in skin and stratified epithelia by constitutively activated PPARalpha.
J. Invest. Dermatol. 126: 374-85, 2006.
49)  Mastronardi C, Smiley GG, Raber J, Kusakabe T, Kawaguchi A, Matagne V, Dietzel A, Heger S, Mungenast AE, Cabrera R, Kimura S, Ojeda SR.
Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function.
J. Neurosci. 26: 13167-79, 2006.
50)  Yin Z, Gonzales L, Kolla V, Rath N, Zhang Y, Lu MM, Kimura S, Ballard PL, Beers MF, Epstein JA, Morrisey EE.
Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression.
Am. J. Physiol. Lung Cell Mol. Physiol. 291: L191-9, 2006.
51)  Niimi T, Kurotani R, Kimura S, Kitagawa Y.
Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells.
Biochem. Biophys. Res. Commun. 349: 588-96, 2006.
52)  Kusakabe T, Hoshi N, Kimura S.
Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid.
Dev. Dyn. 235: 1300-9, 2006.
53)  Yang Q, Kurotani R, Yamada A, Kimura S, Gonzalez FJ.
Peroxisome Proliferator-Activated Receptor {alpha} Activation during Pregnancy Severely Impairs Mammary Lobuloalveolar Development in Mice.
Endocrinology. 147: 4772-80, 2006.
54)  Shin M, Kim I, Inoue Y, Kimura S, Gonzalez FJ.
Regulation of Mouse Hepatic {alpha}-Amino-{beta}-carboxymuconate-{epsilon}-semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-NAD Pathway, by Hepatocyte Nuclear Factor 4{alpha} and Peroxisome-Proliferator Activated Receptor{alpha}.
Mol Pharmacol. 2006.
55)  Chiba Y, Kurotani R, Kusakabe T, Miura T, Link BW, Misawa M, Kimura S.
Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice.
Am. J. Respir. Crit. Care Med. 173: 958-64, 2006.
56)  Amendola E, De Luca P, Macchia PE, Terracciano D, Rosica A, Chiappetta G, Kimura S, Mansouri A, Affuso A, Arra C, Macchia V, Di Lauro R, De Felice M.
A mouse model demonstrates a multigenic origin of congenital hypothyroidism.
Endocrinology. 146: 5038-47, 2005.
57)  Cheung C, Ma X, Krausz KW, Kimura S, Feigenbaum L, Dalton TP, Nebert DW, Idle JR, Gonzalez FJ.
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.
Chem. Res. Toxicol. 18: 1471-8, 2005.
58)  Ohyama K, Ellis P, Kimura S, Placzek M.
Directed differentiation of neural cells to hypothalamic dopaminergic neurons.
Development. 132: 5185-97, 2005.
59)  Yamada A, Kimura S.
Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha.
FEBS Lett. 579: 2221-5, 2005.
60)  Yamada A, Sheikh F, Niimi T, DeMayo FJ, Keegan AD, Donnelly RP, Kimura S.
Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13.
J. Immunol. 175: 5708-15, 2005.
61)  Chiba Y, Srisodsai A, Supavilai P, Kimura S.
Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation.
Immunol Lett. 97: 123-9, 2005.
62)  Shima Y, Zubair M, Ishihara S, Shinohara Y, Oka S, Kimura S, Okamoto S, Minokoshi Y, Suita S, Morohashi K.
Ventromedial Hypothalamic Nucleus-Specific Enhancer of Ad4BP/SF-1 Gene.
Mol Endocrinol. 2005.
63)  Parlato R, Rosica A, Rodriguez-Mallon A, Affuso A, Postiglione MP, Arra C, Mansouri A, Kimura S, Di Lauro R, De Felice M.
An integrated regulatory network controlling survival and migration in thyroid organogenesis.
Dev Biol. 276: 464-75, 2004.
64)  Chiba Y, Kusakabe T, Kimura S.
Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9.
Am J Physiol Lung Cell Mol Physiol. 287: L1193-8, 2004.
65)  Daugherty BL, Mateescu M, Patel AS, Wade K, Kimura S, Gonzales LW, Guttentag S, Ballard PL, Koval M.
Developmental regulation of claudin localization by fetal alveolar epithelial cells.
Am J Physiol Lung Cell Mol Physiol. 287: L1266-73, 2004.
66)  Pan Q, Li C, Xiao J, Kimura S, Rubenstein J, Puelles L, Minoo P.
In vivo characterization of the Nkx2.1 promoter/enhancer elements in transgenic mice.
Gene. 331: 73-82, 2004.
67)  Srisodsai A, Kurotani R, Chiba Y, Sheikh F, Young HA, Donnelly RP, Kimura S.
Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1.
J Biol Chem. 279: 54358-68, 2004.
68)  Ward JM, Nikolov NP, Tschetter JR, Kopp JB, Gonzalez FJ, Kimura S, Siegel RM.
Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice.
Toxicol Pathol. 32: 710-8, 2004.
69)  Kusakabe T, Kawaguchi A, Kawaguchi R, Feigenbaum L, Kimura S.
Thyrocyte-specific expression of Cre recombinase in transgenic mice.
Genesis. 39: 212-6, 2004.
70)  Kimura S.
[Homeodomain transcription factor T/EBP/NKX2.1 in development and differentiation of the thyroid and lung].
Seikagaku. 75: 1493-504, 2003.
71)  Kawano H, Horie M, Honma S, Kawamura K, Takeuchi K, Kimura S.
Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.
Exp Neurol. 182: 103-12, 2003.
72)  Kimura S, Kawabe M, Yu A, Morishima H, Fernandez-Salguero P, Hammons GJ, Ward JM, Kadlubar FF, Gonzalez FJ.
Carcinogensis of the food mutagen PhIP in mice is independent of CYP1A2.
Carcinogensis. 24: 583-587, 2003.
73)  Moeller LC, Kimura S, Kusakabe T, Liao XH, Van Sande J, Refetoff S.
Hypothyroidism in Thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the Thyroid stimulating hormone receptor.
Mol Endocrinol. 17: 2295-2302, 2003.
74)  Yim SH, Ward JM, Dragan Y, Yamada A, Scacheri PC, Kimura S, Gonzalez FJ.
Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles.
Toxicol Pathol. 31: 295-303, 2003.
75)  Gonzalez FJ, Kimura S.
Study of P450 function using gene knockout and transgenic mice.
Arch Biochem Biophys. 409: 153-8, 2003.
76)  Niimi T, Munakata M, Keck-Waggoner CL, Popescu NC, Levitt RC, Hisada M, Kimura S.
A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma.
Am J Hum Genet. 70: 718-25, 2002.
77)  Niimi T, Copeland NG, Gilbert DJ, Jenkins NA, Srisodsai A, Zimonjic DB, Keck-Waggoner CL, Popescu NC, Kimura S.
Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family.
Cytogenet Genome Res. 97: 120-7, 2002.
78)  Snyderwine EG, Yu M, Schut HA, Knight-Jones L, Kimura S.
Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice.
Food Chem Toxicol. 40: 1529-33, 2002.
79)  Wert SE, Dey CR, Blair PA, Kimura S, Whitsett JA.
Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation.
Dev Biol. 242: 75-87, 2002.
80)  Pohlenz J, Dumitrescu A, Zundel D, Martiné U, Schönberger W, Koo E, Weiss RE, Cohen RN, Kimura S, Refetoff S.
Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice.
J Clin Invest. 109: 469-73, 2002.
81)  Pakarinen P, Kimura S, El-Gehani F, Pelliniemi LJ, Huhtaniemi I.
Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice.
Endocrinology. 143: 4477-82, 2002.
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This page was last updated on 6/20/2014.